INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Yinglan Li,Jie Xu,Qingran Guan,Huaizhen Zhang,Zhuang Ding,Qingpeng Wang,Zhengping Wang,Jun Han,Min Liu,Yanna Zhao
Solid dispersions (SDs) possess the potential to enhance the bioavailability of insoluble active pharmaceutical ingredients (APIs) by effectively converting them into amorphous state. However, SDs have a tendency to recrystallize unless appropriate excipients are employed. The objective of this study was to evaluate the ability of hypromellose acetate succinate HF (HPMCAS-HF) and Soluplus® to inhibit the recrystallization of β-carotene and improve its in vivo bioavailability through the fabrication of ternary β-carotene solid dispersions (SDs) with the aid of specific surfactant. Due to rapid micellization , the dissolution profiles of β-carotene SDs based on HPMCAS-HF/Span 20 (5:5, w/w) or Soluplus®/Span 20 (6:4, w/w) combinations exhibited significant improvement, which were almost 7–10 times higher than β-carotene bulk powder. DSC and PXRD analysis indicated a notable reduction in the crystallinity degree of β-carotene within the SDs. The stability study demonstrated a half-life of β-carotene in the SDs exceeding 30 days. Additionally, the in vivo pharmacokinetics analysis confirmed that the cellulose derivatives/surfactant combinations significantly enhanced the bioavailability of β-carotene by 1.37-fold and 2.3-fold, respectively. Notably, the HPMCAS-HF/Span 20 combination exhibited superior performance. Consequently, the HPMCAS-HF/Span 20 combination held potential for the advancement of an effective drug delivery system for β-carotene.
研究领域:
药剂学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
Energy & Environmental Science
·
2024
·
IF 32.4
Huangwei Zhang,Yidan Zhang,Chen Cao,Wanli Zhao,Kai Huang,Yi Zhang,Yue Shen,Zhen Li,Yunhui Huang
The lithium–sulfur (Li–S) battery is a highly promising candidate for next-generation battery systems. However, the shuttle effect of polysulfides or the dendrites and side reactions of lithium metal anodes limit the cycle life of batteries. In particular, at the pouch cell level, achieving long-term cycling stability is extremely challenging. Here, we have constructed a Li–S pouch cell with sulfurized pyrolyzed poly(acrylonitrile) (SPAN) as the cathode and graphite (Gr) as the anode, introducing lithium-ions through a facile in situ pre-lithiation method. In carbonate-based electrolytes, the SPAN cathode can avoid the shuttle effect, while the Gr anode can exclude the interference of lithium metal. By rationally controlling the cycling conditions to suppress the loss of active lithium and the increase in resistance, a SPAN‖Gr pouch cell with 1000 cycles and 99% capacity retention rate can be ultimately obtained. The A h-level pouch cell can stably cycle for 1031 times with 82% capacity retention rate and pass multiple safety tests. This design is expected to fundamentally improve the long-term cycling stability of Li–S pouch cells and it has great potential in the field of large scale energy storage due to its absence of transition metal elements.
研究领域:
能源存储
·
材料科学
·
电化学
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产品关联
DOI
高影响因子
ADVANCED ENGINEERING MATERIALS
·
2025
·Vol. 28
·期 2
·e202501970
·
IF 3.3
Zhishuai Liu,Siran Wang,Yujia Liu,Junwei Sha,Rui Li,Xudong Yang
Achieving the stability of pore structure and the enhancement of mechanical properties is the prominent target for aluminum (Al) foam design. In this work, the effects of manganese (Mn) content on the pore structure, mechanical properties, and deformation behavior of Al Mn foams are investigated. The results show that the appropriate addition of Mn (1.5 wt%) achieves a remarkable balance between energy absorption capacity (4.37 MJ m −3 ) and pore uniformity (standard deviation of 0.95 mm in average pore size), representing substantial enhancements of 193.28% in yield strength and 385.56% in energy absorption capacity compared to pure Al foams. These enhancements are attributed to a refined pore architecture, finely dispersed Al 6 Mn precipitates, and a sequential collapse mechanism, which collectively enable progressive energy dissipation. The application of the entropy weight method is pioneered in this study to establish a predictive framework for multiobjective design, demonstrating that energy absorption and pore uniformity are crucial factors for the matrix design of Al foams. These findings offer a potential strategy for future engineering applications of metal foam design.
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DOI
高影响因子
CHEMISTRY AND PHYSICS OF LIPIDS
·
2018
·
IF 2.766
Huina Ruan,Lujing Xu,Shan Hong,Songbai Liu
A general highly efficient solvent-free esterification of phytosterols with edible magnesium oxide and Span-60 emulsifier catalyst system has been developed. The edible emulsifier dramatically promotes the catalyzing activity of the metal oxide in the reaction. The loading of the magnesium oxide is as low as 0.1 wt% to phytosterols and far lower than the known ones. As demonstrated by the results of scanning electro-microscopy (SEM), the synergistic effect of emulsifier and magnesium oxide presumably results from elimination of nano-scale interfacial barrier between phytosterols and fatty acids and facilitation of mass transfer of reaction agents. The mild, environmentally benign, and highly effective nature of this catalytic transformation suggests its great potential applications.
研究领域:
化学工程
·
生物化学
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产品关联
DOI
PubMed
高影响因子
Materials Today Energy
·
2024
·
IF 9
Yawei Guo,Weijing Zuo,Xiangkun Wu,Lan Zhang
Sulfurized polyacrylonitrile (SPAN) is a promising cathode material for long-life lithium-sulfur batteries (LSBs) due to its enhanced electronic conductivity as well as the eliminated shuttle effect. However, the uncontrollable lithium dendrite issue as well as slow kinetics of thick electrodes still hinders its practical application. Herein, an in situ polymerized electrolyte (PGE) based on vinyl carbonate and lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) is designed and prepared to enhance the plating/stripping stability of the metal lithium while ensuring the cathode/electrolyte interfacial ion transportation. The optimized electrolyte, PGE-D, shows a satisfying ionic conductivity of 0.46 mS/cm at 25 °C; in the meantime, the polymer matrix hinders the diffusion of TFSI − anion and results in a high Li + transference number ( t L i + ) of 0.73. Benefiting from the high affinity of the flowable PGE precursor to the thick SPAN cathode as well as enhanced lithium compatibility, the Li||SPAN battery with high areal loading of 14.1 mg/cm 2 exhibits a high reversible specific capacity of 556.5 mAh/g and retains 76.3% of its capacity after 90 cycles.
研究领域:
材料科学
·
电化学
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DOI
高影响因子
DESALINATION
·
2025
·
IF 9.8
Huilian Sun,Shuai Wang,Shiqi Wang,Yongchen Song,Zheng Ling,Lunxiang Zhang
Green utilization and sustainable desalination based on hydrate formation have attracted considerable attention. However, its industrial application is limited by slow kinetics and low final-conversion considering hydrate phase change. In this study, we creatively present a desalination approach of dispersed hydrate formation by incorporating the non-ionic surfactant Span 80. The addition of Span 80 enhanced the dispersion of cyclopentane (CP) in saline solution and generated the micron emulsion; as a result, the contact of the host water molecules and the guest molecules increased and the CP hydrate formation accelerated. Meanwhile, a maximum water yield of 92.8 % was achieved and the corresponding growth percentage of 97.5 % was realized comparing without Span 80 in a 3.5 wt% NaCl solution. In addition, this dispersed approach of hydrate-based desalination (HBD) also showed great performance in high concentration wastewater treatments like the solutions of saline and heavy metal. A three-stage purification strategy could produce the clean water meeting the stringent drinking water standard. Additionally, this approach exhibited notable pH tolerance under both strongly acidic and alkaline conditions. The results also demonstrated that Span 80 exhibits impressive self-separation recovery characteristics and cycling stability. These findings provide a robust academic foundation for advancing the feasibility and sustainability of the dispersed HBD in practical seawater desalination applications.
研究领域:
环境科学
·
化学工程
·
材料科学
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产品关联
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2024
·
IF 8.2
Zhen-tian Feng,Jiang-bo Xiong,Guo-feng Wang,Lin Li,Chun-fei Zhou,Chun-huo Zhou,Hua-jun Huang
Treatment of swine manure by hydrothermal carbonization (HTC) with the aid of different surfactants was first explored in this study. PEG 400 (polyethylene glycol 400) and Tween 80 facilitated the formation of bio-oil. SLS (sodium lignosulfonate) and SDS (sodium dodecyl sulfate) promoted the formation of water-soluble matters/gases. Span 80 enhanced the formation of hydrochar , which resulted in a 50.19 % mass yield, 92.39 % energy yield, and a caloric value of 28.68 MJ/kg. The hydrochar obtained with Span 80 presented a similar combustion performance to raw swine manure and the best pyrolysis performance. The use of Span 80 promoted the transfer of degradation products to hydrochar, especially hydrophobic ester and ketone compounds. Notedly, Span 80 suppressed the synthesis of PAHs during the HTC process, which was reduced to 0.92 mg/kg. Furthermore, the hydrochar produced with Span 80 contained lower contents of heavy metals. On the whole, Span 80 has shown great potential in enhancing the HTC of swine manure. The acting mechanisms of surfactants in the HTC of swine manure included adsorption, dispersion, and electrostatics repulsion.
研究领域:
环境科学
·
能源工程
·
生物学
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2020
·Vol. 31
·期 9
·2009610
·
IF 16.836
Yong Yan,Chunyue Liu,Hanwen Jian,Xing Cheng,Ting Hu,Dong Wang,Lu Shang,Ge Chen,Peter Schaaf,Xiayan Wang,Erjun Kan,Tierui Zhang
The development of economical, highly active, and robust electrocatalysts for oxygen evolution reaction (OER) is one of the major obstacles for producing affordable water splitting systems and metal-air batteries. Herein, it is reported that the subnanometric CoO x clusters with high oxidation state substitutionally dispersed in the lattice of rutile TiO 2 support (Co-TiO 2 ) can be prepared by a thermally induced phase segregation process. Owing to the strong interaction of CoO x clusters and TiO 2 support, Co-TiO 2 exhibits both excellent intrinsic activity and durability for OER. The turnover frequency of Co-TiO 2 is up to 3.250 s −1 at overpotentials of 350 mV; this value is one of the highest in terms of OER performance among the current Co-based active materials under similar testing conditions; moreover, the OER current density loss is only 6.5% at a constant overpotential of 400 mV for 30 000 s, which is superior to the benchmark Co 3 O 4 and RuO 2 catalysts. Mechanism analysis demonstrates that charge transfer occurs between Co sites and their neighboring Ti atoms, triggering the efficient Co Ti cooperative catalytic centers, in which OH* and O* are preferred to be adsorbed on the bridging sites of Co and Ti with favorable adsorption energy, inducing a lower energy barrier for O 2 generation.
研究领域:
材料科学
·
电化学
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产品关联
DOI
高影响因子
Advanced Materials Interfaces
·
2017
·Vol. 4
·期 12
·1700005
·
IF 4.279
Juan Wang,Jia Wei Chen,Jia Dong Chen,Han Zhu,Ming Zhang,Ming Liang Du
Well-dispersed Pt Cu alloy nanoparticles (NPs) with a diameter of only ≈2 nm encapsulated in carbon nanofibers (CNFs) are synthesized using electrospinning technology followed by a graphitization process in a chemical vapor deposition furnace. Distinctly, even with a small amount of Pt, the Pt Cu/CNFs-1:2 catalyst possesses outstanding hydrogen evolution reaction (HER) activity, including small overpotential, long-term stability, and a high exchange current density as well as large double layer capacitance ( C dl ). The excellent HER performance of the Pt Cu/CNFs-1:2 catalyst is attributed to the synergistic interaction between Pt and Cu, the uniform distribution of the alloy NPs and the use of CNFs with 3D architectures. This development may provide a simple, efficient, and green synthesis method to design bi- or multimetal alloys for use as the cathode electrocatalysts for the HER or other electrocatalytic devices.
研究领域:
材料科学
·
电化学
·
纳米技术
·
催化
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产品关联
DOI
高影响因子
Advanced Energy Materials
·
2026
·
IF 25.5
Shaoheng Yuan,Yanqi Huang,Guangfa Wang,Yiwen Bo,Chao Wang,Zhengxue Zhou,Ding Zhang,Rujun Ma
Electrocaloric (EC) cooling technology offers advantages such as miniaturization, low energy consumption, and solid-state operation. However, the temperature span (Δ T span ) of EC devices remains limited and must be enhanced. Here, we construct a six-layer cascade electrocaloric cooling device (SCECD) that achieves a large Δ T span . The synergy of electrostatic actuation and self-actuation ensures that electrostatic force and deformation force always act in the same direction on the EC stack, enhancing heat transfer efficiency in the SCECD. The copper (Cu) as the electrode is evaporated onto the EC stack to increase its stiffness and raise the critical voltage for instability, which typically manifests as localized wrinkling or dimpling. This enhancement improves the resistance of the EC stack to instability, thus ensuring uniform deformation under actuation conditions. As a result, the SCECD, which combines electrostatic actuation and self-actuation, achieves a Δ T span of 13.07 K and a cooling temperature change (Δ T cooling ) of 6.45 K. The SCECD not only achieves an outstanding cooling performance within the field of polymer-based EC devices, but also contributes to ongoing efforts in developing practical solid-state cooling technologies.
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产品关联
DOI
高影响因子
Science Advances
·
2024
·Vol. 10
·期 10
·
IF 11.7
Ziguang Zhao,Ziquan Cao,Zhixin Wu,Wenxin Du,Xue Meng,Huawei Chen,Yuchen Wu,Lei Jiang,Mingjie Liu
Currently, it remains challenging to balance intrinsic stiffness with programmability in most vitrimers. Simultaneously, coordinating materials with gel-like iontronic properties for intrinsic ion transmission while maintaining vitrimer programmable features remains underexplored. Here, we introduce a phase-engineering strategy to fabricate bicontinuous vitrimer heterogel (VHG) materials. Such VHGs exhibited high mechanical strength, with an elastic modulus of up to 116 MPa, a high strain performance exceeding 1000%, and a switchable stiffness ratio surpassing 5 × 103. Moreover, highly programmable reprocessing and shape memory morphing were realized owing to the ion liquid–enhanced VHG network reconfiguration. Derived from the ion transmission pathway in the ILgel, which responded to the wide-span switchable mechanics, the VHG iontronics had a unique bidirectional stiffness-gated piezoresistivity, coordinating both positive and negative piezoresistive properties. Our findings indicate that the VHG system can act as a foundational material in various promising applications, including smart sensors, soft machines, and bioelectronics.
研究领域:
材料科学
·
软体机器人
·
生物电子学
✓ 已验证
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·Vol. 35
·期 44
·2509658
·
IF 19
Chaoqiang Tan,Zeyu Shen,Shichao Zhang,Zhijun Wu,Shengnan He,Hongge Pan,Hao Cheng,Yingying Lu
Sulfurized polyacrylonitrile (SPAN) recently emerges as a prospective cathode for lithium–sulfur (Li–S) batteries owing to its high S utilization, remarkable cycling stability, and liberty from shuttle effect. Despite weakly solvating ether electrolytes exhibiting simultaneously compatibility for SPAN cathode and lithium (Li) anode, they universally suffer from low ionic conductivity and narrow liquid-phase temperature range. However, conventional ether-based electrolytes with excellent ionic conductivity cannot realize reversible solid–solid conversion of SPAN cathode due to Li polysulfide intermediates (LiPSs) dissolving and shuttling. Here, a series of weakly solvating ethers are evaluated by selectively methylating dimethoxymethane (DMM) to fine-tune their solvation capability and liquid-phase temperature range. Enlightened from weakly solvating ether electrolytes, the contact ion pair (CIP)-dominated electrolyte is designed for satisfactory ionic conductivity of electrolyte and reversible solid–solid conversion of SPAN cathode over wide temperature range. The reinforcement mechanisms of the CIP-dominated electrolyte for the Li anode and SPAN cathode are comprehensively elucidated through experimental characterizations and molecular dynamics simulations. Based on the optimized electrolyte, Li||SPAN full cells can steadily operate over wide temperature range from −20 to 60 °C. Furthermore, the 120 mAh Li||SPAN pouch cell can exhibit 85.5% capacity retention after 45 cycles at 0.2 C.
研究领域:
电化学
·
能源材料
·
锂离子电池
·
电极界面化学
·
电解质工程
·
分子动力学模拟
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）