INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Yin Yan,Lihe Zhang,Xi Zhao,Siyu Zhai,Qian Wang,Cui Li,Xu Zhang
The study presents the preparation of novel biocomposites based on different lignin fractions and polylactic acid (PLA). Based on the improvement of PLA mechanical properties, we proposed a process to assemble a series of lignin samples and PLA matrix using melt blending to investigate the effects on PLA properties from the perspective of the structure and molecular weight for lignin. The lignin was extracted from pine residue using deep eutectic solvent (DES) and was subjected to fractionation with ethanol and acetone as well as esterification modification with succinic anhydride (SAn). The treated lignin samples were used as additives, which not only improved the mechanical properties of PLA on the basis of retaining its thermal stability , but also granted excellent antimicrobial and biocompatibility properties. The results showed that the molecular weight of lignin was negatively correlated with the phenolic hydroxyl content, and the mechanical properties of the composites were also significantly affected by different molecular weights of lignin, indicating that the inhomogeneity of lignin affects its value-added utilization. The enhanced mechanical properties, antibacterial effect, and steady biocompatibility provide potential possibilities for lignin-based composites in biomedical applications.
研究领域:
材料科学
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生物医学工程
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化学工程
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DOI
PubMed
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2025
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IF 4.9
Zhijie Liang,Jinzhuai Li,Hai Huang,Hongmian Jiang,Lifeng Luo,Shaorong Li,Huali Huang,Fangdi Hu
Pancreatic ductal adenocarcinoma (PDAC) poses significant therapeutic challenges due to its unique tumor microenvironment, which is characterized by collapsed blood vessels and elevated intratumoral pressure, severely hindering drug penetration and distribution. Consequently, we synthesized glucose-modified PEG-PLA (polyethylene-polylactice acid) nanoparticles as a drug delivery system for doxorubicin (DOX). We successfully enhanced the permeability and targeting capability of the nanoparticles in pancreatic cancer cells using glycosylation modification, significantly increasing drug accumulation within the tumor microenvironment. Our study demonstrated excellent cellular uptake of the nanoparticles in vitro and their improved penetration in 3D tumor spheroid models. Additionally, in vivo experiments revealed a notable increase in nanoparticle accumulation at the tumor site, along with favorable drug release characteristics. Hence, glucose-modified PEG-PLA nanoparticles hold substantial potential for clinical application in PDAC treatment, effectively enhancing the therapeutic efficacy of chemotherapeutic agents.
研究领域:
药剂学
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肿瘤学
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DOI
高影响因子
MATERIALS LETTERS
·
2025
·
IF 2.7
Zhi Wei Luo,Ren Hui Liao,Shi Ming Du,Kang Xun Zhao,Xiao Ping Cao,Li Juan Chen,Xue Qiu You
This study resolves PLA microneedle production bottlenecks via sheet-based hot embossing and PEG plasticization. Replacing granules with sheets reduced energy by 40 % using TC4 molds (>200 cycles). Orthogonal tests prioritized pressure (F = 76.8), achieving 82 % yield at 200 ± 5°C/190 ± 10 s/0.2 MPa. PEG (60 wt%) enhanced flexibility via hydrogen bonds, maintaining 92 % skin penetration and 95 % drug release. Resultant microneedles matched commercial hollow efficacy (p > 0.05) with 82 % lower pain (0.6 g vs. 3.4 g). The revealed flow-degradation mechanism guides scalable manufacturing.
研究领域:
生物医学工程
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材料科学
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2021
·Vol. 32
·期 21
·25952-25962
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IF 2.478
Wang Yafei,Liang Luyang,Du Ziran,Wang Yaming,Liu Chuntai,Shen Changyu
Environment friendly electromagnetic interference (EMI) shielding materials with excellent EMI-shielding efficiency (SE) are urgently required to deal with the increasing electromagnetic wave and environmental pollution. In this work, biodegradable poly(lactic acid) (PLA)/carbon nanotubes (CNTs)/Ti 3 C 2 T x MXene nanocomposites are prepared via co-coagulation and compression molding techniques. The distribution state of Ti 3 C 2 T x MXene or CNTs, the excellent conductivity and EMI-shielding properties of the nanocomposites are confirmed by scanning electron microscopy (SEM), four-probe conductivity tester and vector network analyzer, respectively. The PLA/CNTs/Ti 3 C 2 T x nanocomposites show efficient EMI SE of 24.4 dB for 7 wt% CNTs/8 wt% Ti 3 C 2 T x at the thickness of 0.5 mm. By increasing the thickness of the film, the EMI SE of PLA/CNTs/Ti 3 C 2 T x nanocomposites can be increased to 39.6 dB at 1.9 mm, nearly 99.989% of electromagnetic wave is shielded. The EM wave reflection is the main shielding mechanism of the PLA/CNTs/Ti 3 C 2 T x nanocomposites. Considering future environmental issues, this work provides a novel way for fabricating MXene-based biodegradable EMI shielding materials.
研究领域:
材料科学
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环境科学
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电磁工程
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纳米技术
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产品关联
DOI
高影响因子
POLYMER BULLETIN
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2021
·Vol. 79
·期 4
·2173-2188
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IF 2.87
Hou Jiazi,Zhou Guibin,Hu Jinlun,Wang Yihuan,Gao Shuang
Microparticles had attracted a lot of attention for biomedical applications because of their injectable and biomimetic properties. We reported a method for preparing Polylactic acid (PLA)/Polyvinylpyrrolidone (PVP) core–shell microparticles by single capillary electrospraying and explored their potential applications for drug-loading. The shape of microparticles can be controlled by varying ratios of PLA and PVP during the electrospraying process. Different morphologies were achieved including spindle-like, erythrocyte-like and disk-like microparticles. Furthermore, the method of preparing core–shell microparticles was simple and repeatable. Compared with spherical microparticles, erythrocyte-like microparticles can flow through capillaries by morphing into a parachute-like shape. When the particle morphology converted to disk-like, the increase of water contact angle attributed to the PVP rapid dissolution and the residual PLA interconnection to form a continuous hydrophobic membrane. Besides, the microparticle membrane was extremely low-toxic to cells by MTT assay. Taken together, we prepared injected core–shell microparticles by single capillary electrospraying, which had potential application in drug-loading.
研究领域:
生物医学工程
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材料科学
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药剂学
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DOI
高影响因子
JOURNAL OF POLYMER SCIENCE
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2024
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IF 3.9
Mingjiao Li,Xinyi Chen,Qiyang Feng,Wanyi Fan,Yitong Ding,Ze Kan,Zhibo Li
Synthetic poly(4-hydroxybutyrate) (P4HB), a flexible and biodegradable polymer, shows great promise in improving the toughness of poly(lactic acid) (PLA), but the inherent immiscibility of PLA and P4HB compromises the toughening efficiency. To address this issue, P4HB grafted glycidyl methacrylate (P4HB-g-GMA) is synthesized for the purpose of enhancing the compatibility within the PLA/P4HB blend. The epoxy groups on P4HB-g-GMA can form strong chemical bonds with PLA chains and remain compatible with P4HB. Rheological data confirm that adding P4HB-g-GMA enhances polymer chain entanglement. Therefore, the phase interface of the blend becomes more diffuse, leading to improved mechanical performance. Specifically, a 3D-printed PLA/P4HB/P4HB-g-GMA blend containing 8% P4HB-g-GMA (PLA/P4HB/G8) achieves an elongation at break of 161.5%, approximately 22.7 times higher than that of a PLA/P4HB blend without the modifier. Moreover, the PLA/P4HB/G8 blends show a higher volume expansion ratio (VER) and better cell morphology due to the increased melt strength from P4HB-g-GMA. This study demonstrates a simple and efficient method to improve the compatibility between PLA and P4HB, resulting in superior mechanical performance of PLA/P4HB blends and broadening their potential applications in foaming. Graphical
研究领域:
材料科学
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高分子工程
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生物降解聚合物
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泡沫技术
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产品关联
DOI
高影响因子
POLYMER
·
2024
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IF 4.1
Jing Xu,Pingbo Zhang,Mingming Fan,Pingping Jiang,Shijun Chen,Xunxun Sheng
To improve the weak interaction between poly (butylene adipate‐co‐terephthalate) (PBAT) and poly (lactic acid) (PLA) blends, this study added modified metal-organic frameworks (MOFs) to enhance the interfacial bonding strength between PBAT and PLA. MOF-5 nanoparticles were synthesized by room temperature synthesis and modified with KH-560. PBAT/PLA/KH-560@MOF films were prepared by solvent casting. The microscopic morphology, mechanical properties, thermal properties, hydrophobicity, water vapor transmission rate and antimicrobial properties of the composite films were investigated. The results showed that KH-560@MOF nanoparticles were uniformly dispersed in the polymer matrix of PBAT and PLA, reducing phase interface defects. Mechanical properties of PLA/PBAT improved in the presence of KH-560@MOF. The breaking elongation and tensile strength values were maximized when adding 1 wt% KH-560@MOF. Doping of KH-560@MOF improves hydrophobicity and water vapor transmission rate of films. Zn 2+ in MOF-5 imparts antimicrobial properties to the film, showing antimicrobial activity against both Gram-positive and Gram-negative food-borne pathogens (i.e., E. coli and S.aureus ). This work enriched the design of compatibilizer for the PLA/PBAT blend and provided a novel approach for expanding the application of MOFs.
研究领域:
材料科学
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生物学
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食品科学
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DOI
高影响因子
Polymers
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2022
·Vol. 14
·期 12
·2317
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IF 4.967
Juliene Oliveira Campos de França,Deborah da Silva Valadares,Mateus Freitas Paiva,Sílvia Cláudia Loureiro Dias,José Alves Dias
Poly(lactic acid) (PLA) is an important polymer that is based on renewable biomass resources. Because of environmental issues, more renewable sources for polymers synthesis have been sought for industrial purposes. In this sense, cheaper monomers should be used to facilitate better utilization of less valuable chemicals and therefore granting more sustainable processes. Some points are raised about the need to study the total degradability of any PLA, which may require specific composting conditions (e.g., temperature, type of microorganism, adequate humidity and aerobic environment). Polymerization processes to produce PLA are presented with an emphasis on D,L-lactic acid (or rac-lactide) as the reactant monomer. The syntheses involving homogeneous and heterogeneous catalytic processes to produce poly(D,L-Lactic acid) (PDLLA) are also addressed. Additionally, the production of blends, copolymers, and composites with PDLLA are also presented exemplifying different preparation methods. Some general applications of these materials mostly dedicated to the biomedical area over the last 10–15 years will be pointed out.Keywords:poly(lactic acid)-PLA;polymerization based on D,L-lactic acid;D,L-lactide;stereo polymerization of D,L-lactic acid;blends of PLA;poly(DL-lactide-co-polymer);composites of PDLLA
研究领域:
高分子化学
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生物材料学
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环境科学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2018
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IF 6.735
Fan Wu,Jingqi Zheng,Zhixiong Li,Mingxian Liu
Three-dimensional (3D) printed polymer scaffolds can build engineered tissue constructs with complex and hierarchical structures, mechanical and biological heterogeneity. However, the interactions between the scaffolds and cells should be optimally designed for their practical application. In this work, 3D printed polylactic acid (PLA) pattern was functionalized by a polydopamine (PDA) interlayer to firmly bond the halloysite nanotubes (HNTs) on the surfaces of the PLA pattern for guiding cell orientation. A series of 3D printed PLA patterns with different stripe widths were characterized by scanning electron microscopy (SEM), polarized light microscopy (POM), 3D optical profiler and so on. The successful introduction of HNTs on PLA pattern was verified by field emission scanning electron microscopy (FE-SEM), X-ray photoelectron spectroscopy (XPS), water contact angle (WCA), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analyzer (TGA). The HNTs coating could effectively improve roughness and hydrophilicity of PLA pattern. In addition, in vitro human mesenchymal stem cells (hMSCs) culture experiments suggested that 3D printed PLA patterns with different strip widths exhibited different ability to induce cell orientation. The smaller the stripe width of the PLA pattern, the more suitable for cell orientation. When the layer height was set to 0.05 mm, the effect of inducing cell orientation was optimal. Meanwhile, the 3D printed PLA pattern with HNTs coating was more suitable for the adhesion and proliferation of cells. This works provides a general routine for improving the cell affinity of 3D printed PLA structure by the simple coating of nanoparticles, which shows the promising application in cell culture scaffolds, wound healing materials, and biosensors.
研究领域:
生物材料
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组织工程
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细胞生物学
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纳米技术
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2021
·
IF 6.953
Yongqin Wang,Jie Hou,Yangze Huang,Yu Fu
Polylactic acid (PLA) is increasingly being considered as an ideal biodegradable candidate to replace petroleum-based polymers. However, its practical applications are often hampered by the poor mechanical robustness and solo functionality. Herein, based on the mechanical property improvement of PLA we proposed a simple process of assembling lignin-hybridized modifier and PLA matrix, as opposed to the traditional trade-off between mechanical strength and functionality, while anchoring a biofluorescent moiety onto lignin surfaces. Specifically, the fluorophore group could act as interfacial compatibilizer of complex and facilitate the shape-tailored hybrids for promoting functionality flexibility. With the bimetallic hetero-particles, the preferable lignin-assembled complex could be controllably configured as an antibacterial, fluorophore and photothermal agent. Thus, mechanical enhancement, fluorescence introduction and favorable photothermal ability of the resulting PLA composites were successfully achieved for integrated unification of structural robustness, geometric integrity and functional multiplicity, which was never seen in the other reports. The results showed that PLA composites containing 5 wt% modified lignin, 10 wt% zinc oxide, and 5 wt% silver presented excellent mechanical, fluorescent, photothermal conversion properties. By controlling the ZnO content and morphology, strong inhibition of Escherichia coli (Gram-negative) than that of Staphylococcus Aureus (Gram-positive) was also observed. The flake-shaped ZnO /Ag hybrids contributed to better overall performance of PLA composites than the rod-shaped ZnO/Ag. In this work we developed a facile strategy to assemble a bioderived fluorophore with lignin particles for constructing a structure-controlled complex as a multitasking modifier, featuring mechanical unity and functional adaptability. Specifically, the lignin reinforcement and bimetallic hybrids with different morphologies were explored as an effective fluorophore, antibacterial and photothermal agent. Through multiple dehydration reactions, a conjugating fluorophore was successfully grafted on lignin surfaces to serve as an interface modifier without physical changing its structural robustness. And morphology-tailored hybrid was advantageously immobilized on predefined hetero-particle carrier of fluorescent lignin and endowed composites with desirable antimicrobial properties . The developed strategy would expand the functional applications of PLA materials in food packaging, biopharmaceuticals and simple fluorescent anti-counterfeiting.
研究领域:
材料科学
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生物技术
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纳米技术
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聚合物科学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Guofeng Zhong,Mengyu Qiu,Junbo Zhang,Fuchen Jiang,Xuan Yue,Chi Huang,Shiyi Zhao,Rui Zeng,Chen Zhang,Yan Qu
In this study, a novel nanofiber material with Polylactic acid (PLA), natural plant polysaccharides- Bletilla striata polysaccharide (BSP) and Rosmarinic acid (RA) as the raw materials to facilitate wound healing was well prepared through coaxial electrospinning. The morphology of RA-BSP-PVA@PLA nanofibers was characterized through scanning electron microscopy (SEM), and the successful formation of core-shell structure was verified under confocal laser microscopy (CLSM) and Fourier transform infrared spectroscopy (FTIR). RA-BSP-PVA@PLA exhibited suitable air permeability for wound healing, as indicated by the result of the water vapor permeability (WVTR) study. The results of tension test results indicated the RA-BSP-PVA@PLA nanofiber exhibited excellent flexibility and better accommodates wounds. Moreover, the biocompatibility of RA-BSP-PVA@PLA was examined through MTT assay. Lastly, RA-BSP-PVA@PLA nanofibers can induce wound tissue growth, as verified by the rat dorsal skin wound models and tissue sections. Furthermore, RA-BSP-PVA@PLA can facilitate the proliferation and transformation of early wound macrophages, and down-regulate MPO + expression of on the wound, thus facilitating wound healing, as confirmed by the result of immunohistochemical. Thus, RA-BSP-PVA@PLA nanofibers show great potential as wound dressings in wound healing.
研究领域:
材料科学
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生物医学工程
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药剂学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2022
·Vol. 139
·期 28
·e52621
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IF 3.057
Xiao-Qiong Cheng,Wei Liu,Chun Zhang,Xiao-Cheng Chen,Shu-Qian Duan,Hai Fu
In recent years, the problem of oily sewage has seriously affected the ecological environment and human health. Thus, we prepared a novel biodegradable poly (lactic acid) (PLA) membrane with antibacterial property and oil–water separation function via electrospinning method. First, the matter of silver ion glass microbeads (AgGB) loaded with layered double hydroxides (LDHs) and the LDH@AgGB modified with 3-triethoxysilyl-1-Propanamine (APTES) were synthesized. Then, the LDH@AgGB were blended with PLA to prepare PLA/LDH@AgGB composite. And the PLA nanofibrous membranes were electrospun. The results showed that APTES could significantly improve the dispersion and compatibility of LDH@AgGB in PLA matrix. The addition of A-LDH@AgGB could greatly improve the crystallinity, and control the porosity and pore-size of PLA membranes. The maximum water contact angle of the PLA membranes could reach to 109.31°, while the oil contact angle of the PLA membranes decreased to 0° resulting in a high oil absorption capacity, and fast oil absorption rate performance. Meanwhile, the PLA membrane had efficient antibacterial property against Escherichia coli . The reported novel LDH@AgGB and its PLA composite membrane provided a method for designing and preparing environmental-friendly, high-performance materials with both excellent antibacterial property and oil–water separation.
研究领域:
材料科学
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环境科学
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生物医学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）