Theranostics
·
2018
·
IF 8.537
Wenjing Zhang,Cong Ning,Weiguo Xu,Hanze Hu,Mingqiang Li,Guoqing Zhao,Jianxun Ding,Xuesi Chen
Peripheral nerve blockade (PNB) is a conventional strategy for the management of acute postoperative pain. However, the short duration of the associated analgesia and the potential systemic toxicity due to the low molecular weights of local anesthetics limit their application. Methods: An in situ forming injectable Gel-microsphere (Gel-MS) system consisting of PLGA-PEG-PLGA Gel (Gel) and Gel-immobilized bupivacaine-loaded microsphere (MS/BUP) was prepared for precision-guided long-acting analgesia. A series of in vitro characterizations, such as scanning electron microscopy, rheology analysis, confocal laser scanning microscopy, drug release, and erosion and degradation, were carried out. After that, the in vivo analgesia effect of the Gel-MS system, the immobilization effect of Gel on the MS, and biocompatibility of the system were evaluated using a sciatic nerve block model. Results: The BUP release from the Gel-MS system was regulated by both the inner MS and the outer Gel matrix, demonstrating sustained BUP release in vitro for several days without an initial burst release. More importantly, incorporation of the Gel immobilized the MS and hindered the diffusion of MS from the injection site because of its in situ property, which contributed to a high local drug concentration and prevented systemic side effects. In vivo , a single injection of Gel-MS/BUP allowed rats to maintain sensory and motor blockade significantly longer than treatment with MS/BUP ( P < 0.01) or BUP-loaded Gel (Gel-BUP, P < 0.01). Histopathological results demonstrated the excellent biodegradability and biocompatibility of the Gel-MS system without neurotoxicity. Conclusion: This precision-guided long-acting analgesia, which provides an in situ and sustained release of BUP, is a promising strategy for long-acting analgesia, and could represent a potential alternative for clinical pain management.
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DOI
PubMed
高影响因子
ChemElectroChem
·
2019
·Vol. 6
·期 17
·4437-4443
·
IF 3.975
Yiqun Du,Shimeng Zhao,Cheng Xu,Wenyang Zhang,Shuming Fan,Pan Li,Huixin Jin,Youjian Zhang,Jianxin Zhang
Graphical Interc-Al-ation for batteries : A high-capacity cathode with porous α-MnSe is designed for rechargeable aluminum batteries. The fundamental reaction mechanism of the α-MnSe cathode is deeply researched in the manuscript. The synergistic effect of nanostructure and porosity could efficiently mitigate volume changes of the α-MnSe and enhance intercalation kinetics of Al 3+ , which sheds new light on the establishment of advanced energy-storage devices. Aluminum batteries (ABs) have been considered as a viable candidate for new-generation energy-storage devices due to its low cost and high theoretical volumetric capacity. Despite these advantages, the large-scale application of ABs is constrained by scarce options of suitable cathode materials. Herein, three-dimensional nanostructured α-MnSe microspheres with porous properties are reported as a cathode for ABs. The nanosized and porous structure of α-MnSe could offer numerous open channels and the short ionic transport path, which would efficiently mitigate volume changes and enhance electrochemical reaction kinetics. Moreover, the pseudocapacitive characteristic of Al 3+ storage in α-MnSe contributes to the fast kinetics of the cathode. It is demonstrated that the reversible Al 3+ insertion/extraction occurs in the α-MnSe cathode during the cycling process. The resulting aluminum battery based on the α-MnSe cathode, AlCl 3 /[EMIm]Cl ionic liquid electrolyte, and aluminum anode exhibits an ultrahigh reversible capacity of 408 mA h g −1 at 0.2 A g −1 . Even for a current density at 1 A g −1 , a discharge capacity of 131 mA h g −1 could be retained with a Coulombic efficiency of 97 % over 150 cycles. This strategy has referential significance in aspects of the selection of compatible cathode for ABs.
研究领域:
材料科学
·
电化学
·
能量存储
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DOI
高影响因子
THIN SOLID FILMS
·
2013
·
IF 1.604
Qian Li,Kui Cheng,Wenjian Weng,Piyi Du,Gaorong Han
Sb-doped ZnO microsphere film was fabricated by a carboxylate ion assisted hydrothermal route coupled with a post-calcination process. The structure, chemical composition and optical band gap of the Sb-doped ZnO microsphere film were characterized by X-ray diffraction, X-ray photoelectron spectroscopy, inductively couple plasma optical emission spectroscopy and UV–visible spectrophotometry, and compared with the un-doped ZnO microsphere film. The results suggest that the formation of zinc–antimony tartrate complex species during hydrothermal growth is the key to realize Sb-doped ZnO microstructures, and the present hydrothermal method with post-calcination is an effective way to dope Sb into ZnO. Furthermore, the Sb-doped ZnO microsphere film based electrochemical biosensor exhibits a good sensing performance for the detection of hydrogen peroxide, with a sensitivity of 271 μA mM − 1 cm − 2 which is more than three times higher than that of the un-doped ZnO biosensor.
研究领域:
材料科学
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电化学
·
生物传感
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DOI
高影响因子
Soft Matter
·
2014
·Vol. 10
·期 44
·8905-8912
·
IF 4.151
Chuanzhuang Zhao,Guangcui Yuan,Charles C. Han
Gelation and glass transition in a mixed suspension of polystyrene (PS) microsphere and poly(N-isopropylacrylamide) (PNIPAM) microgel were studied as a function of the total colloid volume fraction and mixing ratio of these two components. The PNIPAM microgel, which is adsorbable on the PS microsphere surface, can induce bridging or stabilizing effect between microspheres depending on whether the volume fraction of microgel (ΦMG) is smaller or larger than the saturated adsorption concentration (Φ*MG) for a given volume fraction of the microsphere (ΦMS). Φ*MG is in a linear relationship with ΦMS, and the value of ΦMG/Φ*MG can be taken as an approximate measure of surface coverage. A state diagram of gelation and glass transition is constructed with the short-ranged attractive interaction, resulting from the well-defined bridging bonding. Keeping ΦMG/Φ*MG = 0.20 and increasing ΦMS from 0.25 to 0.55, the mixed suspension transforms from a bridging gel into an attractive glass; moreover, while keeping ΦMS = 0.45 and increasing ΦMG/Φ*MG from 0.20 to 1.2, the mixed suspension changes from a bridging gel into an attractive glass, and then to a repulsive glass. The bridging effect and the cage effect can be distinguished by the yielding behaviors in rheological measurements. In the nonlinear dynamic rheological experiments, one-step yielding, corresponding to the disconnecting of bridge network, is observed in the bridging gel, and one-step yielding, corresponding to the breaking of cage, is observed in the repulsive glass. However, a two-step yielding behavior is found in the bridging-induced attractive glass, which is attributed to the bridging effect of microgels and the caging effect of the dense environment.
研究领域:
材料科学
·
软物质物理
·
胶体化学
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DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2021
·Vol. 34
·期 3
·2106502
·
IF 30.849
Jia-Xin Yu,Shuai Xing,Guang-Yu Dai,Shuang-Yi Ling-Hu,Fu-Xing Gu
Monolayer transition metal dichalcogenides (TMDs) have emerged as widely accepted 2D gain materials in the field of light sources owing to their direct bandgap and high photoluminescence quantum yield. However, the monolayer medium suffers from weak emission because only a single layer of molecules can absorb the pump energy. Moreover, the material degradation when transferring these fragile materials hinders their cooperation with the optical cavity further. In this study, for the first time, a high-quality monolithic structure is developed by directly growing single-domain tungsten diselenide (WSe 2 ) bilayers on single silica microsphere (MS) cavities. Such a completely wrapped structure guides the indirect-to-direct bandgap transition of WSe 2 bilayers, leading to a significantly improved photoluminescence intensity by about 60-fold. Moreover, the high-quality monolithic structure enhances the confinement factor of the cavity by more than 20-fold. Based on the above advantages, a bilayer WSe 2 /MS microlaser is realized with an ultralow threshold of 0.72 W cm −2 , nearly an order of magnitude lower than the existing records. The results demonstrate the possibility of using multilayer TMD materials as 2D gain media and provide insights into a new ultracompact monolithic platform of TMD material/cavity for lasing devices.
研究领域:
光学
·
材料科学
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DOI
PubMed
高影响因子
Advanced Science
·
2022
·Vol. 9
·期 9
·2105278
·
IF 17.521
Feika Bian,Lingyu Sun,Hanxu Chen,Yu Wang,Li Wang,Luoran Shang,Yuanjin Zhao
Information security occupies an important position in the era of big data. Attempts to improve the security performance tend to impart them with more additional encryption strategies. Herein, inspired by the wettability feature of Stenocara beetle elytra and signal model of traffic light, a novel array of perovskite nanocrystals (PNs)-integrated PhC microsphere for information security is presented. The photoluminescent PNs are encapsulated in angle-independent PhC microspheres to impart them with binary optical signals as coding information. Through the multimask superposition approach, PNs-integrated PhC microspheres with different codes are placed into fluorosilane-treated PDMS substrate to form different arrays. These arrays could converge moisture on PhC microspheres in wet environment, which avoids the ions loss of the PNs and effectively prevented mutual contamination. In addition, the fluorescence of the PNs inside PhC microspheres could reversibly quench or recover in response to the environmental moisture. Based on these features, it is demonstrated that the PNs-integrated PhC microsphere arrays could realize various information encryption modes, which indicate their excellent values in information security fields.
研究领域:
材料科学
·
光学
·
信息安全
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DOI
PubMed
高影响因子
Biomimetics
·
2023
·Vol. 8
·期 1
·104
·
IF 4.5
Lili Zhang,Jitang Zhang,Aijiao Xu,Zhiping Lin,Zongpeng Wang,Wenwu Zhong,Shijie Shen,Guangfeng Wu
The electrocatalytic hydrogen evolution activity of transition metal sulfide heterojunctions are significantly increased when compared with that of a single component, but the mechanism behind the performance enhancement and the preparation of catalysts with specific morphologies still need to be explored. Here, we prepared a Co9S8/MoS2heterojunction with microsphere morphology consisting of thin nanosheets using a facile two-step method. There is electron transfer between the Co9S8and MoS2of the heterojunction, thus realizing the redistribution of charge. After the formation of the heterojunction, the density of states near the Fermi surface increases, thed-band center of the transition metal moves downward, and the adsorption of both water molecules and hydrogen by the catalyst are optimized. As a result, the overpotential of Co9S8/MoS2is superior to that of most relevant electrocatalysts reported in the literature. This work provides insight into the synergistic mechanisms of heterojunctions and their morphological regulation.Keywords:heterojunction;thin nanosheets;Co9S8;MoS2;electrocatalyst;hydrogen evolution reaction
研究领域:
材料科学
·
电化学
·
催化
·
纳米技术
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DOI
PubMed
高影响因子
CHEMICAL PHYSICS LETTERS
·
2023
·
IF 2.8
Mayifei Rong,Xiaoguang Xu,Kai Wang,Liying Lu,Yihua Bai,Yuping Tian,Zhaopeng Hou,Ruitao Zhao,Yingli Ma,Yong Jiang
Hydroxyapatite (HAp) is an inorganic material that can be used as an adsorption material. Here we report a novel HAp-based hollow porous microsphere , in which Fe 3 O 4 nanoparticles are uniformly embedded in the HAp microsphere shell. The specific surface area is 98.6 m 2 /g with an average pore size of 11.4 nm. The microsphere has been demonstrated to be a high-efficient absorbent for copper ion. Owing to the superparamagnetic property of Fe 3 O 4 nanoparticles, the microspheres can be well dispersed in water and effectively segregated by magnet. Therefore, HAp-Fe 3 O 4 hollow microsphere is a promising candidate for copper ion treatment.
研究领域:
材料科学
·
环境科学
·
纳米技术
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DOI
高影响因子
COMPOSITES PART B-ENGINEERING
·
2025
·
IF 14.2
Hongyuan Guo,Qiao Lu,Weicheng Jiao,Xingwen Yuan,Shuxin Ren,Haomiao Sun,Xiaodong He
Phase change materials (PCMs) exhibit high energy density, reversibility, and broad temperature selectivity. Unfortunately, the inherent trade-off between functionality and mechanical strength inevitably arises during application, necessitating the breakthrough of the thermal-mechanical-functional coupling bottleneck to establish an efficient thermal storage system. This work innovatively designs a multi-dimensional composite PCMs based on supramolecular polymers and graphene-encapsulated paraffin microspheres, achieving cross-scale synergy between thermal conduction networks, energy storage units, mechanical support structures, and functional design. The multi-level strong-weak hydrogen bond interactions within the supramolecular construct a physically cross-linked framework that combines toughness and stability, while paraffin-graphene microspheres enhance energy storage density. The three-dimensional thermally conductive and electrically conductive framework endows PCMs with photo/electro-thermal energy conversion and response capabilities. Simultaneously achieving high phase change enthalpy (190.2 J g −1 ), ultra-low leakage rate (<0.47 wt%), and high strength ranging from 16.0 to 29.6 MPa, with programmable shape memory and recyclable molding capabilities, overcoming the bottleneck of synergistically suppressing thermal hysteresis and mechanical fatigue in PCMs. Further construction of intelligent temperature sensing arrays enables interaction between high and low-temperature environments. This work proposes a feasible strategy to promote the evolution of PCMs from passive thermal storage media to embodied intelligent components.
研究领域:
材料科学
·
储能技术
·
智能材料
·
热管理
·
传感器与传感技术
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DOI
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2021
·Vol. 330
·期 3
·1271-1280
·
IF 1.371
Zhu Hui,Zhou Jian,Ding Pingping,Liao Hui,Jin Yifan,Ding Weicheng
In this work, a novel honey/bayberry (HSHB) microsphere was prepared via a simple and green hydrothermal method to investigate the UO 2 2+ adsorption behavior in simulated nuclear effluent. The results showed that spherical HSHB (about 40 nm) had the maximum adsorption capacity of 271.00 mg/g at 328.15 K and displayed a desirable selectivity for the UO 2 2+ . Furthermore, combined with the characterization analysis and adsorption experimental results, the phenolic hydroxyl group of HSHB could be combined with UO 2 2+ through chelation. Therefore, these facts indicate that HSHB could be used as a low-cost and environmentally friendly adsorbent for UO 2 2+ removal from nuclear effluent.
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
Joule
·
2018
·
IF 0
Yuruo Qi,Zizheng Tong,Junmei Zhao,Lu Ma,Tianpin Wu,Huizhou Liu,Chao Yang,Jun Lu,Yong-Sheng Hu
The large-scale application of rechargeable batteries in electric vehicles and energy-storage systems is still hindered by their high cost, particularly from the active materials. Here we proposed a concept of integration of extraction-separation and materials-preparation to further reduce the materials' cost. The power of this concept was demonstrated by the large-scale room-temperature synthesis (150 g per batch) of multi-shelled Na 3 (VOPO 4 ) 2 F microspheres based on in situ generated bubbles as soft templates. The as-prepared Na 3 (VOPO 4 ) 2 F shows superior rate capability with discharge capacity of 81 mAh g −1 at 15 C current rate and capacity retention of 70% after 3,000 cycles. Ex situ UV-vis was first employed to characterize the variation of oxidation state for vanadium during the charging and discharging process. This is the first report of a rapid and facile large-scale room-temperature controllable synthesis of Na 3 (VOPO 4 ) 2 F microspheres, and this approach could be extended to synthesize other similar compounds.
研究领域:
材料科学
·
电化学
·
储能
·
无机合成
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DOI
MACROMOLECULAR MATERIALS AND ENGINEERING
·
2021
·Vol. 306
·期 9
·2100198
·
IF 4.367
Shengqu Liu,Xiaoyu Wang,Yinjie Peng,Zhisen Wang,Rong Ran
Starch-based hydrogel is widely used as an excellent biocompatibility and biodegradability material. However, due to the disadvantages of poor mechanical properties, brittleness, and low stretchability attribute that remains a challenge to prepare multifunctional starch hydrogel integrating high stretchability, strength, and conducting capacity. In this study, macromolecular microspheres with various wettability are successfully incorporated into the hydrogel prepared using the carboxymethyl starch and polyacrylamide cross-linked by Fe 3+ and covalent cross-linker, respectively. The obtained double-network (DN) hydrogel performs good mechanical properties (the fracture stress 483 ± 38 kPa and the elongation at break 1615 ± 25%). Impressively, the obtained DN hydrogels by solvent soaking still maintain excellent mechanical strength and flexibility at −40 °C. Furthermore, it can be assembled to be a resistance-type strain sensor to detect multiscale strain. Therefore, the strategy can shed light on the preparation of multifunctional starch-based hydrogel for broad applications.
研究领域:
材料科学
·
生物医学工程
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DOI
高影响因子
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