International Journal of Nanomedicine
·
2024
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IF 6.6
Dong Zhang,Mogen Zhang,Huiping Fan,Rui Sun,Jiayun Liu,Weiyuan Ma
Background Melanoma is an aggressive skin tumor with limited therapeutic options due to rapid proliferation, early metastasis, and poor prognosis. Baicalin (BA), a natural flavonoid, shows promise in inducing ferroptosis and apoptosis but faces challenges of poor solubility and bioavailability. To address these issues, we developed a multifunctional drug delivery system: manganese-doped ZIF-8 nanoparticles (ZIF(Mn)) loaded with BA and modified with folic acid (FA) and polyethylene glycol (PEG). FA targets melanoma cells by exploiting folate receptor overexpression, while PEG enhances biocompatibility and systemic circulation. Manganese enables magnetic resonance (MR) imaging for real-time, non-invasive therapy monitoring.Methods BA-loaded ZIF(Mn)/FA-PEG nanoparticles were synthesized via a one-pot method, enabling drug encapsulation, Mn²+ incorporation, and surface modification. The nanoparticles were comprehensively characterized (particle size, Zeta potential, FTIR, and XRD). Cytotoxicity and cellular uptake were evaluated in B16-F10 melanoma cells, and in vivo experiments in C57BL/6J mice investigated MR imaging capability, antitumor efficacy, and biosafety.Results BA@ZIF(Mn)/FA-PEG nanoparticles demonstrated excellent stability, a BA loading capacity of 33.50 ± 0.04%, and pH-responsive release, with accelerated drug release under acidic tumor conditions. Mn²+ provided strong T1-weighted MR imaging contrast. Cellular and animal studies showed enhanced uptake, reduced premature drug release, and improved compatibility. Mechanistically, the nanoparticles induced significant ferroptosis and apoptosis in melanoma cells, leading to potent antitumor effects.Conclusion The BA@ZIF(Mn)/FA-PEG nanoplatform effectively integrates targeted delivery, imaging guidance, and dual ferroptosis-apoptosis induction, offering a promising strategy for improving melanoma treatment outcomes.
研究领域:
药剂学
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肿瘤学
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医学影像学
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DOI
PubMed
高影响因子
CONSTRUCTION AND BUILDING MATERIALS
·
2026
·
IF 8.9
Aofei Guo,Haowei Ma,Youqian Geng,Hu Feng,Zhenyun Yu,Chengcheng Fan,Kuangyu Dai,Yunlong Cheng,Mifeng Cai,Lei Ren,Kuang He
To address the rapid setting issue of alkali-activated fly ash/ground granulated blast furnace slag recycled aggregate concrete (AAFGRC), a portion of the alkali originally provided by the waterglass and sodium hydroxide was substituted with anhydrous Na₂CO₃. A series of tests were conducted to examine the effect of anhydrous Na₂CO₃ on the setting kinetics and mechanical properties of AAFGRC. The results showed that as the alkali equivalent contribution of anhydrous Na₂CO₃ increased, the mechanical properties of AAFGRC gradually decreased, and the setting time was correspondingly extended. Microhardness testing and backscattered electron imaging indicated that the use of anhydrous Na₂CO₃ did not significantly alter the thickness of the interfacial transition zone (ITZ) nor the microhardness and porosity of the ITZ and the new mortar matrix. Isothermal calorimetry (IC) results revealed that adding anhydrous Na₂CO₃ reduced the hydration rates at both the dissolution peak and the polymerization peak, delayed the occurrence of these characteristic peaks, and decreased the cumulative heat release of the alkali activation reaction at 72 h. Based on thermogravimetric testing, X-ray diffraction testing, and Fourier transform infrared spectroscopy testing, it was found that increasing the anhydrous Na₂CO₃ content led to an increase in the content of carbonates and poorly crystalline calcium carbonate, while the content of gel products such as C-(A)-S-H and N-A-S-H decreased. Overall, when the alkali equivalent contribution of anhydrous Na₂CO₃ is 1.7%, a good balance between setting time and mechanical strength can be achieved. In this case, the initial and final setting times could be extended by 137.04% and 140.63%, respectively, compared with the control group, while the 28-day cubic compressive strength, axial compressive strength, and splitting tensile strength decreased by only 4.04%, 7.36%, and 2.62%, respectively.
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Hengyi Li,Tongle Bu,Jing Li,Zhipeng Lin,Junye Pan,Qianhui Li,Xiao-Li Zhang,Zhiliang Ku,Yi-Bing Cheng,Fuzhi Huang
To accelerate the commercial application of organic–inorganic hybrid perovskite solar cells (PSCs), it is necessary to develop simple and low-cost methods to prepare pinhole-free large-area perovskite films with high quality. A one-step blade coating method is regarded as a scalable technique. It is demonstrated that with the addition of N,N′-dimethylpropyleneurea (DMPU) in an FA-dominated perovskite precursor, a large-area high-quality perovskite film can be obtained by blade coating, achieving improved photovoltaic performance, thermal stability, and storage stability. It is found that the strong interaction between DMPU and Pb2+ ions is beneficial to delay the nucleation crystallization process, increase the size of crystal grains, and improve the crystallinity of the perovskite film. Planar n–i–p solar cells introducing DMPU exhibit power conversion efficiencies of 20.20% for 0.16 cm2 devices and 17.71% for 5 × 5 cm2 modules with an aperture area of 10 cm2. In addition, the devices without encapsulation placed at 50 °C for 500 h and with a relative humidity of 20 ± 5% for 1000 h still maintain efficiencies above 80 and 90%, respectively, showing outstanding stability.
研究领域:
材料科学
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能源科学
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化学工程
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DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
·
2018
·Vol. 2018
·期 39
·4375-4384
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IF 2.507
Na An,Huiming Lin,Fengyu Qu
Graphical GNRs@mSiO 2 core–shell nanoparticles have been synthesized as host to load ICG and DOX molecules by the layer-by-layer assembly method through electrostatic interactions. A sensitive Se–Se linker was synthesized and grafted to ensure controlled release. Under NIR irradiation, the enhanced cytotoxicity to cancer cells is derived from the synergistic effect of chemotherapy, PTT, and PDT. A novel GNRs@mSiO 2 core–shell nanocomposite has been synthesized to integrate sensitive chemotherapy with photodynamic therapy (PDT) and photothermal therapy (PTT) for enhanced antitumor treatment by using gold nanorods (GNRs) as the core and mesoporous silica (mSiO 2 ) as the shell. After modifying with -NH 2 , Indocyanine Green (ICG, negative charge) and doxorubicin hydrochloride (DOX, positive charge) molecules could be stored in the mesopores by the layer-by-layer assembly method through electrostatic interactions. To inhibit leakage from the mesopores, a sensitive Se–Se linker was synthesized and adopted as a nanovalve coated on the outside of the nanoparticles (GNRs@mSiO 2 -ICG-DOX@Se-Se). Under NIR (808 nm) irradiation, heat elevation (derived from GNR/ICG) and generation of reactive oxygen species (ROS, derived from ICG) can also be detected in vitro. Owing to the redox sensitivity of Se–Se, GNRs@mSiO 2 -ICG-DOX@Se-Se showed reduction (GSH)- as well as oxidation (ROS)-triggered DOX release. To further ensure specific targeting, folic acid (FA) was grafted to the outside of the nanoparticles, because of the high expression of FA receptors on tumor cells. Detailed cell experiments performed with the nanoparticles and HepG2 as typical cancer cells showed enhanced cytotoxicity towards the cancer cells owing to the synergistic effect of chemotherapy, PTT, and PDT. On account of the different GSH concentrations in cancer and normal cells and the switch-on/off application of NIR irradiation, the GNRs@mSiO 2 -ICG-DOX@Se-Se-FA nanoparticles show potential for applications in cancer therapy.
研究领域:
纳米医学
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肿瘤学
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生物材料学
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DOI
高影响因子
Journal of Material Cycles and Waste Management
·
2023
·Vol. 25
·期 4
·1781-1791
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IF 3.1
Duan Yin,Zheng Lin,Zhao Yimeng,Long Ling,Liu Xiaobo,Jiang Xuguang
MgO-based cementitious material (MCM) is a potential green substitute for solidifying municipal solid waste incineration fly ash (MSWI FA). Sodium hexametaphosphate (SHMP), a commonly used dispersant, has a great influence on the hydration process of MCM-MSWI FA blends. In this study, the effect of different SHMP additions on the performance of the MCM-MSWI FA (3:7 in mass ratio) blends was investigated. The compressive strength and leaching toxicity of the blends were measured, and the structural evolution was analyzed by XRD, FTIR, TG/DTG, and SEM. These tests revealed that the addition of SHMP could significantly optimize the effect of MCM solidifying MSWI FA since SHMP could promote the dispersion of hydration products in the blends. The blends containing more than 1% SHMP exhibited immobilization efficiencies higher than 97.5% for heavy metals (Cd, Pb, and Zn) after curing for 28 days. Collectively, this work demonstrates the indispensable role of SHMP in the application of MCM solidifying MSWI FA, providing theoretical support for practical engineering.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
Advanced Science
·
2025
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IF 14.1
Dongjian Song,Qiuliang Liu,Zechen Yan,Qi Wang,Meng Su,Hui Zhang,Longyan Shi,Yingzhong Fan,Qian Zhang,Heying Yang,Da Zhang
This study investigates the molecular mechanisms by which superparamagnetic iron oxide nanoparticles (SPIONs) loaded with the WSGC peptide (WSGC@FA@PEG/PEI-SPIONs)—a 40-amino acid polypeptide derived from apoC-III—modulate chemotherapy resistance in gastric adenocarcinoma (GA). Emphasis is placed on their role in regulating mitophagy and mitochondrial homeostasis via the Notch signaling pathway. The physicochemical properties of WSGC@FA@PEG/PEI-SPIONs are thoroughly characterized, demonstrating favorable biocompatibility, stable size distribution, and efficient peptide loading. In vitro experiments show that these nanoparticles significantly inhibit GA cell proliferation, migration, and invasion by downregulating mitophagy-associated proteins (LC3, PINK1, and Parkin), primarily through modulation of the Notch pathway. In vivo studies, using a GA nude mouse model, confirm the therapeutic potential of WSGC@FA@PEG/PEI-SPIONs, revealing marked tumor growth inhibition and increased apoptotic activity. Collectively, the findings highlight the WSGC peptide as a promising therapeutic agent for overcoming chemotherapy resistance in GA by targeting the Notch signaling pathway and suppressing mitophagy, thereby presenting a novel strategy for polypeptide-based cancer therapy.
研究领域:
纳米医学
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肿瘤学
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分子生物学
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药理学
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生物化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL RESEARCH
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2022
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IF 1.097
Zhicheng Fan,Chuwu Xing,Yi Tan,Jinxia Xu,Lingyun Liu,Yuanming Zhou,Yan Jiang
Black-phase formamidinium lead iodine with 1.48 eV bandgap is considered to be the most promising material for improving the near-theoretical limit efficiency of perovskite solar cells, but at room temperature, black-phase formamidinium lead iodine easily transforms into the yellow non-perovskite phase formamidinium lead iodine. Here, different ratios of Cs+-incorporated formamidinium lead iodine prepared by one-step processing with the stability and power conversion efficiency of formamidinium lead iodine perovskite solar cells are investigated. FA0.85Cs0.15PbI3 shows the highest power conversion efficiency of 10.63% (Voc = 1.04 V, Jsc = 16.81 mA cm−2, and fill factor = 0.60), and the unencapsulated device maintained 60% of the initial power conversion efficiency after storage in air with 40% humidity for 186 h with an active area of 0.1 cm2, when the ratios of Cs+ reached 15% (x = 0.15) in formamidinium lead iodine. However, the efficiency of perovskite solar cell–based formamidinium lead iodine is still low. In this work, a simple but an effective strategy was carried out to rapidly and fully oxidize hole transport layer solution by doping CO2 or O2 under ultraviolet light irradiation to increase the conductivity of hole transport layer, thereby improving the power conversion efficiency of solar cells. The results show that FA0.85Cs0.15PbI3 solar cells by CO2-doped hole transport layer for 90 s exhibited the highest power conversion efficiency of 16.11% (VOC = 1.11 V, JSC = 19.73 mA cm−2, and fill factor = 0.74). The improved photovoltaic performance is attributed to CO2-doped spiro-OMeTAD increasing charge carrier density and accelerating charge separation, thereby inducing higher conductivity. CO2 or O2 doped can rapidly and fully oxidize spiro-OMeTAD, and reduce the solar cell fabrication time; it is beneficial to the commercial use of perovskite solar cells.
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DOI
高影响因子
DALTON TRANSACTIONS
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2021
·Vol. 50
·期 25
·8927-8937
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IF 4.39
Ying Liu,Na Wang,Zhongqiao Sun,Yide Han,Junli Xu,Yan Xu,Junbiao Wu,Hao Meng,Xia Zhang
MOF/polymer hybrid membranes integrate the surface activity of MOFs and the advantages of PVDF membranes, and can be used as adsorption membranes in the efficient removal of target organics. In this work, a new hybrid membrane of ZIF-67/PVDF with varying ZIF-67 dosages has been fabricated through a facile mechanical blending followed by a lyotropic phase transition. Methods including field-emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), FT-IR analyses and surface hydrophobicity/hydrophilicity measurements are applied to characterize the structure, physicochemical properties and membrane performances. Two synthetic triarylmethane dyes, cationic malachite green (MG) and anionic fuchsin acid (FA), are chosen as the main adsorption targets to evaluate the adsorption capacities of the resulting ZIF-67/PVDF hybrid membranes. Interestingly, all of the ZIF-67/PVDF hybrid membranes exhibit distinctly favorable efficiencies and selectivities toward MG and FA compared to pristine PVDF, which proves the positive roles of ZIF-67 in the adsorption ability of the hybrid membranes. The adsorption conditions are optimized and the adsorption kinetics and thermodynamics are analysed to study the adsorption mechanism. The reusability and the structural stability of the hybrid membranes undergoing cyclic adsorption processes are also discussed. To the best of our knowledge, this is the first time that good adsorption capacities for MG and FA for these MOF/PVDF membranes have been reported. This work highlights the prospective applications of MOF/PVDF hybrid membranes in the rapid and effective removal of target organics in the treatment of waste water.
研究领域:
环境科学
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材料科学
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化学工程
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2023
·
IF 7.2
Xiaosha Guo,Fengwu Tian,Tian Tang,Xixi Di,Wei Wang,Zuoping Zhao,Xiaohui Ji,Xianzhao Shao
Formic acid (FA) is a prospective hydrogen storage agent, which has attracted much attention for its low toxicity and stability and plays a significant role in the comprehensive implementation of the hydrogen economy . In this regard, it is very important to utilize additive free FA dehydrogenation , for which few heterogeneous catalysts are available. Herein, we report ultra-small PdAuIr nanoparticles (NPs) supported on amine-based amorphous porous organic polymers (POPs), which exhibit excellent FA dehydrogenation activity with an initial total turnover number (TOF) of 9635 h −1 without additives at room temperature and apparent activation energy ( Ea app ) of 36.5 kJ/mol. The results show that the excellent performance can be attributed to the synergistic effect of trimetallic alloys and strong metal-support interaction effect (SMSI), as well as to the amine groups (-NH 2 ) grafted on POPs which facilitates the O–H bond splitting on FA. Overall, the simple and efficient synthetic strategy provides a new method for the selective dehydrogenation of FA.
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING RESEARCH & DESIGN
·
2024
·
IF 3.7
Xia Liu,Shanshan Dai,Peng Liu,Jian Lan,Yuanqiang Zhu
Oily wastes are the serious environmental hazards in petroleum industry . Solvent extraction has commonly been used to remove oil from these wastes. However, the traditional solvents suffer from challenges such as difficult separation of oil and solvent, and high solvent consumption. Here, oil separation and solvent reuse were well achieved through the phase transition of ionic liquid system (D-230-FA system) between one phase and two phases, which the process procedure was simple. The ionic liquid (D-230-FA) was successfully formed by poly (propylene glycol) bis (2-aminopropyl ether) D-230 and fatty acids, which was demonstrated by 1 HNMR and FT-IR. The acid-basic switchability of the D-230-FA system was studied by pH, FT-IR. The process of separating oil based on the D-230-FA system was studied by SEM, infrared spectrophotometry test, Soxhlet extraction and molecular dynamics simulation. The results show that the D-230-FA system exhibited excellent acid-basic switchability, the extraction rate could reach 97.59 % and the residual oil rate in the solvent was less than 0.1495 %. Thus, the acid-base switchable D-230-FA system will be expected to treated as the effective extractant for sustainable separation of oily wastes.
研究领域:
环境科学
·
化学工程
·
材料科学
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产品关联
DOI
高影响因子
BIORESOURCE TECHNOLOGY
·
2022
·
IF 11.889
Xiheng Kang,Jian Peng,Arthur J. Ragauskas,Xiaofei Ren,Chuanling Si,Shuangfei Wang,Xueping Song
The complexity of polysaccharide hydrothermal products increases the difficulty of exploring the formation of biochar, limiting the development of biochar. This work clarifies the completive effects of glucan’s main hydrolysates on biochar formation from three aspects: experimental, thermodynamic, and kinetic. The products distribution illustrates that 5-HMF, FA, and LA are mainly involved in the formation of biochar. Biochar mainly includes furan ring, ether group, and ester group by the analysis of magic-angle-spinning nuclear magnetic resonance, X-ray photoelectron spectroscopy, and elemental analysis. Combined experiments and density functional theory analysis, the etherification reaction of 5-HMF itself is most likely to occur and is key to form biochar, followed by the esterification of FA with 5-HMF, and then the etherification of 5-HMF and LA. The further verified experiments also manifest these results. This work will develop a foundation for exploring the complex formation mechanism of cellulose-based biochar.
研究领域:
化学
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环境科学
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生物质能
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DOI
PubMed
高影响因子
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
·
2026
·Vol. 40
·期 16
·e70106
·
IF 1.8
Xing Hong,Yuxin Wen,Benjiang Xiao,Qi Jiang,Meng Chen,Pengyu Chen,Rui Qian,Qiong Wang,Jingjing Li,Fang Huang,Zhuang Huang,Lintao Han
Objective This study aimed to investigate the therapeutic mechanisms of CY in treating UC using an integrated metabolomics and proteomics approach. Methods A murine UC model was induced using dextran sulfate sodium (DSS). The therapeutic efficacy of CY was evaluated via histological examination (H&E staining) of colon tissues to assess inflammation, epithelial necrosis, and crypt abscesses. Serum and colon tissues were collected for ELISA, immunofluorescence, Western blotting, metabolomics, and proteomics analyses. Additionally, an in vitro intestinal epithelial barrier model was established using LPS-induced Caco-2 cells. Cell viability, barrier function (TEER and FITC-Dextran permeability), cell damage (LDH), and inflammatory cytokine levels (IL-6 and IL-1β) were measured. The expression and distribution of tight junction proteins (ZO-1 and occludin) and signaling proteins (FAK, p-FAK, paxillin, and p-paxillin) were analyzed via immunofluorescence and Western blotting. Results CY treatment significantly reduced the Disease Activity Index (DAI) and suppressed the levels of pro-inflammatory cytokines (IL-6, IL-1β, and TNF-α) in UC mice. Proteomic analysis identified Caveolin-1 (CAV1) and the focal adhesion pathway as key therapeutic targets and signaling pathways. Metabolomic profiling revealed 17 endogenous metabolites, highlighting tryptophan metabolism and butyrate metabolism as critical pathways. Furthermore, CY intervention modulated arachidonic acid and linoleic acid metabolism. Mechanistically, CY upregulated the expression of CAV1 and FAK while downregulating AKT and paxillin phosphorylation. In vitro experiments demonstrated that CY-containing serum restored the barrier function of LPS-induced Caco-2 cells by regulating FAK/paxillin phosphorylation, upregulating tight junction proteins, and mitigating inflammatory responses. Conclusion CY involvement in colonic mucosal healing attenuates inflammation and enhances intestinal barrier function in DSS-induced colitis, likely through the modulation of the CAV1/FA axis. These findings provide a theoretical basis for the clinical application of CY and offer novel insights for the development of therapeutic agents for UC.
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DOI
PubMed
高影响因子
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