MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Rong Deng,Zhilan Wang,Jing Chen,Lianqin Zhu,Yaqin Shi,Wenli Xue
Ti 3 C 2 QDs with good water solubility and photoluminescence properties was prepared by nitrogen and phosphorus doping (N,P-Ti 3 C 2 QDs). The probe has a fluorescence emission peak at 420 nm and emits bright blue fluorescence, which can distinguish and detect two antibiotics with similar structures, chlortetracycline (CTC) and tetracycline (TC). The fluorescence enhancement effect can be realized by the interaction with CTC. The linear range is 2–22 μM, and the detection limit is as low as 0.53 μM. And the change of fluorescent color from bright blue to bright purple can be observed with the naked eye. At the same time, with the addition of TC, the fluorescence of N,P-Ti 3 C 2 QDs can be quenched by static quenching effect, and the fluorescence color changes from bright blue to yellowish green. The detection range is 4.1–20.5 μM, and the detection limit is as low as 0.16 μM.Therefore, on this basis, a strategy for simultaneous detection and recognition of CTC and TC is proposed. The method has been successfully applied to the determination of CTC and TC in milk samples. This paper provides a new detection method for the identification of tetracycline antibiotics and taps the application potential of Ti 3 C 2 QDs in food detection.
研究领域:
分析化学
·
食品安全
·
环境科学
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产品关联
DOI
高影响因子
JOURNAL OF LUMINESCENCE
·
2012
·
IF 2.102
Zhengqing Liu,Pengfei Yin,Huiping Gong,Pingping Li,Xiaodan Wang,Youqiu He
Aqueous glutathione (GSH)-capped CdTe / ZnS QDs with the diameter of 3–4 nm were synthesized. The fluorescence of CdTe / ZnS QDs at 577 nm was quenched in the presence of rifampicin (Rfp), with excitation wavelength at 350 nm. The mechanism of the interaction of CdTe / ZnS QDs with Rfp was investigated. Under the optimal conditions, the calibration plot of ln( F 0 /F ) was linear in the range 0.83–56 μg mL −1 with concentration of Rfp, and the detection limit was 0.25 μg mL −1 . The proposed method was successfully applied to the determination of Rfp in its commercial capsules, and satisfactory results were obtained. The recovery of the method was in the range 98.6–103.2%.
研究领域:
分析化学
·
药学
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DOI
高影响因子
Materials Today Bio
·
2026
·
IF 10.2
Tingting Liu,Wenyan She,Ruili Du,Yali Bao,Zhibin Guo,Qichao Gao,Hanping Li,Pengfei Suo,Yi Liu,Yujiao Liu
It is important yet challenging to enhance immunotherapy responses using biosafe agents due to the immunosuppressive tumor microenvironment. To address this challenge, BD3PP was constructed by encapsulating black phosphorus quantum dots (BPQDs), a synthesized thioredoxin reductase inhibitor 3c, and Dir (the fluorescent dye) into PLGA nanoparticles, followed by conjugation with a PDL1 antagonist for synergistic multimodal therapy and imaging. The mechanism and efficiency of BD3PP were investigated through density functional theory (DFT) calculations, molecular docking, and in vitro and in vivo experiments. The PDL1 antagonist served as a targeting moiety that binds PDL1 on the tumor cell surface, enabling the controlled intracellular release of the three therapeutic agents. Self-passivated bilayer BPQDs converted optical energy into heat for photothermal therapy and generated singlet oxygen ( 1 O 2 ) from O 2 for type Ⅱ photodynamic therapy, showing far superior to non-passivated bilayer BPQDs or bulk BP. Meanwhile, 3c selectively inhibited thioredoxin reductase, leading to the production of · and H 2 O 2 . These effects synergistically induced immunogenic cell death (ICD), promoted macrophage polarization toward the M1 phenotype, and remodeled the tumor microenvironment to facilitate tumor clearance. The near-infrared fluorescent dye Dir enabled real-time imaging both in vitro and in vivo . DFT calculation revealed that BPQDs were ultimately degraded into biocompatible phosphoric acid. Along with the other biocompatible components in BD3PP, biosafety was guaranteed. This research introduces an efficient and biosafe nanoplatform based on self-passivated bilayer BPQDs, which exhibits prolonged blood circulation and enhanced multimodal real-time photothermal and near-infrared imaging. Importantly, this nanoplatform enables integrated photothermal, photodynamic, and targeted therapies, demonstrating promising potential for anti-tumor preclinical and clinical applications.
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产品关联
DOI
PubMed
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2016
·Vol. 18
·期 45
·31211-31216
·
IF 4.449
Xiaolong Lu,Rongguo Wang,Lifeng Hao,Fan Yang,Weicheng Jiao,Ping Peng,Feng Yuan,Wenbo Liu
Oxidative etching has been proved to be an efficient top-down method to prepare quantum dots (QDs) of layered transition-metal dichalcogenides which possess unique properties and have potential applications in various areas. Here, one facile and green oxidative etching method induced by UV irradiation is reported to prepare the QDs of MoS2/WS2 in aqueous solution, respectively. A prominent morphology change occurred to the nanosheets of MoS2/WS2 after irradiation and finally they were etched to ultrasmall nanoparticles which were proved to be the QDs. Insight into the etching mechanism was discussed in detail and hydroxyl free radicals (˙OH) were conclusively demonstrated to play the main role in etching nanosheets. From another point of view, this work also proves the crucial long-term photo instability of MoS2/WS2 since there are increasing photo-related applications of them and points out an easy way to degrade their nanosheets.
研究领域:
材料科学
·
纳米技术
·
光化学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2021
·
IF 5.816
Ying Wang,Jiaru Peng,Yangfan Xu,Hongcun Bai,Ruiyang Zhao,Jishu Han,Lei Wang
Novel Cd 0.67 Mo 0.33 Se/In 2 O 3 hollow nanotubes were prepared for photocatalytic hydrogen production application. Under visible light irradiation , Cd 0.67 Mo 0.33 Se/In 2 O 3 hollow nanotubes showed enhanced photocatalytic performance. And the apparent quantum efficiency of 34.86% was obtained when irradiated with 420 nm monochromatic light. The modification of Cd 0.67 Mo 0.33 Se QDs on the surface of In 2 O 3 hollow nanotubes effectively improved the utilization rate of light absorption, increased the separation and migration rate of electrons, inhibited the recombination of photo-generated electron and hole pairs, thus enhancing the photocatalytic activity of water splitting to produce hydrogen . It would be an efficient photocatalyst for hydrogen production application in future.
研究领域:
材料科学
·
能源科学
·
光催化技术
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Mengjun liang,Jiancong Zhang,Karthick Ramalingam,Qiang Wei,Kwan San Hui,Su Htike Aung,Kwun Nam Hui,Fuming Chen
Herein, we propose a stable and efficient photo-driven electrochemical desalination technique without any external bias. The whole desalination process is driven by CdS quantum dots (QDs) sensitized BiVO 4 photoanode, where I - /I 3 - redox couples are recirculated as the electrolyte. Two salt streams are sandwiched between the photoanode and cathode. The salt ions in desalted stream are continuously extracted by the redox reaction of I - /I 3 - electrolyte at their respective electrode chambers. The initial photocurrent of 2.58 mA/cm 2 can be obtained in the present photoanode-assisted desalination device, which is much greater than the previous reported results. Besides, the electrical current of the photo-electricity conversion system is extremely stable in the current system. Within the four batch cycles, the variation of salt removal rate is as low as 2.3 μg/(cm 2 •min) without significant decay. The photoanode-electrolyte interface, charge separation and transportation are further investigated by photoluminescence, electrochemical impedance spectroscopy and Mott-Schottky analysis. The promising desalination performance can be attributed to the synergistic effect of CdS QDs and BiVO 4 heterojunction which is applied in the field of solar-driven desalination for the first time. This work is significant for the design of high light-absorbing heterojunction photocatalysts for the dual functions of energy production and water desalination.
研究领域:
环境科学
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材料科学
·
物理化学
·
能源工程
·
水处理技术
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DOI
高影响因子
OPTICAL MATERIALS
·
2021
·
IF 3.08
Bowang Shu,Yajing Chang,Supeng Yang,Li Dong,Jinhua Zhang,Xiaopeng Cheng,Dabin Yu
The blue-emitting CsPbBr 3 quantum dots (QDs) have currently received widespread attention due to high photoluminescence quantum yields (PLQYs), but their instability mainly caused by self-aggregation or environmental erosion (i.e. moisture and oxygen) should be solved to gain more progress in further application. This paper presented a feasible approach to high-quality blue-emitting CsPbBr 3 QDs-polymethylmethacrylate (PMMA) films, in which PMMA provided a solid framework to protect CsPbBr 3 QDs by the chelation between C O and Pb 2+ ions, thus resulting in the stability of CsPbBr 3 QDs. The CsPbBr 3 QDs-PMMA films exhibited remarkable properties including water resistance, flexibility, deep-blue emission (465 nm), and comparatively high PLQY (45%). The blue LED fabricated by the films displayed a CIE coordinate (0.14, 0.10), which was corresponding to the standard blue CIE coordinate (0.14, 0.08) according to National Television System Committee (NTSC).
研究领域:
材料科学
·
光学工程
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2019
·
IF 2.12
Xuanping Tan,Qin Li,Jidong Yang
A simple and sensitive method for detecting LFO was developed based on electron transfer mechanism quenched the fluorescence of GSH-CdTe QDs. LFO, as an effective electron acceptor , is added into the QDs solution for electron transfer, the transfer of electrons from the conduction band of QDs to LFO prevents the recombination of free electrons and valence band holes of QDs, thus causing the fluorescence quenching of QDs. Under the optimal experimental conditions, the fluorescence quenching degree of QDs has a good linear relationship with the concentration of LFO within the range of 0.73–7.30 μg mL −1 , the correlation coefficient is 0.9978, and the detection limit is 1.53 ng mL −1 . In addition, the reaction mechanism and experimental conditions were investigated, and the method was successfully applied to the detection of LFO in milk and serum samples.
研究领域:
分析化学
·
食品安全
·
生物医学
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产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2014
·
IF 2.129
Fang fei Liu,Ying Yu,Bi xia Lin,Xiao gang Hu,Yu juan Cao,Jian zhong Wu
Daminozide (B9) is a growth inhibitor with important regulatory roles in plant growth and development. Locating and quantifying B9-binding proteins in plant tissues will assist in investigating the mechanism behind the signal transduction of B9. In this study, red fluorescent Mn-doped CdTe quantum dots (CdTeMn QDs) were synthesized by a high-temperature hydrothermal process. Since CdTeMn QDs possess a maximum fluorescence emission peak at 610 nm, their fluorescence properties are more stable than those of CdTe QDs. A B9-CdTeMn probe was synthesized by coupling B9 with CdTeMn QDs. The fluorescence intensity of the probe is double that of CdTeMn QDs; its fluorescence stability is also superior under different ambient conditions. The probe retains the biological activity of B9 and is unaffected by interference from the green fluorescent protein present in plants. Therefore, we used this probe to label B9-binding proteins selectively in root tissue sections of mung bean seedlings. These proteins were observed predominantly on the surfaces of the cell membranes of the cortex and epidermal parenchyma.
研究领域:
植物学
·
分子生物学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE BIOLOGY
·
2016
·Vol. 249
·期 6
·757-767
·
IF 1.991
Lai Lu,Li Ya-Ping,Mei Ping,Chen Wu,Jiang Feng-Lei,Liu Yi
The mitochondrial toxicity induced by GSH-CdTe Quantum dots (QDs) of different sizes was investigated. The decreases in absorbance and transmission electron microscopy images show that QDs induce the swelling of mitochondria. Results of flow cytometry indicate that QDs cause a reduction of mitochondrial membrane potential (MMP). A remarkable increase in fluidity of protein regions of mitochondrial membrane is observed, whereas the lipid regions are not obviously affected. Cyclosporin A (CsA) effectively prevents the QD-induced mitochondrial swelling. On the basis of these results, it is proposed that QDs induce mitochondrial permeability transition (MPT). Moreover, with increasing QDs size, a pronounced MPT is observed. The difference between the membrane fluidity induced by QDs and Cadmium ion and the ineffective protective effects of EDTA suggests that the mitochondrial toxicity of QDs cannot be only attributed to the release of metal ion. The protective effects of HSA indicate that the interaction of QDs with pore-forming protein gives rise to the increase in membrane fluidity. This hypothesis is demonstrated by the interaction of QDs with model membranes and proteins using differential scanning calorimetry and isothermal titration microcalorimetry. In conclusion, as the size of QDs increases, the binding affinity of QDs with membrane protein increases, and therefore causes a pronounced mitochondrial damage.
研究领域:
纳米技术
·
毒理学
·
细胞生物学
·
生物物理学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2017
·Vol. 19
·期 9
·1-11
·
IF 2.02
Zhou Shang,Huo Danqun,Hou Changjun,Yang Mei,Fa Huanbao
The recognition of tumor markers in living cancer cells has attracted increasing interest. In the present study, the turn-on fluorescence probe was designed based on the fluorescence of thiolated chitosan-coated CdTe QDs (CdTe/TCS QDs) quenched by hyaluronan, which could provide the low background signal for sensitive cellular imaging. This system is expected to offer specific recognition of CD44 receptor over other substances owing to the specific affinity of hyaluronan and CD44 receptor (~8–9 kcal/mol). The probe is stable in aqueous and has little toxicity to living cells; thus, it can be utilized for targeted cancer cell imaging. The living lung cancer cell imaging experiments further demonstrate its value in recognizing cell-surface CD44 receptor with turn-on mode. In addition, the probe can be used to recognize and differentiate the subtypes of lung cancer cells based on the difference of CD44 expression on the surface of lung cancer cells. And, the western blot test further confirmed that the expression level of the CD44 receptor in lung cancer cells is different. Therefore, this probe may be potentially applied in recognizing lung cancer cells with higher contrast and sensitivity and provide new tools for cancer prognosis and therapy.
• Hyaluronan functionalizing sulfhydryl chitosan-coated CdTe QDs were designed as a “turn-on” fluorescence probe for recognizing cancer cells. • The fabricating probe is based on the high affinity of hyaluronan and CD44 receptor for specific recognition of CD44 receptor in lung cancer cell. • The probe can be used to recognize and differentiate the subtypes of lung cancer cells based on the difference of CD44 expression on the surface of lung cancer cells. • The probe showed the lower background signal than that of always-on nanoprobes avoiding the non-specific adsorption on the surface of the normal cells.
研究领域:
生物医学工程
·
分子生物学
·
癌症研究
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产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2021
·
IF 4.098
Hualai Wang,Fubin Pei,Chun Liu,Yue Ni,Mingzhu Xia,Shasha Feng,Qingli Hao,Tinghai Yang,Wu Lei
In the paper, a novel fluorescent probe based on Ag 2 S QDs/g-C 3 N 4 composite was synthesized by loading Ag 2 S quantum dots (Ag 2 S QDs) on the surface of g-C 3 N 4 through in-situ synthesis method and developed to detect Nitrofurazone (NFZ) sensitively. The results showed that the linear detection range of Ag 2 S QDs/g-C 3 N 4 to NFZ was 0–30 μM, with a low detection limit of 0.054 μM. The results of time-fluorescence-resolved spectroscopy and UV–vis absorption spectroscopy exhibited that the possible detection mechanism of Ag 2 S QDs/g-C 3 N 4 to NFZ was proposed to be Internal Filtration Effect (IFE). Moreover, Multiwfn wavefunction analysis was employed to uncover the possible interaction between the Ag 2 S QDs/g-C 3 N 4 and NFZ, thereby further revealing the fluorescence detection mechanism from the scale of atoms. Combining experiments and theoretical calculations, we proposed the sensing mechanism of the formation of non-fluorescent ground state complex linked by hydrogen bonds. This work indicated that the Ag 2 S QDs/g-C 3 N 4 composite processed the ability to detect NFZ efficiently and sensitively.
研究领域:
分析化学
·
环境科学
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）