JOURNAL OF HAZARDOUS MATERIALS
·
2021
·
IF 10.588
Yaru Hu,Dandan Lei,Da Wu,Jing Xia,Wang Zhou,Changzheng Cui
The discharge of pharmaceutical wastewater introduces numerous pollutants into the environment, and their pollution level reduction has aroused extensive concern. This study investigated the variation in residual antibiotics and ecotoxicity to two nutritional-level model organisms in the pharmaceutical wastewater treatment process (PWTP). The wastewater in the equalization tank contained massive organic matters (2.9–18.7 times higher than the permissible values in GB21903-2008) and antibiotics (310.88 μg/L), posing extremely toxic effects to Vibrio fischeri ( V. fischeri ) and Daphnia magna ( D. magna ) . The biological anaerobic/aerobic treatment units contributed the most to the reduction of antibiotics and the ecotoxicity to both organisms, with the removal rates of 72% and > 90%, respectively. The ecotoxicity of pharmaceutical wastewater was strongly and positively correlated with the residual antibiotics, amoxicillin, cephalexin, ammonia nitrogen, and total phosphorus ( P < 0.05). However, the detected amounts of amoxicillin and cephalexin were approximately 10 5 times lower than the predicted no-effect concentrations of amoxicillin and cephalexin to V. fischeri and D. magna in freshwater, which implied the joint ecotoxicity posed by multicomponent mixtures, such as the residual antibiotics and organic toxic substances, rather than the specific residual antibiotics. This study provides a better understanding of the variations and residual levels of pollutants in PWTPs , including their ecotoxicity risk to the aquatic environment, highlighting the need to optimize pharmaceutical wastewater treatment technologies .
研究领域:
环境科学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2022
·
IF 10.753
Lu Zhang,Tian Xia,Qi Liu,Lei Gu,Yunfei Sun,Zhou Yang
Nitrogenous pollutants derived from human activities not only pose direct risk on aquatic organisms but may also indirectly endanger the stability of interspecific relations. To date, the effects of the nitrogen-containing pollutants on the induced defense remain unclear. Here, we aim to investigate the induced defense of an aquatic keystone species , Daphnia pulex, which responds to predation risk under nitrite pollution at environmentally relevant concentrations and simultaneously evaluate the effects of their induced defenses on nitrite tolerance. Results showed that increasing nitrite significantly reduced the survival time of D. pulex and posed severe reproductive toxicity, consequently reducing the offspring and broods. In the morphological defensive responses, early nitrite exposure interfered with the spine elongation, but the relative spine length induced by the predation risk was unaffected by the nitrite concentrations with exposure time prolonged, although high-dose nitrite inhibited the spine elongation and the increase of the body size. The integration of biomarker response index analyses further indicated that the reproductive capacity was more seriously impaired than the morphology and the survival. Moreover, the sensitivity analyses of growth and reproduction indicated that predation risk significantly reduced Daphnia's tolerance to nitrite. Conclusively, these findings highlight that long-term nitrite exposure exacerbates the predator-induced miniaturization of zooplanktons, and predation risk also reduces their tolerance to nitrite, which provides new insights into the performance changes of zooplanktons exposed to pollutants under predation risk and the vulnerability of predator–prey interspecific relationships in polluted environments.
研究领域:
生态毒理学
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环境科学
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产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2023
·
IF 9.8
Yuming Zhang,Wenjie Xiu,Miao Yan,Xinrui Guo,Zhihua Ni,Jihai Gu,Ting Tang,Fengsong Liu
Sulfamethoxazole (SMZ), a kind of sulfonamide antibiotic, is widely used in both human and veterinary medicine. Frequent detection of SMZ in natural aquatic environments has prompted growing attention and posed ecological risks to the ecosystem and human health. In this study, we investigated the ecotoxicological properties of SMZ upon Daphnia magna , and the mechanisms of the deleterious effects of SMZ were attempted to be elucidated by investigating a chain of parameters, including survival, reproduction, growth, locomotor behavior, metabolism, as well as levels of related enzyme activity and gene expression. After a 14-d sub-chronic exposure to SMZ at environmentally relevant concentrations, we observed virtually no lethal effect, weak growth inhibition, significant reproductive damage, evident ingestion rate decline, obvious change in locomotor behavior, and remarkable metabolic disorder. Notably, we identified SMZ as an inhibitor against acetylcholinesterase (AChE)/lipase in D. magna both in vivo and in vitro, which explained the adverse effects of SMZ on locomotor ability and lipid metabolism at the molecular levels. Furthermore, the direct interactions between SMZ and AChE/lipase were confirmed by using fluorescence spectrum and molecular docking. Together, our findings provide a new insight to advance the understanding of the environmental effects of SMZ on freshwater organisms.
研究领域:
生态毒理学
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环境科学
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水生毒理学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
·
2023
·
IF 8.9
Jingyi Guo,Na Liu,Qiting Xie,Lizhong Zhu,Fei Ge
Ubiquitous microplastics (MPs) may affect the trophic transfer of nanoparticles (NPs), in turn threatening aquatic organisms and even human health. Thus, this study explored the influence of polystyrene microplastics (PS MPs) on the biotoxicity and biomagnification of ZnO nanoparticles (ZnO NPs) in the aquatic food chain from Chlorella vulgaris ( C. vulgaris ) to Daphnia magna ( D. magna ). The results showed that PS MPs facilitated the biotoxicity of ZnO NPs towards D. magna after dietary exposure. Compared to the control (single ZnO NPs), the heart rate and the level of reactive oxygen species were remarkably increased by 21.25% and 16.32% in the combined system (PS MPs + ZnO NPs), respectively. Notably, PS MPs suppressed the ZnO NPs accumulation in C. vulgaris , while remarkably facilitating the trophic transfer of ZnO NPs to D. magna . The biomagnification of ZnO NPs was evident with a maximal biomagnification factor (BMF) of 1.49 under acute dietary exposure of PS MPs (72 h), but was absent in the single ZnO NPs system (BMF <0.90). Moreover, PS MPs resulted in a larger biomagnification of ZnO NPs with a maximal BMF of 2.11 under chronic dietary exposure (21 days). Furthermore, the Zn element (including ZnO NPs and released Zn 2+ ) was observed to accumulate in the intestine, thus causing ultrastructural damage and lipid droplet (LD) aggregate. Overall, these findings highlight the importance of considering the impact of MPs on co-existed pollutants and contribute to a better understanding of the ecological risks of MPs in aquatic ecosystems .
研究领域:
环境科学
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水生生态学
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纳米毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2023
·
IF 9.8
Jin J. Li,Min J. Dai,Jun Z. Xue
Exposure to disinfection by-products (DBPs) has been found to induce a range of toxic effects in aquatic organism. Previous studies have consistently demonstrated that a majority of DBPs have the ability to induce in vivo toxicity in aquatic organisms. However, the impact of DBPs on the metabolic processes of Daphnia magna ( D. magna ) and the underlying molecular toxicity mechanisms are still not well understood. Therefore, we investigated the effects of 14 DBPs on two oxidative stress enzymes and malondialdehyde (MDA) levels in D. magna . Additionally, we employed molecular docking to simulate the toxicity of DBPs to D. magna at the molecular level. This comprehensive analysis allowed us to gain further insights into the toxicity of DBPs on D. magna . The results showed that among the aliphatic DBPs, the more bromine substituents, the lower the toxicity effect, and it's opposite in the aromatic DBPs. In the detection of oxidative stress level, catalase (CAT) enzyme and superoxide dismutase (SOD) enzyme in D. magna under compound stress showed a low increase and decrease with the increase of concentration. The level of MDA showed a positive correlation with the concentration. In the last, molecular docking simulations have shown promise in predicting the toxicity of DBPs and providing insights into their toxic effects to a certain extent, and the docking situation of P53 is slightly different. Hence, it is imperative to further regulate the presence of aromatic DBPs due to their pronounced toxic effects on D. magna , and these simulations can be complemented with actual experiments to enhance our understanding of the toxicity mechanisms of DBPs.
研究领域:
环境科学
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毒理学
✓ 已验证
DOI
PubMed
高影响因子
Water Biology and Security
·
2026
·
IF 4.3
Yuming Zhang,Jinghua Lv,Yiwen Zhang,Yajie Zhang,Manxin Chen,Zifei Wang,Mei Wang,Moran Zhang,Penglong Zhao,Jihai Gu,Fengsong Liu
The spread of antibiotic resistance genes (ARGs), particularly through plasmid-mediated horizontal gene transfer, has emerged as a significant health concern. Tetracycline (TET) is among the most prevalent antibiotics in the aquatic environment. As a key crustacean zooplankton, Daphnia magna may ingest antibiotic-resistant microorganisms and promote the spread of ARGs under TET pressure. Herein, intragenus and intergenus conjugative transfer experiments were established between a donor strain, Escherichia coli MG1655 (carrying the multidrug-resistant RP4 plasmid), and D. magna -associated microbiota. Results demonstrated that TET exposure enhanced the horizontal transfer of RP4 to both recipient bacteria ( E. coli HB101) and D. magna -associated microbiota. The underlying mechanism involved the overproduction of reactive oxygen species, increased secretion of extracellular polymeric substances, enhanced membrane permeability, and improved energy metabolism. Furthermore, the RP4 plasmid was transferred to D. magna -associated microbiota via ingestion, and the predominant taxa within D. magna -associated microbiota served as a transconjugal pool for the plasmid. Specifically, TET exposure promoted the enrichment of potential pathogen taxa in D. magna -associated microbiota. Given the pivotal role of D. magna in freshwater food chains, the trophic transfer of ARGs induced by TET residues in aquatic environments warrants serious consideration.
✓ 已验证
DOI
高影响因子
WATER RESEARCH
·
2024
·
IF 11.4
Yao Li,Wenhong Fan,Xiaolong Yang,Shu Liu,Ying Wang,Wen-Xiong Wang
Cosmetics and personal care products containing titanium dioxide nanoparticles (TiO 2 NPs) may enter aquatic environments, where the surface coatings of TiO 2 NPs may change with aging due to environmental factors such as light, and potentially affect their bioaccumulation and toxicity. This study examined how aging impacted the physicochemical properties of three commercially available TiO 2 NPs and subsequent influence on the bioaccumulation and toxicity of copper (Cu) in Daphnia magna ( D. magna ). We demonstrated that aging significantly affected the hydrophobicity of TiO 2 NPs, which affected their binding to water molecules and adsorption of Cu. Changes of bioaccumulation of TiO 2 NPs and Cu in D. magna ultimately affected the activities of intracellular antioxidant enzymes such as SOD, CAT, GSH-Px, and the transmembrane protein Na + /K + –ATPase. Molecular docking calculations demonstrated that changes of activities of these biological enzymes were due to the interaction between TiO 2 NPs, Cu, and amino acid residues near the sites with the lowest binding energy and active center of the enzyme. Such effect was closely related to the hydrophobicity of TiO 2 NPs. Our study demonstrated the close relationship between surface properties of TiO 2 NPs and their biological effects, providing important evidence for understanding the behavior of nanomaterials in aquatic environments.
研究领域:
环境科学
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毒理学
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纳米生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2023
·
IF 6.1
Tingting Yuan,Hui Jiao,Lina Ai,Yafang Chen,Deyu Hu,Ping Lu
Sulfoxaflor is a promising neonicotinoid. However, the negative implications of sulfoxaflor on nontarget aquatic organisms have been rarely studied. In this study, the risks of sulfoxaflor and its main metabolites X11719474 and X11519540 on Daphnia magna were characterized, including acute toxicity, reproduction, swimming behavior, biochemical markers, and gene transcription. Acute toxicity measurements indicated that X11719474 and X11519540 have high toxicity than the parent compound sulfoxaflor. Chronic exposure reduced reproduction and delayed the birth of the firstborn D. magna. Swimming behavior monitoring showed that exposure to three compounds stimulated swimming behavior. The induction of catalase, superoxide dismutase, and acetylcholinesterase activities was observed with oxidative stress, whereas malondialdehyde content was remarkably increased with exposure to sulfoxaflor, X11719474, and X11519540. Moreover, transcriptomics profiles showed that sulfoxaflor, X11719474, and X11519540 induced KEGG pathways related to cellular processes, organismal systems, and metabolisms. The findings present valuable insights into the prospective hazards of these pesticides and emphasize the critical importance of conducting a systematic evaluation of combining antecedents and their metabolites.
研究领域:
环境毒理学
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水生生态学
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分子生物学
✓ 已验证
DOI
PubMed
高影响因子
ENVIRONMENTAL RESEARCH
·
2020
·
IF 5.715
Hongliang Dai,Tongshuai Sun,Ting Han,Zechong Guo,Xingang Wang,Yong Chen
The widespread applications of zinc oxide nanoparticles (ZnO NPs) have raised increasing concerns due to their adverse environmental effects. The ubiquitous natural organic matter in natural aqueous environments can interact with ZnO NPs, thereby affecting their aggregation, sedimentation and biotoxicity. Here, we systematically investigated the effects of humic acid (HA) and sodium alginate (SA) on the aggregation behavior of ZnO NPs and their biotoxicity to Daphnia magna . High concentrations (9.0 mg/L) of HA and SA accelerated the aggregation of ZnO NPs with maximum aggregation rates (ΔD/Δt) of 22.1 and 19.2 nm/min, respectively. Both HA and SA led to 31.2% and 30.1% decrease of ZnO NPs concentration compared with the control experiment. The results calculated by Derjaguin-Landau-Verwey-Overbeek theoretical formula were consistent with these of aggregation and sedimentation of ZnO NPs. Furthermore, excitation-emission-matrix fluorescence spectroscopy verified that the carboxylic groups of HA and SA have high complexation capacity with ZnO NPs. Daphnia magna was used to evaluate the biotoxicity of ZnO NPs, and the toxicity of ZnO NPs to Daphnia magna was alleviated as the HA concentration increased from 0 to 1.2 mg/L. Toxicity mitigation experiments confirmed that photocatalytic generation of reactive oxygen species was more toxic to Daphnia magna than dissolved Zn 2+ in acute and chronic toxicity tests . Moreover, the attacks of active oxygen free radical damaged the antioxidant system of Daphnia magna . The information obtained will help us to improve the understanding of the impacts of ZnO NPs on freshwater ecosystems .
研究领域:
环境科学
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水生毒理学
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纳米技术
·
生态学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
·
2015
·
IF 4.143
Xinghao Wang,Ruijuan Qu,Jiaoqin Liu,Zhongbo Wei,Liansheng Wang,Shaogui Yang,Qingguo Huang,Zunyao Wang
Experiments were conducted to investigate the effect of four different carbon nanotubes single- and multi-walled carbon nanotubes (SWCNTs and MWCNTs) and hydroxylated and carboxylated multi-walled carbon nanotubes (OH-MWCNTs and COOH-MWCNTs) on Cd toxicity to the aquatic organism Daphnia magna . The acute toxicity results indicated that all CNTs could enhance the toxicity of Cd to D. magna . Furthermore, the filtrate toxicity and adsorption tests showed that the toxicity-increasing effect of SWCNTs and MWCNTs in the overall system was mainly caused by catalysts impurities from the pristine CNTs, whereas the greater adsorption of Cd onto OH-MWCNTs (30.52 mg/g) and COOH-MWCNTs (24.93 mg/g) was the key factor contributing to the enhanced toxicity. This result raised a concern that the metal catalyst impurities, adsorption capacities, and accumulation of waterborne CNTs were responsible for the toxicity of Cd to aquatic organism.
研究领域:
环境科学
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毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
·
2014
·Vol. 33
·期 11
·2522-2528
·
IF 2.826
Chao Wang,Zhongbo Wei,Mingbao Feng,Liansheng Wang,Zunyao Wang
Hydroxylated multiwalled carbon nanotubes (OH-MWCNTs), with large amounts of hydrophilic groups attached on the nanoparticle surface, have caused considerable concern because of their inevitable release into aquatic environments. They may interact with other contaminants such as heavy metals and even influence their toxicity, fate, and transport. In the present study, the stability of OH-MWCNTs suspended in aerated Nanjing tap water (moderately hard) was evaluated using the spectrophotometric method. The toxicity of OH-MWCNTs to Daphnia magna was determined, and nontoxic concentrations were used in acute toxicity, accumulation, and sorption tests. It was found that OH-MWCNTs increased the Ni toxicity in a concentration-dependent manner under different pH levels. Nickel adsorption onto the OH-MWCNTs and the uptake of OH-MWCNTs increased the exposure of D. magna to Ni, which was verified by sorption and accumulation tests conducted under different pH levels. The lower pH level contributed to a higher overall toxicity, which could be interpreted by the increasing amount of Ni adsorption onto OH-MWCNTs with the decreasing pH levels. Environ Toxicol Chem 2014;33:2522–2528 . © 2014 SETAC
研究领域:
环境毒理学
·
纳米科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2013
·
IF 2.203
R.-J. Qu,X.-H. Wang,M.-B. Feng,Y. Li,H.-X. Liu,L.-S. Wang,Z.-Y. Wang
This study investigated the effect of pH on cadmium toxicity to three aquatic organisms: Photobacterium phosphoreum , Daphnia magna and Carassius auratus . The acute toxicity of Cd 2+ to P. phosphoreum and D. magna at five pH values (5.0, 6.0, 7.0, 8.0, and 9.0) was assessed by calculating EC 50 values. We determined that Cd 2+ was least toxic under acidic conditions, and D. magna was more sensitive to the toxicity of Cd than P. phosphoreum . To evaluate Cd 2+ -induced hepatic oxidative stress in C. auratus at three pH levels (5.0, 7.25, 9.0), the activity of antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase), the level of glutathione and the malondialdehyde content in the liver were measured. Oxidative damage was observed after 7 d Cd exposure at pH 9.0. An important finding of the current research was that Cd 2+ was generally more toxic to the three test organisms in alkaline environments than in acidic environments.
研究领域:
环境科学
·
水生毒理学
·
生态毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）