JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Ying Jiang,Hao Lu,Lingli Lei,Daniel Scherman,Yingshuai Liu
The design of nanomedicines targeting specific tumor microenvironment (TME) characteristics, such as low pH, hypoxia, and elevated glutathione (GSH) concentration, holds significant potential for selectively killing cancer cells. In this study, we have developed a TME-responsive nanoparticle, i.e. , MIL-53(Fe)@MnO 2 stabilized with polyethylene glycol (FMP), which is capable of depleting GSH and sustainably generating hydroxyl radical (•OH) for enhanced chemodynamic therapy of cancer. After endocytosis, the FMP nanoparticles undergo gradual decomposition, resulting in GSH depletion while releasing Fenton-active Fe 2+ and Mn 2+ ions. These ions then subsequently catalyze a Fenton-like reaction to generate highly toxic •OH, ultimately inducing oxidative cell death. As a synergistic effect, the depletion of GSH further enhances therapeutic efficacy by inhibiting intracellular •OH scavenging. In vivo experiments demonstrated that this synergistically chemotherapeutic approach efficiently suppressed tumor growth without inducing significant systemic toxicity. This work presents a promising nanotherapeutic strategy that simultaneously depletes intracellular GSH and sustains cytotoxic •OH generation for enhanced tumor treatment.
研究领域:
纳米医学
·
癌症治疗
·
生物无机化学
·
活性氧治疗
·
靶向药物递送
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2020
·
IF 6.785
Lan Guo,Ya-Jie Zhang,Yong-Liang Yu,Jian-Hua Wang
Butyrylcholinesterase (BuChE), the primary source of serum cholinesterase activity, is an indispensable biochemical marker for clinical diagnosis of liver function and organophosphorus poisoning. The requirement for bulky and expensive instruments represents a huge hindrance for point-of-care testing (POCT) of BuChE, especially in resource-limited settings. Herein, an easy-operated, economic, and portable photothermal (PT) biosensing platform for high-throughput BuChE detection was rationally designed. BuChE could “light up” the PT signal through in situ generation of Prussian blue (PB) by MIL-53 (Fe), which allowed us to translate biological signals into temperature signals. Such temperature change signals could be monitored at high throughput (six samples for a single measurement) by a miniature self-made integrated PT device via combining separable 96-well plates, a three-dimensional (3D) printed sample bracket, 808 nm lasers, and thermometers, satisfying the requirement for rapid on-site detection in a large batch with low cost. In addition, the large specific surface area, 3D network structure, and high porosity of MIL-53 (Fe) offered a beneficial platform for its reaction with enzymatic hydrolysate, resulting in high sensing sensitivity and low detection limit (0.3 U L–1), which was at least 20 000 times lower than the normal human serum BuChE activity. This facile, affordable, and broad applicability PT sensing platform provides a beneficial reference for the rational design of other disease diagnostic approaches suitable for POCT.
研究领域:
生物化学
·
分析化学
·
医学诊断
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2024
·
IF 4.5
Ziheng Zhao,Chunfan Xu,Liang Yu,Huimin Liu,Ru Zhou,Min Hao,Chi-Min Shu,Juncheng Jiang
High-density polyethylene (HDPE) composites are made by melt blending HDPE with MIL-53(Fe), amino-functionalized NH 2 -MIL-53(Fe), aluminum diethyl hypophosphite (ADP), and expandable graphite (EG). The experimental disclosed showed that the aminated NH 2 -MIL-53(Fe) could improve residual carbon quality and exert a better flame retardant effect than MIL-53(Fe). When 25 wt% of EG/ADP/NH 2 -MIL-53(Fe) was added and the ratio of EG to ADP/ NH 2 -MIL-53(Fe) was 1:1, HDPE/EG/ADP/NH 2 -MIL-53(Fe) composites could achieve a limiting oxygen index of 31.1 %, which passed UL-94 testing and was rated V-0. This results in a considerable improvement in flame retardant efficiency as the peak heat release rate was lowered by 83.4 % and the total heat release was reduced by 35.8 % when compared to the pure HDPE material. Therefore, NH 2 -MIL-53(Fe)/ADP/EG synergistic flame retardancy can lead to high flame retardancy efficiency in HDPE. This provided a new potential direction for the preparation of highly efficient flame retardants.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL RESEARCH
·
2024
·
IF 7.7
Xueyan Li,Lei Wang,Xin Zheng,Xiang Tu,Anhong Cai,Jing Deng
In this study, a UV-driven photocatalytic activation of peroxymonosulfate (PMS) system was constructed using bimetallic metal-organic frameworks to degrade pharmaceuticals and personal care products (PPCPs). Mn-MIL-53(Fe) was successfully synthesised by adjusting the doping ratio of Mn using solvothermal method. The removal of ibuprofen (IBP) by UV/Mn-MIL-53(Fe)/PMS process was as high as 79.7% in 30 min with a Mn doping ratio of 1.0 (molar ratio of Mn to Fe), and the reaction rate constant was 26.9% higher than undoped. Mn-MIL-53(Fe) had been systematically characterized in terms of its physical structure, microscopic morphology, surface functional groups and photoelectric properties. The mechanism investigation revealed that the cycling of Mn and Fe accelerated the rate of electron transfer in the system, which significantly increased the activation efficacy of PMS to generate more hydroxyl and sulfate radicals for IBP degradation. A total of 13 transformation products were detected during the degradation of IBP by the UV/Mn-MIL-53(Fe)/PMS process. Theoretical calculations were used to predict the sites on the IBP molecule that were vulnerable to attack, and four possible degradation pathways were deduced. The excellent stability and efficient catalytic properties of Mn-MIL-53(Fe) provided a promising solution to the problem of water treatment contaminated with PPCPs.
研究领域:
环境科学
·
化学工程
·
材料科学
·
药学
✓ 已验证
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2016
·
IF 8.328
Yaowen Gao,Simiao Li,Yixi Li,Linyu Yao,Hui Zhang
Photocatalysis based on metal-organic frameworks (MOFs) is being actively investigated as a potential technology in visible light harvesting and utilizing processes. Herein we report that MIL-53(Fe), an earth-abundant Fe-containing MOF material, shows photocatalytic activity for the degradation of Acid Orange 7 (AO7) from aqueous solution under visible LED light irradiation, yet the photocatalytic performance of bare MIL-53(Fe) was not satisfactory due to the fast recombination of photoinduced electron-hole pairs. This can be effectively overcome by adding the external electron acceptor (e.g., persulfate, PS) to the catalytic process. The accelerated photocatalytic degradation of AO7 is demonstrated by the result that the degradation efficiency of AO7 in the MIL-53(Fe)/PS/Vis process reached almost 100% within 90 min as compared to only 24% under the identical experimental conditions for the MIL-53(Fe)/Vis process. To investigate the mechanism of the MIL-53(Fe)/PS/Vis process, photoluminescence (PL) spectra, electrochemical measurements and electron paramagnetic resonance (EPR) analysis were performed. It was concluded that the efficient separation of photogenerated electrons and holes by the introduced PS and the subsequent formation of reactive radicals resulting from the activation of PS by photogenerated electrons accounted for the accelerated photocatalytic degradation of AO7 in the MIL-53(Fe)/PS/Vis process. Furthermore, the applicability of MIL-53(Fe) used in the persulfate-mediated photocatalytic process was systematically investigated in terms of the identification of reactive radicals, the reusability and stability of the photocatalyst, as well as the effect of operating parameters. The findings of this work highlighted the great potential of MOFs as photocatalysts and elucidated a new opportunity for persulfate remediation of contaminated water.
研究领域:
环境科学
·
材料科学
·
化学工程
·
光化学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Junxue Liu,Yufei Wang,Mingqin He,Xiaohong Chen,Chenyu Zhou,Jiyang Li
Determination of glucose and maltose is crucial for food production and human health. Herein, a novel Au/CD@MIL-53(Fe)-NH 2 self-cascade nanozyme was constructed via host–guest assembly with “three-in-one” features, including blue fluorescence, H 2 O 2 production as an oxidase mimic, and •OH generation as a peroxidase mimic. Theoretical and experimental results proved that the incorporation of carbon dots renders the composite with high peroxidase-like activity and extremely high affinity for H 2 O 2 (K m : 0.011 mM), 336 times higher than that of the natural enzyme. The self-cascade catalytic process could oxidize colorless 3,3′,5,5′-tetramethylbenzidine (TMB) to blue ox-TMB, which further quenched the fluorescence and produced a photothermal effect. Consequently, colorimetric/fluorescence/photothermal-based multimodal detection of glucose and maltose was first achieved, obtaining low detection limits of 12/7.5/1.1 and 18/11.3/1.4 μM, respectively. This study offers a promising strategy for designing efficient nanozyme-based cascade systems that help enhance food quality determination.
研究领域:
食品科学
·
生物化学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 14
·40534-40550
·
IF 5.8
Fang Lei,Wu Guojian,Yao Keyu,Zhang Dongyang,Zhou Yongchao
A novel heterogeneous catalyst named MoS 2 /MIL-53(Fe, Cu) (MMFC) was prepared by hydrothermal method and applied in a heterogeneous electro-Fenton (hetero-EF) system for lomefloxacin (LOM) degradation in this work. Under the optimal conditions of current density 3 mA/cm 2 , catalyst dosage 0.100 g/L, and initial pH 6, 93.5% LOM (2 mg/L) removal efficiency was achieved in the MMFC hetero-EF system within 60 min, indicating an obvious improvement compared with the MIL-53(Fe, Cu) hetero-EF system. The good catalytic activity was attributed to more effective active sites of the catalyst and the conversion of Fe(II)/Fe(III) and Cu(I)/Cu(II) promoted by Mo(IV) in MoS 2 , which could be inferred by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS) characterizations. The reusability and stability of MMFC were explored based on five cyclic experiments, and the average degradation efficiency reached 73.9%. Furthermore, the hetero-EF system could achieve the total removal of moxifloxacin and tetracycline within 6 min and 40 min, respectively. Quenching experiments revealed that the hydroxyl radicals (·OH) were the main reactive radicals while superoxide radicals (·O 2 − ) and singlet oxygen ( 1 O 2 ) played a certain part in LOM degradation. Finally, the possible mechanism of the hetero-EF process and LOM degradation pathways were proposed, including substitution, elimination, and cleavage of ring structures. Accounting for good catalytic performance, low preparation cost, and satisfactory versatility, the MMFC exhibited good potential to work as a hetero-EF catalyst for wastewater treatment.
研究领域:
环境科学
·
化学工程
·
材料科学
·
废水处理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Yanyu Song,Xianbo Sun,Long D. Nghiem,Jun Duan,Wen Liu,Yongdi Liu,Zhengqing Cai
Building a heterojunction is a fascinating option to guarantee sufficient carrier separation and transfer efficiency, but the mechanism of charge migration at the heterojunction interface has not been thoroughly studied. Herein, MIL-53(Fe)/Bi 4 O 5 I 2 photocatalyst with a Z-scheme heterojunction structure is constructed, which achieves efficient photocatalytic decontamination under solar light. Driven by the newly-built internal electric field (IEF), the formation of Fe-O-Bi electron migration channel allows for rapid separation and transfer of charge carriers at the heterojunction interface, confirmed by the material characterization and density functional theory (DFT) calculation. The narrower band gap and improved visible light response also contribute to the enhanced photocatalytic activity of composite materials. With levofloxacin as the target pollutant, the optimal MIL-53(Fe)/Bi 4 O 5 I 2 achieves complete removal of pollutant within 150 min, the photocatalysis rate of which is ca. 4.4 and 26.0 times that of pure Bi 4 O 5 I 2 and MIL-53(Fe), respectively. Simultaneously, the optimal composite material exhibits satisfactory photodegradation of seven fluoroquinolones, and the photocatalysis rates are as follows: lomefloxacin > ciprofloxacin > enrofloxacin > norfloxacin > pefloxacin > levofloxacin > marbofloxacin. DFT calculations reveal a positive relationship between degradation rate and Fukui index (ƒ 0 ) of main carbon atoms in seven fluoroquinolones. This study sheds light on the existence of electron migration channels at Z-scheme heterojunction interface to ensure sufficient photoinduced carrier transfer, and reveals the influence of pollutant structure on photolysis rate.
研究领域:
材料科学
·
环境科学
·
化学
·
光化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano Research
·
2024
·Vol. 17
·期 7
·5863-5871
·
IF 9.5
Ke Yanjing,Zhang Jiaxing,Peng Xin,Zhang Zhiyi,Wang Xu,Qi Wei,Wang Mengfan
Recently, many efforts have been dedicated to construct artificial catalysts with enzyme-like activity. However, it is still a big challenge to endow artificial catalysts with specific substrate selectivity. In this study, we developed a facile strategy to construct a MIL-53(Fe)-based nanocatalyst with designable selectivity in the degradation of oxytetracycline (OTC). Through the Fe–O–P conjunction, oxytetracycline aptamer (OA) can be easily anchored on MIL-53(Fe) to provide the specific site for OTC binding. We verified that the obtained MIL-53(Fe)-Apt nanocatalyst displayed enhanced catalytic ability in the degradation of OTC, whereas obvious suppression toward other substrate analogues. This performance therefore brings about an anticipated selectivity toward OTC. Moreover, we highlighted that the configuration of aptamers on MIL-53(Fe) can be modulated through varying conjunction mode. Structure–function analysis revealed that aptamer configuration affects the local concentration of substrate around catalytic site, which thus decides the catalytic performance toward OTC. This work presented a facile and promising strategy for developing artificial catalysts with designable selectivity.
研究领域:
环境科学
·
催化化学
·
生物技术
✓ 已验证
产品关联
DOI
高影响因子
Energy Advances
·
2024
·
IF 3.2
Kunpeng Liu,Xu Wang,Nan Wang,Ruiyong Zhang,Meinan Yang,Baorong Hou,Wolfgang Sand
Rationally designing high-efficiency catalysts for electrochemical two-electron water oxidation reaction (2e− WOR) to produce hydrogen peroxide (H2O2) is extremely important, while designing bimetallic metal–organic frameworks (MOFs) is of great significance for effective 2e− WOR. Herein, MIL-53(Fe) and different proportions of Co-doped MIL-53(Fe) were prepared by a hydrothermal method. The structural characterization and elemental analysis showed that the Co ions were successfully doped into MIL-53(Fe) to form a MIL-53(Fe/Co) bimetallic MOF, and the morphology of MIL-53(Fe/Co) became more regular after Co doping. We found that the optimized MIL-53(Fe/Co) exhibits remarkable 2e− WOR performance, which gave an overpotential of 150 mV at 1 mA cm−2. The overpotential of MIL-53(Fe/Co) was approximately 220 mV (at 1 mA cm−2) lower than that of MIL-53(Fe), which may be attributed to the change of microstructure of MIL-53(Fe) after Co doping and the synergistic effect between Fe/Co. Our work introduces a strategy for designing bimetallic MOF-based electrocatalysts, opening up new possibilities for efficient 2e− WOR systems.
研究领域:
材料科学
·
电催化
·
能源化学
✓ 已验证
产品关联
DOI
高影响因子
CELLULOSE
·
2021
·Vol. 29
·期 1
·355-365
·
IF 5.044
Chen Jiahao,Li Huiqin,Zhu Hejin,Gong Jixian,Zhang Chunchun,Li Zheng,Li Qiujin,Liu Xiuming,Xu Jianlin,Zhang Jianfei
As an acoustic metamaterial, Metal–organic frameworks (MOFs) can absorb sound energy abnormally. In this research, a thin and flexible acoustic material was prepared by growing MOF on the fabric. The successful growth of MIL-53(Fe) on the fiber surface was confirmed by SEM, FTIR, XRD and XPS. From the sound absorption and sound insulation test results of MIL-53(Fe)@fabric, the in-situ growth of MIL-53(Fe) greatly improves the sound absorption and sound insulation performance of the fabric, and gives the fabric an abnormal acoustic effect. From the calculation results of the theoretical model, the growth of the sub-wavelength scale MIL-53(Fe) significantly increases the flow resistance of the fabric, which is the root cause of the abnormal sound absorption of the material. It is worth noting that the sound transmission loss of the prepared flexible material doesn’t follow the mass law and exhibits excellent sound insulation performance. This is not only related to the increase in the sound energy reflected by the fabric, but also to the abnormal sound absorption of MIL-53(Fe). Here, the sound insulation performance of MOFs@fabric is reported for the first time. This work promotes the research and application of MOFs in the field of acoustics, and provides a method and theoretical basis for the design and preparation of acoustic protection textiles. Graphical abstract
研究领域:
材料科学
·
声学工程
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2024
·
IF 5.4
Le Wang,Mengyue Zhang,Manyu Zhang,Zhongke Sun,Zifu Ni,Yanli Yin,Dapeng Wu,Qipeng Yuan
The multifunctional composites Fe 3 O 4 /GO/NH 2 -MIL-53(Fe) with excellent adsorption-degradation performance was prepared for the removal of Aflatoxin B 1 (AFB 1 ). The adsorption function of Fe 3 O 4 /GO/NH 2 -MIL-53(Fe) was based on the large specific surface area and abundant adsorption sites. The degradation function of Fe 3 O 4 /GO/NH 2 -MIL-53(Fe) was based on the activation of H 2 O 2 by the catalytic active center formed by the coordination of metal ions and oxygen-containing groups in the system, resulting in hydroxyl radicals (·OH), superoxide anion radicals (O 2- ) and singlet oxygen ( 1 O 2 ). The adsorption of nanozyme accelerated the degradation reaction process, and the adsorption site was further exposed as the degradation process progressed. The synergistic effect realized the efficient removal of AFB 1 . Construction of Fe 3 O 4 /GO/NH 2 -MIL-53(Fe) as the carbon-doped iron-based nanozyme provided novel approaches of the removal for risks control of AFB 1 . Accompanied by the AFB 1 adsorption, the advanced oxidation of nanozyme to the AFB 1 degradation provided a promising way for the synergistic removal of AFB 1 .
研究领域:
食品安全
·
生物化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）