Advanced Science
·
2024
·
IF 14.3
Rui Qiao,Zhongwen Yuan,Meijin Yang,Zhiying Tang,Lizhen He,Tianfeng Chen
Exploring efficient and low-toxicity radiosensitizers to break through the bottleneck of radiation tolerance, immunosuppression and poor prognosis remains one of the critical developmental challenges in radiotherapy. Nanoheterojunctions, due to their unique physicochemical properties, have demonstrated excellent radiosensitization effects in radiation energy deposition and in lifting tumor radiotherapy inhibition. Herein, they doped selenium (Se) into prussian blue (PB) to construct a nano-heterojunction (Se@PB), which could promote the increase of Fe 2+ /Fe 3+ ratio and conversion of Se to a high valence state with Se introduction. The Fe 2+ -Se-Fe 3+ electron transfer chain accelerates the rate of electron transfer on the surface of the nanoparticles, which in turn endows it with efficient X-ray energy transfer and electron transport capability, and enhances radiotherapy physical sensitivity. Furthermore, Se@PB induces glutathione (GSH) depletion and Fe 2+ accumulation through pro-Fenton reaction, thereby disturbs the redox balance in tumor cells and enhances biochemical sensitivity of radiotherapy. As an excellent radiosensitizer, Se@PB effectively enhances X-ray induced mitochondrial dysfunction and DNA damage, thereby promotes cell apoptosis and synergistic cervical cancer radiotherapy. This study elucidates the radiosensitization mechanism of Se-doped nanoheterojunction from the perspective of the electron transfer chain and biochemistry reaction, which provides an efficient and low-toxic strategy in radiotherapy.
研究领域:
纳米技术
·
肿瘤学
·
放射治疗
·
材料科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Ke Deng,Qin Huang,Xiaotong Yan,Yan Dai,Juan Zhao,Xia Xiong,Hailan Wang,Xianggui Chen,Pengfei Chen,Li Liu
Achieving the controllable detachment of polysaccharide-based wound dressings is challenging. In this study, a novel, photodetachable salecan-based hydrogel dressing with injectable, self-healing, antibacterial, and wound healing properties was developed using a green and facile approach. A salecan hydrogel with a uniform porous structure and water content of 90.4 % was prepared by simply mixing salecan and an Fe 3+ –citric acid complexing solution in an acidic D-(+)-glucono-1,5-lactone environment. Metal coordinate interactions were formed between the released Fe 3+ ions and carboxyl groups on the salecan polysaccharide, inducing homogeneous gelation. Benefiting from this dynamic and reversible crosslinking, the salecan hydrogel exhibited self-healing and injectable behavior, facilitating the formation of the desired shapes in situ. The exposure of Fe 3+ –citric acid to UV light (365 nm) resulted in the reduction of Fe 3+ to Fe 2+ through photochemical reactions, enabling phototriggered detachment. Moreover, the hydrogel exhibited excellent biocompatibility and satisfactory antibacterial efficacy against Escherichia coli and Staphylococcus aureus of 72.5 % and 85.3 %, respectively. The adhesive strength of the salecan hydrogel to porcine skin was 1.06 ± 0.12 kPa. In vivo wound healing experiments further highlighted the advantages of the prepared hydrogel in alleviating the degree of wound inflammation and promoting tissue regeneration within 12 days.
研究领域:
材料科学
·
生物材料
·
伤口愈合
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TETRAHEDRON
·
2023
·
IF 2.1
Jianping Zhang,Jinming Liu,Gengwen Yin,Wenlong Hou,Haiquan Zhang
Nucleophilic substitution reaction of 1,7-dibromo-perylene diimide derivatives can expend the chemical structure and photophysical properties of perylene diimide. Here, we reported firstly the synthesis and mechanism of 1-bromo-7-hydroxyl perylene diimide derivative by the 1,7-dibromo-perylene diimide derivative in electron donor solvents (such as, NMP, DMF and etc) and under visible light irradiation . The structure of 1-dibromo-7-hydroxyl perylene diimide was confirmed by HR-MS, UV–Vis absorption spectra and comparison of UV–Vis absorption spectra with product from the heating chemical reaction. Furthermore, the 1-bromo-7-hydroxyl-perylene diimide derivative showed a higher optical response to some metal ions , such as Fe 3+ , Cu 2+ and etc.
研究领域:
有机化学
·
光化学
·
材料科学
✓ 已验证
DOI
高影响因子
CHEMOSPHERE
·
2021
·
IF 7.086
Chongqing Wang,Ruirui Sun,Rong Huang,Yijun Cao
Hydrogen peroxide activation by pyrite for degradation of recalcitrant contaminants receives increasing attention. The improvement of catalytic efficiency of natural pyrite is still a challenging issue. This work provides a novel strategy of enhancing catalytic efficiency via pre-reaction between pyrite and hydrogen peroxide. Effects of process factors including pre-reaction time, hydrogen peroxide, solution pH and initial dye concentration were examined. Natural pyrite with low purity was characterized by Raman, scanning electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. Reaction kinetic verifies tremendous improvement of the reaction rate through pre-reaction. Enhanced dye degradation is ascribed to hydroxyl radical production promoted by self-regulation of pH, Fe 2+ releasing and Fe 2+ /Fe 3+ cycle. The plausible mechanism was proposed based on multiple determinations. Dye degradation in different water matrix was efficiently obtained, as well as multicomponent dyes. Additionally, broad operation pH and good reusing performance make the developed process highly attractive for application. This work provides a solid step-forward of pyrite/hydrogen peroxide Fenton process for treatment of recalcitrant contaminants in wastewater.
研究领域:
环境科学
·
化学工程
·
废水处理
·
催化
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Yun Liu,Meng Xiao,Ningxia Xu,Mengsu Yang,Changqing Yi
This study reports a new ratiometric fluorescence probe (referred to as [email protected] @bCDs) and a smartphone-based sensing system for on-site quantitation of Fe 3+ , ascorbic acid (AA), alkaline phosphatase (ALP) and 2,4-dichlorophenoxyacetic acid (2,4-D). [email protected] @bCDs with well-resolved dual emissions is facilely synthesized by covalent conjugation of red-emissive quantum dots (rQDs), the internal standard, with blue-emissive carbon dots (bCDs), the Fe 3+ -specific fluorescent indicator . 2,4-D can specifically inhibit the enzymatic activity of ALP, leading to suppress the production of AA which can reduce Fe 3+ to Fe 2+ and thereafter trigger the fluorescence response of [email protected] @bCDs. Taking advantages of these highly specific cascade catalytic reactions , ratiometric fluorescence schemes are established for sensing Fe 3+ , AA, ALP and 2,4-D both in aqueous solution and on paper-based microarray . The smartphone-based fluorescence detector integrated with the [email protected] @bCDs-based microarray demonstrated good sensing performance with a wide linear range and low detection limit, and is successfully applied to quantitate 2,4-D in cabbage and tap water samples. The reported method which enables point-of-need quantitation in a sample-in-result-out manner and highlights its features of cost-effectiveness and ease-of-use, is ideally for food safety inspection, environment surveillance, health monitoring at point-of-need, especially in low resource settings.
研究领域:
分析化学
·
环境科学
·
食品安全
·
生物技术
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-14
·
IF 16.6
Fang Fang,Wang Sa,Song Yueyue,Sun Meng,Chen Wen-Cheng,Zhao Dongxu,Zhang Jinfeng
Nanomedicine holds great promise to enhance cancer therapy. However, low active pharmaceutical ingredient (API) loading content, unpredictable drug release, and potential toxicity from excipients limit their translational capability. We herein report a full-API nanodrug composed of FDA-approved 5-aminolevulinic acid (ALA), human essential element Fe 3+ , and natural bioactive compound curcumin with an ideal API content and pH-responsive release profile for continuous spatiotemporal cancer therapy achieved by multi-step tandem endogenous biosynthesis. First, ALA enzymatically converts into photosensitizer protoporphyrin IX (PpIX). Afterward, multiple downstream products including carbon monoxide (CO), Fe 2+ , biliverdin (BV), and bilirubin (BR) are individually biosynthesized through the PpIX-heme-CO/Fe 2+ /BV-BR metabolic pathway, further cooperating with released Fe 3+ and curcumin, ultimately eliciting mitochondria damage, membrane disruption, and intracytoplasmic injury. This work not only provides a paradigm for exploiting diversified metabolites for tumor suppression, but also presents a safe and efficient full-API nanodrug, facilitating the practical translation of nanodrugs.
研究领域:
纳米医学
·
癌症研究
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Bio
·
2023
·
IF 8.2
Wenxin Zhang,Xiaodie Li,Jialin Zeng,Xin Wen,Chao Zhang,Yinan Zhang,Jian He,Lihua Yang
Radiation therapy (RT) has emerged as one of the most promising anti-tumor strategies for neuroblastoma. Nevertheless, the special tumor microenvironment (TME), including hypoxic and GSH-overexpressed TME, often greatly restricts the RT outcome. In this study, we demonstrated a dual-channel parallel radicals nanoamplifier (ATO@PAE-PEG-AS1411/Fe 3+ ). The nanoamplifier was shaped into a bilayer shell-core structure, in which atovaquone-loaded poly (β-amino esters)-poly (ethylene glycol) (ATO@PAE-PEG) served as the core while Fe 3+ -absorbed AS1411 aptamer (AS1411/Fe 3+ ) served as the shell. Taking advantage of the targeting ability of AS1411, ATO@PAE-PEG-AS1411/Fe 3+ specifically accumulated in tumor cells, and then released ATO as well as Fe 3+ in response to the acidic TME. The released ATO dramatically inhibited the mitochondrial respiration of tumor cells, thus sparing vast amounts of oxygen for the generation of free radicals during RT process, which was the first free radicals-amplifying pathway Meanwhile, the released Fe 3+ could consume the tumor-overexpressed GSH through the redox reaction, thus effectively preserving the generated free radicals in RT process, which was the second free radicals-amplifying pathway. Taken together, our study demonstrates a dual-channel parallel free radicals-amplifying RT strategy, and it is expected this work will promote the clinical application prospects of RT treatment against neuroblastoma.
研究领域:
肿瘤学
·
纳米技术
·
放射治疗
·
药学
✓ 已验证
DOI
PubMed
高影响因子
Energy Technology
·
2020
·Vol. 8
·期 7
·2000278
·
IF 3.404
Xiang Guan,Yuanxing Yong,Qingping Wu,Xiaowan Zhang,Xuhong Guo,Chilin Li,Jun Xu
High-capacity silicon anodes have attracted tremendous interest for next-generation lithium-ion batteries (LIBs). However, its further application is limited by the large volume expansion during cycling. Designing nanostructured silicon is an effective strategy to acquire high-performance anodes, but it will face problems of high cost and poor coulombic efficiency. As a comparison, surface modification of micron silicon is more economically viable. Herein, a novel route is proposed to synthesize metal-chelated biomimetic polyelectrolyte as a powerful binder, which wraps micron silicon particles in a thin Fe 3+ –polydopamine (PDA) layer with a thickness of 2–5 nm. The introduced Fe 3+ can form powerful metal-chelated bonds with PDA at appropriate hydrothermal temperature (160 °C). As a result, the mechanical strength of the protective layer is enhanced and the electrochemical activity of micron silicon is improved. Meanwhile, the 3D crosslinking structure formed through the esterification between the elastic polymer layer and polyacrylic acid (PAA) further guarantees the structural stability of anodes. Batteries using Si@Fe 3+ –PDA–160/PAA anode exhibit excellent cycling performance with stable capacity of 2000 mAh g −1 over 200 cycles at 0.5 C and high capacity retention ratio of 80% after 100 cycles at 0.1 C.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
DOI
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2024
·
IF 3.5
Mamuhe Yeerlan,Meng Zhang,Pengpeng Dai
Fe 3+ ions as near-infrared (NIR) activators are emerging as an alternative to Cr 3+ . 1–5 However, it is a challenge to develop Fe 3+ -activated NIR phosphors featuring tunable optical properties, high efficiency, and thermal stability. Herein, we present a series of near-unity internal quantum efficiency (IQE), wavelength-tunable and thermal stability NIR-emitting phosphors Sr 2− y Ca y Sc 1− x SbO 6 : x Fe 3+ (S 2− y C y S 1− x S: x Fe 3+ ). Sr 2 ScSbO 6 :1%Fe 3+ (SSS:1%Fe 3+ ) phosphor shows broadband NIR emission at 904 nm and near-unity IQE under excitation at 300 nm. Experimental and theoretical calculation results demonstrate that introduced Ca ions could increase the bandgap value and Debye temperature (Θ D ) of host from E g = 3.702 eV, Θ D = 609 K of y = 0 to E g = 3.801 eV, Θ D = 692 K of y = 2. Significantly, the resultant S 2− y C y S 1− x S:1%Fe 3+ NIR phosphors show wavelength-tunable emission from 904 to 952 nm and high IQE of 84.6%–97.5% as well as enhanced thermal stability ( I 423K / I 298K = 76.9%) of Ca 2 ScSbO 6 :1%Fe 3+ (CSS:1%Fe 3+ ) in comparison with that ( I 423K / I 298K = 70.6%) of pristine sample. We fabricated an NIR light-emitting diodes (LED) device by using CSS:1%Fe 3+ NIR phosphors with ultraviolet LED chip and demonstrated its potential applications in anticounterfeiting, information encryption, and night vision.
研究领域:
材料科学
·
光学
·
光子学
·
固体物理
✓ 已验证
DOI
高影响因子
JOURNAL OF POWER SOURCES
·
2018
·
IF 6.945
Peng Zhang,Xiaotong Yang,Tong Wang,Nobuyuki Imanishi,Osamu Yamamoto,Miao Wang
We demonstrate a novel rechargeable energy storage system having a metallic lithium negative electrode and a liquid–solid hybrid positive electrode of Fe 3+ /Fe 2+ /Fe in N,N-Dimethylformamide, which are separated by an impermeable NASICON–type Li 1.4 Al 0.4 Ge 0.2 Ti 1.4 (PO 4 ) 3 –epoxy resin composite film with a lithium ion conductivity of ca. 5.0 × 10 −4 S cm −1 . The discharge curve for the battery shows two plateaus. The first plateau corresponds to Li + FeCl 3 = LiCl + FeCl 2 , while the second one is associated with 2 Li + FeCl 2 = 2 LiCl + Fe. In the process of reduction of Fe 3+ to Fe 2+ , it delivers a stable discharge capacity of ca. 110 mAh g FeCl3 −1 with a Coulombic efficiency higher than 95% and is capable of enduring over 60 circles at a high current density of 1.0 mA cm −2 without any catalyst. Furthermore, a stable discharge capacity up to ca. 455 mAh g FeCl3 −1 is achieved for conversion of FeCl 3 /FeCl 2 /Fe with a three–electron reaction. This work demonstrates a proof of feasibility of hybrid liquid–solid hybrid positive electrode, since these reactions are reversible confirmed by x–ray diffraction patterns and EDX mapping test.
研究领域:
材料科学
·
电化学
·
能源存储系统
·
电池技术
✓ 已验证
产品关联
DOI
高影响因子
Food Bioscience
·
2024
·
IF 4.8
Yanyan Zhang,Shengjun Ma,Haixia Li,Peizi Liu,Keyi Chen,Wei Cai
Research on Polygonatum cyrtonema Hua has focused extensively on its main active components, yet antioxidant peptides remained less explored. This study optimized the preparation process of antioxidant peptides from P. cyrtonema via protein hydrolysis using response surface methodology. The peptide mixture was separated into four fractions using ultrafiltration and G-25 gel chromatography, based on antioxidant capacity. Notably, the F2 exhibited significantly higher Fe 3 ⁺ reducing power (17.17%) and ABTS· radical scavenging rate (30.1%) compared to other fractions at the same concentration. Characterization by Nano-LC-Q Exactive Plus quadrupole Orbitrap MS revealed that F2 contained 11,704 peptides, markedly more than the endogenous (2,454) and crude protein peptides (2,334). Bioinformatics and molecular docking identified three peptides—QFLPF, FVPF, and FPNLF—as having the highest antioxidant potential. These peptides increased cell viability in oxidative damage-induced HepG2 cells by 6.39%, 14.51%, and 9.98%, respectively, compared to the model group. This study lays the groundwork for future mechanistic investigations into the antioxidant peptides of P. cyrtonema.
研究领域:
药理学
·
生物化学
·
分子生物学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2016
·
IF 4.758
Lihong Shi,Bo Zhao,Xiaofeng Li,Guomei Zhang,Yan Zhang,Chuan Dong,Shaomin Shuang
We report an eco-friendly strategy for fabrication of nitrogen-doped carbon nanodots (N-CDs) and demonstrate their applications for multicolor cell imaging, patterning, and biosensing. N-CDs have been synthesized using wool as raw material via pyrolysis and microwave treatment, providing a green way for the production of N-CDs without the use of toxic/expensive solvents and starting materials. The prepared N-CDs exhibit exceptional advantages including high fluorescent quantum yield (22.5%), excellent biocompatibility, low toxicity, and satisfactory chemical stability. Depending on these superior properties, the N-CDs have been applied in multicolor bioimaging, patterning, and biosensing. Imaging of living cells has been observed with high resolution using N-CDs as a probe, which validates their use in imaging applications and their multicolor property in the living cell system. Additionally, the obtained N-CDs have been used as fluorescent inks for drawing luminescent patterns, showing favorable application in anti-counterfeit and optoelectronic dimensions. Most strikingly, the as-prepared N-CDs could visualize Fe 3+ fluctuations in living cells with negligible autofluorescence based on their high sensitivity and selectivity detection for Fe 3+ ions with a linear range of 0.1–10 μM and a detection limit of 10 nM.
研究领域:
材料科学
·
纳米技术
·
生物传感器
·
细胞生物学
·
光电
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）