GREEN CHEMISTRY
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2022
·Vol. 24
·期 22
·8812-8819
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IF 11.034
Qiyu Liu,Liang Zhou,Xinyi Xie,Di Fan,Xinping Ouyang,Wei Fan,Xueqing Qiu
Selective production of glucose from cellulose in a molten salt hydrate (MSH) shows high efficiency but the separation of glucose is still challenging. To address this issue, we proposed a stepwise method, where cellulose was first hydrolyzed into glucan oligomers and separated via anti-solvent precipitation, followed by being hydrolyzed into glucose under mild conditions. For potential industrial applications, using raw biomass as a substrate is more attractive due to its commercial advantages. However, directly hydrolyzing raw corn stover in an MSH resulted in a low glucan oligomer yield and sugar concentration, together with insufficient separation efficiency. This work demonstrated that the generation of acetic acid during hemicellulose hydrolysis is the critical factor affecting glucan oligomer selectivity. To address this issue, a pre-extraction method using auto-hydrolysis was proposed to remove hemicellulose before MSH hydrolysis. After pre-extraction, the obtained glucan oligomer yield could be enhanced from 59.9% to 79.5%, with the separation efficiency increased from 53.7% to 80.6% by methanol precipitation. Besides, increasing the raw corn stover concentration led to an increase in acetic acid and resulted in glucan oligomer degradation. However, after removing hemicellulose, the concentration of glucan oligomers could be significantly enhanced from less than 72.1 to 121.5 mg mL−1. Thus, pre-extraction of hemicellulose followed by MSH hydrolysis provides a potential application for directly producing glucan oligomers from raw biomass with improved yield and separation efficiency.
研究领域:
化学工程
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生物技术
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生物化工
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产品关联
DOI
高影响因子
Nature Communications
·
2022
·Vol. 13
·期 1
·1-10
·
IF 17.694
Li Shuo,Zhang Yong,Liang Xiaoping,Wang Haomin,Lu Haojie,Zhu Mengjia,Wang Huimin,Zhang Mingchao,Qiu Xinping,Song Yafeng,Zhang Yingying
Numerous studies have shown flexible electronics play important roles in health management. The way of power supply is always an essential factor of devices and self-powered ones are very attractive because of the fabrication easiness, usage comfort and aesthetics of the system. In this work, based on the metal-air redox reaction, which is usually used in designing metal-air batteries, we design a self-powered chemoelectric humidity sensor where a silk fibroin (SF) and LiBr gel matrix containing parallel aligned graphene oxide (GO) flakes serve as the electrolyte. The abundant hydrophilic groups in GO/SF and the hygroscopicity of LiBr lead to tight dependence of the output current on the humidity, enabling the sensor high sensitivity (0.09 μA/s/1%), fast response (1.05 s) and quick recovery (0.80 s). As proofs of concept, we design an all-in-one respiratory monitoring-diagnosing-treatment system and a non-contact human-machine interface, demonstrating the applications of the chemoelectric humidity sensor in health management.
研究领域:
柔性电子
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健康监测
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可穿戴设备
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传感器
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 25
·14254-14259
·
IF 3.049
Qiaoyun Qi,Yanru Li,Wu Qiu,Wenhai Zhang,Chenyang Shi,Chen Hou,Wen Yan,Jiani Huang,Likun Yang,Hao Wang,Wenxi Guo,Xiang Yang Liu,Naibo Lin
Transient devices have attracted extensive interest because they allow changes in physical form and device function under the control of external stimuli or related commands and have very broad application prospects for information security, biomedical care and the environment. Transient bioelectrical devices were fabricated inspired by a silkworm moth breaking out of its cocoon, which has shown many advantages, including the use of mild stimulation, biocompatible materials, a simple process, and a universal strategy. For the fabrication of the transient devices, heat-sensitive microspheres with a 9.3 mol L−1 LiBr solution in wax shells were prepared by microfluidic technology, which were then assembled into silk fibroin (SF) electronic materials/devices, such as SF conductive film, an LED circuit on SF film, and a Ag/SF film/Pt/SF film memristor. The contribution from the LiBr/wax microspheres to the transient time of the SF films upon exposure to heat was quantitatively investigated. This approach was applied to transiently dissolve a flexible Ag-nanowire resistance circuit line on a SF substrate. Moreover, memristors constructed with a functional layer of SF were destroyed by melting the LiBr/wax microspheres. This technique paves the way for realizing transient bioelectrical devices inspired by biological behavior, which have been well optimized by nature via evolution.
研究领域:
材料科学
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生物医学工程
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纳米技术
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生物电子学
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微流控技术
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产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2017
·
IF 7.78
Li Zhang,Xiaofen Xiao,Yuzhi Xu,Danping Chen,Jun Chen,Yingjun Ma,Zong Dai,Xiaoyong Zou
A simple electrochemical strategy is reported for continuous monitoring of dynamic DNA methylation process over time. An electrochemical sensor was prepared by co-assembling of DNA probe and 6-mercapto-1-hexanol onto a gold electrode. The top of the DNA probe was labeled with 6-ferrocenylhexanethiol modified gold nanoparticle . The charge density between the C•G base pair was verified to be slightly reduced by DNA methylation, and could be further decelerated by ~ 25% upon co-locating a Br group onto methylated cytosine (mC). Therefore, in the presence of NaIO 4 /LiBr, the progressively methylated DNA on the sensor showed a clearly decreasing current over methylation time. The dynamic DNA methylation process was indicated continuously from the current decrease ratio, with a limit of detection of 0.0372 µM. The strategy is convenient, cost-effective, and enable continuous profiling methylation process without distortion. Besides, the strategy was successfully applied for the studies on inhibitor screening and flanking sequence preference of DNA methyltransferase 3a. The results show that the activity of DNA methyltransferase 3a can be mildly inhibited by epigallocatechin gallate , and varies towards different flanking sequence with an order of 5′-CCGG-3′ < 5′-CGCG-3′ < 5′-CGCA-3′.
研究领域:
电化学
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分子生物学
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生物技术
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产品关联
DOI
PubMed
高影响因子
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