ACS Applied Materials & Interfaces
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2019
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IF 8.456
Zhongxi Xie,Shuang Liang,Xuechao Cai,Binbin Ding,Shanshan Huang,Zhiyao Hou,Ping’an Ma,Ziyong Cheng,Jun Lin
Hypoxia and overexpression of glutathione (GSH) are typical characteristics of the tumor microenvironment, which severely hinders cancer treatments. Here, we design a novel biodegradable therapeutic system, O2–Cu/ZIF-8@Ce6/ZIF-8@F127 (OCZCF), to simultaneously achieve GSH depletion and O2-enhanced combination therapy. Notably, the doped Cu2+ doubles the O2 storage capacity of the ZIF-8 matrix, which makes OCZCF an excellent pH-sensitive O2 reservoir for conquering tumor hypoxia, enhancing the photodynamic therapy (PDT) efficiency of chlorin e6 (Ce6) under 650 nm laser irradiation. Moreover, the released Cu2+ can act as a smart reactive oxygen species protector by consuming intracellular GSH. The byproduct Cu+ will undergo highly efficient Fenton-like reaction to achieve chemodynamic therapy (CDT) in the presence of abundant H2O2. The accompanying O2 will further alleviate hypoxia. The in vitro and in vivo experimental data indicate that OCZCF could cause remarkable tumor inhibition through enhanced synergetic PDT and CDT, which may open up a new path for cancer therapy.
研究领域:
癌症研究
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纳米技术
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生物医学工程
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药学
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DOI
PubMed
高影响因子
COLLOID AND POLYMER SCIENCE
·
2017
·Vol. 295
·期 4
·703-707
·
IF 1.723
Lu Wangting,Zhang Geng,Wei Feng,Li Wenhui,Cheng Kun,Ding Fei,Zhang Jiying,Zheng Wanquan
Palladium nanocrystals (NCs) are highly useful functional materials in many applications, and the performances of Pd NCs were strongly depended on the crystalline facet exposed on their surface. In this work, Pd NCs were synthesized in aqueous solutions by using Na 2 PdCl 4 as the precursor, citric acid as the capping agent, and Pluronic F127 as both stabilizer and reductant. By adjusting the reaction parameters, Pd cuboctahedrons, octahedrons, and triangular nanoplates with well-defined facets can be produced. This study provides a new pathway for the shape-controlled preparation of noble metal NCs.
研究领域:
材料科学
·
化学
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DOI
高影响因子
LANGMUIR
·
2026
·
IF 4.4
Mingze Xu,Yanwei Yang,Gai Liu,Chunyun Wang,Xu Xu,Bohan Ye,Lei Liu,Xiaoyu Wu,Shiyong Song
Pluronic F127 is widely used in micelle formulations, yet its application is limited by its poor stability and low drug loading capacity. Structural modification of F127 is therefore necessary to overcome these drawbacks. Carrier materials with intrinsic pharmacological activity can reduce metabolism-related toxicity and exert synergistic effects with loaded drugs, offering broad application prospects. Solanesol (SOL), a long-chain unsaturated polyisoprenoid, exhibits antitumor activity and favorable lipophilicity. In this study, a solanesol derivative, monosolanesyl succinate (MSS), was synthesized and conjugated via an amide bond to Pluronic F127 as a hydrophobic segment, forming a pH-sensitive therapeutic nanocarrier. The critical micelle concentration (CMC) of F127-MSS was 10-fold lower than that of F127, indicating a significantly improved stability. The resulting doxorubicin-loaded F127-MSS micelles (F127-MSS-DOX) had an average particle size of approximately 130 nm and a drug loading capacity of ∼ 6.2%, which was about 4 times higher than those of F127-DOX micelles. The F127-MSS-DOX micelles exhibited pH-responsive drug release, promoting drug accumulation at tumor sites while reducing the toxicity in normal tissues. They also demonstrated excellent dilution, plasma, and storage stability. Blank F127-MSS micelles showed inherent inhibitory effects on HepG-2 and MCF-7 cells, attributed to the pharmacological activity of MSS. Furthermore, F127-MSS-DOX micelles displayed potent antitumor activity, comparable to that of free DOX at high concentrations. In vivo studies confirmed that blank F127-MSS micelles moderately suppressed tumor growth, while F127-MSS-DOX micelles significantly inhibited tumor progression and markedly reduced the systemic toxicity of free DOX, owing to their high drug loading, superior stability, pH sensitivity, and synergistic antitumor effect. These findings highlight the great potential of F127-MSS-DOX micelles for tumor treatment.
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PubMed
高影响因子
International Journal of Nanomedicine
·
2023
·
IF 8
Jing Lin,Chaoyue Zhao,Cuijuan Liu,Shiyao Fu,Luying Han,Xinping Lu,Chunrong Yang
Introduction The development of nanodrug carriers utilizing tumor microenvironment has become a hotspot in reversing multidrug resistance (MDR).Materials and methods This study synthesized a redox-sensitive copolymer, Pluronic F127-disulfide bond-d-α-tocopheryl polyethylene glycol 1000 succinate (FSST), through the connection of the reduction-sensitive disulfide bond between F127 and d-α-tocopheryl polyethylene glycol 1000 succinate. This polymer could induce the elevation of reactive oxygen species (ROS) levels, ultimately resulting in cytotoxicity. Moreover, the redox-responsive mixed micelles, F127-folate (FA)/FSST/P123 (FFSSTP), based on FSST, Pluronic F127-FA, and Pluronic P123, were prepared to load paclitaxel (PTX).Results The in vitro release study demonstrated that FFSSTP/PTX accelerated the PTX release through the breakage of disulfide bond in reductive environment. In cellular experiment, FFSSTP/PTX induced significant apoptosis in PTX-resistant MCF-7/PTX cells through inhibiting adenosine triphosphate (ATP)-binding cassette proteins from pumping out PTX by interfering with the mitochondrial function and ATP synthesis. Furthermore, FFSSTP/PTX induced apoptosis through elevating the intracellular levels of ROS.Conclusion FFSSTP could become a potential carrier for the treatment of MDR tumors.
研究领域:
药剂学
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肿瘤学
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纳米医学
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药物递送系统
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DOI
PubMed
高影响因子
Gels
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2025
·Vol. 11
·期 11
·878
·
IF 5.3
Shangpeng Liu,Min Sun,Zhen Fan
Effective management of multidrug-resistant cancers depends on effective, localized drug release and accumulation within the tumor microenvironment. In our work, Pluronic P105 and F127 mixed nanogels (PM) were fabricated through self-assembly to combat multidrug-resistant cancer. The approximate diameter of our prepared PM is 115.7 nm, an optimal size for tumor accumulation through the enhanced permeability and retention (EPR) effect. An in vitro drug release assay indicated that ultrasound could accelerate the drug release rate in doxorubicin-loaded Pluronic nanogels (PM/D). Additionally, the resistance reversion index (RRI) in the ultrasound-treated PM/D group was 4.55 and was two times higher than that in the free PM/D group, which represented better MDR reverse performance. Cell experiments demonstrated that, after 3 min of ultrasound, a greater amount of chemo-drug was released and absorbed by the MDR human breast cell line (MCF-7/ADR), resulting in significant cytotoxicity. Such enhanced therapeutic efficiency could be attributed to the combined effects of the two independent mechanisms: (i) ultrasound-controllable drug release realized effective release within resistant tumors with spatial and temporal precision and (ii) the contained Pluronic in the PM/D inhibited P-gp-mediated efflux activity to overcome MDR in tumors. Collectively, our findings support the feasibility of ultrasound-responsive PM as a drug-delivery platform for resistant cancers.
研究领域:
纳米医学
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癌症治疗
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药物递送系统
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生物医学工程
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药剂学
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产品关联
DOI
PubMed
高影响因子
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
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2015
·
IF 2.101
Zhuojun Gu,Meng Wang,Qiongyan Fang,Huaiyu Zheng,Feiyue Wu,Dai Lin,Ying Xu,Yi Jin
Context: Polyamidoamine (PAMAM) dendrimers have attracted lots of interest as drug carriers. And little study about whether pluronic-attached PAMAM dendrimers could be potential drug delivery systems has been carried on.Objective: Pluronic F127 (PF127) attached PAMAM dendrimers were designed as novel drug carriers.Methods: Two conjugation ratios of PF127-attached PAMAM dendrimers were synthesized. 1H nuclear magnetic resonance (1H-NMR), Fourier transform infrared spectrum (FTIR), element analysis and ninhydrin assay were used to characterize the conjugates. Size, zeta potential and critical micelle concentrations (CMC) were also detected. And DOX was incorporated into the hydrophobic interior of the conjugates. Studies on their drug loading and drug release were carried on. Furthermore, hemolysis and cytotoxicity assay were used to evaluate the toxicity of the conjugates.Results and discussion: PF127 was successfully conjugated to the fifth generation PAMAM dendrimer at two molar ratios of 19% and 57% (PF127 to surface amine per PAMAM dendrimer molecular). The conjugates showed an increased size and a reduced zeta potential. And higher CMC values were obtained than pure PF127. Compared with unconjugated PAMAM dendrimer, PF127 conjugation significantly reduced the hemolytic toxicity and cytotoxicity of PAMAM dendrimer in vitro. The encapsulation results showed that the ability to encapsulate DOX by the conjugate of 19% conjugation ratio was better than that of 57% conjugation ratio. And the maximum is ∼12.87 DOX molecules per conjugate molecule. Moreover, the complexes showed a sustained release behavior compared to pure DOX.Conclusion: Findings from the in vitro study show that the PF127-attached PAMAM dendrimers may be potential carriers for drug delivery.
研究领域:
药学
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生物医学工程
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DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2014
·Vol. 16
·期 38
·8994-9000
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IF 3.858
Tiantian Xing,Yongbing Lou,Qilong Bao,Jinxi Chen
Nanocrystals of ZIF-8 have been successfully prepared in the presence of non-ionic triblock copolymers P123 and F127 under microwave irradiation. Noticeably, the reaction time could be significantly reduced down to 1 min. The obtained ZIF-8 nanocrystals had sizes of sub-104 nm and exhibited a high BET surface area of 1599 m2 g−1. This approach is expected to be an efficient and environmentally friendly method for the preparation of ZIF-8.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2026
·
IF 6.7
Yijie Si,Huanyu Bai,Caifu Yi,Xuebin Song,Chengliang Duan,Daliang Guo,Linxin Zhong,Zhou Sha,Jing Li,Yinchao Xu,Xin Zhang
This study reports a novel method for fabricating carbon paper (CP) self-supporting electrodes via the synergistic modification of phenolic resin with Pluronic F127 and boron-nitrogen co-doped carbon (CNB). Results demonstrated that the soft-templating effect of Pluronic F127, in conjunction with the synergistic heteroatom doping derived from urea (N) and boric acid (B), facilitated the formation of a mesopore-dominated hierarchical pore structure within the CP self-supporting electrodes. The F127-CNB@CP electrode exhibited the tensile and flexural strengths of 11.40 MPa and 633.83 MPa, which are 146% and 77% higher than those of CP electrode, respectively. It also exhibited lower in-plane and through-plane resistivities, which was attributed to attributed to improved interfacial electron transport pathways. Electrochemical tests revealed that the F127-CNB@CP electrode delivered an areal capacitance of 1589.93 mF cm −2 at a current density of 1 mA cm −2 , retains 81.4% of its capacitance at 10 mA cm −2 ，and achieves energy and power densities of 0.22 mWh cm −2 and 4.85 mW cm −2 , respectively. A symmetric supercapacitor assembled with F127-CNB@CP electrode maintains 92.8% of its initial capacitance after 30,000 cycles, delivering an energy density of 0.14 mWh cm −2 and a power density of 0.9 mW cm −2 . This work provides new insights and a theoretical basis for the design of high-performance CP based self-supporting supercapacitor electrodes.
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DOI
高影响因子
Progress in Natural Science-Materials International
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2023
·
IF 4.7
Kaiting Cheng,Yiming Fang,Liang Bai,Feng Gui,Junchi Ma,Huimin Gao,Yadong Zhao,Xingtao Xu
In everyday life, traditional dressings such as band-aid and gauze are used for dealing with small wounds. However, these dressings have shortcomings such as pain caused by tearing, inapplicability to joints, single functionality, and adverse reactions. Therefore, there is a great need for an inexpensive, comfortable, and multi-functional wound dressing. In this study, quaternized chitosan (QCS) with a high degree of substitution (107.84 %) was successfully prepared and characterized using ultraviolet–visible (UV–vis) spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), and proton nuclear magnetic resonance ( 1 H NMR). A series of QCS/F127 thermosensitive hydrogels were prepared by physical cross-linking and used as potential wound dressings. Then the temperature sensitivity, hemostatic ability, antibacterial activity, and sustained drug release effect of the hydrogels were investigated to evaluate their multifunctionality as wound dressings. Finally, the effect of QCS concentration on hydrogel properties was explored. The results show that the composite hydrogels have significant hemostatic, antibacterial, and sustained drug release abilities, and they can be rapidly transformed into a gel state and adhere to skin upon reaching body temperature. In addition, the properties of the hydrogels can be adjusted by varying the concentration of QCS, which allows for the preparation of wound dressings that are responsive to needs. Therefore, multifunctional QCS/F127 hydrogels with temperature-response characteristics are of great clinical research value as wound dressings.
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高影响因子
Polymers
·
2023
·Vol. 15
·期 4
·850
·
IF 5
Linlin Liu,Yue Zhang,Youliang Cheng,Jing Chen,Fengjuan Li
The photocatalytic degradation of organic dyes in waste water using carbon quantum dots (CQDs) remains a hot topic due to the importance of environmental protection. However, identifying suitable carbon resources and successful surface modification are still challenging. Herein, the hydrothermal method and surface modification of ammonia and thionyl chloride were applied to synthesize CQDs with different surface groups using PEO106PPO70PEO106(Pluronic F127) as a carbon source. The average particle size of the as-prepared CQDs was in the range of 2.3–3.5 nm. The unmodified CQDs had the highest relative photoluminescence intensity, while all as-prepared CQDs exhibited abnormal photoluminescence located outside the scope of the visible spectrum. Interestingly, CQDs modified with ammonia achieved a degradation rate of 99.13% (15 d) for 50 mg/L indigo carmine solution, while CQDs modified with thionyl chloride reached a degradation rate of 97.59% (15 d) for light green SF yellowish solution. Therefore, in this work, two typical organic dyes can be effectively photocatalytically degraded by as-prepared CQDs, with suitable surface modification.Keywords:carbon quantum dots;hydrothermal method;photocatalytic activity
研究领域:
环境科学
·
材料科学
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DOI
PubMed
高影响因子
Advanced Optical Materials
·
2025
·
IF 7.2
Junheng Gao,Fu Tang,Yuting Li,Likang Zhang,An Hu,Shuo Li,Lidong Li
Fluorescent hydrogels have immense potential and are widely studied for on demand displays. Response rate of fluorophores upon stimuli within the hydrogel matrix is a key role to improve the timely responsiveness, but rare reports are elaborated on it. In this work, the photoisomeric spiropyran methacrylate (SPMA) is introduced into the poly (2-hydroxyethyl methacrylate) hydrogel to fabricate a stimuli-responsive fluorescent hydrogel. Interestingly, the photoresponse rate of SPMA in the hydrogel is greatly accelerated at the presence of F127 micelles than without it. Both of the absorbance and fluorescence intensity of the hydrogels at the photostationary state are improved obviously with micelles. Besides, the normalized absorbance and the fluorescence kinetic studies indicated a more than 2 times quicker isomerization process. The absolute fluorescence quantum yields of SPMA in the hydrogel is also increased. These can be attributed to the hydrophobic microenvironment provided by the F127 micelles that facilitated the conformation transition of SPMA. Thus, the synergetic effect of the increased amount of activable SPMA and the promoted speed of isomerization contributed to the accelerated photoresponse of the prepared hydrogel. Taking advantage of these virtues, a timely and multi-responsive on-demand information encryption system is realized.
研究领域:
材料科学
·
化学
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产品关联
DOI
高影响因子
Nanoscale
·
2015
·Vol. 8
·期 2
·1140-1146
·
IF 7.394
Chunmei Gao,Shaoyu Lü,Mingzhu Liu,Can Wu,Yun Xiong
The synthesis and properties of CO2 responsive and fluorescent dendritic polymers, poly(amido amine)/Pluronic F127 (PAMAM/F127), are reported in this paper. The morphologies and sizes of PAMAM/F127 dendritic polymers were investigated by dynamic light scattering (DLS) and transmission electron microscopy (TEM). PAMAM/F127 dendritic polymers showed unimolecular micelle morphologies at low concentrations, and changed to multimolecular micelles at higher concentrations. Additionally, fluorescence spectra and confocal laser scanning microscopy images showed that PAMAM/F127 dendritic polymers exhibited a fluorescent enhancement response to the presence of CO2. Apart from that, the release behavior of PAMAM/F127 gels under simulated body fluids was investigated by choosing curcumin as the hydrophobic drug. The results indicated that PAMAM/F127 dendritic polymers can be used to improve the solubility of curcumin, and the drug released faster in the presence of CO2. Such CO2 responsive fluorescent dendritic polymers are potentially applicable in cellular imaging or drug controlled release.
研究领域:
材料科学
·
生物医学工程
·
药学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）