CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Dejun She,Shaojun Peng,Li Liu,Huihui Huang,Yingyan Zheng,Yiping Lu,Daoying Geng,Bo Yin
Hypothermal photothermal therapy (HPTT) employs hyperthermia (<45 °C) to destroy tumor cells with negligible side effects to the surrounding normal tissues. Despite extensive studies, the clinical translation of HPTT is severely hindered, owing to the discounted therapeutic effect and maximum permissible power of near-infrared (NIR) laser by food and drug administration (FDA). Herein, we report a rational design of red blood cell membranes (RBCs) coated FeS 2 (FeS 2 @RBCs) with strong absorption at NIR-Ⅱ window for effective HPTT augmented chemodynamic therapy (CDT). FeS 2 @RBCs exhibits prolonged blood circulation and negligible immune response, leading to improved tumor accumulation for enhanced HPTT. Furthermore, the CDT effect of FeS 2 @RBCs is significantly augmented by the temperature elevation in the tumor region, which leads to the synergetic HPTT and CDT. Lipidomics analysis reveals that the damage of tumor cells by CDT is via the lipid peroxidation. In addition, FeS 2 @RBCs exhibits self-enhanced magnetic resonance imaging after reacting with H 2 O 2 in tumor region for imaging-guided laser irradiation. Thus, FeS 2 @RBCs achieves remarkable inhibition of subcutaneous 4T1 breast tumor growth without obvious side effects by a 1064 nm laser irradiation of 1.0 W/cm 2 (FDA approved power density). Overall, this work provides a HPTT augmented CDT strategy for effective cancer therapy with a clinical approved laser power, which may pave the way for the clinical application of HPTT augmented CDT in the future.
研究领域:
癌症治疗
·
生物医学工程
·
纳米技术
·
分子生物学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Chao Shen,Yiqian Liu,Yaru Shi,Xiaoyu Liu,Yong Jiang,Shoushuang Huang,Jiujun Zhang,Bing Zhao
The all-solid-state lithium batteries (ASSLBs) with high energy density are considered to be one of the most promising candidates for next-generation lithium battery systems. Nevertheless, the low ionic and electronic conduction inside the cathode and the poor interfacial contact of the cathode/electrolyte seriously impede the large-scale application of ASSLBs . In this work, a novel multiple ion–electron conductive network is constructed on the FeS 2 cathode to realize a high-energy all-solid-state battery. The internal disordered carbon matrix acts as electronic network to accelerate the electronic transmission. Meanwhile, reduced graphene oxide (rGO) tightly wrapping FeS 2 /C microspheres’ surface serves as external electronic pathway. Moreover, the in-situ formed Li 7 P 3 S 11 electrolyte infiltrates into the nanoparticles to improve lithium-ion transport kinetics. Therefore, the dual-carbon framework and Li 7 P 3 S 11 coating layer strategies significantly enhance ion–electron transport kinetics and improve interfacial contact during cycling. As expected, the FeS 2 @C/rGO@Li 7 P 3 S 11 cathode exhibits excellent rate capability and cycling stability, showing a reversible discharge capacity of 350.3 mAh/g at 0.5C after 200 cycles. More importantly, ex-situ XPS and dQ/dV results reveal that the synergistic effect of dual-carbon frameworks and Li 7 P 3 S 11 coating layer not only provides fast electron–ion transfer channels, but also wraps the reaction products with poor electrochemical activity such as Fe 0 , FeS y , and S to accelerate the reaction kinetics and strengthens the reaction reversibility. This work provides valuable insights for improving the electrochemical performance and understanding the reaction mechanism of the conversion-type metal sulfide cathodes in ASSLBs .
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
DOI
高影响因子
ACS Applied Bio Materials
·
2020
·
IF 0
Wei Ding,Haibo Liu,Weiwen Zhao,Jie Wang,Linlin Zhang,Yuewei Yao,Cheng Yao,Chan Song
Recently, the development of nanozymes with high catalytic performance is gaining more and more attention due to the ever-growing demands for their practical applications. The elaborate design of its morphology has demonstrated to be an effective approach to improve the performance of these nanozymes. Herein, a hybrid of iron disulfide nanoparticles (FeS2 NPs) encapsulated by two-dimensional (2D) carbon nanosheets (NSs), denoted as FeS2@C NSs, demonstrates both superior peroxidase-like activity and excellent stability. The incorporation of 2D carbon sheets endows the proposed FeS2@C nanozymes with high specific surface area, providing abundant active sites to facilitate the contact with substrates. Moreover, the embedded FeS2 NPs are kept from aggregation due to the encapsulation and confinement of 2D carbon sheets, avoiding the conventional failure of single-component nanozymes. Based on glucose oxidase (GOx) and the elaborately designed FeS2@C nanozymes, a colorimetric method for glucose detection is then developed with excellent simplicity and sensitivity. The detection limit of the sensing platform is as low as 0.19 μM for a glucose assay. More notably, this method can be successfully employed for the glucose assay in some real samples, indicating the great potential of this FeS2@C NS-based nanozymes in the fields of biotechnology and clinical diagnostics.
研究领域:
材料科学
·
纳米技术
·
分析化学
·
生物技术
·
临床诊断
✓ 已验证
产品关联
DOI
PubMed
MICROCHIMICA ACTA
·
2022
·Vol. 189
·期 11
·1-10
·
IF 6.408
Fan Ru,Tian Jinrong,Wang Huili,Wang Xuedong,Zhou Peipei
By employing NH 2 -MIL-88 as a template, we synthesized the intermediate Fe@CN under high-temperature calcination and further fabricated the FeS 2 @CN nanocomposites in the presence of sulfur powder. Under varying temperatures (300–600 °C) and Fe@CN-to-S ratios (1:3–6), FeS 2 @CN 500-5 nanocomposites had the highest peroxidase-mimetic activity. Under optimized conditions (incubation temperature 40 °C; solution pH 4.0 and nanocomposite concentration 10 μg/mL; 652-nm absorption), the Michaelis-Menten constant ( K m ) of FeS 2 @CN was much lower than that of horseradish peroxidase (HRP), therefore demonstrating that it had a higher affinity for both chromogenic substrates than conventional HRP. The limits of detection for H 2 O 2 and glucose were 0.15 and 0.30 μmol/L, respectively, and the recoveries for glucose were 91.8–103% with RSDs <5.2%. The novelty of this study lies in (1) the FeS 2 @CN was confirmed to possess stronger enzyme-mimetic activity than its precursors (NH 2 -MIL-88 and Fe@CN); (2) the enhanced activity resulted from the unsaturated sites of N and S doping and the plentiful defects on the porous carbon surface; and (3) free radical trapping experiments evidenced that •OH played a major role in the catalytic reaction, while h + and •O 2 − simultaneously participated in the catalytic process. These convincing performance metrics lead us to postulate that the FeS 2 @CN-based colorimetric biosensor provides a promising approach for several real-world applications, such as point-of-care diagnosis and workplace health evaluations. Graphical abstract
研究领域:
生物化学
·
分析化学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2019
·
IF 9.518
Chan Song,Wei Ding,Weiwen Zhao,Haibo Liu,Jie Wang,Yuewei Yao,Cheng Yao
In the last decades, enzyme mimics have been regarded as strong substitutes to natural enzymes . The construction of biosensors based on these enzyme mimics with competitive catalytic activity and substrate specificity has attracted a lot of research interest. Herein, for the first time, we investigated the capability of nanoscale FeS 2 to serve as enzyme mimics. Then, a facile and effective biosensor is fabricated based on its intrinsic peroxidase-like catalytic activity. In the presence of H 2 O 2 , FeS 2 nanoparticles (NPs) possess high peroxidase-like activity to 3,3′,5,5′-tetramethylbenzidine (TMB) oxidation , which can be ascribed to the generation of hydroxyl radicals (·OH) from the H 2 O 2 decomposition catalyzed by FeS 2 NPs. As for TMB, the resulting Michaelis−Menten constant ( K m ) value of FeS 2 NPs is found to be about 12 times lower than that of natural horseradish peroxidase (HRP), highlighting the superiority of FeS 2 NPs. Based on these intriguing observations, a reliable colorimetric method is then developed for detection of H 2 O 2 and glutathione (GSH) by a simple mix-and-detect strategy. The detection limits of H 2 O 2 and GSH are as low as 0.91 μM and 0.15 μM (3σ/slope), respectively. Moreover, FeS 2 NPs can also catalyse the photoluminescence (PL) substrate terephthalic acid (TA) under the assistance of H 2 O 2 . This work remarkably extends the utilization of FeS 2 NPs in the construction of colorimetric and PL biosensors in the fields of biosensing, environmental monitoring, and medical diagnosis.
研究领域:
生物传感
·
环境监测
·
医学诊断
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Shuxiang Xu,Shuyi Zhou,Luoyijun Xie,Wenlong Dou,Rongjun Zhang,Bingxia Zhao,Yang Xu,Xuemei Fu,Miaomiao Yuan
Due to the heterogeneous and complex tumor microenvironment (TME), it remains challenging to effectively treat solid tumors with monotherapy. The development of a versatile nanomaterial strategy for synergistic chemodynamic/photodynamic/photothermal therapies has the potential to overcome this challenge. Herein, we designed and synthesized NiS 2 /FeS 2 hybrid nanoparticles (NiS 2 /FeS 2 NPs), which are further modified with polyvinyl pyrrolidone (PVP) to improve their biocompatibility. PVP-NiS 2 /FeS 2 NPs exhibit synergistic activities of chemodynamic therapy (CDT), photodynamic therapy (PDT), and photothermal therapy (PTT) with multimodal imaging capabilities. With the presence of Fe 2+ /Fe 3+ and Ni 2+ /Ni 3+ redox couples, the PVP-NiS 2 /FeS 2 NPs exhibit GSH peroxidase-like reactivity and trigger Fenton reaction, leading to robust ·OH generation and pyroptosis/ferroptosis after near infared irradiation (NIR). In response to the PVP-NiS 2 /FeS 2 NPs and PVP-NiS 2 /FeS 2 NPs + NIR treatment, the breast tumors formed in the syngeneic BABL/c mice were eliminated and their metastases suppressed by inhibiting the EMT pathway. Consistent with the apparent involvement of these programmed cell death pathways in activating tumor immunity, we demonstrate that PVP-NiS 2 /FeS 2 NPs + NIR can eliminate metastatic tumors in an immune system dependent manner. Therefore, PVP-NiS 2 /FeS 2 NPs represent a promising strategy to treat metastatic breast cancer.
研究领域:
纳米技术
·
癌症治疗
·
生物医学工程
·
材料科学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2024
·
IF 0
Xu Xiangwei,Ying Yunzhan,Liang Shikun,Song Wenkai,Wu Zenglong,Zhang Fayang,Yan Haoxiang,Yao Yuyuan
Developing highly effective iron-based catalyst to selectively remove organic contaminants has garnered considerable attention. Herein, a magnetic Fe 0 /FeS 2 -doped carbon nanolayer (S-Fe@NC) was synthesized through a straightforward one-step pyrolysis method, pyrolyzing a mixture composed of 4,6-dihydroxypyrimidine, trithiocyanuric acid, and FeCl 3 ·6H 2 O. With the presence of PMS, S-Fe@NC demonstrated the ability to remove almost 100% bisphenol-A (50 μM) within 3 min, attributed to its excellent graphitization degree and high FeS 2 /Fe 0 content. Furthermore, the S-Fe@NC catalyst demonstrated an impressive k obs value of 1.476 min −1 , which surpassed the traditional Fenton system by 77 times and even exceeded the commercial Fe 0 catalyst by 127 times. More importantly, the S-Fe@NC/PMS system succeeded in selectively removing organic contaminants based on the hydrophobic interaction between catalyst and contaminants. Besides, the result of electron paramagnetic resonance and the radical quenching experiments indicated that ·OH, SO 4 ·− , 1 O 2 , and O 2 ·− were involved in the organic contaminants removal. Interestingly, after adding ascorbic acid (AA) to the S-Fe@NC/PMS system, more ROS could be generated to result in the k obs augmenting by 4.16 times (6.133 min −1 ), completely different from the common sense that AA was usually used as a radical quencher. Additionally, the magnetically separable catalyst also exhibited excellent reusability and broad pH adaptability (2.0–12.0). This study provided a valuable insight for developing highly selective and effective Fe-based catalyst for practical wastewater treatment.
研究领域:
环境科学
·
催化
·
水处理
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
Small Methods
·
2025
·Vol. 9
·期 8
·2500282
·
IF 9.1
Yishun Xie,Jinlian Yu,Lisan Cui,Guangchang Yang,Shaorong Lu,Xiaohui Zhang,Feiyan Lai,Lin Qin,Xin Fan,Hongqiang Wang
Structural design combined with crystal engineering is an external and internal modifying strategy for metal oxides and sulfides as anode materials for lithium/sodium-ion batteries (LIBs/SIBs). In this paper, the low-cost iron-based oxide of Fe 2 O 3 shaped into dendritic nanostructure is locally in situ phase converted to FeS 2 and form porous Fe 2 O 3 /FeS 2 polycrystalline texture. The Fe 2 O 3 /FeS 2 maintains the original porous, cross-linked and low-dimension structural advantages of the Fe 2 O 3 precursor for electron transport and ions exchange and alleviating volume expansion. Then, the abundant heterogeneous in the converted Fe 2 O 3 /FeS 2 dramatically enhances electron diffusion in crystal and the structural stability at phase boundary. The prepared anode achieves superior rate capability and ultra-long cycling stability with high capacity both in LIBs and SIBs. Specially, it shows 1017 and 1016 mAh g −1 at 10 A g −1 in LIBs and SIBs, separately. After 3000 cycles, the electrodes maintain 266 mAh g −1 at 10 A g −1 in LIBs and 279 mAh g −1 in SIBs. In addition, the LiFePO 4 //Fe 2 O 3 /FeS 2 and (Na 3 V 2 (PO 4 ) 3 )//Fe 2 O 3 /FeS 2 full cells are successfully packaged and also show satisfactory electrochemical performances.
研究领域:
材料科学
·
电化学
·
纳米科技
·
能源存储
·
晶体工程
·
电池技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Yuxuan Xiong,Fei Sun,Pei Liu,Zhe Yang,Jingguo Cao,Haojie Liu,Ping Liu,Jianli Hu,Zushun Xu,Shengli Yang
Constructing versatile theranostic nanoplatforms that combine diagnostic and therapeutic moieties has shown great promise in the area of precision nanomedicine. However, the limitations on biosecurity, efficiency, and accessibility still need to be addressed. Herein, Bi 2 S 3 /FeS 2 nanohybrids (NHs) were fabricated by a facile and biomimetic one-pot strategy using bovine serum albumin (BSA) as both the sulfur provider to achieve the nucleation and reaction nanocages to regulate the growth of NHs. Upon modification with folic acid (FA), the final obtained Bi 2 S 3 /FeS 2 @BSA-FA NHs could successfully target folate receptor α overexpressed 4T1 tumor cells. Moreover, CCK-8 assay and histopathologic evaluation confirmed the favorable biocompatibility of Bi 2 S 3 /FeS 2 @BSA-FA NHs, which is the premise of subsequent research. In addition, both in vitro and in vivo tests demonstrated that the Bi 2 S 3 /FeS 2 @BSA-FA NHs can serve as computed tomography (CT)/magnetic resonance (MR) dual mode imaging contrast agents, which possess a high X-ray absorption coefficient of 8.02 HU mM −1 and transverse relaxivity (53.9 mM −1 s −1 ). And these two clinical imaging modes could complement each other. After intravenous injection, Bi 2 S 3 /FeS 2 @BSA-FA NHs exhibited efficient tumor homing, as shown by imaging and biodistribution measurement. Notably, when irradiated with 808 nm NIR laser (1.5 W.cm −2 ), the tumor growth of Bi 2 S 3 /FeS 2 @BSA-FA-treated group could be suppressed effectively, proving the high efficacy of photothermal therapy with these NHs. Thus, our research represents a facile and “green” approach for the construction of multifunctional theranostic reagents.
研究领域:
纳米医学
·
癌症治疗
·
成像技术
·
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2021
·
IF 4.527
Yao Wang,Hongyu Zhao,Jian Wang,Dayi Zhou,Lijie Chang,Qi Chen,Liangchao Chen,Hongsheng Jia,Hongan Ma,XiaoPeng Jia
This paper reports the synthesis of bulk pyrite (FeS 2 ) polycrystals at high pressure and high temperature (HPHT) for the first time. The HPHT method markedly improves the speed of synthesis, reducing the time for synthesizing bulk pyrite from several hundred hours to several hours. A unique honeycomb-type structure was introduced into the system by the primary reaction to refine the size of the reactants. On this basis, the sulfur-deficient contamination phase Fe 7 S 8 was effectively eliminated by secondary synthesis. Using Raman spectroscopy and X-ray diffraction (XRD), the crystalline phase of the product was confirmed to be the cubic pyrite phase. The crystal structure and initial crystal parameters of pyrite crystals synthesized under HPHT conditions were obtained for the first time by Rietveld refinement with GASA software. In combination with a scanning electron microscope (SEM) assay, the reaction process was traced, and the significance of secondary synthesis for HPHT was analyzed. Seebeck data showed that as the temperature increased, the sample changed from p-type to an n-type semiconductor and the conductivity increased monotonically, revealing the typical semiconductor characteristics of pyrite. UV reflectance spectra and VSM tests revealed the bandgap width and magnetic properties of pyrite.
研究领域:
材料科学
·
物理化学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Xingliang Chen,Tao Shi,Kailiang Zhong,Guanglei Wu,Yun Lu
The composite hybrid with novel hierarchical structure composed of 1T/2H MoS 2 nanoflower and watermelon-like FeS 2 @carbon nanospheres (FeS 2 @C@MoS 2 ) were synthesized via a facile method. Morphologies and structures of the hybrid were investigated thoroughly by using SEM, TEM, XRD, Raman, XPS and BET. The optimized composite hybrid with an appropriate ratio of carbon, FeS 2 and MoS 2 performs a high specific capacitance (1321.4 F·g −1 at 2 A·g −1 ) and a capacitance retention rate of 81.2% at 6 A·g −1 after 1000 cycles charge-discharge. Such new material has the potential to be a strong competitor in high performance supercapacitor electrode materials, and this facile synthesized method can hopefully be applied or as a reference to develop other metal sulfide@MoS 2 hybrid or multiple sulfides hybrid.
研究领域:
材料科学
·
能源存储
✓ 已验证
产品关联
DOI
高影响因子
Energy Technology
·
2022
·Vol. 10
·期 4
·2100885
·
IF 4.149
Jing Hu,Xin-Liang Wang,Hao Guo,Ming Yang,Jin-Xiu Yuan,Ying Chu,Li-Li Zhao
Transition metal sulfide is the most widely used cathode material for thermal batteries. The development of modern weapons requires higher quality and output of transition metal sulfide cathode materials. However, the current synthesis processes have some limitations for large-scale industrial production due to the long production cycle and low production efficiency. Herein, by controlling the synthesis temperature and adopting a high-temperature solid-state method, sulfide FeS 2 , CoS 2 , and NiS 2 with single-phase and good crystalline structure are synthesized. This method with a simple production process, short production cycle, and high single output is suitable for engineering production. Hence, guidance for large-scale industrial synthesis of pure phase FeS 2 , NiS 2 , and CoS 2 is provided, embodying important scientific significance and application value.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）