SEPARATION SCIENCE AND TECHNOLOGY
·
2021
·
IF 2.475
Tian Haixi,Hui Li,Mao Lin,Li Kegang
Fabrication of a post-synthesis imprint modification method for metal-organic frameworks in order to improve its selectivity in the field of separation and analysis is of great interest. For this purpose, a pinoresinol diglucoside (PDG) imprinted polymer was attempted to graft on the surface of metal-organic frameworks MIL-101 to produce a new composite material named MIPs@ED-MIL-101. This modification procedure was monitored by using X-Ray Diffraction, fourier transforms infrared spectroscopy and scanning electron microscopy in the crystal structure, chemical groups and particles topography, respectively. Adsorption kinetics and thermodynamics behavior, rebinding selectivity and applicability in solid-phase extraction for this new material obtained were evaluated. The kinetics test indicated this composite material improved adsorption dynamics relative to the MIL-101, with a 28.6% decrease in adsorption equilibrium time. The adsorption capacity for the MIPs@ED-MIL-101 toward PDG was shown higher than that for the MIL-101 and nonimprint-modified material NIPs@ED-MIL-101 at the same substrate concentration when adsorption was carried out at 298 K in acetonitrile-H2O mixed solution (1:1, V/V). Freundlich model can best fit the isotherm data for the MIPs@ED-MIL-101, indicating site heterogeneity in this composite material and mean adsorption energy of 19.60 kJ mol-1 obtained by Dubinin–Radushkevich model fitting might imply chemical adsorption the main rebinding process. In addition, this imprint composite material could selectively bind template and be utilized as the adsorbent in solid-phase extraction to capture target compound from plant crude extract. This new material can also be reused many times with a slight decrease in adsorption capacity.
研究领域:
材料科学
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分析化学
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植物化学
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 3
·737
·
IF 4.2
Yunhui Liao,Feng Chen,Haishan Tang,Wubliker Dessie,Zuodong Qin
To increase the effectiveness of using typical biomass waste as a resource, iridoids, chlorogenic acid, and flavonoids from the waste biomass ofEucommia ulmoidesleaves (EULs) were extracted by deep eutectic solvents (DESs) in conjunction with macroporous resin. To optimize the extract conditions, the experiment of response surface was employed with the single-factor of DES composition molar ratio, liquid–solid ratio, water percentage, extraction temperature, and extraction time. The findings demonstrated that the theoretical simulated extraction yield of chlorogenic acid (CGA), geniposidic acid (GPA), aucubin (AU), geniposide (GP), rutin (RU), and isoquercetin (IQU) were 42.8, 137.2, 156.7, 5.4, 13.5, and 12.8 mg/g, respectively, under optimal conditions (hydrogen bond donor–hydrogen bond acceptor molar ratio of 1.96, liquid–solid ratio of 28.89 mL/g, water percentage of 38.44%, temperature of 317.36 K, and time of 55.59 min). Then, 12 resins were evaluated for their adsorption and desorption capabilities for the target components, and the HPD950 resin was found to operate at its optimum. Additionally, the HPD950 resin demonstrated significant sustainability and considerable potential in the recyclability test. Finally, the hypoglycemic in vitro, hypolipidemic in vitro, immunomodulatory, and anti-inflammatory effects of EUL extract were evaluated, and the correlation analysis of six active components with biological activity and physicochemical characteristics of DESs by heatmap were discussed. The findings of this study can offer a theoretical foundation for the extraction of valuable components by DESs from waste biomass, as well as specific utility benefits for the creation and development of natural products.
研究领域:
植物化学
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天然产物开发
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药理学
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Jian-Dong Wang,Yan-Hao Liu,Yu-Jie Fu
This study presented the development of a nanoscale, tunable surfactant-free microemulsion (SFME) formulated with natural deep eutectic solvents (NaDES) for the efficient extraction of phytochemicals. The NaDES-SFME, composed of octanol, thymol, ethanol and water, was characterized using a ternary phase diagram, conductivity measurements and UV absorption spectroscopy. The optimal NaDES-SFME composition (15 % v/v NADES, 45 % v/v ethanol and 40 % v/v water) demonstrated superior extraction performance compared to conventional solvents, achieving extraction yields of seven phytochemicals from Eucommia ulmoides leaves that were 1.15–3.55 times higher. FT-IR, dynamic light scattering (DLS) and fluorescence microscopy revealed a reverse W/O structure at 46.7 nm, mimicking cell membranes to penetrate plant matrices and dissolve compounds. Ultrasound-assisted extraction, optimized via response surface methodology, achieved a maximum total yield of 9.763 mg/g under the conditions of 50 °C, 41 min and a solid–liquid ratio of 31 mg/mL. The Pareto plot indicated that the extraction time was the main factor affecting the extraction efficiency and the secondary kinetic model could better fit the dissolution pattern of the phytochemicals. Density functional theory (DFT) analysis confirmed hydrogen bonding as the key mechanism for the high extraction yield. Finally, the combination of ethanol addition and rotary evaporation allowed for a high recovery of the phytochemicals, with a recovery rate of more than 96 %. This green, cost-effective and high-yield microemulsion holds promise for industrial-scale phytochemical extraction and utilization.
研究领域:
植物化学
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药用植物学
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提取技术
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产品关联
DOI
高影响因子
International Journal of Chemical Engineering
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2016
·
IF 0
Lili Li,Yupin Guo,Chunchao Zhao,Mengxia Wei,Junling Liu,Yuangang Zu,Fei Wang,Lei Yang
In order to hydrolyze geniposide and extract geniposidic acid, a novel microwave irradiation heating method for simultaneous hydrolysis and extraction for preparation of geniposidic acid from Eucommia ulmoides bark using basic imidazolide ionic liquid was developed in this work. Basic ionic liquid paired by imidazolide anion and 1-hexyl-3-methylimidazolium cation ([C6mim]Im) was used as a dual hydrolysis catalyst and extraction solvent in the proposed approach. The optimal concentration of [C6mim]Im was 0.4 mol/L. And the independent parameters optimized by Box-Behnken design (BBD) based on single-factor tests were as follows: microwave irradiation time of 20 min at power of 415 W and liquid-solid ratio of 15 mL/g. Yield of geniposidic acid was increased to μmol/g. DM130 macroporous resin, after reaction, was selected to separate geniposidic acid from hydrolysate. The plant materials with different treatment were analyzed by scanning electron microscopy (SEM) and thermogravimetric analysis (TG). The analysis of SEM and TG further indicated that IMSHE is an efficient preparation method for geniposidic acid. It is reasonable to assume that the method and the dual hydrolysis catalyst and extraction solvent would offer an alternative for the preparation of some other kinds of bioactive substances from plant materials.
研究领域:
植物化学
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药用植物学
✓ 已验证
产品关联
DOI
JOURNAL OF MOLECULAR LIQUIDS
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2022
·
IF 6.633
Yicong Wang,Leilei Liu,Zhijian Tan
Owing to their unique characteristics, deep eutectic solvents (DESs) have the potential to replace organic solvents in the extraction and separation of chemicals from natural sources. In this study, a novel biphasic system composed of hydrophilic and hydrophobic DESs was designed for the selective separation of geniposidic acid (GPA) and aucubin (AU) from Eucommia ulmoides male flowers. Fifteen DESs with different hydrophilicity/hydrophobicity were used to design the biphasic system. The biphasic system designed using tetrabutyl ammonium chloride-hexanoic acid and choline chloride- D, L -malic acid was found to be an optimal extraction system. The influence of the phase volume ratio, system concentration, water content in the DESs, equilibrium temperature, and pH of the phosphate buffer solution was investigated through single-factor experiments. Under optimal conditions, maximum extraction efficiencies were observed for GPA in the top phase ( E GPA = 94.59%) and AU in the bottom phase ( E AU = 80.41%). Further, density functional theory calculations indicated that H-bond interaction was the main factor influencing the selective separation of GPA and AU. This DES-based biphasic system is efficient and environmentally friendly and could be used in the separation of other homologues present in natural products.
研究领域:
植物化学
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天然产物分离
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环境科学
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产品关联
DOI
高影响因子
JOURNAL OF FOOD BIOCHEMISTRY
·
2022
·Vol. 46
·期 8
·e14204
·
IF 3.654
Tao Liu,Xingze Cao,Dongmin Cao
Osteoarthritis (OA) is a disabling disease and seriously affects the quality of life of patients. is A potential medicine for the treatment of OA is Eucommia ulmoides leaves (EULs). However, its active compounds and therapeutic mechanisms are unclear. Therefore, it is necessary to develop a method using LC–MS and network pharmacology for the detection and identification of compounds and the mechanisms of action of EULs. The compounds were detected and identified based on ultra-high-performance liquid chromatography coupled with Quadrupole Exactive-Orbitrap MS (UHPLC-Q Exactive-Orbitrap MS) and followed by the network pharmacology analysis. Seventy-three compounds, including 15 flavonoids, 8 iridoids, 10 lignans, 24 phenolic acids, and 16 additional compounds, were identified by UHPLC-Q Exactive-Orbitrap MS. The network of the pharmacological analysis revealed that 29 active compounds regulated 17 main pathways through 38 target genes, including NF-kappa B signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, etc. In conclusion, EULs were effective in the treatment of OA by regulating the abovementioned key pathways. This study showed that LC–MS/MS followed by network pharmacology analysis is useful to elucidate the complex mechanisms of action of Chinese herb. Practical applications This study describes a rapid method of detecting and identifying the constituents and systematic mechanism of Eucommia ulmoides based on LC–MS and network pharmacology. Our results show that 73 compounds of E. ulmoides leaves were identified and predicted that E. ulmoides leaves were effective in the treatment of OA by regulating key pathways, including NF-kappa B signaling pathway, PI3K-Akt signaling pathway, and AMPK signaling pathway by network pharmacology, which lays the foundation for subsequent research.
研究领域:
中药学
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分析化学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
Polymers
·
2019
·Vol. 11
·期 12
·
IF 3.164
Yan Wang,Jinhui Liu,Lin Xia,Mei Shen,Liping Wei,Zhenxiang Xin,Jinkuk Kim
Novel, fully biobased shape memory thermoplastic vulcanizates (TPVs) were prepared using two sustainable biopolymers, poly(lactic acid) (PLA), and modified naturalEucommia ulmoidesgum (EUG-g-GMA), via a dynamic vulcanization technique. Simultaneously, in situ compatibilization was achieved in the TPVs to improve interfacial adhesion and the crosslinked modifiedEucommia ulmoidesgum (EUG) was in “netlike” continuous state in the PLA matrix to form “sea-sea” phase structure. The promoted interface and co-continuous structure played critical roles in enhancing shape memory capacity and toughness of the TPVs. The TPV with 40 wt % modified EUG displayed the highest toughness with an impact strength of 54.8 kJ/m2and the most excellent shape memory performances with a shape fixity ratio (Rf) of 99.83% and a shape recovery ratio (Rr) of 93.74%. The prepared shape memory TPVs would open up great potential applications in biobased shape memory materials for smart medical devices.
✓ 已验证
DOI
高影响因子
Antioxidants
·
2026
·Vol. 15
·期 9
·1207
·
IF 8.2
Kaiwen You,Yixuan Li,Wanqing Zhong,Jie Yu,Yamei Wu,Yuqi Guo,Haoyang Liu,Haiping Xie,Kai Yuan,Yihong Chen,Lei Wang
Due to the hypoxic environment caused by global warming and intensive aquaculture process, fish are susceptible to oxidative damage and death.Eucommia ulmoidesextract (EUE) has demonstrated antioxidant and anti-inflammatory properties. However, whether EUE can mitigate hypoxia-induced negative effects remains uninvestigated in fish. This study investigated the effect of 0 and 1.0 g/kg EUE on acute hypoxia-induced damage in largemouth bass and its potential mechanisms. The results showed that EUE alleviated the deterioration of plasma activities (ALT and AST) induced by acute hypoxic stress, decreased the number of macrophages and increased the total number of blood cells. EUE was effective in reducing the level of apoptosis and the content of ROS, Ca2+, and NO in blood cells. Additionally, EUE alleviated liver tissue injury caused by acute hypoxic stress, which could be associated with increased total antioxidant capacity and antioxidant enzyme activities (SOD, CAT and GSH-Px). Furthermore, EUE up-regulated the expression levels ofNrf2andCAT, activatedXBP1andIREexpression and down-regulatedGRP78expression, relieving the endoplasmic reticulum (ER) stress response. The down-regulation ofCaspase3andCaspase9is evidence that EUE inhibited apoptosis in acute hypoxic stress. In summary, EUE reduced oxidative damage, ER stress, and apoptosis caused by hypoxic stress via the Nrf2/Keap1 signaling pathway in largemouth bass. This study presents a part of the theoretical foundation for the EUE to resist damage caused by hypoxic stress, thereby establishing a basis for sustainable development in aquaculture.
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DOI
高影响因子
BIORESOURCE TECHNOLOGY
·
2022
·
IF 11.889
Cong-Jia Duan,Xu Han,Yuan-Hang Chang,Jian Xu,Gan-Lu Yue,Ying Zhang,Yu-Jie Fu
A novel ternary deep eutectic solvent (DES), consisted of choline chloride, oxalic acid and ethylene glycol, was developed as a green, low-cost and recyclable pretreatment system for multi-stage utilization of Eucommia ulmoides seed shells. Under optimum conditions, 79.7 % hemicellulose and 65.6 % lignin were quickly removed while 84.0 % cellulose was retained. After DES pretreatment , the yield and purity of gutta-percha achieved 85.1 mg/g and 96.2 %, which increased 1.4 and 1.8 folds higher than that of un-treatment ones. Meanwhile, 69.1 % enzymatic digestibility of cellulose was obtained, that was 2.3 folds higher than that of raw substrates. Moreover, 53.6 % low-condensation lignin with aromatic structures and valuable aryl-ether linkages was well collected. Importantly, the DES that has been recycled five runs can still remove 73.9 % hemicellulose and 58.0 % lignin. Overall, the DES was determined to efficiently promote the separation and conversion of high-quality gutta-percha, value-added lignin and high-yield glucose from Eucommia ulmoides seed shells.
研究领域:
生物化学
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CONSTRUCTION AND BUILDING MATERIALS
·
2026
·
IF 8.9
Yifan Wang,Guokai Zhao,Huanjin Cheng,Zhide Liu,Mingyang Song,Yujiao Wang,Fang Gu,Mingqiang Zhu
Conventional electromagnetic interference (EMI) shielding materials remain heavily mold-dependent. This constrains design freedom, limiting structural customizability and manufacturing flexibility for modern electronics. This study successfully fabricated multifunctional polylactic acid/ Eucommia ulmoides gum/silver-coated carbon fiber (PLA/EUG/CF@Ag) composites via fused deposition modeling (FDM) three-dimensional (3D) printing. Uniform dispersion and aligned orientation of CF@Ag within the polymer matrix were achieved through ball milling and twin-screw extrusion, constructing efficient conductive and thermal networks. A gradient porous structure based on triply periodic minimal surfaces (TPMS) was designed and printed, which significantly enhanced electromagnetic wave absorption and heat dissipation. With a CF@Ag loading of 25 wt%, the composite exhibited a total electromagnetic interference shielding effectiveness (EMI SE) of 36 dB in the X-band (8.2–12.4 GHz). Compared to solid board structures, the gradient structure improved heat dissipation efficiency by 230% while simultaneously reducing the electromagnetic wave reflection coefficient from 0.90 to 0.68, demonstrating superior reflection-reduced shielding. This work provides a novel strategy for developing lightweight, customizable, and multifunctional electromagnetic interference shielding materials with promising applications in electronic packaging and aerospace.
✓ 已验证
DOI
高影响因子
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2025
·
IF 4.6
Ziping Pan,Ziwei Zou,Yue Guo,Bingjian Guo,Sanshan Luo,Linlin Feng,Lijun Deng,Xiaolong Ma,Zhenwu Liang,Shihan Pan,Hongyan Wei,Minling Wei,Yan Huang,Xiongmei Huang,Jinbin Wei,Yonghong Liang,Zhiheng Su
Dietary supplements, with nutritional and health benefits, are widely used worldwide. Ensuring the quality of dietary supplements has become particularly important as demand increases. Current traditional methods of quality assessment tend to concentrate solely on the content of certain active ingredients; nevertheless, the bioactivity of a product, which serves as a more direct indicator of its quality, is frequently overlooked. Thus, a comprehensive "Content-Extractives-Activity" quality evaluation system was developed for dietary supplements using a portable near-infrared spectrometer combined with entropy weight method in this study. Taking Eucommia ulmoides granules as the object of study, near-infrared spectroscopy (NIRS) was used to predict the pinoresinol diglucoside content, ethanol-soluble extractives content, bioactivity indicators related to antioxidant damage such as cell viability value and intracellular malondialdehyde content, as well as comprehensive index. The best models all obtained satisfactory prediction results with correlation coefficient of prediction in the range of 0.89~0.97 and residual predictive deviation in the range of 1.81~4.19, which demonstrated the feasibility of the method for the rapid evaluation of the integrated quality of dietary supplements by NIRS.
研究领域:
中药学
·
分析化学
·
食品科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）