FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Xuhui Kan,Yingjia Yao,Zengshan Chen,Haihong Wang,Chao Che,Quanjin Rong,Fengfeng Du,Jixiang Liu,Xixi Li,Xiaojing Liu,Dongrui Yao
Green tea processing enriched flavonoids in sea buckthorn leaves. • Sea buckthorn leaf green tea extract (SBGT) exerted immunomodulatory effects. • SBGT improved intestinal barrier by upregulating tight junction proteins. • SBGT reshaped gut microbiota and increased short-chain fatty acids. Sea buckthorn leaf green tea prepared from Hippophae rhamnoides L. leaves contains a complex mixture of bioactive phytochemicals, yet its immunoregulatory potential remains unclear. The study aimed to investigate the immunomodulatory effects and underlying mechanisms of sea buckthorn leaf green tea extract (SBGT) in cyclophosphamide-induced immunosuppressed mice. Widely targeted metabolomics revealed that green tea processing significantly increased the contents of flavonoids and polyphenols in sea buckthorn leaves. Animal experiments showed that SBGT effectively alleviated cyclophosphamide-induced atrophy of the thymus and spleen, restored the secretion of cytokines and immunoglobulins, and improved systemic immune function. Meanwhile, SBGT repaired intestinal mucosal damage, increased goblet cell numbers, and upregulated the expression of tight junction proteins ZO-1, Occludin, and Claudin, thereby enhancing intestinal barrier integrity. Furthermore, SBGT remodeled the gut microbiota structure by increasing the abundance of beneficial genera such as Muribaculaceae , Bacteroides , and Ligilactobacillus , promoting short-chain fatty acids production, and reversing gut microbial dysbiosis. Collectively, SBGT exerts significant immunomodulatory effects and can be used as a promising natural functional tea product. Download: Download high-res image (293KB) Download: Download full-size image
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高影响因子
Marine Drugs
·
2020
·Vol. 18
·期 3
·164
·
IF 4.073
Zhongbin Cheng,Wan Liu,Runzhu Fan,Shouye Han,Yuanli Li,Xiaoyun Cui,Jia Zhang,Yinan Wu,Xin Lv,Yun Zhang,Zhuhua Luo,Siti Aisyah Alias,Wei Xu,Qin Li
A chemical study of the ethyl acetate (EtOAc) extract from the deep-sea-derived fungusPenicilliumthomiiYPGA3 led to the isolation of a new austalide meroterpenoid (1) and seven known analogues (2−8), two new labdane-type diterpenoids (9and10) and a known derivative (11). The structures of new compounds1,9, and10were determined by comprehensive analyses via nuclear magnetic resonance (NMR) and mass spectroscopy (MS) data. The absolute configurations of1,9, and10were determined by comparisons of experimental electronic circular dichroism (ECD) with the calculated ECD spectra. Compound1represented the third example of austalides bearing a hydroxyl group at C-5 instead of the conserved methoxy in other known analogues. To our knowledge, diterpenoids belonging to the labdane-type were discovered from species ofPenicilliumfor the first time. Compound1showed cytotoxicity toward MDA-MB-468 cells with an IC50value of 38.9 μM. Compounds2and11exhibited inhibition against α-glucosidase with IC50values of 910 and 525 μM, respectively, being more active than the positive control acarbose (1.33 mM).Keywords:Penicillium thomiiYPGA3;deep-sea-derived fungus;austalide meroterpenoid;labdane-type diterpenoid;bioactivities
研究领域:
化学
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药理学
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海洋生物学
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PubMed
高影响因子
FOOD CHEMISTRY
·
2020
·
IF 6.306
Peipei Yin,Airong Jia,Kirsten Heimann,Miansong Zhang,Xin Liu,Wei Zhang,Changheng Liu
Hot water pretreatment of sea cucumbers potentially changes nutritional benefits. This study aimed to quantify hot water pretreatment-induced changes in metabolite profiles of sea cucumber body walls. ICP-OES, GC-MS, and LC-MS analyses of untreated- (UT-BW), hot water-treated body walls (HW-BW) of Apostichopus japonicus , and the hot water extract (HW-E) determined significant losses of minerals (25–50% w/w), protein (~11% w/w), carbohydrate (33% w/w), saponins (~41% w/w), and spermidine (100%), a potential antipsychotic from hot water-treated samples. Multivariate comparisons of HW-BW with UT-BW and HW-BW with HW-E showed increases in amino acids and fatty acids, suggesting hot water-induced degradation or transformation or easier extraction of protein, lipid or other components. Presence of 80 to 88.5% of compounds in the HW-E and lower DHA, EPA and glycerophospholipids levels in HW-BW suggested extraction of these metabolites. These data indicate that novel processing technologies are required to preserve the full nutritional benefits of sea cucumbers.
研究领域:
海洋生物学
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食品科学
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营养学
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代谢组学
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DOI
PubMed
高影响因子
CHEMOSPHERE
·
2022
·
IF 8.943
Minglan Xu,Narcisse T. Tsona,Jianlong Li,Lin Du
Microcystins are the most toxic toxins released by cyanobacteria and they have adverse effects on aquatic ecosystems and even human health. Although the removal and detoxification of microcystins in various water bodies have been extensively studied, the interaction mechanism and reaction process of microcystins once they enter the atmosphere are largely unknown, especially at the organic-enriched sea spray aerosol (SSA) interface. Herein, using the surface technique of Langmuir trough coupled in-situ infrared reflection-absorption spectra, we studied the interfacial behavior of microcystin-LR (MC-LR) in artificial seawater containing humic acid and typical surfactants in the presence or absence of UV-irradiation. Zwitterionic 1,2-distearoyl- sn -glycero-3-phosphocholine (DSPC) and anionic stearic acid (SA) were chosen as typical film-forming species, results obtained from the surface pressure-area isotherms showed that MC-LR caused greater expansion of the DSPC monolayer. The comparable results of MC-LR in DSPC/SA-containing systems indicated that the interaction ability was closely related to the monolayer molecular structure and was regulated by electrostatic interaction. Furthermore, the presence of humic acid (HA) could enhance the interaction between microcystin and monolayer molecules. UV-irradiation experiments showed that the photosensitized reaction greatly promoted the removal of microcystin embedded in the SSA surface compared with the direct photolysis effect in the absence of HA. These findings highlight that the toxic effects of microcystins after entering the atmosphere may be weakened by photochemical reactions .
研究领域:
环境科学
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毒理学
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大气化学
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PubMed
高影响因子
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2022
·
IF 4.52
Jingtao Cui,Jun Cao,Jiachen Ge,Xingchen Qu,Pengyan Li,Chuan Li
Cobia ( Rachycentron canadum ) is a significant fish species for mariculture with high nutritional value . This research aims to comprehensively investigate the lipid profiles of cobia tissues, including fatty acid profiles, characteristics of phospholipids (PL) and triacylglycerols (TAG), and lipid molecular species. The results showed that cobia contained high levels of total lipids (2.89 −32.09 % of wet weight), docosahexaenoic acid (DHA, 10.83 −14.69 % of total fatty acids) and eicosapentaenoic acid (EPA, 3.54 −9.68 %). Compared with TAG, higher levels of polyunsaturated fatty acids , DHA/EPA in particular, were concentrated in PL. Interestingly, DHA was predominantly distributed in the sn-1 position of PL and the sn-2 position of TAG, whereas EPA was predominantly distributed in the external positions of PL and TAG. Additionally, at least 693 molecular species from 23 subclasses were identified by ultrahigh-performance liquid chromatography-quadrupole exactive-mass spectrometry (UPLC-Q-Exactive-MS). Glycerophospholipids (63.19 −66.61 %) and glycerolipids (19.17 −22.21%) were the major lipid classes in cobia tissues, and the majority of them contained DHA and EPA. Hence, this comprehensive analysis will help to evaluate the lipid nutritional values and facilitate exploitation in cobia consumption and processing.
研究领域:
水产养殖学
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营养学
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脂质组学
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 47
·期 6
·3140-3150
·
IF 3.925
Xingrui Qi,Zhidong Zhao,Nian Li,Zijian He,Yufang Chen,Tao Jin
At present, water resources contaminated by pathogenic microorganisms have an increasingly serious impact on human health. Photocatalytic sterilization using solar energy is an inexpensive and effective method. However, how to effectively utilize solar energy and improve the photocatalytic performance of catalysts is the main problem at present. In this work, urchin-like WO3−x and Cu-doped WO3−x were synthesized by a simple method. The synthesized photocatalysts were characterized in detail, and the sterilization performance of the catalysts was investigated under simulated sunlight. The sterilization rates of WO3−x against Escherichia coli and Staphylococcus aureus were 65.74% and 94.73%, respectively, while the sterilization rates of WO3−x doped with Cu against these two bacteria were 99.95% and 99.24%, respectively. Cu–WO3−x shows excellent photocatalytic bactericidal performance, which is attributed to the enhanced oxygen vacancies of WO3−x and the separation of photogenerated electron–hole pairs by the doping of Cu. This work is expected to provide an effective way to develop solar photocatalytic sterilization.
研究领域:
环境科学
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材料科学
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微生物学
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高影响因子
Nutrients
·
2023
·Vol. 15
·期 2
·378
·
IF 5.9
Ruizhen Ru,Gengzhan Chen,Xiaoxia Liang,Xudong Cao,Lihong Yuan,Minjie Meng
Bladder cancer is a highly recurrent disease and a common cause of cancer-related deaths worldwide. Despite recent developments in diagnosis and therapy, the clinical outcome of bladder cancer remains poor; therefore, novel anti-bladder cancer drugs are urgently needed. Natural bioactive substances extracted from marine organisms such as sea cucumbers, scallops, and sea urchins are believed to have anti-cancer activity with high effectiveness and less toxicity. Frondoside A is a triterpenoid glycoside isolated from sea cucumber,Cucumaria frondosa. It has been demonstrated that Frondoside A exhibits anti-proliferative, anti-invasive, anti-angiogenic, anti-cancer, and potent immunomodulatory effects. In addition, CpG oligodeoxynucleotide (CpG-ODN) has also been shown to have potent anti-cancer effects in various tumors models, such as liver cancer, breast cancer, and bladder cancer. However, very few studies have investigated the effectiveness of Frondoside A against bladder cancer alone or in combination with CpG-ODN. In this study, we first investigated the individual effects of both Frondoside A and CpG-ODN and subsequently studied their combined effects on human bladder cancer cell viability, migration, apoptosis, and cell cycle in vitro, and on tumor growth in nude mice using human bladder cancer cell line UM-UC-3. To interrogate possible synergistic effects, combinations of different concentrations of the two drugs were used. Our data showed that Frondoside A decreased the viability of bladder cancer cells UM-UC-3 in a concentration-dependent manner, and its inhibitory effect on cell viability (2.5 μM) was superior to EPI (10 μM). We also showed that Frondoside A inhibited UM-UC-3 cell migration, affected the distribution of cell cycle and induced cell apoptosis in concentration-dependent manners, which effectively increased the sub-G1 (apoptotic) cell fraction. In addition, we also demonstrated that immunomodulator CpG-ODN could synergistically potentiate the inhibitory effects of Frondoside A on the proliferation and migration of human bladder cancer cell line UM-UC-3. In in vivo experiments, Frondoside A (800 μg/kg/day i.p. for 14 days) alone and in combination with CpG-ODN (1 mg/kg/dose i.p.) significantly decreased the growth of UM-UC-3 tumor xenografts, without any significant toxic side-effects; however, the chemotherapeutic agent EPI caused weight loss in nude mice. Taken together, these findings indicated that Frondoside A in combination with CpG-ODN is a promising therapeutic strategy for bladder cancer.Keywords:bladder cancer;Frondoside A;CpG oligodexynucleotides;cell viability;apoptosis;cell migration
研究领域:
肿瘤学
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药理学
·
免疫学
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PubMed
高影响因子
Nanoscale
·
2025
·
IF 5.1
Kaishen Chen,Duoduo Yang,Yiping Cheng,Jianyong Luo,Zhiyu Liu,Weiwei Xing,Shusheng Pan,Chengyun Zhang
Conventional photocatalytic materials, predominantly in powder form, face challenges such as difficulty in recovery and secondary pollution, limiting their practical applications. In this study, a three-dimensional porous graphene framework (3DGF) nanostructure was induced on the surface of polyimide (PI) using laser processing, providing abundant binding sites for zinc oxide (ZnO). By adjusting the laser parameters, 3DGF nanostructures with varying crystallinity and framework characteristics were fabricated, and sea urchin-like ZnO nanoflowers were grown on the surface through a hydrothermal method. Different ZnO morphologies, such as orchid-like nanoflowers and nanorods, were achieved by varying the precursor concentrations. Under UV LED irradiation, 3DGF@ZnO/HMTA (2 : 2) exhibited remarkable photocatalytic degradation efficiencies of 89.62%, 100%, and 92.96% for methylene blue (MB), rhodamine B (RhB), and methyl orange (MO) within 90, 120, and 180 min, respectively. After multiple cycles of RhB photodegradation, the efficiency remained at 96.53%, and even after 20 tape adhesion tests, the photocatalytic degradation efficiency for RhB was sustained at 89.81%. The superior performance and stability highlight the potential of 3DGF@ZnO/HMTA for sustainable water pollution remediation.
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PubMed
高影响因子
CHEMICAL GEOLOGY
·
2022
·
IF 4.685
Jianlin Liao,Jieyun Chen,Xiaoming Sun,Zhongwei Wu,Yinan Deng,Xuefa Shi,Yanjingyu Wang,Yuxi Chen,Andrea Koschinsky
Recent studies suggest that pelagic sediments can enrich rare-earth elements (REE) acting as a significant reservoir for the global REE budget as well as a potential resource for future exploitation. Although Ca-phosphate (e.g., bioapatite fossils) and Fe-Mn (oxyhydr)oxides (e.g., micronodule) have been considered important REE carriers in deep-sea sediments, the proportion of REE held by each mineral phase remains enigmatic. Here, we have investigated the sediments from two promising REE-rich prospective areas: the Tiki Basin in the Southeast Pacific (TKB) and the Central Indian Ocean Basin (CIOB). The mineral grains including bioapatite fossils and Fe-Mn micronodules have been inspected individually by in-situ microscale analytical methods. Correspondently, the REE bound to Ca-phosphate and Fe-Mn (oxyhydr)oxides have been sequentially extracted and quantified. The crucial role of Ca-phosphate is substantiated by sequential leaching which reveals its dominance in hosting ~69.3–89.4% of total REE. The Fe-Mn (oxyhydr)oxides carry ~8.2% to 22.0% of REE in bulk sediments, but they account for ~70.0–80.5% of Ce owing to their preferential adsorption of Ce over the other REE. Surface sediment on modern seafloor can accumulate high REE contents resulting from the REE scavenging by the host phases within the range of sediment-seawater interface. Differences between TKB and CIOB samples indicate that the REE enrichment in the deep-sea environment may be controlled by multiple factors including the productivity of overlying seawater (e.g., phosphorus flux), water depth relative to carbonate compensation depth (CCD), sedimentation rate, redox condition, and hydrothermal vent input (e.g., Fe-Mn precipitations).
研究领域:
海洋地质学
·
地球化学
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高影响因子
ESTUARINE COASTAL AND SHELF SCIENCE
·
2016
·
IF 2.335
Dong-Yang Cui,Jiang-Tao Wang,Li-Ju Tan,Ze-Yi Dong
The South China Sea (SCS), which is the largest marginal sea in East Asia, plays a significant role in regional climate change . However, research on the phytoplankton community structure (PCS) response to atmospheric wet deposition remains inadequate. In this study, field incubation experiments were performed to survey the impact of atmospheric wet deposition on the PCS in the SCS in December 2013. Results indicate that the mean dissolved inorganic nitrogen/dissolved inorganic phosphorous (DIN/DIP) ratio in rainwater was 136, which was higher than that in seawater. Under low initial nutrient concentrations, rainwater inputs not only significantly increased total chlorophyll a (Chl a ) concentrations but also potentially altered the PCS. The total Chl a concentration increased 1.7-, 1.9-, and 1.6-fold; microphytoplankton increased 2.6-, 3.2-, and 1.7-fold with respect to their initial values in the 5%, 10% addition, and 10% addition (filtered) treatment samples, respectively. Finally, microphytoplankton contributed 61% to the total Chl a concentration in 10% addition treatment samples. Differences in the nutrients induced by atmospheric wet deposition resulted in a shift in the advantage from picophytoplankton to microphytoplankton. Diatoms became the predominant species, accounting for 55% of the total abundance after rainwater addition.
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高影响因子
NANO
·
2025
·
IF 1.1
Jingtong An,Xiangyan Chen,Xintao Gao,Yifei Zhang,Jiqing Dong,Yan Lei,Yantao Li
This study aimed to develop novel urolithin–gelatin nanoparticles for cancer treatment. Urolithin–gelatin nanoparticles with stick-like (UG-S nanoparticles) and sea urchin-like (UG-U nanoparticles) morphologies were prepared by the anti-solvent method. Transmission electron microscopy showed that the particle size of UG-U nanoparticles was approximately 4 3 4 . 3 ± 8 . 5 nm. UG-U nanoparticles demonstrated a higher drug loading rate of 49.32%, along with a significantly increased encapsulation efficiency of 98.64%. The changes in surface charge and crystal structure were explored through zeta potential and X-ray diffraction analyses. Fourier transform infrared spectroscopy confirmed the successful encapsulation of each component and the interaction between them. In vitro studies indicated that both UG-S and UG-U nanoparticles could reduce cell viability, but UG-U nanoparticles had superior cell uptake ability. The scratch assay showed that UG-U nanoparticles had a stronger inhibitory effect on the migration of tumor cells. Further studies revealed that compared with UG-S nanoparticles and free urolithin A, UG-U nanoparticles could more effectively promote the accumulation of reactive oxygen species, damage mitochondria and induce apoptosis in A549 cells. In conclusion, sea urchin-like UG-U nanoparticles hold great promise for cancer treatment due to their exceptional properties and potent anti-cancer mechanisms.
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高影响因子
Marine Drugs
·
2026
·Vol. 24
·期 4
·125
·
IF 5.7
Zi-Han Xu,Zheng-Biao Zou,Chun-Xiu Wang,Chen Li,Xian-Wen Yang,Jun-Song Wang
Inhibition of inflammation and oxidative stress is increasingly recognized as a promising therapeutic strategy for neurodegenerative diseases. In this study, we isolated two new dimeric naphtho-γ-pyrone (aS)-fonsecinones B and D (1and2) and 14 known compounds (3–16) from the deep-sea-derived fungusAspergillus niger3A00562. Their structures were unambiguously determined through integrated physicochemical and spectroscopic analyses. Screening for neuroinflammatory inhibitors using a BV2 microglial cell model identified TMC 256 A1 (10) as the most potent candidate. Compound10significantly suppressed LPS-induced inflammation in BV2 cells without cytotoxicity. It concurrently inhibited LPS-triggered ROS overproduction and neutrophilic infiltration in zebrafish. Subsequent proteomics revealed that10targets NOS2 to modulate Alzheimer’s disease (AD)-associated pathways and the KEAP1-NRF2 axis. Molecular docking and dynamics simulations demonstrated that10occupies the NOS2 heme-binding pocket, thereby preventing dimerization and inhibiting enzymatic activity. Finally,10ameliorated locomotor deficits in an AD zebrafish model. Collectively, these findings highlight compound10as a candidate compound for preventing inflammatory and oxidative stress damage during treatment of neurodegenerative diseases, particularly AD.
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高影响因子
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