RSC Advances
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2016
·Vol. 6
·期 35
·29592-29597
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IF 3.289
Lei Cao,Qianqiu Tang,Gengchao Wang
Poly(3,4-ethylenedioxythiophene) (PEDOT) is a promising conductive polymer due to its high conductivity and optical transparency. However, two main challenges remain to be solved for its practical application, including improving the humidity stability and water resistance. Here, a novel cross-linkable copolymer of methacryloyloxyethyl isocyanate grafted poly(styrene sulfonate-co-2-hydroxyethyl acrylate) [MOI-P(SS-HEA)] is synthesized by a radical polymerization and condensation reaction. MOI-P(SS-HEA) is used as a multi-functional counter anion to obtain the UV-curable conductive dispersion of PEDOT:MOI-P(SS-HEA). The electrical conductivity, humidity stability, and water resistance of the cross-linked PEDOT:MOI-P(SS-HEA) [PEDOT:MOI-P(SS-HEA)-C] conductive films are investigated. The results indicate that the UV cross-linked reaction significantly improves the humidity stability and water resistance of the PEDOT:MOI-P(SS-HEA)-C conductive film.
研究领域:
材料科学
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
Natural Product Communications
·
2025
·
IF 1.4
Longwei Fang,Zhen Ni,Yanglei Shen,Feng Gao,La Yang,Nanling Liu,Zhuoma Duoji,Dongzhi Zhuoma,Wangdui Suolang,Zhuoma Basang
ObjectiveTo study the chemical constituents of Synotis solidaginea (SS) from Tibet. In our previous research, it was found that the extract of Synotis solidaginea stems has potential inhibitory activity against the proliferation of melanoma cells. Therefore, we hope to separate, extract and structurally identify the extracts of Synotis solidaginea stems, and determine the main components that exert potential inhibitory activity on the proliferation of melanoma cells.MethodsThe compounds were separated and purified using silica gel, polyamide, reversed phase C18 column chromatography, and preparative high performance liquid chromatography. The structure of each compound was identified based on the spectral data and literature comparisons. To verify the inhibitory activity of each component against melanoma cells, cell and enzyme assay were conducted.ResultsA total of 7 compounds were isolated from the dichloromethane extract of Synotis solidaginea. The irimofen lactone structure compound SS-1 and SS-5 were isolated from Synotis solidaginea for the first time. Among these, irimofin sesquiterpenoid compound SS-2 exhibited strong inhibitory activity against B16F10 of melanoma cells. Meanwhile, the iremorphene sesquiterpenoid SS-2 exhibited significant tyrosinase inhibitory activity, and the docking results explained the mechanism of its action.DiscussionSolidaginea has laid the foundation for the prevention and treatment of melanoma with the active ingredients of Tibetan medicine.
研究领域:
天然药物化学
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肿瘤学
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分子生物学
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药理学
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植物化学
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转化医学
✓ 已验证
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
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2018
·
IF 5.08
Huikang Yang,Nianhua Wang,Lei Mo,Mei Wu,Ruimeng Yang,Xiangdong Xu,Yugang Huang,Jiantao Lin,Li-Ming Zhang,Xinqing Jiang
Tumor-targeted multifunctional nanocarriers play an important role in tumor diagnosis and treatment. Herein, disulfide bonds linked amphiphilic hyaluronan-SS-poly(ε-caprolactone) diblock copolymers (HA-SS-PCL) were synthesized and studied as theranostic nanocarriers for tumor diagnosis and treatment. The chemical structure of HA-SS-PCL was confirmed by Fourier transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance ( 1 H NMR). The self-assembling behavior of the HA-SS-PCL into GSH-responsive micelles and their degradation were characterized by fluorescence spectroscopy, dynamic light scattering (DLS) and transmission electron microscopy (TEM). Theranostic nanocarriers encapsulating doxorubicin (DOX) and superparamagnetic iron oxide (SPIO) were formed via a dialysis. In vitro drug release results suggested that the HA-SS-PCL micelles possessed reductant-triggered doxorubicin release ability, which was confirmed by 100% of DOX release from HA-SS-PCL micelles within 12 h under 10 mM of glutathione (GSH), whereas about 40% of DOX was released under non-reductive condition within 24 h. Both flow cytometry and confocal laser scanning microscopy (CLSM) analysis revealed that the HA-SS-PCL micelles loaded with DOX were internalized in HepG2 cell via a receptor mediated mechanism between hyaluronan and the CD44 receptor. Furthermore, the MTT assay and cell apoptosis analysis revealed that the DOX-loaded HA-SS-PCL micelles exhibited pronounced antitumor ability towards HepG2 cells compared with that of the reduction-insensitive HA-PCL micelles at the same DOX dosage. The r 2 relaxivity value of the DOX/SPIO loaded HA-SS-PCL micelles was up to 221.2 mM −1 s −1 (Fe). Thus, the obtained HA-SS-PCL block copolymers demonstrate promising potential as tumor targeting theranostic nanocarriers in the field of tumor diagnosis and treatment.
研究领域:
生物材料
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肿瘤学
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药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2017
·
IF 4.3
Yunfang Zhou,Shuanghu Wang,Xuhua Ying,Yifan Wang,Peiwu Geng,Aiping Deng,Zhihong Yu
Multidrug resistance (MDR) against chemotherapeutic agents has become one of the major obstacles to successful cancer therapy and MDR-associated proteins (MRPs)-mediated drug efflux is the key factor for MDR. In this study, a redox-responsive polymer based on dextran (DEX) and indomethacin (IND), which could reduce MRPs-mediated efflux of chemotherapeutics, was synthesized, and the obtained polymer could spontaneously form stable micelles with well-defined core-shell structure and a uniform size distribution with an average diameter of 50 nm and effectively encapsulate doxorubicin (DOX); the micelles contain a disulfide bridge (cystamine, SS) between IND and DEX (DEX-SS-IND). In vitro drug release results indicated that DEX-SS-IND/DOX micelles could maintain good stability in a stimulated normal physiological environment and promptly depolymerized and released DOX in a reducing environment. After incubating DEX-SS-IND/DOX micelles with drug-resistant tumor (MCF-7/ADR) cells, the intracellular accumulation and retention of DOX were significantly increased under the synergistic effects of redox-responsive delivery and the inhibitory effect of IND on MRPs. In vitro cytotoxicity showed that DEX-SS-IND/DOX micelles exhibited higher cytotoxicity against MCF-7/ADR cells. Moreover, DEX-SS-IND/DOX micelles showed significantly enhanced inhibition of tumor in BALB/c nude mice bearing MCF-7/ADR tumors and reduced systemic toxicity. Overall, the cumulative evidence indicates that DEX-SS-IND/DOX micelles hold significant promise for overcoming MDR for cancer therapy.
研究领域:
药学
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肿瘤学
✓ 已验证
DOI
高影响因子
FOOD HYDROCOLLOIDS
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2020
·
IF 7.053
Kang Ni,Yating Gao,Xiaodong Ye
The structure and formation mechanism of 15S globulin of soybeans were investigated. After purification, 15S-rich fraction (75.6%) and 11S-rich fraction (94.3%) were obtained and further characterized with analytical ultracentrifugation (AUC) and transmission electron microscope (TEM). The results show that the molar masses of 11S and 15S are 313 kDa and 651 kDa, respectively, and the weight percentages of the monomer , dimer, and trimer in the TEM images are consistent with those of 11S, 15S, and 21S fractions measured by AUC, indicating that 15S and 21S are dimers and trimers of 11S monomer, respectively. The size of the 15S molecules is 21.1 nm × 10.4 nm, suggesting that two 11S molecules interact with each other from the side position. Moreover, the contents of subunits were determined by a combination of AUC and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) with the addition of 20 mM sodium dodecyl sulfate (SDS) and 10 mM 2-mercaptoethanol (2-ME). The content of the species with a sedimentation coefficient of 4.3 S in 15S-rich fraction, which is assigned as AB-SS-AB subunits, is significantly higher than that in 11S-rich fraction with the addition of SDS; this species disappears with the addition of 2-ME, demonstrating that AB-SS-AB subunits are formed by disulfide groups from two AB subunits. These disulfide groups may locate in a non-polar interior, which is not accessible to 2-ME when the protein remains its native structure.
研究领域:
植物生物化学
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蛋白质结构与功能
✓ 已验证
DOI
高影响因子
ACS Applied Nano Materials
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2026
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IF 5.8
Qinyang Lin,Huanhuan Tan,Wenrun Li,Yong Li,Juan Li,Yonghong Ran,Qiuping Wang,Yazhen Zhao,Yuhui Hao
Radiotherapy is an essential method for breast cancer treatment, primarily characterized by directly or indirectly damaging tumor cells. However, owing to the high DNA repair mechanism of tumor cells, the therapeutic efficacy of radiotherapy is frequently affected. To address this dilemma, it is of great significance to develop effective radiosensitizers. Herein, we design DSF/Cu3BiS3@SS nanoparticles (DCBSS NPs) to potentiate radiotherapy efficacy for breast cancer via amplification of cuproptosis and apoptosis. This material exhibits several key features: (1) In the tumor microenvironment, DCBSS NPs have pH-responsive properties. (2) Cu2+ leads to the depletion of glutathione, which facilitates the reduction of Cu2+ to Cu+, collectively inducing intracellular Cu+ overload and triggering cuproptosis. (3) The resultant Cu+ catalyzes Fenton-like reactions, generating abundant reactive oxygen species to intensify oxidative stress. (4) The high-Z (Bi) element can enhance radiation energy deposition, effectively induce DNA damage, and further arrest the cell cycle at the radiosensitive G2/M phase, and Cu2+ reacts with DSF to form CuET, together ultimately amplifying apoptosis. In vivo, DCBSS NPs exhibit effective tumor accumulation via the enhanced permeability and retention effect and achieve an excellent antitumor effect when combined with radiotherapy, with excellent biosafety. This study demonstrates a robust radiosensitization strategy for breast cancer but also introduces an innovative way for cancer therapy based on the regulation of cuproptosis and apoptosis pathways.
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2018
·
IF 3.909
Cihui Tian,Sajid Asghar,Yurui Xu,Zhipeng Chen,Jingwei Zhang,Qineng Ping,Yanyu Xiao
Redox-sensitive micelles based onhydrophilic hyaluronic acid-ss-hydrophobic curcumin conjugate were designed as a novel delivery system for gliomas targeting. Furthermore, the obtained micelles were further functionalized with Tween 80 (CUR-THSC) for better brain penetration. Dynamic light scattering experiment and in vitro release study showed that the synthetic disulfide-linked conjugate possessed redox-sensitivity under high glutathione conditions. Spherical micelles with a mean particle size of 74.2 nm, negative zeta potential (−30.25 mV), high entrapment efficiency (94.12%) and drug loading (8.9%) were obtained. XRD analysis of micelles revealed amorphous form of the encapsulated drug. CUR-THSC micelles showed good plasma stability and did not induce any hemolysis in erythrocytes. In addition, highest cytotoxicity in G422 cells was observed compared to the free curcumin group and non-sensitive micelles group. These results indicate that the Tween 80-modified hyaluronic acid-ss-curcumin micelles could emerge as a promising platform for the delivery of curcumin in the treatment of gliomas.
研究领域:
药剂学
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肿瘤学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
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2016
·
IF 4.219
Xinyu Hu,Yongmei Wang,Liangliang Zhang,Man Xu,Wei Dong,Jianfa Zhang
Salecan is a novel water-soluble extracellular β-glucan and possesses excellent physicochemical and biological properties. Here, redox/pH dual stimuli-responsive hydrogel based on Salecan grafted with itaconic acid (IA) and 2-hydroxyethyl methacrylate (HEMA) were prepared using disulfide-functionalized crosslinker N,N - bis (acryloyl)cystamine (BAC) for controlled drug delivery. The introduction of carboxylic groups endows the system with pH-sensitive character, swelling behavior of the hydrogel was conducted by changing the pH and Salecan content. It was demonstrated that DOX was efficiently loaded into the hydrogels and released in a controlled fashion via pH-control and swelling-shrinking mechanism. More importantly, DOX-loaded hydrogels showed dose dependent cytotoxicity toward A549 cell, and efficient cell killing was observed. Furthermore, a key point of this study was that the presence of disulfide linkage in system favored the degradation of hydrogels in the reductive environment. These results highlight the potential of Salecan- g -SS-poly(IA- co -HEMA) hydrogel as a novel system for the controlled release of anti-cancer drugs.
研究领域:
药学
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材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
·
IF 9.4
Yun Ling,Maosheng Zhang,Guokun Liu,Deyin Wu,Jing Tang
Plasmon-mediated chemical reaction (PMCR) is a highly attractive field of research. Here we report in situ surface-enhanced Raman spectroscopic (SERS) monitoring of plasmonic-mediated S S bond-forming reaction. The reaction is thought to be a self-coupling reaction proceeding by photoinduced aromatic S C bond arylation. Surprisingly, the S C arylation and S S coupling are found to be occurred on both partially oxidized silver and silver nanoparticles. The results demonstrated that silver oxide or hydroxide and small molecule donor sacrifice agent played a crucial role in the reaction. This work facilitates the in-situ manipulation and characterization of the active silver electrode interface in conjunction with electrochemistry, and also establishes a promising new guideline for surface plasmon resonance photocatalytic reactions on metal nanostructures with high efficiency.
研究领域:
化学
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材料科学
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光催化
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2023
·
IF 4.2
Chuang Li,Senqing Fan,Jiaojiao Chen,Yu Chen,Mingxia Yang,Jiaxin Meng,Haijie Qing,Yangchao Liu,Zeyi Xiao
An electrocatalytic membrane structured reactor with a stainless steel membrane as the Co3O4 catalyst carrier (Co3O4@SS EMSR) has been fabricated for benzyl alcohol oxidation coupled with hydrogen evolution. The structural characterization shows that the Co3O4 catalyst with the average size of 20 nm has been immobilized in the membrane pores. The electrochemical characterization indicates that the electrochemical active surface area can be increased and faster electron transfer can be achieved. During the process of benzyl alcohol oxidation coupled with hydrogen evolution by Co3O4@SS EMSR via flow-through mode, the benzyl alcohol conversion of 99% and the selectivity of benzoic acid of 97.7% with the Faraday efficiency of 95.9% for benzoic acid production can be achieved. The hydrogen production from the experiments is approximately consistent with the theoretically calculated hydrogen production, and a Faraday efficiency of 99% for hydrogen evolution can be achieved. The cell voltage during benzyl alcohol oxidation coupled with hydrogen evolution under the flow-through mode is reduced by 850 mV, and energy consumption is reduced by 2.03 kWh NmH2–3 under the condition of a current density of 2.6 mA cm–2, compared with those of hydrogen production by water electrolysis with the oxygen evolution reaction.
研究领域:
化学工程
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材料科学
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
PHARMACEUTICAL BIOLOGY
·
2023
·
IF 3.8
Jiake Yu,Shuying Wang,Jie Yang,Wuxinrui Huang,Beikang Tang,Weijun Peng,Jing Tian
Context Zengye decoction (ZYD) has been considered to have a curative effect on Sjogren’s syndrome (SS). However, its therapeutic mechanisms remain obscure.Objectives This research explores the mechanisms of ZYD against SS.Materials and methods The active compounds and targets of ZYD were searched in the TCMSP and BATMAN-TCM databases. SS-related targets were obtained from the GeneCards database. The GO and KEGG enrichment analyses elucidated the molecular mechanisms. Animal experiments were performed using 8 C57BL/6 mice that served as the control group (physiological saline treatment) and 16 NOD mice randomly divided into the model group (physiological saline treatment) and the ZYD group (ZYD treatment) for 8 weeks to verify the therapeutic effects of ZYD on SS.Results Twenty-nine active compounds with 313 targets of ZYD and 1038 SS-related targets were screened. Thirty-two common targets were identified. β-Sitosterol and stigmasterol might be important components. GO analysis suggested that the action of ZYD against SS mainly involved oxidative stress, apoptotic processes, and tumor necrosis factor receptor superfamily binding, etc. KEGG analysis indicated the most significant signaling pathway was apoptosis-multiple species. Animal experiments showed that ZYD improved lymphocytic infiltration of the submandibular glands (SMGs), reduced the serum levels of TNF-α, IL-1β, IL-6, and IL-17, upregulated the expression of Bcl-2, and downregulated the expression of Bax and Caspase-3 in the model mice.Discussion and conclusion ZYD has anti-inflammatory and anti-apoptotic effects on SS, which provides a theoretical basis for the treatment of SS with ZYD.
研究领域:
药理学
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免疫学
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中医药学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF REFRACTORY METALS & HARD MATERIALS
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2021
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IF 3.871
Ke-Han Wu,Yu Wang,Kuo-Chih Chou,Guo-Hua Zhang
The compound carbide of refractory metal had great potential applications in ultra-high temperature, biomedical and nuclear fields. In the present study, a novel method composed of vacuum carbothermal reduction followed by calcium treatment was proposed to synthesize single-phase compound carbide. It was found that the required temperature for the formation of single-phase Ta 4 HfC 5 solid solution in liquid calcium was above 1573 K. Meanwhile, the single-phase binary carbides (NbTaC 2 ), ternary carbides (TiNbTaC 3 , ZrNbTaC 3 ), quaternary carbides (TiHfNbTaC 4 , ZrHfNbTaC 4 ), pentanary carbides (TiZrHfNbTaC 5 ) and hexanary carbides (TiZrHfVNbTaC 6 ) were also synthesized by the current method. The formation mechanism of the single-phase compound carbide was discussed and two parameters T SS (based on the mixing enthalpy change and mixing entropy change) and δ a (based on the difference of lattice parameter) were proposed for predicting the formation ability of solid solution. It was found that the necessary conditions for formation of solid solution by current method were T SS < 1800 K and δ a < 3.2%. In addition, when the value of T SS was lower than 5.5 × 10 3 ·ln(1/ δ a )-19 × 10 3 , the single-phase compound carbides could be easily synthesized.
研究领域:
材料科学
·
化学工程
·
冶金学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）