Neuropsychiatric Disease and Treatment
·
2022
·
IF 2.989
Yuxi Jia,Ping Li,Fei Wu,Fanjie Zeng,Beilin Zhang,Jinpeng Wang
Background: In clinic, valproic acid (VPA) has been widely used in the treatments of epilepsy and is currently under clinical trials for the treatments of multiple diseases. However, gravidas receiving VPA treatment during their early stage of pregnancy were reported to be associated with elevated incidences of autism in their child. In this study, the potential influences of n-3/n-6 polyunsaturated fatty acids (PUFAs) as supplements were investigated in VPA-induced autistic rat model.Materials and Methods: A rat model of autism spectrum disorder (ASD) was established by VPA exposure at the E12.5 day of gestation. Neonatal male Wistar rats (n = 24) were divided into VPA group, A group and B group, while normal neonatal male Wistar rats served as controls. At P21 days, animals in the control and VPA groups were fed with standard chow, while rats in the A group were fed with n-3 PUFA free chow, and those in the B group with n-3/n-6 PUFA (1:5) chow. The duration of the diet was from P21 days to 3 months. All rats were subjected to the examinations of repetitive stereotyped behaviors and changes in social interaction at the end of supplement. The neuroinflammation in the brain and serum was also evaluated. Hematoxylin–eosin (HE) staining and Nissl staining were used to observe the neuronal injury in hippocampus.Results: In the B group, the repetitive stereotyped behaviors reduced, the social communication was improved, the neuronal loss and proinflammatory cytokines in the hippocampus reduced, and the extracellular STAT3 activation was inhibited in the hippocampus, as compared to the B group.Conclusion: Supplements with n-3/n-6 PUFA (1:5) rescues repetitive stereotyped behaviors and social deficits in neonatal rats exposed to VPA, likely due to the improved inflammatory responses through the alteration of STAT3 signaling. This study provides evidence for the use of n-3/n-6 PUF in the treatment of autism in humans.
研究领域:
神经科学
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药理学
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营养科学
·
行为科学
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Xiaoqi Ban,Jin Yao,Wanzhong Yin,Yu Xie,Weifan Du,Taozhong Zhang,Yulian Wang
This study introduces N-[3-(Isodecyloxy)propyl]propane-1,3-diamine (IOPDA), a novel cationic surfactant, as a collector in the reverse flotation desilication of magnesite. It systematically evaluates IOPDA’s selective collecting performance in the flotation separation of magnesite from quartz. Single-mineral and artificial mixed mineral flotation experiments were conducted at pH 6.0 and an IOPDA concentration of 80 mg/L, where results showed significant improvements in flotation separation efficiency. The final concentrate achieved an MgO grade of 46.55 %, SiO2 grade of 1.97 %, and a quartz removal rate of 92.51 %. Compared to the conventional Dodecylamine (DDA), the flotation Selectivity Index (SI) and Separation Efficiency (SE) under IOPDA conditions were notably superior, demonstrating its enhanced selective collecting ability. To elucidate the selective adsorption mechanism of IOPDA, advanced techniques—such as contact angle measurements, Zeta potential testing, FTIR, XPS, AFM, and TOF-SIMS—were employed to analyze adsorption on magnesite and quartz surfaces. The study found that IOPDA preferentially adsorbs on the oxygen sites of quartz through electrostatic interactions and hydrogen bonding, while its adsorption on magnesite is weaker. This selective adsorption enhances the wettability difference between the minerals, facilitating highly efficient flotation separation.
研究领域:
矿物加工工程
·
材料化学
·
界面化学
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产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 99
·97036-97047
·
IF 3.289
Mei Wang,Jianling Xia,Jianchun Jiang,Shouhai Li,Mei Li
Dipentene-maleic anhydride (DPMA) was prepared by the Diels–Alder addition of dipentene with maleic anhydride. DPMA was converted via ammonolysis with para-aminobenzoic acid (PABA) to form N-(3-amino-benzoic acid)terpene-maleamic acid (ABDPMA), which was then converted to zinc soap (ABDPMA-Zn) or calcium soap (ABDPMA-Ca). Their chemical structures were confirmed by FT-IR and ICP-AES. Thermal stabilizing effects of ABDPMA-Ca/ABDPMA-Zn were compared with ABTMA-Ca/ABTMA-Zn (ABTMA: N-(3-amino-benzoic acid)tung-maleamic acid), C36DA-Ca/C36DA-Zn (C36DA: dimer fatty acid), ZnMA/ZnO (MA: maleic acid), EFC/ZnSt2/ESBO (EFC: calcium salt of epoxidised fatty acid; ESBO: epoxidised soybean oil, and CaSt2/ZnSt2 (St: stearic acid). Thermal stabilities of poly(vinyl chloride) (PVC) compounds were determined using Congo Red test, discoloration test, ultraviolet-visible spectroscopy analysis and thermogravimetric analysis. Dynamic mechanical and tensile properties of the PVC compounds were also studied. Besides better plasticization performance, ABDPMA-Ca/ABDPMA-Zn improved the long thermal stability of PVC compared with ABTMA-Ca/ABTMA-Zn, C36DA-Ca/C36DA-Zn, and CaSt2/ZnSt2.
研究领域:
高分子化学
·
材料科学
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塑料加工
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热稳定化
·
功能添加剂
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2016
·
IF 3.994
Liang Ju,Fang Cailin,Wu Wenlan,Yu Pinghua,Gao Jiayu,Li Junbo
As a new kind of drug carries, pH-sensitive liposomes have been widely studied in tumor therapy for their advantages of target ability and sustained-release. Here, we synthesized a pH-sensitive material, N-(3-Aminopropyl)imidazole-cholesterol (IM-Chol) and prepared a novel pH-sensitive liposomes using IM-Chol and phosphatidylcholine . IM-Chol was synthesized through amidation reaction between the amino group of N-(3-Aminopropyl)imidazole and acyl chloride group of cholesteryl chloroformate in a weak base solution. Optimal conditions to prepare liposomes were obtained by the orthogonal experiment with the higher encapsulation efficiency as the evaluation indicator. The properties of liposomes, such as particle size, zeta potential , morphology, encapsulation efficiency, drug release behavior and in vitro cell toxicity were evaluated by transmission electron microscopy (TEM), dynamic light scattering (DLS) and MTT assay respectively. The results showed that the average particle size of IM-Chol liposomes was 141 nm (PDI 0.323). Liposomes can assemble into uniform spheres at pH 7.4, but under the condition of pH 5.0, the spherical structure of IM-Chol liposomes was broken, exhibiting pH-sensitive property. In vitro drug releasing studies demonstrated the controlled-release behavior of the curcumin (CUR) in the IM-Chol liposomes. The cumulative release of CUR reached to 72.5% in the first 24 h at pH 5.0, faster than that at pH 7.4, which confirmed that the drug carrier displayed pH-sensitive release behaviors. In addition, the MTT assay was employed to test the cytotoxicity of IM-Chol liposomes and CUR IM-Chol liposomes. All cell viabilities were greater than 80% after incubating for 24 h, even up to the highest dose of 500 mg/L, indicating that IM-Chol liposomes had good biocompatibility . The tumor inhibitory results towards EC109 cells of free CUR and CUR-loaded IM-Chol liposomes indicated that IM-Chol liposomes indeed enhanced the cell killing effect of CUR. These results showed that the novel IM-Chol liposomes prepared in this paper had pH-sensitive property and were expected to play a huge potential in tumor treatment.
研究领域:
药学
·
生物技术
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药物递送系统
·
癌症治疗
✓ 已验证
DOI
PubMed
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2018
·Vol. 20
·期 30
·19900-19905
·
IF 3.906
Caili Dai,Qianru Yang,Mingwei Gao,Mingwei Zhao,Jianfeng Jiang
To indicate the difference between pH and CO2 stimuli mechanisms, a dual responsive system is constructed with the aid of N-[3-(dimethylamino)propyl]docosanamide (NDPD) and sodium salicylate (NaSal), which is responsive to pH and CO2. The dual responsive system is characterized by rheometry, cryo-TEM and 1H NMR spectroscopy. After bubbling CO2 or adjusting the pH, the rheological properties indicate the formation of wormlike micelles. The cyro-TEM images also confirmed wormlike micelles. The effect of temperature is also clarified. By comparing the rheological properties of the wormlike micelles with pH and CO2 stimuli conditions, combined with cryo-TEM and 1H NMR results, the stimuli mechanisms of pH and CO2 to the dual responsive system are shown. Through this work, we expect to deepen our understanding of the responsiveness of a self-assembled system.
研究领域:
胶体科学
·
材料化学
·
物理化学
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产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Xiaoliang Qi,Wei Wei,Junjian Li,Ting Su,Xihao Pan,Gancheng Zuo,Jianfa Zhang,Wei Dong
Salecan is a new linear extracellular β-glucan. The unique structure and beneficial properties of Salecan makes it an appealing material in biomedical applications. In this work, novel drug devices based on Salecan in a hydrogel matrix of poly( N -(3-dimethylaminopropyl)acrylamide- co -acrylamide) (Salecan/PDA) were fabricated via free radical polymerization for controlled release of amoxicillin. It was demonstrated that amoxicillin was efficiently encapsulated into the developed hydrogels and released in a Salecan dose-dependent and pH-sensitive manner. Furthermore, cell toxicity and adhesion assays confirmed that these drug carriers were biocompatible. Altogether, this study opens a new avenue to fabricate hydrogel devices for controlled delivery of drug.
研究领域:
药学
·
生物医学工程
·
药物递送系统
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yunpeng Gao,Xin Tian,Xueru Xiong,Yushi Wang,Wen Huang,Xuetao Shi,Yong-Guang Jia,Zhong-Kai Cui
The catechol moiety found within mussel proteins plays a pivotal role in enhancing their adhesive properties. Nonetheless, catechol compounds, such as dopamine (DOP) derivatives, are susceptible to oxidation, leading to the formation of q0uinone. This oxidation process poses a significant challenge in the development of DOP-based hydrogels, hampering their adhesion capabilities and hindering polymerization. To protect DOP moieties from oxidation, DOP and N-(3-aminopropyl)methacrylamide (AMA) moieties were grafted onto the side groups of biocompatible poly(glutamic acid) (PGA). Subsequently, the DOP unit, serving as a second guest, would be captured by a polymerizable rotaxane of cucurbituril (CB[n]), in which the host molecule CB[8] complexed with the first guest, polymerizable methyl viologen (MV), forming a protective function and dynamic cross-linking. Upon exposure to light curing, a composite network emerged through the synergy of covalent cross-linking and supramolecular host-guest complexation of DOP with CB[8]. The generated complexation between DOP and CB[8] could protect the DOP moieties, resulting in photocured hydrogels with exceptional adhesive strength and remarkable tensile capabilities. Moreover, 3D printing technology was used to create various models with these DOP-based hydrogels, demonstrating their promising applications in future.
研究领域:
材料科学
·
化学
·
生物医学工程
·
高分子科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULAR PHARMACEUTICS
·
2014
·
IF 4.787
Yanping Li,Yangyang Zhou,Bowen Qi,Tao Gong,Xun Sun,Yao Fu,Zhirong Zhang
Parkinson’s disease (PD) has become one of the most deadly diseases due to a lack of effective treatment. Herein, N-3,4-bis(pivaloyloxy)dopamine-3-(dimethylamino)propanamide (PDDP), a brain-specific derivative of dopamine, was designed and synthesized, which consists of a brain targeted ligand, N,N-dimethyl amino group, and two dipivaloyloxy groups for lipophilic modification. PDDP was investigated both in vitro and in vivo by comparing with L-DOPA and another derivative (BPD) without N,N-dimethyl amino group. PDDP showed a more pronounced accumulation in mouse brain microvascular endothelial cells (bEnd.3) than BPD via an active transport process. The increased cellular uptake of PDDP was proven to be mediated by putative pyrilamine cationic transporters. Following intravenous administration, the concentration of PDDP in the brain was 269.28-fold and 6.41-fold higher than that of L-DOPA and BPD at 5 min, respectively. Additionally, PDDP effectively attenuated the striatum lesion caused by 6-hydroxydopamine (6-OHDA) in rats. More importantly, PDDP presented antioxidant and antiapoptotic effects on 6-OHDA-induced toxicity in human neuroblastoma cells (SH-SY5Y). Thus, N,N-dimethyl amino group-based PDDP represents an effective and safe treatment for PD.
研究领域:
神经科学
·
药理学
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2026
·
IF 7.1
Boruo Yang,Pei Lin,Jin Liu,Mei Lan,XuanYi Liu,Weihao Xiong,Min Zhang,Luan Lin,Peng Liang
Frozen pre-cooked minced meat products rich in n-3 polyunsaturated fatty acids (FPMP) have a broad market and require heating before consumption. This study compared nutritional quality and flavor in FPMP under different reheating methods and explored the flavor formation mechanism of reheated FPMP by constructing a correlation network. The results showed that after reheating, microwaved, and control FPMP exhibited similar flavor and quality profiles, while fried FPMP displayed the most distinctive aroma and quality properties. Compared to other treatments, microwave reheating better preserved the original flavor and quality properties of FPMP while causing the least damage to n-3 polyunsaturated fatty acids. Correlation networks revealed that after reheating, 2-undecanone and 1-hepten-3-one in FPMP showed significant negative correlations with Lys and Tyr, respectively, while 2-nonanone exhibited significant positive correlations with C18:1n9c, C20:3n3c, and C20:5n3c. These results provide theoretical support for selecting FPMP reheating methods and understanding flavor formation.
✓ 已验证
DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
·
2019
·
IF 3.17
Qi-meng Liu,Qing Xiao,Xiang Zhu,Kai-feng Chen,Xia-wen Liu,Ru-chao Jiang,Dan Wu,Jun-min Shi,Li-jun Dai,Jun-jun Huang
Benign prostatic hyperplasia (BPH) is a common disorder of the urinary system in aging men. 2-(1H-indol-3-yl)-N-[3-(4-(2-methoxyphenyl) piperazinyl) propyl] acetamide (HJZ-3), which is derived from naftopidil , exhibited 97.7- and 64.6-fold greater inhibitory effects for a 1D adrenoceptor than for a 1B - and a 1A -adrenoceptors in vitro, respectively. To investigate the therapeutic potential for treating BPH, we evaluated the pharmacological activity of HJZ-3. Specifically, we evaluated through estrogen/androgen-induced rat benign prostatic hyperplasia model in vivo. HJZ-3 effectively prevented the progression of rat prostatic hyperplasia by suppressing the increase in prostate index and reducing the quantitative analysis of the relative acinus volume, relative stroma, epithelial volume and epithelial thickness and expression of proliferating cell nuclear antigen and α -smooth muscle actin. HJZ-3 decreased α 1A - and α 1D -adrenoceptor protein expressions in prostate tissue. HJZ-3 is a good alternative for α 1A - and α 1D -adrenoceptor blocker. It may relax smooth muscle tone and relieve symptoms of BPH.
研究领域:
药理学
·
泌尿外科
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF DENTISTRY
·
2021
·
IF 4.379
Kang Li,Zhongni Zhang,Yuhong Sun,Hongye Yang,James Kit Hon Tsoi,Cui Huang,Cynthia Kar Yung Yiu
Objectives To evaluate the anti-proteolytic and cross-linking effect of N -(3,4-dihydroxyphenethyl)methacrylamide (DMA) on the demineralized dentin matrix in vitro . Methods Four experimental solutions were selected: 50% ethanol/water solution (Control); 1, 5, and 10 mmol/L DMA dissolved in 50% ethanol/water solution. Sound human molars were sectioned to produce dentin beams with dimension of 1×1×6 mm. The dentin beams were demineralized with 10% phosphoric acid for 8 h to remove the apatite . The demineralized specimens were randomly separated into four groups and immersed in the four experimental solutions for 1 h. After the treatment , the ultimate tensile strength (UTS), loss of dry mass and the release of hydroxyproline by storing the treated specimens in 0.1 mg/mL collagenase solution for 24 h were assessed. The swelling ratio of another ten specimens from each group were evaluated. The interaction between DMA with dentin matrix was observed under Field Emission Scanning Electron Microscopy (FESEM). UTS data was analyzed by two-way ANOVA followed by Tukey test, and the other data was analyzed by one-way ANOVA followed by Tukey test (α = 0.05). Results The two-way ANOVA factors, different solutions ( p < 0.001), collagenase degradation ( p < 0.001) and their interactions ( p < 0.001) all significantly affected the UTS. The 10 mM DMA treatment significantly decreased the percentage of loss of dry mass, release of hydroxyproline and swelling ratio of demineralized dentin matrix compared to other treatment groups ( p < 0.05). The FESEM observation depicted that with increasing concentration of DMA, the structure of dentin matrix was protected and the porosity within dentin collagen network was decreased. Conclusions The treatment by 10 mM DMA/ethanol solution for 1 hour is capable of enhancing the mechanical properties of demineralized dentin matrix against collagenase degradation and may be clinically useful to improve the durability of hybrid layer. Clinical Significance The 10 mM DMA/ethanol primer may offer an alternative choice for dentists to strengthen the mechanical properties of demineralized dentin matrix and resist its degradation by collagenase.
研究领域:
牙科学
·
材料科学
·
生物材料
✓ 已验证
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2017
·
IF 4.3
Quan-Quan Zhuang,Zhi-Hang Lin,Yan-Cheng Jiang,Hao-Hua Deng,Shao-Bin He,Li-Ting Su,Xiao-Qiong Shi,Wei Chen
Dendrite-like cobalt selenide nanostructures were synthesized from cobalt and selenium powder precursors by a solvothermal method in anhydrous ethylenediamine. The as-prepared nanocrystalline cobalt selenide was found to possess peroxidase-like activity that could catalyze the reaction of peroxidase substrates in the presence of H2O2. A spectrophotometric method for uric acid (UA) determination was developed based on the nanocrystalline cobalt selenide-catalyzed coupling reaction between N-ethyl-N-(3-sulfopropyl)-3-methylaniline sodium salt and 4-aminoantipyrine (4-AAP) in the presence of H2O2. Under optimum conditions, the absorbance was proportional to the concentration of UA over the range of 2.0–40 μM with a detection limit of 0.5 μM. The applicability of the proposed method has been validated by determination of UA in human serum samples with satisfactory results.
研究领域:
材料科学
·
分析化学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）