Nanomaterials
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2022
·Vol. 12
·期 18
·3191
·
IF 5.719
An-Tian Huang,Jun Du,Zhi-Yong Liu,Guang-Cong Zhang,Weinire Abuduwaili,Jia-Yan Yan,Jia-Lei Sun,Ru-Chen Xu,Tao-Tao Liu,Xi-Zhong Shen,Ling Dong,Ji-Min Zhu,Yuhao Li
Hepatocellular carcinoma (HCC) accounts for the predominant form of liver malignancy and presents a leading cause of cancer-related death globally. Sorafenib (SOR), a first-line targeted drug for advanced HCC treatment, has a battery of untoward side effects. Photothermal therapy (PTT) has been utilized as an effective adjuvant in synergy with other approaches. However, little is known about the tumoricidal efficacy of combining SOR with PTT for HCC. Herein, a novel versatile nanoparticle, Cu2−x[email protected]@PEG (CSP), that is based on a photothermal Cu2−xSe core and SOR for simultaneously reinforcing PTT and reducing the adverse effects of SOR was constructed. The synthesized CSP exhibited a remarkably enhanced therapeutic effect upon 808 nm laser irradiation via dampening HCC cell propagation and metastasis and propelling cell apoptosis. The intravenous administration of CSP substantially suppressed tumor growth in a xenograft tumor mouse model. It was noted that the CSP manifested low toxicity and excellent biocompatibility. Together, this work indicates a promising and versatile tool that is based on synergistic PTT and molecular-targeted therapy for HCC management.Keywords:sorafenib;hepatocellular carcinoma;copper(I) selenide;photothermal therapy;synergistic therapy
研究领域:
肿瘤学
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纳米医学
·
生物材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2020
·
IF 5.339
Li Jun Gong,Yuan Fang Li,Hong Yan Zou,Cheng Zhi Huang
Heparin (Hep) is a mucopolysaccharide sulfate anticoagulant drug widely used in clinic and thus the quantification of Hep concentration is of great significance. In this work, a simple resonance light scattering (RLS) method for the determination of Hep concentration using plasmonic copper selenide nanoparticles (Cu 2-x Se NPs) was developed. The positively-charged Cu 2-x Se NPs capped by cetyltrimethyl ammonium bromide (CTAB) were aggregated by negatively-charged Hep, consequently inducing a significant enhancement in the RLS signals of plasmonic Cu 2-x Se NPs. Under the optimal reaction conditions, the increased RLS intensity is linearly correlated with the concentrations of Hep in the range of 0.01–0.60 μg mL −1 (R 2 = 0.999), with a low detection limit (LOD) of 4.0 ng mL −1 (3σ). This method offered a simple, sensitive and selective strategy for determining Hep, which can be further successfully applied to quantify Hep in the heparin sodium injection.
研究领域:
分析化学
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生物医学工程
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药物分析
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 25
·11725-11734
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IF 4.682
Cheng Haoyan,Xia Wanting,Zhao Zhipeng,Wang Wenjing,Song Kexing,Li Haitao,Cheng Chu,Hu Hao
Solar-driven water evaporation, a promising method to obtain freshwater resources, has drawn intensive attention recent years due to the abundance of solar energy and scarcity of clean water. Here, we introduce a robust strategy to obtain a series of polydopamine-modified Cu 2− x Se nano-composites (Cu 2− x Se@PDAs) with core@shell structure, which has strong absorption in solar spectrum and outstanding photothermal conversion efficiency for freshwater production. Temperature of the obtained Cu 2− x Se@PDA30 aqueous solution could increase from 19.4 to 70.6 °C in 5 min under the irradiation of 980-nm NIR laser with the power density of 0.002 kW·cm −2 . Under 0.5 simulated sunlight irradiation, water evaporation rates were as high as 3.36 kg·m −2 ·h −1 when using the Cu 2− x Se@PDA30 for desalination, indicating excellent evaporation efficiency under weak light. Moreover, the obtained Cu 2− x Se@PDA30 can also apply to wastewater purification and the evaporation rate could reach 2.71 kg·m −2 ·h −1 under an irradiation of simulated sunlight with intensity of 1 kW·m −2 . These results provided new insight into solar desalination and wastewater treatment using nanoscale semiconductor materials.
研究领域:
材料科学
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环境科学
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能源科学
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2018
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IF 8.097
Jiali Jiang,He Li,Tao Fu,Bing-Joe Hwang,Xue Li,Jinbao Zhao
In this work, nonstoichiometric Cu2–xSe fabricated by a facile water evaporation process is used as high-performance Al-ion battery cathode materials. Cu2–xSe electrodes show high reversible capacity and excellent cycling stability, even at a high current density of 200 mA g–1, the specific charge capacity in the initial cycle is 241 mA h g–1 and maintains 100 mA h g–1 after 100 cycles with a Coulombic efficiency of 96.1%, showing good capacity retention. The prominent kinetics of Cu2–xSe electrodes is also revealed by the GITT, which is attributed to the ultrahigh electronic conductivity of the Cu2–xSe material. Most importantly, an extensive research is dedicated to investigating the detailed intercalation and de-intercalation of relatively large chloroaluminate anions into the cubic Cu2–xSe, which is conducive to better understand the reaction mechanism of the Al/Cu2–xSe battery.
研究领域:
材料科学
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电化学
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能源存储
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纳米材料
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电池技术
✓ 已验证
DOI
高影响因子
Nanoscale
·
2014
·Vol. 6
·期 17
·10289-10296
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IF 6.739
Shao Qing Lie,Dong Mei Wang,Ming Xuan Gao,Cheng Zhi Huang
Copper chalcogenide nanocrystals (CuCNCs) as a type of semiconductor that can also act as efficient catalysts are rarely reported. Herein, we study water-soluble size-controlled Cu2−xSe nanocrystals (NCs), which are copper deficient and could be prepared by a redox reaction with the assistance of surfactants. We found them to have strong near-infrared localized surface plasmon resonance (LSPR) properties originating from the holes in the valence band, and also catalytic activity of more than a 500-fold enhancement of chemiluminescence (CL) in a luminol–H2O2 system. Investigations into the mechanisms behind these results showed that the high concentration of free carriers in Cu2−xSe NCs, which are derived from their high copper deficiencies that make Cu2−xSe NCs both good electron donors and acceptors with high ionic mobility, could greatly enhance the catalytic ability of Cu2−xSe NCs to facilitate electron-transfer processes and the decomposition of H2O2 into OH˙ and O2˙−, which are the commonly accepted key intermediates in luminol CL enhancement. Thus, it can be concluded that controllable copper deficiencies that are correlated with their near-infrared LSPR are critically responsible for the effective catalysis of Cu2−xSe NCs in the enhanced CL.
研究领域:
材料科学
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化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF PHYSICS-CONDENSED MATTER
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2022
·Vol. 34
·期 25
·255001
·
IF 2.745
Baomei Wang,Xingna Liu,Zhen Liu,Zinan Ma,Zhongwei Li,Bingrui Wang,Xiao Dong,Yongyong Wang,Xiaohui Song
In this work, copper selenide (Cu2−xSe) thin films were grown on FTO conductive glass substrates using a facile microwave-assisted hydrothermal method. The effects of synthesis parameters such as precursor components and deposition time on the stoichiometry and morphology of the synthesized films were systematically investigated through different techniques including XRD, SEM, and AFM. In order to evaluate the electrochemical catalytic performance of the synthesized copper selenide in electrolyte containing the sulfide/polysulfide redox couple, we assembled liquid-junction quantum dots-sensitized solar cells (QDSSC) using the synthesized copper selenide thin films as counter electrodes and CdSe quantum dots-sensitized mesoporous TiO2 as photoanodes. Under the illumination of one Sun (100 mW cm−2), the QDSSC assembled with the optimal copper selenide CEs (Cu:Se = 1:1) exhibited a power conversion efficiency of 2.07%, which is much higher than that of traditional Pt counter electrode (0.76%).
研究领域:
材料科学
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能源技术
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电化学
✓ 已验证
DOI
高影响因子
TALANTA
·
2024
·
IF 5.6
Yangyang Lu,Xuechi Yin,Mei Li,Wanlu Ma,Sining Du,Zixuan Wang,Nannan Qiu,Xubo Zhao
In the study, an eccentric heterogeneous core-shell nanomaterial Au@Cu 2-x Se was simply and rapidly synthesized. This novel nano-structure exhibits superior colorimetric intensity, enhanced antibody coupling efficiency, and strong broadband absorption across the visible to near-infrared spectrum, with a photothermal conversion efficiency of 59.40%. As proof of concept, we applied Au@Cu 2-x Se as a signal amplification marker in LFIA for the rapid detection of zearalenone (ZEN), enabling dual-mode quantitative detection via colorimetric and photothermal signals (CM/PT). The Au@Cu 2-x Se-LFIA demonstrated a cut-off value of 10 ng/mL in colorimetric mode and 5 ng/mL in photothermal mode, representing a two fold increase in sensitivity compared to traditional AuNPs-based LFIAs. The outstanding colorimetric signal and prominent photothermal signal make the proposed Au@Cu 2-x Se nanomaterial show better application prospects in CM/PT mode detection in LFIA, providing broad application prospects for the broad-spectrum detection of mycotoxins in food in the future.
研究领域:
食品安全检测
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纳米生物技术
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分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2026
·
IF 8.7
Feixiao Ma,Anqi Ji,Beng Ma,Pingjuan Yang,Jiayi Li,Shuxin Liao,Haonan Yao,Xuanhu Xie,Zhiwei Wang,Linlin Shi,Shegan Gao,Xin Hou
Purpose Esophageal cancer (EC) ranks among the most prevalent and lethal malignancies worldwide, and conventional therapeutic modalities, including surgery, radiotherapy, and chemotherapy, are constrained by inherent limitations. Recent advances in nanomedicine have opened new avenues for EC treatment. To achieve efficient and precise tumor eradication, this study developed a pH-responsive composite nanoplatform featuring a hollow architecture to enable high-efficiency loading of photosensitizers and realize multimodal synergistic therapy against EC through the integration of photothermal therapy (PTT), photodynamic therapy (PDT), and chemodynamic therapy (CDT).Methods A pH-responsive Cu2-xSe/PDA/IR820 composite nanoplatform was constructed by coating hollow Cu2-xSe nanoparticles with polydopamine PDA and loading the near-infrared photosensitizer IR820. Morphology, crystalline phase, elemental composition, and surface chemistry were characterized by TEM, XRD, XPS, and FT-IR. Photothermal conversion efficiency was quantified under 808 nm laser irradiation. IR820 release kinetics were monitored under different pH conditions of 5.0, 6.0, and 7.0 to assess pH-responsive behavior. In vitro studies on KYSE-150 EC cells included viability by CCK-8 assay, apoptosis by flow cytometry, ROS generation by DCFH-DA probe, mitochondrial membrane potential by JC-1 staining, and cellular uptake analysis. In vivo antitumor efficacy and biosafety were evaluated in an AKR tumor-bearing C57BL/6J mouse model via intratumoral injection and 808 nm laser irradiation, followed by tumor volume measurement, histopathological analysis with H&E, Ki-67, and TUNEL staining, and systemic toxicity assessment.Results The hollow Cu2-xSe/PDA/IR820 nanoparticles exhibited a uniform size of approximately 164 nm, excellent colloidal stability, and a high photothermal conversion efficiency of 44.56% under 808 nm laser irradiation. IR820 release displayed pronounced pH sensitivity, with a cumulative release of 23.07% at pH 5.0 within 30 minutes. In vitro, the nanoplatform combined with laser irradiation reduced KYSE-150 cell viability to 1.2% at 100 μg/mL, with an IC50 value of 18.74 μg/mL, induced 28.57% apoptosis, elevated intracellular ROS levels, decreased mitochondrial membrane potential, and depleted glutathione to 335 μmol/gprot. In vivo fluorescence imaging confirmed effective tumor accumulation via the EPR effect, with peak signal at 24 hours post-injection. Combined PTT/PDT/CDT treatment significantly suppressed tumor growth, reducing final tumor volume to 17.8% of the control group, and induced extensive apoptosis and necrosis in tumor tissues. Systemic biosafety evaluations revealed no significant hematological or histopathological abnormalities.Conclusion Hollow Cu2-xSe/PDA/IR820 composite nanoparticles loaded with IR820 were successfully fabricated and demonstrated remarkable advantages in multimodal combination therapy against EC.
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DOI
PubMed
高影响因子
Redox Biology
·
2025
·
IF 11.9
Ding Liu,Yuanzhi Ye,Zirong Lan,An Chen,Xingchen Zhou,Zhenhao Li,Xin Wen,Jisheng Xiao,Fan Ouyang,Jianyun Yan
Vascular calcification, prevalent in patients with chronic kidney disease, atherosclerosis, and diabetes, is strongly associated with elevated cardiovascular morbidity and mortality, highlighting the urgent need for effective treatments. Oxidative stress is a key contributor to the progression of vascular calcification. Nanozymes, nanomaterials with enzyme-like catalytic properties, exhibit strong reactive oxygen species (ROS) scavenging abilities and good biocompatibility, making them promising therapeutic candidates. This study aims to investigate whether polyvinylpyrrolidone (PVP)-functionalized ultrasmall Cu 2-x Se nanoparticles (CSP NPs) act as nanozymes for treating vascular calcification. In vitro , CSP NPs significantly inhibit calcification of rat and human vascular smooth muscle cells (VSMCs) and reduce the expression of osteogenic markers Runx2 and BMP2. Moreover, CSP NPs alleviate calcification of rat and human arterial rings. In a mouse model, CSP NPs localize to certain areas, such as the aortic arch and abdominal aortas, and are safely metabolized by the liver and kidneys without organ toxicity. Further analyses confirm that CSP NPs inhibit mouse and chronic kidney disease (CKD) rat aortic calcification. Mechanistically, CSP NPs inhibit oxidative stress and mitochondrial dysfunction. Additionally, CSP NPs decrease the expression of NF-κB and NLRP3, thus reducing the levels of inflammatory cytokines IL-1β and IL-6. CSP NPs suppress NLRP3 activator-induced calcification in VSMCs and arterial rings. This study provides the first evidence that CSP NPs alleviate vascular calcification by inhibiting oxidative stress and NF-κB/NLRP3-mediated inflammation, suggesting a promising therapeutic approach.
研究领域:
纳米医学
·
心血管研究
·
炎症生物学
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氧化应激
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Energy Storage Materials
·
2019
·
IF 0
Yunjie Li,Xiucai Sun,Zhenjie Cheng,Xiao Xu,Jun Pan,Xianfeng Yang,Fang Tian,Yanlu Li,Jian Yang,Yitai Qian
Transitional metal chalcogenides , one important family of promising candidates as electrode materials for sodium-ion batteries, gradually convert to Cu 2 S or Cu 2 Se in the discharge/charge processes, due to electrochemically driven copper diffusion. Thus, their performances after the electrochemical activation, actually come from copper chalcogenides . In this regard, the thorough investigation on the electrochemical properties of copper chalcogenides is important and necessary for the rational design of transitional metal chalcogenides . Here, mesoporous Cu 2-x Se nanocrystals synthesized by a simple solvothermal reaction, are used as a model. They experience the complicated intercalation reaction and the conversion reaction upon cycling, as supported by in-situ / ex-situ techniques and first-principle calculations. All these reactions are highly reversible, leading to 96.1% of the theoretical capacity. These nanocrystals preserve 88% of the initial capacity after 3000 cycles at 5 A g −1 . Even at 10 A g −1 , the capacity is still kept as 92.1% of that at 0.1 A g −1 . In full cells, the nanocrystals without any pre-sodiation and pre-activation, present a lifespan up to 2000 cycles at 0.5 A g −1 and a capacity retention about 74.2%.
研究领域:
材料科学
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电化学
·
纳米科技
·
能源存储
·
无机化学
✓ 已验证
DOI
ACS Applied Nano Materials
·
2023
·
IF 5.9
Ming Zhong,Xue Guo,Lingling Li,Yun-Wu Li,Kun Zhao,Hui Peng,Xiaobo Zhang
Owing to the mixed insertion and multielectron conversion reaction mechanisms, nonstoichiometric copper selenide (Cu2–xSe) has been known as a potential anode for lithium-ion batteries. However, huge volume changes during discharge and charge limit its ability for lithium-ion storage. Constructing heterophase nanocomposite uniformly distributed in the carbon network has been recognized as an effective approach to address the above issue. In this work, polyoxometalate-based metal–organic frameworks were used as the self-template to derive octahedral mesoporous carbon-coated heterophase copper selenide and molybdenum dioxide (MoO2/Cu2–xSe@C) nanocomposites, and the phase transformation of copper selenides from CuSe to Cu2–xSe can be achieved by tuning the pyrolysis temperature, thus optimizing the electrochemical performance. As a result, the optimized electrode delivers a high reversible specific capacity of 864.8 mAh g–1 at 0.2 A g–1 after 100 cycles, an excellent rate capability with a capacity of 480.9 mAh g–1 at 2.0 A g–1, and a long-term stability up to 500 cycles with a capacity decay rate per cycle of only 0.003%. Also, the reaction mechanism and structural stability after cycling were analyzed in detail.
研究领域:
材料科学
·
能源存储
✓ 已验证
产品关联
DOI
高影响因子
ACS Nano
·
2019
·
IF 13.903
Qian Huang,Shaohua Zhang,Hao Zhang,Yaobao Han,Hanghang Liu,Feng Ren,Qiao Sun,Zhen Li,Mingyuan Gao
The small difference between tumor and normal tissues in their responses to ionizing radiation has been a significant issue for radiotherapy of tumors. Herein, we report that dumbbell-shaped heterogeneous copper selenide-gold nanocrystals can serve as an efficient radiosensitizer for enhanced radiotherapy. The mean lethal dose of X-rays to 4T1 tumor cells can be drastically decreased about 40%, that is, decreasing from 1.81 to 1.10 Gy after culture with heterostructures. Due to the synergetic effect of heterostructures, the dose of X-rays is also much lower than those obtained from mixture of Cu2–xSe + Au nanoparticles (1.78 Gy), Cu2–xSe nanoparticles (1.72 Gy) and Au nanoparticles (1.50 Gy), respectively. We demonstrate that the sensitivity enhancement ratio of Cu2–xSe nanoparticles was significantly improved 45% (i.e., from 1.1 to 1.6) after the formation of heterostructures with gold. We also show that the heteronanocrystals exhibit an enhanced photothermal conversion efficiency, due to the synergetic interactions of localized surface plasmon resonance. These properties highly feature them as a multimodal imaging contrast agent (particularly for photoacoustic imaging, computed tomography imaging, and single photon emission computed tomography after labeled with radioisotopes) and as a radiosensitizer for imaging guided synergetic radiophotothermal treatment of cancer. The research provides insights for engineering low-Z nanomaterials with high-Z elements to form heteronanostructures with enhanced synergetic performance for tumor theranostics.
研究领域:
生物医学工程
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癌症治疗
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纳米医学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）