Journal of Water Process Engineering
·
2025
·
IF 6.7
Lian Yang,Haoran Qiu,Lijun Zhao,Ping Xiao,Guoliang Liu,Jiang Chang,Tianbei Zhang,Shaoxia Yang,Feng Xiao
Polyvinylidene fluoride (PVDF)-N-isopropylacrylamide (NIPAM)-Graphene oxide (GO) (PNG) membrane can dramatically change their microstructure and performance in response to temperature variations in raw water. However, the research on the effect of responsible temperature and individual component in this membrane is lack of clarity. In this study, the permeability-selectivity index was established to determine the responsible temperature of the PNG membrane at 35 °C (PNG-35). And the biofilter effluent from Beijing wastewater reclamation treatment plant was used to investigate the contribution of each composition in the PNG membrane. It can be noticed that with the addition of GO could increase the permeability 23.33 %，while selectivity increased 15.05 %. After the further introduction of NIPAM, subsequently the permeability could increase 82.86 % with the selectivity increased 11.35 %. Finally, comparing the effluent of membrane by EEM, molecular weight distribution and FTICR-MS, the results showed that the humic-like substances were the main contaminants with molecular weights of 142 Da, 397 Da, and 1147 Da, characterized by their sulfur content, hydrophilicity, and negative charged. Humic-like substances were the main contaminants which the sequence of removal was PNG-35 > PNG > PG > PVDF. Apparently, the adding of GO, NIPAM and the responsible temperature could improve the removal of humic-like substances that attributed to the R ir decreased the value at 0.201, 0.092 and 0.041. And charge effects between the contaminants and membrane surface played a significant role under the responsible temperature.
研究领域:
环境科学
·
材料科学
·
水处理技术
·
膜技术
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
Advanced Science
·
2022
·Vol. 9
·期 22
·2201155
·
IF 17.521
Xiaocheng Wang,Yunru Yu,Chaoyu Yang,Luoran Shang,Yuanjin Zhao,Xian Shen
Biological scaffolds hold promising perspectives for random skin flap regeneration, while the practical application is greatly limited by their insufficient vascularization ability and the lack of responsiveness during the dynamical healing process. Herein, a novel MXene-incorporated hollow fibrous (MX-HF) scaffold with dynamically responsive channels is presented for promoting vascularization and skin flap regeneration by using a microfluidic-assisted 3D printing strategy. Benefiting from the photothermal conversion capacity of the MXene nanosheets and temperature-responsive ability of poly(NIPAM) hydrogels in the MX-HF scaffolds, they display a near-infrared (NIR)-responsive shrinkage/swelling behavior, which facilitates the cell penetration into the scaffold channels from the surrounding environment. Moreover, by incorporating vascular endothelial growth factor (VEGF) into the hydrogel matrix for controllable delivery, the MX-HF scaffolds can achieve promoted proliferation, migration, and proangiogenic effects of endothelial cells under NIR irradiation. It is further demonstrated in vivo that the NIR-responsive VEGF@MX-HF scaffolds can effectively improve skin flap survival by promoting angiogenesis, decreasing inflammation, and attenuating apoptosis in skin flaps. Thus, it is believed that such responsive MX-HF scaffolds are promising candidates for clinical random skin flap regeneration as well as other diverse tissue engineering applications.
研究领域:
组织工程
·
生物医学工程
·
再生医学
·
材料科学
·
生物材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2020
·
IF 6.306
Huihuang Xiong,Lan Guo,Xuejin Mao,Ting Tan,Hao Wan,Yiqun Wan
A magnetic hydrophilic molecularly imprinted material (MIM) with multiple stimuli-responses was prepared for efficient recognition of bisphenol A (BPA). MIM consisted of a magnetic core, an inner silica dioxide shell and an outer hydrophilic polymer shell, responsive for rapid magnetic separation, protection of the magnetic core and pH-/thermo-sensitivity to BPA, respectively. Controlled adsorption and release of BPA by pH/temperature regulation were realized through the reversible components of poly[N-isopropylacrylamide- co -2-(dimethylamino)ethyl methacrylate (NIPAM-DMAEMA)] (PND). The resultant MIM possessed superior affinity, selectivity and kinetics to BPA in aqueous solution. MIM was successfully applied to detect BPA in beverages via dispersive solid-phase extraction (d-SPE) coupled with high performance liquid chromatography (HPLC), exhibiting satisfactory recoveries of 80.70–108.18% with relative standard deviations (RSD) below 6.08%. The limit of detection of BPA was obtained as low as 3.75 nmol/L. The versatile MIM could be a promising alternative for extraction/removal of BPA in complicated samples by multiple-stimuli regulations.
研究领域:
分析化学
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2023
·Vol. 33
·期 26
·2300710
·
IF 19
Yaodong Zhao,Bingcheng Yi,Jilin Hu,Dongjie Zhang,Guotai Li,Yun Lu,Qihui Zhou
When skin trauma occurs, rapid achievement of the post-wound closure is required to prevent microbial invasion, inhibit scar formation and promote wound healing. To develop a wound dressing for accelerating post-wound-closure and wound healing, a thermo-responsive and tissue-adhesive hydrogel with interpenetrating polymer networks (IPN) is fabricated based on N -dimethylbisacrylamide (NIPAM) and glutaraldehyde (GTA) cross-linked hyaluronic acid (HA). Results not only confirm the thermo-stimulated self-contraction and tissue adhesiveness of the HA-based IPN (PNI-HA), which effectively aids wound closure via mechanical stretch, but also verify the hemocompatibility and cytocompatibility of PNI-HA that tend to accelerate wound healing. In vivo, a mouse model of total skin defect demonstrates that PNI-HA acting as hydrogel sealant significantly achieves the sutureless post-wound-closure at the early stage of wound healing, and then promotes wound healing by reducing inflammatory cells infiltration, promoting angiogenesis as well as reducing collagen deposition. These results indicate that the developed thermo-responsive and tissue-adhesive hydrogel dressing offers a candidate to serve as a tissue sealant for wound healing.
研究领域:
生物材料
·
组织工程
·
伤口愈合
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULES
·
2018
·
IF 5.914
Jinqiao Xue,Wei Bai,Hanyi Duan,Jingjing Nie,Binyang Du,Jing Zhi Sun,Ben Zhong Tang
We studied the aggregation-induced emission (AIE) phenomenon in a nanoconfined environment, where the AIE-active molecule, namely, 1,1,2,2-tetrakis(4-methanoylphenyl)ethane (TPE-4ALD), was held in space via four acylhydrazone bonds within the thermosensitive microgel networks. The thermosensitive microgels, namely N-AH-TPE, were synthesized via the copolymerization of N-isopropylacrylamide (NIPAM) and 4-acylhydrazine-(2-hydroxy-3-(methacryloxypropyl)pyridine hydrochloride (AH monomer) with TPE-4ALD as cross-linker via surfactant free emulsion polymerization (SFEP) in aqueous solution at 70 °C. Acylhydrazone-bonded tetraphenylethene (TPE-4AH) moieties were thus constructed and worked as the fluorophore in N-AH-TPE microgels. The aqueous suspensions of N-AH-TPE microgels exhibit strongly bluish-green fluorescence under ultraviolet excitation because the four arms of TPE-4AH moieties were held and their intramolecular motions are strongly restricted. It is estimated that there is one TPE-4AH moiety per about 394 nm3 for the swollen N-AH-TPE microgels. The fluorescent properties of N-AH-TPE microgels can be modulated via the change of hydrophilic and hydrophobic environments of TPE-4AH moieties exerted by external stimuli, like addition of various good solvents for TPE-based structures, i.e., N,N-dimethylformamide (DMF), methanol, ethanol, tetrahydrofuran (THF), and N,N-dimethyl sulfoxide (DMSO), varying the solution temperature as well as the counteranions of the microgels. An unusual enhancement in the fluorescent intensity is observed when specific amounts of organic solvent are added into the aqueous suspensions of N-AH-TPE microgels, which can be attributed to the cononsolvency of the polyNIPAM network chains. The shrinkage of N-AH-TPE microgels caused by the cononsolvency effect further strengthens the confinement of TPE-4AH moieties and hence enhances the fluorescent emission of the microgels even though the organic solvents added are good solvents for TPE-4AH. Increasing the solution temperature of N-AH-TPE microgels or introducing hydrophobic counteranions into the microgels also significantly enhances the fluorescent emission of the microgels.
研究领域:
材料科学
·
化学
·
高分子科学
·
纳米技术
·
光学
✓ 已验证
产品关联
DOI
高影响因子
ACS Biomaterials Science & Engineering
·
2018
·
IF 4.432
Lixia Yu,Anjie Dong,Ruiwei Guo,Muyang Yang,Liandong Deng,Jianhua Zhang
Chemo-photothermal therapy has shown enormous potential in treating cancer. To achieve the chemo-photothermal synergistic effect, an efficient nanoparticulate system with the ability for simultaneous codelivery of chemotherapeutic drug and photothermal agent as well as photothermal-triggered drug release is highly desirable. Herein, an in situ polymerization within liposome template was designed to prepare liposome-coated poly(N-isopropylacrylamide-co-acrylamide) (P(NIPAM-co-AAM)) nanogels, which can efficiently coencapsulate a NIR dye indocyanine green (ICG) and high amount of doxorubicin hydrochloride (DOX). The DOX/ICG coloaded hybrid nanogels, denoted as DI-NGs@lipo, integrated the desirable functions of PEGylated liposomes and thermosensitive nanogels. The PEGylated liposome shell provided excellent storage stability, hemodynamic stability, and fluorescence stability. Meanwhile, the thermosensitive P(NIPAM-co-AAM) nanogels core endowed DI-NGs@lipo with volume phase transition temperature (VPTT) at about 40 °C, allowing for thermo-controlled transformation and drug release. The significant photothermal effect of DI-NGs@lipo and the simultaneous hyperthermia-triggered DOX release were observed under NIR light irradiation. The DI-NGs@lipo was demonstrated to be uptaken by 4T1 murine breast cancer cells via endocytosis, enhancing the distribution of DOX in the cell nucleus. Compared with chemo or photothermal treatment alone, the combination treatment of DI-NGs@lipo with NIR light irradiation induced significantly higher cytotoxicity to 4T1 cells, demonstrating the chemo-photothermal synergistic therapeutic effects on tumor cells. In a word, the strategy provided here offers a facile approach to develop a multifunctional nanoplatform for codelivery of DOX and ICG, which can synergistically improve the cancer-cell-killing efficiency, demonstrating great potential in chemo-photothermal therapy.
研究领域:
纳米技术
·
癌症治疗
·
药物递送系统
·
光热疗法
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2020
·
IF 4.192
Fan Yang,Jincheng Wang,Shiqiang Song,Pinhua Rao,Runkai Wang,Shihui Liu,Liqi Xu,Feng Zhang
A novel type of temperature and pH dual-stimuli-responsive microspheric soil conditioner was prepared for the controlled release of urea. First, poly(N-isopropylacrylamide-co-methacrylic acid) [P(NIPAM-co-MAA)] was synthesized, and the microspheric soil conditioner was prepared on the basis of chitosan-coated P(NIPAM-co-MAA) via the emulsion cross-linking method. The structure and morphology of the microsphere were characterized by Fourier transform infrared spectroscopy, hydrogen nuclear magnetic resonance, polarization optical microscopy, and scanning electron microscopy. The microsphere showed controlled release behavior in different temperature and pH conditions, indicating good stimuli responsiveness. The plant experiment revealed that the microsphere can effectively promote plant growth in acidified soil and high-temperature conditions, and the pH value of acidified soil could be improved. In addition, the microsphere possessed good biodegradation property in the soil. Therefore, the multi-responsive microspheric soil conditioner owns a great potential value to amend soil conditions and promote plant growth in agriculture applications.
研究领域:
农业科学
·
土壤学
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 40
·24843-24851
·
IF 3.361
Pengfei Chen,Shun Yao,Dongmei Zheng,Zhiyuan Xu,Jinling Yu,Tingting Liang
Herein, a novel temperature-sensitive magnetic composite (Fe3O4@SiO2@P(NIPAM-co-VI)/Cu2+) with a uniform core–shell–shell structure was successfully prepared via a layer-by-layer method. The resulting magnetic composite revealed good magnetic properties and remarkable affinity to papain with a maximum adsorption capacity of 199.17 mg g−1. The adsorption equilibrium data fitted the pseudo-second-order kinetic and Freundlich models well, and the major thermodynamics parameters indicated that adsorption was an endothermic and spontaneous process. Fe3O4@SiO2@P(NIPAM-co-VI)/Cu2+ could thermally protect papain, which is attributed to the reversible hydrophilic–hydrophobic transition of the composite at temperatures below and above the lower critical solution temperature. More importantly, the magnetic composite could be recycled at least six times without a remarkable loss in its adsorption capacity, and the process of adsorption and elution had no significant effect on the activity and structure of papain. This work could provide a novel separation method for papain without loss of its activity.
研究领域:
材料科学
·
化学工程
·
生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Jiahui Zhang,Wei Xin,Yechi Qin,Yuhao Hong,Zijie Xiahou,Kunxi Zhang,Peiliang Fu,Jingbo Yin
Based on “bottom-up” strategy, cell-laden 3D bioprinting is an important process of fabricating sophisticated biomimetic structures. Stem cell spheroids possess better biological properties and are advanced as printing units. However, efficient and convenient preparation, collection and printing of cell spheroids remains a challenge. The present study developed a composite granular hydrogel acted as “all-in-one” multi-functional bioink to realize Adipose-derived stem cell (ASC) spheroids Production and reorganization. Poly(sulfobetaine methacrylate) (PSBMA) based microspheres were fabricated and self-assembled to a granular hydrogel. Then, N -isopropylacrylamide (NIPAM) and SBMA were co-polymerized in-situ inside of assembled PSBMA microspheres to further crosslink the assembled microspheres, forming a composite granular hydrogel, which possesses bulk feature and shear-thinning, self-healing properties. Caves were created by compressing composite granular hydrogels into sugar particles that removed via dissolution in water. Due to the non-fouling feature and the porous structure, numerous ASC spheroids were formed spontaneously inside the porous composite granular hydrogel, which were transferred conveniently to 3D printer. The spheroids-laden composite granular hydrogels showed well-performed extrudability and fidelity, realizing reorganization of the produced spheroids to the stable 3D constructs for further in vitro culture . ASC spheroids in granular hydrogel after 3D printing showed high level of viability and stemness, as well as efficient chondrogenic/osteogenic/adipogenic differentiation. The composite granular hydrogel thus shows potential toward stem cell researches such as organoids construction. The results of both in vitro drug toxicity and in vivo cartilage regeneration experiments showed spheroids-laden granular hydrogel is promising in drug screening and tissue regeneration.
研究领域:
组织工程
·
干细胞生物学
·
生物打印
·
材料科学
·
再生医学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yang Pang,Zhichuang Qi,Liangliang Cui,Zhangmi Huang,Chunyan Hu,Zhijia Zhu,Baojiang Liu
Photonic crystal hydrogels (PCHs) are innovative materials that translate imperceptible deformations and humidity changes into visible colors, broadening the applications of photonics in bioengineering and smart materials. To overcome poor mechanical properties of traditional PCHs limited by weak intermolecular forces, we designed a PCH with a dual-network framework comprising N-isopropylacrylamide-co-acrylamide (NIPAM-co-AM) and biomass lotus root starch (LR). Since LR is rich in hydroxyl groups, it can undergo molecular linkage entanglement with the NIPAM-co-AM hydrogel matrix, forming hydrogen bonds that significantly enhance the mechanical properties of the PCH. We have prepared PCH films capable of conveying multidimensional information about the extent and distribution of transient deformation by encapsulating magnetic photonic crystal microspheres (MPCMs) within a hydrogel matrix. The PCH films were found to have ultrafast response time (< 10 s), full-color tunable range, high spatial resolution, excellent mechanical toughness (tensile up to 0.17 MPa) and sensitivity (2.52 nm % −1 ), and were able to sense relative humidity (RH) from 11 % to 98 %. Equipped with a dynamically reconfigurable lattice, this dual-responsive (tensile/humidity) PCH not only facilitates the creation of water-rewritable photonic films but also holds promise for integration into structural color elastic fabrics, thereby presenting novel prospects for smart textile applications.
研究领域:
材料科学
·
生物工程
·
智能材料
·
纺织工程
·
光子学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Hongwei Zheng,Hong Lin,Xiangfeng Chen,Jianxin Sui,Mati Ullah khan,Tushar Ramesh Pavase,Xiangning Han,Limin Cao
Rapid detection of pathogenic bacteria particularly in food samples demands efficient separation and enrichment strategies. Here, hydrophilic temperature-responsive boronate affinity magnetic nanocomposites were established for selective enrichment of bacteria. The thermo-responsive polymer brushes were developed by surface-initiated atom transfer radical polymerization of N -isopropylacrylamide (NIPAm) and allyl glycidyl ether (AGE), followed by a reaction of epoxy groups, and incorporation of fluorophenylboronic acid. The physical and chemical characteristics of the magnetic nanocomposites were analyzed systematically. After optimization, S. aureus and Salmonella spp. showed high binding capacities of 32.14 × 10 6 CFU/mg and 50.98 × 10 6 CFU/mg in 0.01 M PBS (pH 7.4) without bacteria death. Bacterial bindings can be controlled by altering temperature and the application of competing monosaccharides. The nanocomposite was then utilized to enrich S. aureus and Salmonella spp. from the spiked tap water, 25% milk, and turbot extraction samples followed by multiplex polymerase chain reaction (mPCR), which resulted in high bacteria enrichment, and demonstrated great potential in separation of bacteria from food samples.
研究领域:
材料科学
·
纳米技术
·
生物技术
·
食品安全
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2016
·Vol. 4
·期 29
·7083-7092
·
IF 5.066
Yajiao Song,Jianhua Lü,Bingxin Liu,Changli Lü
Thermo-responsive block copolymer brushes of PNIPAM-b-P(MQ-co-GMA) were successfully grafted from graphene oxide (GO) by consecutive reversible addition–fragmentation chain transfer (RAFT) polymerization based on the monomers of N-isopropylacrylamide (NIPAM), 5-(2-methacryloyl-ethyloxymethyl)-8-quinolinol (MQ) and glycidyl methacrylate (GMA). The 8-hydroxyquinoline units in the polymer brushes could coordinate with Al3+ to form green luminescent copolymer brushes containing tris(8-hydroxyquinoline)aluminum (Alq3) on the GO surface. The resulting fluorescent hybrid could be used as a nano-platform for the sensitive and robust detection of 2,4,6-trinitrophenol (TNP). The green fluorescence of the polymer brush modified GO hybrid in aqueous solution could be quenched by TNP via charge transfer and the observed linear fluorescence intensity change allowed the quantitative detection of TNP with a detection limit down to 2.38 × 10−9 M. The fluorescent nanohybrids exhibited a robust temperature-responsive behavior as a result of the conformation change in PNIPAM chains of polymer brushes.
研究领域:
材料科学
·
高分子化学
·
纳米技术
·
分析化学
·
环境科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）