NEUROCHEMICAL RESEARCH
·
2018
·Vol. 43
·期 7
·1439-1453
·
IF 2.772
Jia Jingjing,Zhang Ting,Chi Jieshan,Liu Xiaoma,Sun Jingjing,Xie Qizhi,Peng Sijia,Li Changyan,Yi Li
CeO 2 nanoparticles (nanoceria) have been used in many studies as a powerful free radical scavenger, and LXW7, a small-molecule peptide, can specifically target the integrin αvβ3, whose neuroprotective effects have also been demonstrated. The objective of this study is to observe the neuroprotective effect and potential mechanism of CeO 2 @PAA-LXW7, a new compound that couples CeO 2 @PAA (nanoceria modified with the functional group of polyacrylic acid) with LXW7 via a series of chemical reactions, in H 2 O 2 -induced NGF-differentiated PC12 cells. We examined the effects of LXW7, CeO 2 @PAA, and CeO 2 @PAA-LXW7 on the viability of primary hippocampal neurons and found that there was no significant difference under control conditions, but increased cellular viability was observed in the case of H 2 O 2 -induced injury. We used H 2 O 2 -induced NGF-differentiated PC12 cells as the classical injury model to investigate the neuroprotective effect of CeO 2 @PAA-LXW7. In this study, LXW7, CeO 2 @PAA, and CeO 2 @PAA-LXW7 inhibit H 2 O 2 -induced oxidative stress by reducing the production of reactive oxygen species (ROS) and regulating Bax/Bcl-2, cleaved caspase-3 and mitochondrial cytochrome C (cyto C) in the apoptotic signaling pathways. We found that the levels of phosphorylation of focal adhesion kinase (FAK) and of signal transducer and activator of transcription 3 (STAT3) increased significantly in H 2 O 2 -induced NGF-differentiated PC12 cells, whereas LXW7, CeO 2 @PAA, and CeO 2 @PAA-LXW7 suppressed the increase to different degrees. Among the abovementioned changes, the inhibitory effect of CeO 2 @PAA-LXW7 on H 2 O 2 -induced changes, including the increases in the levels of p-FAK and p-STAT3, is more obvious than that of LXW7 or CeO 2 @PAA alone. In summary, these results suggest that integrin signaling participates in the regulation of apoptosis via the regulation of ROS and of the apoptosis pathway in H 2 O 2 -induced NGF-differentiated PC12 cells. LXW7, CeO 2 @PAA, and CeO 2 @PAA-LXW7 can play neuroprotective roles by counteracting the oxidative stress and apoptosis induced by H 2 O 2 in NGF-differentiated PC12 cells. CeO 2 @PAA-LXW7 exerting a more powerful synergistic effect via the conjunction of LXW7 and CeO 2 @PAA.
研究领域:
神经科学
·
药理学
·
细胞生物学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Weiting Tang,Li Feng,Xiujuan Wei,Guoyong Lai,Haopeng Chen,Zeheng Li,Xiuhuan Huang,Shuxing Wu,Zhan Lin
The large volume expansion hinders the commercial application of silicon oxide (SiOx) anodes in lithium-ion batteries. Recent studies show that binders play a vital role in mitigating the volume change of SiOx electrodes. Herein, we introduce the small molecule tannic acid (TA) with high branching into the linear poly(acrylic acid) (PAA) binder for SiOx anodes. The three-dimensional (3D) crosslinked network with multiple hydrogen bonds is formed by the incorporation of abundant hydroxyl groups with unique carboxyl groups, which increases the interfacial adhesive strength with SiOx particles. As a consequence, SiOx electrodes based on the PAA-TA binder show an excellent cycling performance with a high specific capacity of 1025 mA h g–1 at 500 mA g–1 after 250 cycles. Moreover, the SiOx||NCM811 full cell exhibits a reversible capacity of 143 mA h g–1 corresponding to 87.4% capacity retention after 100 cycles.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Yu Guo,Jiawei Huang,Wenzhong Yang,Hui Xu
To address the persistent challenge of antibiotic contamination in aquatic systems, we developed a novel bimetallic hydrogel composite, i.e., Co/Zn-UiO-66-PAA/chitosan @biochar (Co/Zn-UPCB) through strategic integration of polyacrylic acid (PAA)-functionalized metal organic frameworks (UiO-66), lotus leaf-derived biochar, and natural chitosan. This hierarchically porous architecture synergistically combines chemical functionality (abundant carboxyl/amino groups), structural stability (3D crosslinked network), and bimetallic active sites (Co²⁺/Zn²⁺), exhibiting remarkable adsorption capacities of 1693.45 mg/g for tetracycline (TC) at pH of 7 and 1201.63 mg/g for ofloxacin (OFL) at pH of 5. Additionally, kinetic and isotherm studies reveal distinct removal pathways. TC adsorption follows chemisorption-dominated monolayer binding via coordination and hydrogen bonding, while OFL removal occurs through physisorption-driven electrostatic interactions. The Co/Zn-UPCB composite maintains near 80% efficiency after ten regeneration cycles and demonstrates strong anti-interference capability against common coexisting ions (except Ca²⁺). This work provides a sustainable design leveraging waste-derived biochar and biopolymer for efficient adsorption of TC/OFL, enabling precision water remediation.
研究领域:
环境科学
·
材料科学
·
水体修复
·
纳米技术
·
吸附技术
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULES
·
2025
·
IF 5.2
Wenyuan Lang,Wanting Zhang,Nuojin Zhang,Hao Huang,Feng Lin,Aimin Ge,Bing Xue,Shuguang Yang
Polymer complexes containing multiple interactions have attracted considerable interest in the development of advanced and multifunctional materials. The fundamental study on multi-interacted polymer complexes helps understand their properties and facilitates rational material design; however, it has been less systematically explored. In this work, a PEOX-EI-50/PAA complex with a dual interaction of hydrogen bonding and electrostatic force is prepared via stepwise interfacial complexation. Quartz crystal microbalance with dissipation (QCM-D) measurements indicate pH-dependent PEOX-EI-50/PAA complexation with the optimal assembly pH at 4. Isothermal titration calorimetry (ITC) results prove the coexistence of the hydrogen bond and electrostatic interaction in the PEOX-EI-50/PAA assembly at specific pH levels and reveal that the high-affinity binding site transits from hydrogen bonding to electrostatic bonding as the pH increases from 3 to 4. In addition, hydrogen bonding could alleviate the inhibition of the electrostatic interaction between complementary polymers by salt, leading to the successful assembly of PEOX-EI-50/PAA in the presence of 1 M NaCl. A pseudo-mass-loss phenomenon is observed during PEOX-EI-50/PAA complexation, which can be further amended by eliminating charge density mismatch through pH/salt concentration adjustment. PEOX-EI-50/PAA exhibits improved pH stability compared with the PEOX/PAA hydrogen-bonding system and exceptional salt stability compared with the PEI/PAA polyelectrolyte pairs, indicating the advantage of the polymer complex with dual interaction.
研究领域:
聚合物科学
·
材料化学
·
物理化学
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Liying Wan,Peijie Li,Meiling Yan,Jianhong Wang,Xibao Li
Conductive hydrogels have attracted much attention in soft electronic devices. However, it is still a challenging to be integrated with outstanding mechanical performance, self-healing, shape memory and conductive capability. Herein, we developed a multifunctional conductive hydrogel via interpenetrating network (IPN) and multiple hydrogen bond interaction. Poly (acrylic acid)-polyaniline (PAA-PANI) and polyvinyl alcohol (PVA) form bones of IPN through chemical and physical double cross-linking. Chemically crosslinking of IPN was obtained by in situ polymerization of acrylic acid and aniline. Physical crosslinking is realized by more multiple hydrogen bonds (N–H···O, O–H···O, O–H···N, N–H···N) interaction among PVA, polydopamine and PF127 diamino oxygen derivatives. PANI forms a conductive path in the IPN to ensure its conductivity. IPN hydrogels with multiple hydrogen bonds has excellent mechanical strength, which is much higher than conventional conductive hydrogels. Moreover, the structure endowed the hydrogel low swelling property, good self-healing and thermal-responsive shape memory effect. The multifunctional IPN conductive hydrogel have potential applications in smart devices including self-healing electronic devices, soft robot, and sensors.
研究领域:
材料科学
·
电化学
·
软体机器人
·
传感器
·
智能材料
✓ 已验证
产品关联
DOI
高影响因子
Water
·
2024
·Vol. 16
·期 23
·3533
·
IF 3
Feilong Dong,Jiayi Cheng,Yifeng Cheng,Xiaoyan Ma
Diethyl phthalate (DEP) is a commonly utilized plasticizer that has gained significant attention due to its widespread occurrence in the environment and its harmful impact on human health. The primary objective of this study was to evaluate and compare several (ultraviolet) UV-(peracetic acid) PAA advanced oxidation processes based on hydroxyl radicals to degrade DEP. The effect of UV-LEDs incorporating PAA at different UV ranges (UV-A, λ = 365 nm; UV-C, λ = 254 nm and VUV, λ = 254 nm) was evaluated. The results demonstrated that DEP was successfully degraded in both the UVC/PAA (removal rate 98.28%) and VUV/PAA (removal rate 97.72%) processes compared to the UVA/PAA process (removal rate of 2.71%). The competitive method evaluated the contribution of R-O•, which were 24.08% and 33.92% in UVC/PAA and VUV/PAA processes, respectively. We also evaluated the effects of peroxymonosulfate (PMS) dosages, UV irradiation, pH and anion coexistence on the removal of DEP. In the UVC/PAA system, DEP degradation was particularly effective (removal rate about 95.52%) over a wider pH range (3–9). As the concentration of HCO3−ions increased, there may have been some inhibition of DEP removal. The inhibitory effect of HA and Cl−ions on DEP removal were negligible. Analysis of the intermediates revealed that DEP degradation primarily occurred via two pathways: hydrolysis and hydroxylation reactions. This study presents a potential mnethod for the removal of phthalates and offers some guidance for the selection of appropriate disinfection technologies in drinking water treatment.
研究领域:
环境科学
·
水处理技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2017
·
IF 6.035
Bowen Cheng,Zongjie Li,Quanxiang Li,Jingge Ju,Weimin Kang,Minoo Naebe
A smart tree-like nanofiber membrane with pH-responsivity was successfully fabricated by electrospinning poly(vinylidene fluoride)-graft-poly(acrylic acid) (PVDF-g-PAA). X-ray photoelectron spectroscopy, field emission scanning electron microscopy , Fourier transform infrared spectroscopy , and Brunauer-Emmett-Teller surface area measurement were employed to study the molecular structure and morphology of membranes. Through realizing protonation and deprotonation in response to the pH of the aqueous media, the as-prepared membrane is able to alter its wettability and conformation, resulting in the switchable surface oil/water wettability in the aqueous media. More importantly, the as-prepared membrane realized on-demand oil/water separation using gravity alone by switching the pH of the medium. Both separations exhibited excellent efficiency and flux which were attributed to the tree-like structure of the membrane. We believed that this smart membrane with such excellent controllable permeation has potential to be used for several applications, such as water purification , oil recovery and some separation systems.
研究领域:
材料科学
·
环境工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Jingxian Fan,Xiaole Gong,Honglei Liu,Mengyu Cao,Xiuping Liu,Xueying Cao,Liang Cui,Jinhou Fang,Jingquan Liu
Viscose fiber (VF) has been attracting increasing interest owing to its varied advantages like high breathability, high moisture absorption, superior spinning properties, and wear comfort. It can be employed in a multitude of medical applications, including wound care, hygiene products, surgical gowns, sutures, and bed linen. In this paper, RAFT polymerization was utilized to functionalize and modify VF, thereby preparing two kinds of distinct functional materials. The first one is viscose fiber grafted with poly (acrylic acid) and complexed with metal ions (VF-g-PAA-metal ions), which is applied in the domain of antimicrobial. Experimental findings demonstrated that the as-fabricated three composite materials of VF-g-PAA-Ag, VF-g-PAA-Cu, and VF-g-PAA-Zn exhibit significant inhibitory effects on Escherichia coli and Staphylococcus aureus . The second one is viscose fiber grafted with poly (acrylic acid) and then modified with NH 3 + to afford a composite material of VF-g-PAA-NH 3 + , which displays efficient formaldehyde (HCHO) removal efficiency via the formation of an oxime bond (-N=CH 2 ), while generating the only by-product of H 2 O. Our study reveals that 1.0 g of VF-g-PAA-NH 3 + is capable of removing 229.39 mg of HCHO in 24 h at a flow rate of 1.0 L min −1 N 2 at 25 °C. This approach improves the antimicrobial and HCHO removal efficacy of VF. The current novel and environmentally friendly modification strategy not only endows VF materials with antibacterial properties and formaldehyde (HCHO) elimination capabilities, but also exhibits significant environmental compatibility, thereby significantly expanding their applications.
研究领域:
材料科学
·
高分子化学
·
环境工程
·
抗菌技术
·
功能纺织品
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Junwei Feng,Xuanting Wu,Said Amzil,Min Li,Xingchen Liu,Ming Yang,Tingting Yan,Peter Müller-Buschbaum,Ya-Jun Cheng,Jie Gao,Yonggao Xia
Silicon–carbon (Si/C) composites hold great promise as substitutes for conventional graphite anodes in high-specific-energy lithium-ion batteries (LIBs). However, their performance is hindered by silicon’s substantial volume expansion during cycling, which can lead to electrode degradation. Traditional poly(acrylic acid) (PAA) binders often struggle to maintain electrode integrity under these conditions. To address this challenge, polyether modified polyurethane acrylic (PUMA) is used as physicochemical cocrosslinking polymer. PUMA offers superior mechanical properties, elasticity, and interfacial stability, enabling it to effectively accommodate silicon’s volume changes and prevent electrode fracture. Through a simple preparation process, we used PUMA as a slurry additive in combination with PAA to form a functional composite binder, facilitating the construction of a stable and robust SEI film. This is conducive to alleviating the volume expansion of silicon and ensuring the cycling stability of the electrode. In Si/C450 half-cells, electrodes enhanced by our binder show a remarkable longevity, maintaining 97.26% of their capacity post 200 cycles at 0.5 C. The full cells Si/C450||NCM811 display a notable performance, achieving a capacity retention of 82.10% after 100 cycles at 0.2 C. These findings underscore the potential of our innovative binder design in enhancing the efficacy of silicon-based anodes in high-energy LIBs.
研究领域:
材料科学
·
能源技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Bio Materials
·
2025
·
IF 4.7
Xiaolei Guo,Yihang Yao,Tianyu Xu,Zhan Tian,Teng Long,Hua Wang,Xiao Cheng,Chuanjian Zhou
Hydrogels have shown significant potential in the field of flexible electronics; however, their practical application remains limited due to mechanical performance constraints. Inspired by the supramolecular interactions observed in nature, this study designs a water-soluble PhAPSiX polymer and introduces it into an aqueous acrylic acid solution. During in situ polymerization, a hydrogel network is formed through the self-assembly of supramolecular interactions, resulting in the fabrication of a PAA/PhAPSi70 hydrogel with both high strength (2.29 MPa) and high toughness (4.47 MJ/m3). The strain sensors fabricated from this hydrogel demonstrate excellent performance, including high sensitivity (GF = 2.91), fast response time (893 ms), and short recovery time (997 ms), enabling effective monitoring of human motion. Additionally, the PAA/PhAPSi70 hydrogel exhibits exceptional shape adaptability, allowing for the preparation of sensor devices with specific shapes based on demand. Therefore, the PAA/PhAPSi70 hydrogel holds great promise for the next generation of flexible electronics and displays broad application prospects.
研究领域:
材料科学
·
高分子科学
·
柔性电子学
·
传感器技术
·
生物力学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2019
·
IF 7.015
Juan Cheng,Miao Xu,Panpan Cheng,Wanna Zhang,Nan Li,Yong Wang,Jingying Yang,Kaiyuan Liang,Peng Li,Haizhou Yu,Xiaoyan Qiu
As a representative amphiphilic block copolymer , polystyrene- block -poly (acrylic acid) (PS- b -PAA) has great potential in biomedical applications owing to its pH-responsiveness, antibacterial property and biocompatibility. Self-assembly of PS- b -PAA has been widely investigated with regard to micelles and thin films . Whereas, it is difficult to precipitate PS- b -PAA in water to make membrane due to the high hydrophilicity of PAA blocks. Herein, a process is described to fabricate PS- b -PAA isoporous membranes by combining self-assembly of metal-block copolymer complexes and non-solvent induced phase separation. Different antibacterial metal ions were doped in PS- b -PAA casting solution, which not only enhanced the mechanical property significantly, but also adjusted the pore size of the membranes. The membranes exhibited a pH-responsive release property and excellent separation performance based on size or charge differences. Moreover, the antifouling property was significantly enhanced through the synergistic effect of antibacterial metal ions and PAA segments.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
MACROMOLECULAR MATERIALS AND ENGINEERING
·
2016
·Vol. 302
·期 2
·1600359
·
IF 2.834
Lei Zhao,Jiahe Huang,Tao Wang,Weixiang Sun,Zhen Tong
A multiple shape memory and self-healing poly(acrylic acid)-graphene oxide-Fe 3+ (PAA-GO-Fe 3+ ) hydrogel with supertough strength is synthesized containing dual physically cross-linked PAA network by GO and Fe 3+ . The first GO cross-linked hydrogel can be reversibly reinforced by immersing in FeCl 3 /HCl and pure water and softened by immersing in HCl. The tensile strength is 2.5 MPa with the break strain of 700%. Multiple shape memory capability is found depending on this unique feature, the hydrogel can be fixed in four temporary shapes by adjusting the immersing time in FeCl 3 /HCl and pure water, and recovered in sequence by immersing in HCl. This hydrogel also exhibits perfect self-healing behavior, the cut as-prepared hydrogel is almost completely healed by immersing in FeCl 3 /HCl. Besides, the hydrogel shows enhanced electrical conductivity with the presence of GO and Fe 3+ . This supertough hydrogel provides a new way to design soft actuators.
研究领域:
材料科学
·
化学工程
·
纳米技术
·
机械工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）