Nature Communications
·
2025
·Vol. 16
·期 1
·1-14
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IF 15.7
Hu Hao,Guo Songcheng,Li Yiyuan,Dong Kejun,Lu Yan,Ye Keyi,Li Longjie,Zhou Xiaoyu,Cheng Liming,Xiao Xianjin
Detecting small molecules is pivotal across fields like clinical diagnostics, environmental monitoring, and food safety. The CRISPR-Cas12a system, known for its simplicity and sensitivity, offers a promising basis for small molecule detection. However, current CRISPR-based detection methods face challenges, including complex design requirements, high background noise, and limited adaptability to different targets. In our study, we introduce the SBS-Cas system, leveraging a split crRNA mode to induce spatial hindrance on the scaffold strand through molecular binding. This approach prevents the assembly with Cas12a, effectively masking its trans-cleavage activity. By introducing small molecules that competitively bind to the macromolecule, we eliminate this spatial hindrance, activating Cas12a. Our results demonstrate high sensitivity, versatility, and adaptability in small molecule detection across multiple reactions, with successful intracellular imaging and responsive fluctuations in complex environments underscoring the system’s robustness. This innovative CRISPR-Cas12a-based approach establishes a low-background, highly sensitive platform for small molecule detection. SBS-Cas promises not only to enhance tools for clinical, environmental, and food safety applications but also to advance CRISPR research, providing insights and expanding possibilities in molecular detection science.
研究领域:
分子生物学
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临床诊断
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环境科学
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食品安全
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产品关联
DOI
PubMed
高影响因子
Advanced Materials Technologies
·
2023
·Vol. 8
·期 21
·2300898
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IF 6.8
Yuxin Wang,Yang Hong,Xiaokang Hu,Yang Ye,Peike Wang,Jingjing Luo,Ao Yin,Zhongqi Ren,Haipeng Liu,Xue Qi,Jiang Liu,Sisi He,Suzhu Yu,Jun Wei
Long-term effective temperature monitoring using a flexible wearable temperature sensor is critical for future health monitoring, noninvasive clinical biomonitoring, disease diagnosis, and so on. Thermistors have the merits of simple structure, ease of preparation and great sensitivity, but the preparation of thermistors with good flexibility is often at the expense of their sensitivity and requirement of high temperature. Herein, a flexible temperature sensor with stability and high sensitivity by spraying VO 2 /PEDOT:PSS composites on an SBS electrospinning substrate is reported. The sensor exhibits high thermal sensitivity (−2.712%/°C), high precision (85 mK), ultra-fast response time (1 s) and recovery time (2.5 s), enabling accurate real-time temperature detection and meeting the need for long-term temperature monitoring and tracking. As a proof of concept, this sensor is applied to monitor human skin temperature, breathing rate, and temperature recognition, and as a temperature-based input keyboard, demonstrating its tremendous potential to further develop personalized flexible sensors.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS A-PHYSICAL
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2026
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IF 5.1
Xiaohan Sun,Jing Zuo,Zhihao Zhao,Lingyun Xu,Hongyang Liu,Rubing Xi,Qi Song,Zhe Chen,Weijie Wang,Gongmo Xiang,Xiangyu Jiang,Lei Jiang
High-sensitivity, high-precision, and long-life micro tactile sensors hold vast application prospects in fields such as health monitoring and intelligent robotics. However, current technologies typically confine microstructures within a single substrate material, which significantly restricts the application of micro-structured devices and machines across different scenarios. Herein, we have devised a capillary liquid bridge-induced self-assembly method that not only facilitates the miniaturization of tactile sensors but also enables the application of our fabricated micro sensing devices in diverse scenarios. We spatially confined and assembled the styrene-butadiene-styrene block copolymer (SBS) thermoplastic elastomer and aggregation-induced emission (AIE) molecules into a microdot array, and successfully fabricating a microscale tactile fluorescent sensor composed of SBS/AIE dot array. Sensors based on substrates with different stress properties can achieve detection of stress and strain in various application scenarios. Utilizing the fluorescence characteristics of AIE molecules, the sensor demonstrates a favorable response to both pressure and tensile forces. Notably, in conjunction with a convolutional neural network (CNN) simulation algorithm, the SBS/AIE molecular arrays sensors have realized the classification and regression of different pressures. This method of fabricating micron-scale arrays provides a novel and effective pathway for constructing micro tactile sensors suitable for different application scenarios.
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DOI
高影响因子
COMPOSITES PART B-ENGINEERING
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2020
·
IF 7.635
Yingfeng Wen,Yang Xue,Xiaojing Li,Huijie Pei,Xingping Zhou,Yuezhan Feng,Yunsheng Ye,Xiaolin Xie,Yiu-Wing Mai
Rapid developments of miniaturization and integration of modern electronic devices have been accompanied by increasing power density, which bring about urgent demands for polymer-based thermal interface materials (TIMs) with efficient thermal conductive properties. However, poor dispersibility of thermal conductive nano-fillers severely limits further improvement in the thermal conductivity of TIMs. Herein, poly(styrene- b -butadiene- b -styrene) (SBS)/graphite nanoplatelet (GNP) nanocomposites with well-dispersed GNPs were fabricated by in-situ shear exfoliation of graphite in SBS solution, followed by a co-precipitation process. The SBS macro-molecules were immobilized on the surfaces of exfoliated GNPs through π-π interaction, which not only prevented the exfoliated GNPs from restacking in the suspension, but also improved their dispersibility in SBS matrix. Thus, GNPs were uniformly dispersed in SBS/GNP nanocomposites and possessed strong interfacial adhesion with SBS, which formed efficient thermal conductive filler networks with reduced interfacial thermal resistance . Hence, at 14.7 vol% filler, SBS/GNP nanocomposites displayed an excellent thermal conductivity of 1.55 W m −1 K −1 , which is 204% higher than SBS/commercial GNP (c-GNP) composites (0.51 W m −1 K −1 ) prepared by simply adding c-GNPs in SBS matrix. Moreover, SBS/GNP nanocomposites displayed enhanced tensile moduli and higher glass transition temperatures . Therefore, this work has provided a facile and promising route to manufacture high-performance TIMs in large scale.
研究领域:
材料科学
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热管理技术
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产品关联
DOI
高影响因子
CONSTRUCTION AND BUILDING MATERIALS
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2024
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IF 7.4
Meijie Liao,Lei Luo,Yingli Gao,Zhengkang Li,Pengfei Liu
SBS modified asphalt is widely used due to its excellent performance at both high and low temperatures, but its water resistance still needs improvement. To enhance its moisture damage resistance, this study modified SBS asphalt with three hydrophobic materials: polytetrafluoroethylene (PTFE), hydrophobic nano-SiO 2 , and trimethoxymethylsilane (MTMS). Viscosity tests, FTIR analysis, and the Langmuir water diffusion model were used to evaluate the modification effects. The results showed that all three hydrophobic materials effectively reduced viscosity changes of the asphalt in neutral rainwater, seawater, and acid rain.the hydrophobic modifiers significantly enhanced the stability and deformation resistance of SBS modified asphalt mixtures (by 57.7 %, 43.5 %, and 30.5 %) During water aging, asphalt undergoes saturated hydrocarbon degradation and unsaturated functional group oxidation, which is accelerated by acid rain and seawater. PTFE delayed asphalt degradation through crosslinking, while nano-SiO 2 and MTMS formed a Si-O-Si network, reducing water and oxygen diffusion, thereby improving water aging resistance. The hydrophobic modification significantly lowered the asphalt's water absorption and diffusion rate, preventing moisture from reaching the asphalt-aggregate interface. Aging-generated functional groups like carboxyl and ether groups intensified internal moisture diffusion, but the hydrophobic materials effectively delayed aging and prevented water penetration. This study reveals the modification mechanisms of hydrophobic materials in complex water environments, providing theoretical support for improving SBS asphalt's water damage resistance.
研究领域:
土木工程
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材料科学
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产品关联
DOI
高影响因子
PROGRESS IN NUCLEAR ENERGY
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2023
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IF 2.7
Huiyuan Zhang,Hongxing Zhang,Wenchao Zhu,Hailing Xi,Bomou Ma,Yong He
In this research, solutions of styrene-butadiene-styrene block copolymer (SBS) in 2-ethoxyethyl methacrylate (EOEMA) were used to prepare strippable films via rapid visible-light curing, where the mixture of camphorquinone (CQ), diphenylsilane (DPS) and diphenyliodonium hexafluorophosphate (Iod) was employed as the photoinitiating system, LED@405 nm, sunlight or household LED panel light as the light source and no any solvent was involved. The double bond conversion for pure EOEMA under LED@405 nm was firstly monitored by real-time FTIR and it reached 72% within 300 s. The rapid-curing of SBS/EOEMA solutions were systematically investigated and it was found that the solution with 16 wt% SBS became completely dried at the presence of 2.16 mol% crosslinker and 3.6 wt% photoinitiating system after 240 s irradiation under LED@405 nm. The tensile strength , elongation at break and glass transition temperature of the resultant strippable film were determined to be about 4.4 ± 0.5 MPa, 130 ± 11.2% and 6.9 °C, respectively, by mechanical properties testing and DSC measurements. Also, the decontamination efficiencies (DE) of household LED panel light/sunlight cured-strippable film for uranium nitrate on stainless steel , glass, and ceramic surface were evaluated to be higher than 90%. These results indicate that this rapid-curing strippable films would be a good candidate material for large-scale radioactive decontamination.
研究领域:
材料科学
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核能工程
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环境科学
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产品关联
DOI
高影响因子
Case Studies in Construction Materials
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2025
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IF 6.6
Tao Liu,Naisheng Guo,Xiangtian Xu,Yanan Cui,Mingjun Hu,Minda Ren,Jiasheng Dai,Zhongzhe Zhang,Chen Li
s This study aims to enhance the rheological performance of polyurethane solid–solid phase change (PUSSP) modified asphalt by developing a PUSSP/SBS composite system with improved phase stability and thermoregulation. The thermoregulation capacity and heat storage performance of the composites were evaluated through temperature monitoring tests and differential scanning calorimetry (DSC), while the rheological behavior across service temperatures was characterized using a dynamic shear rheometer (DSR) and bending beam rheometer (BBR). In addition, the interfacial interactions and microstructural features were investigated using Fourier transform infrared spectroscopy (FTIR), fluorescence microscopy (FM), and atomic force microscopy (AFM), linking the performance improvement to colloidal structures and surface effects within the asphalt binder. The results reveal that the thermoregulation performance of PUSSP-modified asphalt significantly improves with increasing PUSSP content. During the heating phase, Δ t P-B and Δ T P-B for 10 wt% PUSSP-modified asphalt increased by 54.4 % and 65.5 %, respectively, compared with 5 wt% PUSSP. This enhancement is primarily attributed to the increased heat storage capacity of the PUSSP colloids, which plays a decisive role in thermal regulation. Although PUSSP-modified asphalt demonstrates superior rutting resistance at elevated temperatures, its low-temperature creep resistance is inferior to that of conventional asphalt. At equivalent PUSSP content, the thermoregulation of PUSSP/SBS composite-modified asphalt remains comparable to that of PUSSP-modified asphalt, whereas its rheological properties at both high and low temperatures are markedly improved. Notably, the 5 % PUSSP/5 % SBS composite achieves a PG classification of 82–22. The performance improvement mainly stems from the SBS-induced cross-linking network, which strengthens PUSSP-modified asphalt interfacial bonding and enhances compatibility, micro-elasticity, and crack resistance. Consequently, the cooperative PUSSP–SBS interfacial mechanism achieves a balanced enhancement of rheological and thermoregulatory properties. These findings provide a feasible modification strategy for developing multifunctional asphalt materials, offering meaningful guidance for improving pavement performance in temperature-extreme service environments.
研究领域:
道路工程材料
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高分子复合材料
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热功能材料
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沥青化学
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流变学
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产品关联
DOI
高影响因子
Eng
·
2026
·Vol. 7
·期 9
·433
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IF 3.5
Guangye Si,Genfu Liang,Gen Li,Chongzheng Zhu
To improve the aging resistance of SBS-modified asphalt (SBSMA), this study prepared two metal oxide/montmorillonite nanocomposites, TiO2/montmorillonite (TM) and CeO2/montmorillonite (CM), and investigated their effects on the rheological properties and microstructure of SBSMA before and after long-term aging. The performance differences between the two nanocomposites under different aging modes were also compared. Conventional physical property tests, dynamic shear rheometer tests (temperature sweep and linear amplitude sweep), dynamic mechanical analysis (DMA), and fluorescence microscopy were employed to evaluate the physical properties, high- and low-temperature rheological properties, fatigue resistance, and the microscopic evolution of SBSMA. The results show that before aging, the incorporation of TM and CM significantly improved the high-temperature deformation resistance of SBSMA, enhanced the SBS polymer dispersion state, and promoted the formation of a continuous network structure of polymer phase. After long-term thermal-oxidative aging, both nanocomposites effectively retarded the aging of the asphalt matrix and the SBS network; CM exhibited superior thermal-oxidative aging resistance. After long-term ultraviolet (UV) aging, both nanocomposites also showed significant protective effects, and TM outperformed CM in UV aging resistance. In summary, TM and CM show differentiated advantages in UV protection and thermal-oxidative protection, respectively, providing a theoretical basis for the design of anti-aging materials for SBSMA based on service environments.
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产品关联
DOI
高影响因子
FUEL
·
2024
·
IF 6.7
Yi Zhao,Mengyu Wang,Naixing Liang,Yaru Wang,Zhi Li,Xiao Li
Asphalt pavements are extensively utilized in tunnel pavement owing to comfortable driving, low noise, short-time construction, and simple maintenance. However, asphalt is a flammable material. To enhance fire retardancy of styrene-butadiene-styrene asphalt (SBSA) and its mixture with a preserved pavement performance, a novel hierarchical core-shell architectured fire retardant, cyclic cross-linked polyphosphazene-functionalized magnesium hydroxide (MH@CPZN), was validated via a chemically guilding assembly in this study. The fire retardancy and smoke suppression properties of SBSA containing MH@CPZN were found to be significantly improved.The MH@CPZN (10 wt%)-incorporated SBSA presented a remarkably higher limiting oxygen index (LOI) of 27.4 % relative to 21.5 % of SBSA with MH and 19.8 % of neat SBSA. In parallel, cone calorimeter test results showed that the peak heat release, peak smoke production rate and CO production of SBSA after an inclusion of 10 wt% MH@CPZN were reduced by 40 %, 35 % and 27 %, respectively, with a 20 s delayed ignition time. A large-scale fire test of asphalt mixture revealed a significant suppression of flame propagation after an addition of MH@CPZN. Moreover, the char yield at 800 °C was significantly increased to 24.1 wt% relative to 14.1 wt% of neat SBSA. A comprehensive analysis demonstrated a co-existence of multi-scale optimization of char microstructure in the condensed and radical quenching due to an interface-located polyphosphazene. Additionally, the high-temperature deformation resistance of SBSA was effectively enhanced after the incorporation of MH@CPZN. In perspective, a hierarchical assembly based on polyphosphazene and metal hydroxides exploits a facile yet practical route for multifunctionally reinforcing asphalt and its mixture with well-preserved fire retardant and pavement performance.
研究领域:
材料科学
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土木工程
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火灾安全工程
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产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
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2023
·
IF 6.6
Xiaopeng Xiong,Yugang Wang,Chengtang Zhong
Lately, membrane with asymmetric properties of its two sides has shown promising potential in direct contact membrane distillation (DCMD) application, based on the fact that the hydrophilic side of the asymmetric membrane can effectively mitigate wetting and fouling, while the hydrophobic layer facilitate transportation of water vapor to realize separation. We here report an asymmetric membrane prepared via a facile method of vapor induced phase separation (VIPS). Namely, hydrophobic polymer of poly(styrene- block -butadiene- block -styrene) (SBS) and hydrophilic cellulose acetate (CA) were co-dissolved in tetrahydrofuran , and then cast in an ethanol vapor atmosphere to evaporate solvent. After solvent evaporation (within 10 min), the obtained membrane was observed with scanning electron microscope (SEM) to indicate even microstructure of porous network matrix with nodular morphology, and its top surface consisted of SBS only, while microspheres of CA were found to be evenly embedded in the SBS matrix at the bottom side layer. The membrane was further treated with NaOH aqueous solution for CA deacetylation, which was confirmed by attenuated total reflection Fourier transform infrared spectroscopy , SEM and water contact angle (WCA) analyses. The deacetylated CA exposes OH groups to decrease the WCA of the bottom surface greatly. As a result, an asymmetric membrane with large difference in WCA between the top surface and the bottom surface has been obtained. The asymmetric membrane was employed for DCMD to separate an oily saline emulsion containing n -hexadecane, surfactant of Tween 80, and NaCl . The stable flux and high salt rejection of the asymmetric membrane indicate excellent resistance to wetting and fouling, which is attributed to the hydration layer formed by the OH groups of the deacetylated CA at the bottom surface of the membrane. The facile strategy reported in this work implies possible large scale production of the asymmetric membrane that is suitable for membrane distillation application.
研究领域:
材料科学
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环境工程
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Wenlu Zhang,Mengzhe Bao,Mengyao Chen,Wenbin Li,Chong He,Weilin Xu
High-performance TiO 2 nanotube materials are highly demanded across various fields spanning thermal insulation, catalyst supports, filtration, and so on. However, the practical applications of hollow nanotubes are constrained by the low efficiency and uncontrollable structural properties. Herein, mass production of flexible and high catalytic hollow Al/Si@TiO 2 nanotubes were realized. Through solution blow spinning and atomic layer deposition processes, TiO 2 coated Al/Si@PAN core–shell nanofiber intermediate product was obtained with high efficiency. Hollow tubular structure of Al/Si@TiO 2 nanotubes with wall thicknesses among 150–350 nm was successfully replicated by sacrificing PAN core fibers template through a high-temperature pyrolysis process. Organic polysiloxane and polyalumina were employed as the internal supports to enhance the toughness and elasticity of the hollow Al/Si@TiO 2 nanotube products. Diameters of hollow Al/Si@TiO 2 nanotubes can be controlled ranging from 0.5-2.5 μm through adjusting the flow rate among 10–30 mL/h and air pressure among 0.2–0.4 MPa. Pyrolyzed hollow Al/Si@TiO 2 nanotubes exhibited remarkable elasticity with the compression strain of over 60 %. Hollow Al/Si@TiO 2 nanotubes demonstrated a methylene blue degradation efficiency of reached 61 % and outstanding reusability over multiple cycles, which held promising potential for utilization in high efficiency purification and remediation of water pollutants.
研究领域:
材料科学
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环境科学
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产品关联
DOI
高影响因子
MATERIALS SCIENCE FORUM
·
2020
·
IF 0
Xing Liu,Hong Yuan Xing,Gang Liu,Wei Fu,Wen Bo Zeng
Based on the rheological property master curve, a new definition of ageing index was proposed for styrene-butadiene-styrene block copolymer (SBS) modified bitumen. The UV ageing resistance of the combined-modifier modified SBS bitumen was evaluated. Twelve different methods of combined modification were designed with three kinds of modifiers: ultraviolet absorber (Tinuvin 770), organic montmorillonite (OMMT) and layered double hydroxide (LDHs). With modified SBS bitumen, short-term ageing (TFOT) and laboratory ultraviolet ageing (UV) were performed. The dynamic shear rheometer (DSR) was used to perform frequency sweep test on the samples before and after ageing. The rheological property master curve was obtained by fitting the constitutive model equation. Based on the rheological property master curve, a new definition ageing index was proposed for SBS bitumen to evaluate the modified bitumen with different combined-modifier. The results show that the ageing index could effectively evaluate the UV ageing resistance of SBS bitumen. The evaluation results show that the combined-modifier bitumen exhibits better anti-ultraviolet ageing effects than a single modifier. Among them, the combined-modifier modes of 0.3%Tinuvin770+5%OMMT and 0.6%Tinuvin770+2.5%LDHs performed.
研究领域:
材料科学
·
土木工程
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DOI
危险品化学品经营许可证（带存储）