INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Xinyi Xing,Xian Shi,Mengya Ruan,Qichun Wei,Ying Guan,Hui Gao,Siquan Xu
Introduction of the sulfonic acid group into H-β zeolite to prepare β-SO 3 H bifunctional catalysts for the efficient synthesis of 5-hydroxymethylfurfural (HMF) from cellulose . Catalysts characterization, such as XRD, ICP-OES, SEM (Mapping), FTIR, XPS , N 2 adsorption-desorption isotherm, NH 3 -TPD, Py-FTIR demonstrate the sulfonic acid group was successfully grafted onto the β zeolite. A superior HMF yield (59.4 %) and cellulose conversion (89.4 %) was obtained in the H 2 O(NaCl)/THF biphasic system under 200 °C for 3 h with β-SO 3 H(3) zeolite as catalyst. More valuable, β-SO 3 H(3) zeolite converts other sugars and obtains ideal HMF yield, including fructose (95.5 %), glucose (86.5 %), sucrose (76.8 %), maltose (71.5 %), cellobiose (67.0 %), starch (68.1 %), glucan (64.4 %) and also converts plant material (25.1 % for moso bamboo and 18.7 % for wheat straw) with great HMF yield. β-SO 3 H(3) zeolite catalyst keeps an appreciable recyclability after 5 cycles. Moreover, in the presence of β-SO 3 H(3) zeolite catalyst, the by-products during the production of HMF from cellulose were detected, and the possible conversion pathway of cellulose to HMF was proposed. The β-SO 3 H bifunctional catalyst has excellent potential for the biorefinery of high value platform compound from carbohydrates.
研究领域:
催化
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化学工程
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材料科学
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生物化学
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可再生能源
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产品关联
DOI
PubMed
高影响因子
Analytical Methods
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2015
·Vol. 7
·期 5
·1745-1750
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IF 1.821
Guolin Yuan,Junlin He,Yuan Li,Wailan Xu,Liuliu Gao,Chao Yu
In this work, a novel, ultrasensitive electrochemical immunosensor has been fabricated for the determination of gypican-3 (GPC3) in human serum. A disposable indium tin oxide (ITO) glass array was used as the working electrode on which pyrrole-α-carboxylic acid (Py-α-COOH) was electropolymerised. This approach provided a high content of surface-confined carboxyl groups suitable for the direct covalent binding of GPC3 antibody. In the immunosensor system, the “fluorescence microscopy” technique was first used for the characterisation of carboxyl groups. Meanwhile, the electrode was characterised by scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS). Using GPC3 as a model analyte, the immunoassay exhibited high sensitivity, acceptable stability and reproducibility with a wide linear range from 0.9 pg mL−1 to 9 ng mL−1 and an ultra-low detection limit of 0.3 pg mL−1 (S/N = 3). The results for real sample analysis in human serum demonstrated that the newly constructed immunosensor array provided a rapid, simple and cost-efficient immunoassay with high throughput and sufficiently low detection limits for clinical applications.
研究领域:
分析化学
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生物传感器
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电化学
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医学诊断
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产品关联
DOI
高影响因子
Asian Journal of Pharmaceutical Sciences
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2022
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IF 9.273
Yanjuan Huang,Tao Zhang,Qin Wei,Zishan Zeng,Yujun Gong,Xiaoyu Xu,Meixu Chen,Chunshun Zhao
Posterior capsular opacification (PCO) is the leading cause of vision loss after cataract, mainly caused by the adhesion, proliferation and trans-differentiation of post-operative residual lens epithelial cells (LECs). Effective PCO prevention remains a huge challenge to ophthalmologists and researches for decades. Herein, we developed a “NIR-triggered ROS storage” intraocular implant (CTR-Py-PpIX) based on capsular tension ring (CTR), which is concurrently linked with photosensitizer protophorphyrin IX (PpIX) and energy storage 2-pyridone derivative (Py), to guarantee instantaneous and sustainable ROS generation for LECs killing, aiming to achieve more efficient and safer photodynamic therapy (PDT) to effectively prevent PCO. The silylated PpIX-Si and Py-Si were covalently conjugated to the plasma activated CTR surface to obtain CTR-Py-PpIX. Results demonstrated that CTR-Py-PpIX had dual functions of PDT and battery, in which PpIX could generate ROS extracellularly under irradiation, with one part directly inhibiting LECs by lipid peroxidation (LPO) induction of cell membranes. Meanwhile, the excess ROS stored in Py could be continuously released to amplify LPO levels after the irradiation was removed. Ultimately, the proliferation of LECs in capsular bag was completely inhibited under mild irradiation conditions, achieving a sustainable and controlled PDT effect for effective PCO prevention with good biocompatibility. This NIR-triggered ROS storage intraocular implant would provide a more efficient and safer approach for long-term PCO prevention.
研究领域:
眼科学
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光动力疗法
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生物医学工程
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材料科学
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2020
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IF 8.758
Jia Liu,Lei Zhao,Lin Shi,Ye Yuan,Daan Fu,Zhilan Ye,Qilin Li,Yan Deng,Xingxin Liu,Qiying Lv,Yanni Cheng,Yunruo Xu,Xulin Jiang,Guobin Wang,Lin Wang,Zheng Wang
Cancer chemotherapy is challenged by multidrug resistance (MDR) mainly attributed to overexpressed transmembrane efflux pump P-glycoprotein (P-gp) in cancer cells. Improving drug delivery efficacy while co-delivering P-gp inhibitors to suppress drug efflux is an often-used nanostrategy for combating MDR, which is however challenged by cascaded bio-barriers en route to cancer cells and P-gp inhibitors’ adverse effects. To effectively breach the cascaded bio-barriers while avoiding P-gp inhibitors’ adverse effects, a stealthy, sequentially responsive doxorubicin (DOX) delivery nanosystem (RCMSNs) is fabricated, composed of an extracellular-tumor-acidity-responsive polymer shell (PEG-b-PLLDA), pH/redox dual-responsive mesoporous silica nanoparticle-based carriers (MSNs-SS-Py), and cationic β-cyclodextrin-PEI (CD-PEI) gatekeepers. The PEG-b-PLLDA corona makes RCMSNs stealthy with prolonged blood circulation time. Once tumors are reached, extracellular acidity degrades PEG-b-PLLDA, reversing nanosystem’s surface charges to be positive, which drastically improves RCMSNs’ tumor accumulation, penetration, and cellular internalization. Within cancer cells, CD-PEI gatekeepers detach to allow DOX unloading in response to intracellular acidity and glutathione and functionally act as a P-gp inhibitor, dampening P-gp’s efflux activity by impairing ATP production. Thus, the resultant high-efficacy drug delivery along with reduced P-gp function cooperatively reverses MDR in vitro. Importantly, in preclinical tumor models, DOX@RCMSNs potently suppress MDR tumor growth without eliciting systemic toxicity, demonstrating their potential of clinical translation.
研究领域:
纳米技术
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药学
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肿瘤学
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生物医学工程
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药物递送系统
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癌症治疗
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产品关联
DOI
PubMed
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
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2020
·
IF 4.551
Jipeng Meng,Chuang Li,Xiao Chen,Chengye Song,Changhai Liang
Synthesis of highly-crystallized ZSM-48 zeolite with low SiO 2 /Al 2 O 3 ratio was successfully performed via seed-assisted route. The influence of various factors on the seed-assisted synthesis was investigated systematically, including the seeds dosages, different seeds species, adding order of seeds, hydrothermal temperature and time, silica and aluminum sources, and gel compositions. The crystallinity, morphology, textural and acidic properties of ZSM-48 were characterized by various techniques, such as XRD , SEM, FTIR, Py-IR, N 2 physisorption , 29 Si and 27 Al MAS NMR. Aluminum sources posed a critical influence on the crystallinity with NaAlO 2 more beneficial to obtain well-crystallized ZSM-48, whereas the crystallinity seemed slightly susceptible to silica sources. SEM results revealed that the crystal size was significantly reduced from ca. 20 μm to around 2 μm after introduced the seeds. Kinetic analysis suggested that the added seeds can significantly reduce the apparent activation energy of nucleation and crystallization, encourage the formation of crystal nuclei and promote crystallization. The Pt-supported seed-assisted samples exhibited considerably higher density of acid sites than that loaded on seed-free sample. The hydroisomerization of n -hexadecane was investigated over various Pt-supported catalysts, and the Pt-supported seed-assisted samples exhibited the highest i-C 16 yield of ca. 75 wt% at conversion over 87 wt%.
研究领域:
催化
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材料科学
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化学工程
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产品关联
DOI
高影响因子
LIQUID CRYSTALS
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2023
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IF 2.2
Xiaojing Wu,Xiaoling Niu,Shengbo Zhu,Min Tian,Weiguo Liu
Scientists are faced with a formidable problem in improving the smart properties of multi-stimuli responsive fluorescent materials. Here, we integrated two kinds of stimuli-responsive materials: aggregation-induced emission (AIE) and liquid crystals (LCs) into one system. An AIE-active fluorescence liquid crystal compound of α-cyanodistyrene derivate Py-CN-LBM8 was synthesised using knoevenagel condensation reaction. Its AIE effect, LC behaviour, multi-stimuli responsive properties and mechanisms were investigated by polarised optical microscopes (POM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), UV-visible (UV-vis) absorption spectra and photoluminescence (PL) spectra. The results showed that Py-CN-LBM8 exhibited significant physical response to external stimuli including temperature, mechanical force, solvent, pH and trace water. This work provided a strategy for designing new multi-stimuli responsive materials and made it possible to apply in the multifunction anti-counterfeit, sensor and information storage fields.
研究领域:
材料科学
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化学
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光学
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纳米技术
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DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2021
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IF 8.128
Ruoxuan Guo,Yang Liu,Yingzhong Huo,Anrui Zhang,Jiahui Hong,Yuejie Ai
Covalent organic frameworks (COFs) are promising adsorbents for removing heavy metal ions , and have high crystallinity , a porous structure, and conjugated stability. N -containing functional groups are known to have great affinity for uranyl ions. In this work, to explore the peculiarity of the pyridine N structure as an efficient adsorbent, we chose 2,2′-dipyridine-5,5′-diamine (Bpy) and pyridine-2,5′-diamine (Py) as the core skeletons, and 1,3,5-triformylphloroglucinol (Tp) as the linker to synthesize two crystalline and stable N -containing COFs named TpBpy and TpPy, respectively, through a facile solvothermal method . Characterization results demonstrated that TpBpy and TpPy possessed regularly growing pore sizes, large specific surface areas and relatively strong thermal resistances . The results of batch experiments showed that both COF materials were capable of the effective removal of uranyl with uptake capacities of 115.45 mg g −1 and 291.79 mg g −1 , respectively. In addition, density functional theory (DFT) simulations highlighted the beneficial chelation effect of the double N structure in pyridine monomers for removing uranyl ions. Combining systematic experimental and theoretical analyses, the adsorption process and interaction mode of porous COFs and UO 2 2+ were revealed, to provide predictable support for the application of pyridine N -containing COFs in the field of environmental remediation.
研究领域:
环境科学
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材料科学
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化学工程
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理论化学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）