CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Taotao Huo,Xiaoyu Shan,Ziyi Wang,Jiaqi Song,Liang Shao,Yuquan Bai,Xianyi Yu,Qingyuan Yang,Guangying Li,Rongqin Huang
The particle size of ZIF-8 significantly influences its benefits in drug delivery and release, thereby determining therapeutic efficacy. Here, we investigate the correlations between drugs and ZIF-8 crystallization and discover that emodin can function as a binding template for zinc ions to accelerate nucleation processes via reducing the Gibbs free energy, while also serving as a capping agent on the {100} facets to regulate crystal growth. These dual roles, based on hydroxyl-substituted anthraquinone structure of emodin, can govern ZIF-8 crystallization, enabling the precise control over both size and morphology of emodin-loaded ZIF-8 (E@Z). Consequently, by regulating the feed ratio of emodin, E@Z ranging in size from 900 nm to 80 nm are successfully prepared. The therapeutic outcomes demonstrate that, in addition to enhancing the antibacterial effect of emodin, size-dependent degradation properties of E@Z enable a controlled release of emodin within tumor, ultimately amplifying its anti-tumor efficacy. Additionally, other natural anthraquinones compounds with structures similar to emodin also possess this ability to regulate ZIF-8 size. Our study provides a fundamental framework for the advancement of anthraquinone drugs and their potential applications in the field of ZIF-8-based size-dependent nanotherapeutics.
研究领域:
纳米技术
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材料科学
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药学
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生物化学
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医学研究
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产品关联
DOI
高影响因子
Biomaterials Science
·
2025
·
IF 5.7
Liying Wang,Mengxiang Tian,Bingzhi Dong,Weiqi Li,Liang Shi,Yifan Tong,Wei Chen,Xin Yu,Hongxia Xu,Bo Shen,Hong Yu
Acute pancreatitis (AP) is a common abdominal inflammatory disease, characterized by pancreatic autodigestion, acinar cell necrosis, and systemic inflammation. Currently, there is a lack of specific drugs in the treatment of AP. Traditional Chinese medicine (TCM) is an effective approach in the prevention and treatment of AP, with rheum being one of the key components in commonly used TCM formulas for treating AP. We screened emodin as the core active ingredient of rheum and developed a heparin-modified emodin carrier, EMO@ZIF-8/Heparin (HEZ), which specifically delivers emodin to the inflamed pancreatic tissue via CD44-targeted macrophage activation. The HEZ exhibited higher macrophage uptake efficiency in the inflammatory microenvironment, restored the mitochondrial membrane potential, alleviated oxidative stress, and effectively reduced the levels of cytokines in the AP cell model. Moreover, the formulation exhibited targeted enrichment and retention in the pancreas under AP conditions, blocking the systemic inflammatory amplification cascade, reducing approximately 50% of pathological damage in both pancreatic and lung tissues, decreasing the proportion of apoptotic pancreatic cells, and increasing the 15-day survival rate of AP mice from 15% to around 50%. Mechanistically, the formulation restored impaired macrophage mitochondrial function to a healthy state by inhibiting the JNK pathway. In summary, the multifunctional HEZ provides an upstream therapeutic strategy by targeting macrophages in AP, offering a novel and effective approach to potentially enhance AP treatment in the future.
研究领域:
药理学
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免疫学
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生物材料
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中医学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Jia Wan,Meifang Yin,Feng Wang,Guangtao Huang,Ilaria Dal Pra,Yongzhi Liang,Jun Wu
Bacterial infections following skin injuries can lead to chronic, hard-healing wounds, and the overuse of antibiotics has made infection control a significant clinical challenge. Nature provides numerous antimicrobial agents, inspiring the design of novel antibacterial wound dressings; however, their solubility often presents additional hurdles. Herein, we leverage highly water-soluble chitosan oligosaccharide molecules dispersed within a gelatin-based gel network to overcome the poor solubility of chitosan, a known antibacterial agent. Notably, we first discovered that chitosan oligosaccharides can promote the solubility of poorly water-soluble antibacterial molecules like emodin through Schiff base reactions, thereby enabling synergistic antibacterial effects. The resulting eutectogel exhibits excellent antibacterial activity against both Staphylococcus aureus and Escherichia coli. Additionally, the gel demonstrates superior tensile strength, fracture strain, resistance to desiccation, and biocompatibility, with its outstanding overall performance laying a foundation for wound dressing applications. In animal models of infected wounds, the gel effectively accelerates wound healing, achieving wound closure rates of 166.9 % and 136.9 % of the control group on days 4 and 7, respectively. Mechanistic studies further reveal that the dressing promotes cellular proliferation, migration, and the regeneration of blood vessels and collagen, contributing to the wound healing process.
研究领域:
生物材料
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伤口敷料
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抗菌治疗
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组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYHEDRON
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2018
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IF 2.067
Aohui Yang,Huijun Liu,Zhendong Li,Liuxing Li,Wei Li,Kai Liu
Cyclodextrin metal–organic frameworks (K-CD-MOFs) based on renewable β-cyclodextrin molecules (β-CD) and alkali metals (K) was prepared by modified methanol vapor diffusion method at temperature of 50 °C for 6 h, and this can shorten the reaction time compared with the previous reported. Then the quercetin and emodin were selected to investigate the loading characteristics of K-CD-MOFs and drugs adsorption behavior was studied by changing the reaction time, temperatures, MOFs quality, initial drugs concentration and pH. In results, the crystals showed high adsorption (150.2 and 199.8 mg/g) when the reaction time both at 48 h, the temperatures of 35 and 45 °C, 30 mg K-CD-MOFs, the initial concentration of quercetin and emodin was 3.2 and 2.3 mg/ml and pH 6. Furthermore, the adsorption kinetics of drugs matched a pseudo-second-order model well and chemisorption of quercetin and emodin. Most importantly, XRD pattern analysis showed that the drug loading process did not destroy the crystallinity of the material. In summary, on the basis of optimizing the synthesis of K-CD-MOFs, the crystal stability and drugs adsorption properties were evaluated, which provided a basis for the potential drug delivery.
研究领域:
材料科学
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药物递送
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生物化学
✓ 已验证
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
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2021
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IF 3.196
Xiaodi Kou,Juanjuan Liu,Yuhong Chen,Aihong Yang,Rui Shen
Four new emodin derivatives which inhibit Alzheimer's disease were designed and the related activities such as cholinesterase inhibitor, anti-oxidant and metal chelator were evaluated. Among them, compounds a and b had comparable inhibitory activities of acetylcholinesterase to control drug tacrine. In particular, compound a had the strongest inhibitory effect on acetylcholinesterase with IC 50 value of 0.067 μM. Kinetic analysis of a and b indicated the mixed-type inhibition. Molecular simulation studies showed that they could bind both the catalytically active site and the peripheral anion site of acetylcholinesterase. The antioxidant activities were determined using the superoxide radical ( . O 2 – ) and hydroxyl radical ( . OH) assays. All derivatives showed high anti-oxidative activities. The mechanisms of electrochemical oxidation of emodin and its derivations were studied by cyclic voltammetry. In addition, compounds a-d exhibited obvious chelating abilities with Cu 2+ , Fe 3+ , Zn 2+ and Al 3+ ions. Interestingly, complexes chelated with Cu 2+ and Zn 2+ showed better acetylcholinesterase inhibitory activities and antioxidative activities. Taken together, emodin derivatives have multi-factor anti-Alzheimer's disease activities, and they are worthy of further study as potential candidate drugs for Alzheimer's disease.
研究领域:
药理学
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神经科学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2019
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IF 6.393
Qingqing Hao,Lilin Lu,Xianwen Kan
Molecular imprinted polymer (MIP) has been employed for electrochemical sensor preparation with good selectivity. However, to restrict the non-specific adsorption, the conductivity of MIP is usually unsatisfying, which limits its sensitivity for template detection. To achieve both of selectivity and sensitivity, a MIP electrochemical sensor was designed and fabricated by the electropolymerization of pyrrole in the presence of aloe-emodin (AE, template molecule) on carbon nanoparticles modified electrode in this work. Thionine (TH), being added in solution in advance, played double roles for AE recognition and detection. As an analogue of AE, TH was adsorbed into imprinted cavities and then was replaced by AE, indicating the good selectivity of the sensor. This replacement of TH by AE was also demonstrated by the result of computational simulation. As an electro-active probe, the peak current of TH decreased and peak current of AE increased based on the replacement of TH by AE. A current ratiometric signal defined as |Δ i AE |/|Δ i TH | was used for AE sensitive detection. Thus, the replacements of TH by AE demonstrated that the sensor possessed high sensitivity and good selectivity. A linear range of 1.0 × 10 −7 -1.0 × 10 -4 mol/L for AE detection was obtained with a limit of detection of 7.5 × 10 -8 mol/L. And the sensor has been applied to analyze AE in real samples with satisfactory results. The simple, smart, and effective strategy presented in this work can be further used to prepare electrochemical sensors for other compounds selective recognition and sensitive detection.
研究领域:
分析化学
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电化学
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2021
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IF 6.165
Dandan Huang,H.C. Stephen Chan,Yunshan Wu,Liang Li,Li Zhang,Yang Lv,Xuemei Yang,Zhengzheng Zhou
Carbamazepine ( CBZ ), a Biopharmaceutics Classification System (BCS) class II drug, is widely-used as a first line antiepileptic drug . Numbers of cocrystals have reported to regulate its poor solubility. However, the solubility behaviors are rarely discussed on theoretical calculations and phase solubility diagrams . In this study, two new drug-drug cocrystals (DDC) of CBZ with emodin ( EMO , 1: 1) and paeonol ( PAE , 1: 1) as conformers , which offer the advantages of synergetic therapy and patient compliance are reported for the first time. The solubilities in water and in pH = 1.2, 6.8 buffer solutions, demonstrating that the rank order is as follows: CBZ-PAE > CBZ > CBZ-EMO . CBZ-PAE presents the biggest solubility at 0.563 ± 0.003 mmoL/L of in water among all the investigated samples. The solubilities of all the starting materials and cocrystals in six pure organic solvents such as methanol, ethanol, 2-propanol, acetone, acetonitrile , ethyl acetate were investigated to discuss the phase solubility diagrams. The results indicate that experimental solubilities are consistent with the theoretical solubilities on consideration of solubility product ( K sp ) and solution binding constant ( K 11 ) together. The enthalpy differences between cocrystal and its coformer are calculated through the Perdew-Burke-Ernzerhof (PBE) functional with the projector augmented wave (PAW) pseudopotentials . CBZ-EMO presents the lowest enthalpy (−0.38 kcal/mol) with a highly unfavorable solvation energy (2.42 kcal/mol), resulting in unfavorable in an aqueous environment. Overall, the phase solubility diagrams and theoretical calculations support the solubility regulations on DDCs of CBZ .
研究领域:
药学
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生物医学工程
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物理化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMOSPHERE
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2022
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IF 8.943
Yan Zhang,Lijun Wang,Liushen Lu,Meiling Liu,Zhenbo Yuan,Lifeng Yang,Changmei Liu,Shuping Huang,Yijian Rao
To address the water pollution induced by pharmaceuticals, especially antibiotics, and pathogens , natural product emodin, a traditional Chinese medicine with the characteristic large π-conjugation anthraquinone structure, was used to rationally develop a novel Emodin/HAp photocatalyst by integrating with a thermally stable and recyclable support material hydroxyapatite (HAp) through a simple preparation method. It was found that its photocatalytic activity to generate reactive oxygen species (ROS) was greatly improved due to the migration of photogenerated electrons and holes between emodin and HAp upon visible light irradiation. Thus, this Emodin/HAp photocatalyst not only quickly photodegraded tetracycline with 99.0% removal efficiency but also exhibited complete photodisinfection of pathogenic bacteria Staphylococcus aureus upon visible light irradiation. Therefore, this study offers a new route for the design and preparation of multifunctional photocatalysts using widely available natural products for environmental remediation.
研究领域:
环境科学
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材料科学
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微生物学
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产品关联
DOI
PubMed
高影响因子
AQUACULTURE
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2023
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IF 4.5
Yan Zhou,Yang Hu,Bin Zhu,Lei Liu,Jiong Chen
As a natural small molecule monomer widely found in various traditional Chinese herbs, emodin has garnered substantial attention due to its pharmacological properties. Its widespread exploration for application such as growth enhancement, immune modulation, and antimicrobial activity in aquaculture. In the present study, our focus centers on investigate the anti-spring viremia of carp virus (SVCV) activity of emodin, thereby facilitate the development of commercially viable methods for the prevention and treatment of SVCV infection. We assessed the inhibitory effects of emodin against SVCV through both in vitro and in vivo paradigms. In the in vitro assay, cells were firstly infected with emodin mixed with SVCV to impact of emodin on viral replication, apoptosis, and mitochondrial depolarization. Notably, the results underscore that emodin, at a concentration of 16 μM, engenders a remarkable 99.99% suppression of SVCV infection. Interestedly, it distinctly influences the internalization of viral particles into the cells as well as modulate the antiviral response. Furthermore, in the in vivo assay, zebrafish ( Danio rerio ) fed with an emodin-supplemented commercial diet exhibited a notably elevated survival rate, surpassing that SVCV-exposed group which fed with only commercial diet (up to 22%), a significant reduction in viral load in host was also discerned. Emodin supplementation elicited substantial upregulation of host antiviral related genes, such as interferon-φ ( IFN-φ ), retinoic acid inducible gene I ( RIG-I ), and IFN-stimulated gene product 15 ( ISG15 ), by 4.98-, 3.97-, and 7.42-fold on day 7, respectively. In summation, our results indicate that emodin has anti-SVCV activity, and the confluence of emodin's well-established extraction protocol, environmental friendliness, and multiple bioactivities collectively predict it has the potential for commercial application as an antiviral disease additive in aquaculture.
✓ 已验证
产品关联
DOI
高影响因子
CARDIOVASCULAR DRUGS AND THERAPY
·
2024
·
IF 3.1
Ye Bozhi,Cai Xueli,Liang Xiaohe,Chen Yunxuan,Dai Shanshan,Huang Zhuqi,Huang Weijian,Zhang Lei,Wang Zixuan,Xing Jincheng,Lai Xianhui,Huang Zhouqing,Jia Zhuyin
Purpose Inflammatory responses induced by NLRP3 inflammasome contribute to the progression of atherosclerosis. This study seeks to investigate the effect of emodin on the NLRP3 inflammasome in atherogenesis and to probe the underlying mechanism. Methods ApoE-knockout (ApoE −/− ) mice were treated with a high-fat diet (HFD) for 12 weeks and intragastrically with emodin for 6 weeks. Human mononuclear cell line THP-1 was pretreated with emodin or signaling pathway inhibitors and induced into macrophages using phorbol 12-myristate 13-acetate (PMA) for 48 h. The NLRP3-mediated inflammatory response was studied both in vivo and in vitro. The level of the inflammation was detected by western blot, real-time PCR analysis, and ELISA. Results Emodin attenuated atherosclerotic lesions in HFD-treated ApoE −/− mice. Emodin dramatically decreased the expression of NLRP3, GSDMD, IL-1β, and IL-18 in HFD-treated ApoE −/− mice and PMA-induced macrophages. Moreover, emodin significantly hindered the activation of nuclear factor kappa-B (NF-κB) by inhibiting the formation of the TLR4/MyD88 complex in PMA-induced macrophages. Conclusion Our data demonstrate that emodin can inhibit the development of atherosclerotic plaques by alleviating NLRP3/GSDMD-induced inflammation through repressing the TLR4/MyD88/NF-κB signaling pathway in macrophages. This finding suggests that emodin can be a potential candidate for the treatment of atherosclerosis.
研究领域:
免疫学
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心血管疾病
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药理学
✓ 已验证
DOI
PubMed
高影响因子
Advanced Science
·
2024
·
IF 14.3
Tao Xu,Hao Cheng,Hailiang Pei,Jiameng Wang,Yiwei Shi,Xiangyu Zhang,Di Huang
Eradication of osteomyelitis caused by bacterial infections is still a major challenge. Microwave therapy has the inherent advantage of deep penetration in curing deep tissue infections. However, the antibacterial efficiency of sensitizers is limited by the weak energy of microwaves. Here, a hybrid heterojunction system (Fe 3 O 4 /CuS/Emo) is designed for curing bacterially infected osteomyelitis. As an enhanced microwave sensitizer, it shows supernormal microwave response ability. Specifically, Fe 3 O 4 acts as a matrix to mediate magnetic loss. After CuS loading, the heterogeneous interface forms induce significant interfacial polarization, which increasing dielectric loss. On the basis of the heterojunction formed by the two semiconductors, emodin is innovatively introduced to modify it. This integration not only accelerates the movement of charge carriers but also enhances polarization loss due to the numerous functional groups present on the surface. This further optimizes the microwave thermal and catalytic response. In addition, the unique anti-inflammatory properties of emodin confer the ability of hybrid heterojunction to regulate the immune microenvironment. In vivo studies reveal that heterojunction modified by emodin programmed elimination of bacteria and regulation of the immune microenvironment. It offers a revolutionary approach to the treatment of bacterial osteomyelitis.
研究领域:
医学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2024
·
IF 2.5
Liuxuan Yang,Xianbin Liu,Jing Yang,Ke Wang,Zhenghao Ai,Jinlu Shang,Meiling Zhou
Acute pancreatitis (AP) is a severe inflammatory condition with a rising incidence and high mortality rates, especially in severe cases. Emodin (ED), known for its potent anti-inflammatory properties, holds promise in addressing AP. However, its clinical application is hindered by limitations such as low bioavailability and insufficient target specificity. Herein, we developed a novel drug delivery system using macrophage membrane-coated UiO-66-NH 2 nanoparticles loaded with ED (MVs-UiO-ED). UiO-66-NH 2 was successfully synthesized and characterized, revealing an octahedral structure with a suitable size distribution. The successful loading of ED onto UiO-66-NH 2 was confirmed by ultraviolet and infrared spectroscopy. Subsequently, MVs-UiO-ED was prepared by coating macrophage membrane-derived vesicles onto UiO-ED, resulting in a biomimetic delivery system. In vitro release studies demonstrated that MVs-UiO-ED exhibited a sustained-release profile, indicating its potential for prolonged drug circulation. An AP mouse model was established to evaluate the therapeutic efficacy of MVs-UiO-ED. Compared with the model group, MVs-UiO-ED significantly reduced serum levels of α-amylase and lipase, two indicators of pancreatitis severity. Furthermore, histopathological examinations revealed that MVs-UiO-ED ameliorated pancreatic tissue damage. This study underscores the potential of MVs-UiO-ED as an effective therapeutic approach for AP.
研究领域:
药理学
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纳米技术
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炎症
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药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）