SYNTHESIS-STUTTGART
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2014
·Vol. 46
·期 21
·2917-2926
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IF 2.443
Xin Huang,Chunling Fu,Shengming Ma
We have demonstrated two improved methods for the synthesis of carbohydrate-based terminal allenes from propargyl or homopropargyl glycosides. The reaction of propargyl or homopropargyl glycosides with paraformaldehyde (2.5 equiv) in the presence of copper(I) iodide (10 mol%) and diisopropylamine (1.8 equiv) or copper(I) iodide (50 mol%) and dicyclohexylamine (1.8 equiv) produces sugar-linked terminal allenes in 50–79% yield.
研究领域:
有机化学
·
糖化学
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DOI
高影响因子
BMC Veterinary Research
·
2024
·Vol. 20
·期 1
·1-11
·
IF 2.3
Yang Yuxin,Hu XianWang,Wang Shuangshuang,Tian Yongxiang,Yang Keli,Li Chang,Wu Qiong,Liu Wei,Gao Ting,Yuan Fangyan,Guo Rui,Liu Zewen,Yang Yuying,Zhou Danna
Background Japanese encephalitis virus (JEV) is a mosquito-borne zoonotic pathogen that causes encephalitis in humans and reproductive failure in pigs. The transmission of JEV between humans and animals poses a significant public health threat and results in substantial economic losses. Excessive inflammation in the central nervous system of JEV-infected patients is a major cause of mortality and disability. Rosmarinic acid (RA), a polyhydroxyphenolic compound isolated from medicinal herbs, has been preliminarily shown to possess anti-inflammatory properties and significantly inhibit JEV-induced neuroinflammation in mice. Results This study investigated the antiviral capacity and potential mechanisms of RA in JEV-infected cells. The results demonstrated that RA could inhibit JEV replication in vitro. Furthermore, the expression levels of inflammatory cytokines (including IL-6, IL-1β, CCL-2, and TNF-α), membrane receptors (including RIG-I, TLR3, TLR4, TLR7, and TLR8), NF-κB complex and p62/SQSTM1 were assessed using qPCR, ELISA, and Western blot, respectively. The findings indicated that RA significantly suppressed the expression of IL-6, IL-1α, TNF-α, and CCL-2 in JEV-infected BV-2 cells in a dose-dependent manner. Additionally, RA treatment downregulated the expression levels of RIG-I and p62, while p62 silencing inhibited the upregulation of inflammatory cytokines in JEV-infected BV-2 cells. Conclusion Our present study highlights the important role of RA-mediated reduction of RIG-I and p62 in microglia, conferring resistance to Japanese encephalitis virus-induced inflammation.
研究领域:
病毒学
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免疫学
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药理学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Xiaoqi Liu,Yanyun Zhang,Yan Liu,Ting'an Zhang
In this paper, a novel grafted zeolite/Fe 3 O 4 /chitosan (ZMC-MAH-TEPA) adsorbent was greenly synthesized and evaluated for the removal of Cr(VI) and Ag(I) in single and bi-component solutions. The characterization data of XRF , XRD, FT-IR, VSM, TGA , BET and SEM showed the successful fabrication of the adsorbent with abundant -NH 2 and -NH- as well as great recovery properties (11.70 emu/g). The effects of experimental parameters, including pH value, initial concentration, temperature, time, and coexisting ions on single and bi-component adsorption, were investigated. The results demonstrated that the adsorption capacities increased with the enhanced shaking time and concentration until equilibrium was reached. The optimum pH value was 3 for Cr(VI) adsorption and 5 for Ag(I) adsorption. The maximum adsorption capacities for Cr(VI) and Ag(I) ions, obtained by the Langmuir model, were 50.75 and 70.12 mg·g −1 in single metal solutions and 45.45 and 58.94 mg·g −1 in bi-component metal solutions (Cr(VI)/Ag(I) = 1:1), respectively. Additionally, the adsorption mechanism of Cr(VI) and Ag(I) was explained in terms of electrostatic interaction and hydrogen bonding between metal ions and -NH 2 and -NH- in ZMC-MAH-TEPA. Taken together, this study provides a clean approach to synthesizing chitosan-based adsorbents for the efficient removal of Cr(VI) and Ag(I) ions.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
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2021
·
IF 2.495
Liyan Wang,Cihan Lou,Ming Zhao,Bing Zhao,Huaping Zhao,Wenhui Ma,Aiqi Wang,Xu Wang,Ning Wang,Yifei Li
A small-molecule fluorescent probe ( BNBC ) based on naphthalene for cascade recognition of Hg 2+ and I – in 50% CH 3 CN/H 2 O solution. The sensitive and selective binding behaviors of BNBC were investigated by fluorescence spectroscopy. With the addition of metal ions , the fluorescent probe BNBC showed high sensitivity and selective ratiometric detection of Hg 2+ , which was attributed to the excimer-monomer emissions of naphthalene . Moreover, the BNBC -Hg 2+ complex showed a selective fluorescence “turn-off” for I – via the formation of three-component ensemble.
研究领域:
分析化学
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材料科学
·
光谱学
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Songhao Yu,Guifen Tian,Liduan Li,Fei Wang,Kefeng Wang,Junyu Lei,Haijun Hao,Qinghong Xu
TpFO-PA, a novel spherical hollow mesoporous polyamide, was firstly synthesized by the reaction among 1,3,5-tris(4-aminophenyl)benzene (TAPB), furylamine and oxalyl chloride in using silica-gel nanoparticle as hard template, and the composite Cu(I)@TpFO-PA with high catalytic activities in C-N coupling reactions between (hetero)aryl bromide and (hetero)aryl amines under mild conditions was prepared basing on presence of N in the framework. A maximum activity of the catalyst with yield of C-N coupling product were about 311.9 g (product) /mol Cu(I) ·h and 95 % respectively, and the activity could be maintained at least 5 times after the catalyst was reused. The composite Cu(I)@TpFO-PA is a few heterogeneous catalysts reported in catalyzing coupling reaction between aromatic amines and brominated aromatic compounds.
研究领域:
化学
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材料科学
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DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2013
·
IF 1.977
Tianzhi Yu,Haifang Chai,Yuling Zhao,Chengcheng Zhang,Peng Liu,Duowang Fan
Two new mononuclear Cu(I) complexes based on 2-(2′-pyridyl)benzimidazolyl derivative ligand containing hole-transporting carbazole ( L ), [Cu(L)(DPEphos)](BF 4 ) and [Cu(L)(PPh 3 ) 2 ](BF 4 ), where L = (4-(9 H -carbazol-9-yl)phenyl)methyl-2-(2′-pyridyl)benzimidazole; DPEphos = bis[2-(diphenylphosphino)phenyl]ether and PPh 3 = triphenylphosphine, have been synthesized and characterized on the basis of elemental analysis, 1 H NMR and FT-IR spectra. The structures of the ligand L and the Cu(I) complexes were characterized by single crystal X-ray diffraction. The results reveal that in the Cu(I) complexes the central Cu(I) ions assume the irregular distorted tetrahedral geometry and are tetra-coordinated by the two nitrogen atoms from L ligand and two phosphorus atoms from ancillary ligands. The photophysical properties of the complexes were examined by using UV–vis, photoluminescence spectroscopic analysis. The complexes exhibit weak MLCT absorption bands ranging from 360 to 480 nm, and display strong orange phosphorescence in the solid states at room temperature, which is completely quenched in solutions.
研究领域:
化学
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材料科学
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DOI
PubMed
高影响因子
CHEMOSPHERE
·
2021
·
IF 7.086
Lingxiao Fu,Xiaofeng Wu,Yongbin Zhu,Lei Yao,Chengqiang Wu,Haixiang Cheng,Yiran Xu,Jun Hu,Weijun Gao
Manganese dioxide (MnO 2 ) is a Mn deposit widely accumulated in the corrosion layer of pipelines, and iodide (I − ) is a halogen ion frequently detected in waters. The biofilm dwelling on the corrosion scales often secretes extracellular polymeric substances (EPS) into drinking water . The paper aimed to study the I − oxidation by MnO 2 and iodinated disinfection byproducts (I-DBPs) formation with biofilm EPS as a precursor. More than 93% of formed free iodine was finally converted into organic iodine in the MnO 2 /I − /EPS system. Compared with humic acid , EPS had a lower carbonaceous I-DBPs (C-IDBPs) formation while a higher nitrogenous I-DBPs (N-IDBPs) formation. The formation of iodomethanes (I-THMs), iodoacetonitriles (I-HANs) and iodoacetic acids (I-HAAs) decreased with the increase of pH due to the weakening of polarization effect and redox potential , while the iodoacetamides (I-HAcAms) formation achieved the maximum at pH 6.0 due to the difference between the hydrolysis rate of I-HANs and decomposition rate of I-HAcAms. The I-DBPs formation was positively correlated with I − concentration, while negatively correlated with MnO 2 dose. Protein components displayed a higher formation of N-IDBPs and C-IDBPs than polysaccharide components due to higher nitrogen proportion and more iodination sites. Among 20 protein monomers , aspartic acid was considered as the most important precursor of the four investigated I-DBPs species. The paper is helpful to understand the I-DBPs formation when I − in the bulk water come into contact with Mn deposits attached by biofilm.
研究领域:
环境科学
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水处理
·
化学
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DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2017
·
IF 2.843
Yongli Sun,Hanrong Bi,Haozhen Dou,Huawei Yang,Zhaohe Huang,Baoyu Wang,Rong Deng,Luhong Zhang
For the separation of an ethylene/ethane mixture, a novel copper(I)-based supported ionic liquid membrane (SILM) with high permeability has been fabricated. This SILM was prepared from a polyvinylidene fluoride microporous membrane impregnating the copper(I) based IL which formed by the cuprous chloride (CuCl) and 1-butyl-3-methylimidazolium chloride ([Bmim][Cl]). Scanning electron microscopy, attenuated total reflection Fourier transform infrared spectroscopy, and time of flight mass spectroscopy were used to characterize the SILM. Pure and mixed gas permeation experiments were carried out to investigate the influences of ILs composition, trans-membrane pressure, temperature, and time upon the separation performance. This SILM showed comparable C2H4 permselectivity but outstanding permeability with a long-term stability beyond the reported polymeric membrane upper bound. At the CuCl/[Bmim][Cl] ratio of 2, the C2H4 permeability and permselectivity reached 2653 barrer and 11.8, respectively. Furthermore, the facilitated transport effect was studied by 1H NMR and quantum mechanical calculations. The anionic species formed by sp hybridization of Cu+ possesses unfilled attachment sites to selectively complex with C2H4 and weaken the interionic hydrogen bond of [Bmim][Cl], thus lowering the system’s viscosity.
研究领域:
化学工程
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材料科学
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DOI
高影响因子
ENVIRONMENTAL RESEARCH
·
2022
·
IF 8.431
Fa Fang,Nuo Li,Xian Zhang,Juan Liu,Jingzi Beiyuan,Jielong Cao,Jin Wang,Yanyi Liu,Gang Song,Tangfu Xiao
Due to extreme toxicity of the element of thallium (Tl), increasing aqueous Tl pollution incidents have aroused growing concerns. As the prevalent and stable form, i.e. , monovalent Tl, the highly efficient removal methodologies of Tl(I) from (waste)water remains limited and challenging. In this study, an advanced oxidation method, the feasibility of using zero valent iron (Fe 0 ) coupled with persulfate (PS) to treat Tl(I)-containing synthetic wastewater was investigated. Its influence parameters, including reaction time, initial Tl concentration, dosages of PS and Fe 0 , initial and coagulation pH, temperature, coexisting ions and organic matter (NO 3 − , SO 4 2− , Cl − and HA) were examined. The results revealed that the system can be applied to a wide range of pH and temperature and the reaction equilibrium can be reached in about 30 min. Favorable Tl(I) removal rate (>98%) was observed in the synthetic wastewater with medium and relatively high Tl(I) concentration (≤0.250 mM). The analyses of characterization results including electron spin resonance spectrometer and X-ray photoelectron spectroscopy indicated that ·OH played a vital role in the removal of Tl(I), which was oxidized and removed by co-precipitation. Fe 0 can be served as a stable source of Fe 2+ to efficiently catalyze PS. The remaining Fe 0 can be easily separated because of its magnetism, assuring the promising reusability of the reactant. The study aims to provide references for treatment of real Tl polluted wastewater.
研究领域:
环境科学
·
化学
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DOI
PubMed
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2025
·
IF 6.8
Fei Cai,Jinrong Dong,Peng Xie,Hanlong He,Huiyi Yao,Junxian Guo,Zhibo Yan,Li Ma,Tianfeng Chen
Developing structurally well-defined targeted drugs is an effective way to enhance the chemotherapy efficacy. Herein, a target mitochondrial complex I (complex I) inhibitor was developed for the key methylation site ARG-85 in the key subunit NDUFS2. Based on the unique :NH═C– group of guanidyl and the surrounding environment of ARG-85, the macrocyclic and bulky manganese porphyrin complex [MnIII(TTPPC2–)]+ was selected to insert into the gap of NDUFS2. Experimental and computational analyses revealed that the planar π system of the TTPPC2– ligand and the rotatable benzene ring stably bind between the :NH═C– group of ARG-85 and the manganese metal center, a medium-strong Lewis acid. The Mn-specific recognition of guanidine drives the selective inhibition of complex I activity. Further, MnIII(TTPPC2–)]+ was modified into targeted nanoformulation Mn NPs. In vitro and in vivo experiments confirmed the efficient and mechanism inhibition of complex I activity, offering a novel strategy for targeted drug development.
研究领域:
生物化学
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药物化学
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分子生物学
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DOI
PubMed
高影响因子
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
·
2024
·Vol. 41
·期 1
·1-12
·
IF 4
Li Yang-Nan,Zhu Chen-Yuan,Xu Chen-Lu,Yu Shen,Huan Tong,Zhang Ye-Wang
A heparinase III ( Ns Hep-III) from Niabella sp . was identified, cloned, and expressed as soluble form in E. coli BL21 (DE3). With heparin as substrate, the maximum activity of Ns Hep-III of 90.0 U·mg − 1 was achieved at pH 7.1 Tris-HCl (containing 15 mM Mg 2+ ) and 30 o C. The half-life of Ns Hep-III was determined to be 5 h at 30 o C. The interactions between Ns Hep-III and substrates were studied by molecular docking. The combination of Ns Hep-III and a heparinase I from Bacteroides eggthii ( Be Hep-I) was employed to cleave heparin. Analysis of the enzymatic products of Ns Hep-III by SAX-HPLC showed seven different modified disaccharides, indicating that Ns Hep-III has a wide range of substrate specificity. The results of GPC analysis demonstrated that the average molecular weight of the product of heparin cleavage by the combination of Ns Hep-III/ Be Hep-I was reduced to 3969 Da, which accounted for 90% of all the components, and complied with the requirements of the European Pharmacopoeia. Ns Hep-III has notable activity and efficiency in cleaving heparin, which is potentially useful for the industrial production of low molecular weight heparin.
研究领域:
生物化学
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药学
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DOI
PubMed
高影响因子
SYNTHETIC METALS
·
2015
·
IF 2.252
Jie Zhao,Yu Xie,Dongsheng Hu,Dongsheng Guan,Junhong Chen,Jian Yu,Shuai He,Ying Lü,Huilong Liu,Shaokui Bao,Lei Wang
The graphene (GN)/phenylenediamine–benzaldehyde (PD–BD) Schiff base Ag(I) complexes were synthesized by the Schiff-base reaction. The morphology and phase structure of the samples were characterized by electron microscopy, Fourier transform infrared spectroscopy and X-ray diffraction techniques. Their conductive properties were measured by a four-probe conductivity tester at room temperature. And their magnetic properties were tested by a vibrating sample magnetometer. These results show that the PD–BD Schiff base Ag(I) complexes are chemically bonded onto the GN framework to form an intercalated structure. The conductivity, saturation magnetization, residual magnetization and coercive force of the final complex are found to be 5.07 S cm −1 , 2.93 emu g −1 , 0.69 emu g −1 and 104.68 Oe, respectively. Finally, a possible formation and magnetic mechanism of the composites has also been proposed.
研究领域:
材料科学
·
化学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）