Cell Death & Disease
·
2017
·Vol. 8
·期 8
·e2988
·
IF 5.965
Yan Siyuan,Liu Ling,Ren Fengxia,Gao Quan,Xu Shanshan,Hou Bolin,Wang Yange,Jiang Xuejun,Che Yongsheng
Deficiency of autophagy has been linked to increase in nuclear instability, but the role of autophagy in regulating the formation and elimination of micronuclei, a diagnostic marker for genomic instability, is limited in mammalian cells. Utilizing immunostaining and subcellular fractionation, we found that either LC3-II or the phosphorylated Ulk1 localized in nuclei, and immunoprecipitation results showed that both LC3 and Unc-51-like kinase 1 (Ulk1) interacted with γ -H2AX, a marker for the DNA double-strand breaks (DSB). Sunitinib, a multi-targeted receptor tyrosine kinase inhibitor, was found to enhance the autophagic flux concurring with increase in the frequency of micronuclei accrued upon inhibition of autophagy, and similar results were also obtained in the rasfonin-treated cells. Moreover, the punctate LC3 staining colocalized with micronuclei. Unexpectedly, deprivation of SQSTM1/p62 alone accumulated micronuclei, which was not further increased upon challenge with ST. Rad51 is a protein central to repairing DSB by homologous recombination and treatment with ST or rasfonin decreased its expression. In several cell lines, p62 appeared in the immunoprecipites of Rad51, whereas LC3, Ulk1 and p62 interacted with PARP-1, another protein involved in DNA repair and genomic stability. In addition, knockdown of either Rad51 or PARP-1 completely inhibited the ST-induced autophagic flux. Taken together, the data presented here demonstrated that both LC3-II and the phosphorylated Ulk1 localized in nuclei and interacted with the proteins essential for nuclear stability, thereby revealing a more intimate relationship between autophagy and genomic stability.
研究领域:
肿瘤学
·
分子生物学
·
细胞生物学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2019
·
IF 5.383
Jinhong Huang,Youhao Liao,Guanjie Li,Ning Xu,Mengqing Xu,Weishan Li
The cyclic stability of traditional poly (vinylidenefluoride- co -hexafluoropropylene) (P(VdF-HFP)) and our newly developed poly (butyl methacrylate-acrylonitrile-styrene) (P(BMA-AN-St)) copolymer-based gel polymer electrolyte (GPE) must still be improved to satisfy the increasingly rigid demands of lithium ion batteries that have higher energy densities . Series ratios of P(VdF-HFP) and P(BMA-AN-St) blended membranes were prepared using an electrospinning method to compensate for the disadvantages of a single copolymer-based membrane. The results showed that the compositions of P(VdF-HFP) and P(BMA-AN-St) had sizeable effects on the physical and electrochemical characterization of GPE, in which the P4 membrane and the GPE blending ratio of P(VdF-HFP): P(BMA-AN-St) = 1: 4 had the best properties. Because the P4 membrane showed the best interconnected pore structure and highest porosity, the GPE exhibited the highest ionic conductivity , with a value of 1.4 × 10 −3 S cm −1 at ambient temperature. Due to the better compatibility of the P4-based GPE with a lithium anode and its considerably electrochemical stability, the LiNi 0.5 Mn 1.5 O 4 /GPE/Li coin cell had an excellent cyclic performance, in which a 98% capacity retention under a 1 C rate was maintained after 150 cycles compared to the coin cell that used a pure P(VdF-HFP)-based GPE that maintained 86% of its discharge capacity under the same test conditions. Furthermore, the acceptable rate characterization of the P4-based GPE was presented with a discharge capacity at a 5 C rate that retained 92% of its counterpart at 1 C .
研究领域:
材料科学
·
电化学
·
储能技术
·
高分子科学
·
锂离子电池
✓ 已验证
DOI
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Gang Xie,Yiping Hao,Yang Bai,Xiangyang Xu,Lv Xia,Ting Huang,Weichao Du,Jingjie Ge
Nano-plugging agents have become the key to efficiently extracting shale gas, which is a clean energy source. Poly(St-(1-Octene)-EGDMA) was synthesized by emulsion polymerization of 1-octene, styrene (St), and ethylene dimethacrylate (EGDMA). Fourier transform infrared spectroscopy, laser scattering, thermogravimetric analysis, scanning electron microscopy (SEM), pressure transfer experiment, and artificial mud cake plugging experiments were used to characterize poly(St-(1-Octene)-EGDMA). The results indicate that poly(St-(1-Octene)-EGDMA) has a particle size of 38.8 nm. After 16 h at 180 °C, the particle size is 49 nm. Based on thermogravimetric analysis, poly(St-(1-Octene)-EGDMA) can tolerate temperatures up to 394 °C, demonstrating excellent high-temperature stability. The rheology of the drilling fluid remains unaltered by poly(St-(1-octene)-EGDMA). With the addition of 2% poly(St-(1-octene)-EGDMA) water-based drilling fluid, the permeability decreased to 2.4 × 10–3 mD and the blocking rate increased to 50%. Simulations are performed with Ansys Fluent 19.2 to verify the experimental results. The potential plugging mechanism of poly(St-(1-Octene)-EGDMA) as a plugging agent was explored. Shale nanopores and nanofractures are invaded by poly(St-(1-Octene)-EGDMA) under pressure. Shale nanopores and nanofractures are plugged by poly(St-(1-Octene)-EGDMA). In water-based drilling fluids, poly(St-(1-Octene)-EGDMA) has a broad range of applications as a possible nano-plugging agent.
研究领域:
材料科学
·
石油工程
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2011
·
IF 2.13
Xiao-Jie Song,Jun Hu,Chang-Chun Wang
Poly(St/DVB/GMA) nanospheres (PNs) were prepared by soap-free emulsion polymerization and the surfaces of the PNs were further functionalized by the thiol-epoxy “click-chemistry” of surface pendant epoxy groups with functional thiols. A variety of functional groups were successfully grafted to the PNs surfaces at high densities as exemplified by the reactions with 2-aminoethanethiol, thioglycolic acid, and 2-mercaptoethanol. All the reactions were easily controlled and the modified polymer nanospheres were well-dispersed in water. Very high surface charges were observed for the 2-aminoethanethiol and thioglycolic acid modified PNs in water, a manifestation of the high surface grafting densities of the ionizable groups. The adsorptions of acid orange and toluidine blue to, respectively, the 2-aminoethanethiol and thioglycolic acid functionalized PNs were examined, which fitted well to the Langmuir isotherm model. For the 2-aminoethanethiol modified PNs, the surface amino group density was found to be 1.1 mequiv/g, with an adsorption capacity of 398 mg/g of acid orange; while the thioglycolic acid modified PNs displayed 1.4 mequiv/g carboxylate groups and an adsorption capacity of 416 mg/g for toluidine blue. The new synthetic method appears to be general in scope and adaptive to a variety of surface functionalities and potential applications.
研究领域:
材料科学
·
化学工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2025
·
IF 6.3
Yazhou Duan,Weihan Tao,Yinchun Fang,Xianfeng Wang
Textiles-based wearable sensors with colorimetric sensing can transform external stimuli to visible color changes, which are ideal for the development of low-cost wearable sensors. Among them, textile-based water-response structural color colorimetric sensors have received wide attention for their pollution-free and eco-friendly characteristics. In this research, poly (styryl-methyl methacrylate-[3-(methylacrylamide) propyl] trimethyl ammonium chloride) (P(St/MMA/MAPTMA)) microspheres with hydrophilic quaternary ammonium salt groups were prepared, which were atomized and deposited on textile fabrics anticipating to prepare textile-based water response colorimetric sensors. P(St/MMA/MAPTMA) microspheres with different particle diameters were obtained by adjusting the mass ratios of the monomers, which were assembled on the fabrics to form different structural colors. These structural colors showed fast water response property to change color when they were wetted by water within 2 s. The P(St/MMA/MAPTMA) microspheres structural colors on the fabrics can return to their original structural colors after drying showing the reversible water responsiveness, which have the promising application prospect of water-response colorimetric sensors. Moreover, the antibacterial rates of these structural colors on fabrics were greater than 98 % showing excellent antibacterial properties. This research shows that this textile-based water-response structural color colorimetric sensors exhibit potential application prospects in the field of water content monitoring, such as the diapers for monitoring the amount of baby’s urine, or the clothing for monitoring the amount of human sweat.
研究领域:
材料科学
·
传感器与传感技术
·
可穿戴电子
·
光子材料
·
智能纺织品
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Yuyang Wu,Xincheng Jiang,Jiangya Ma,Jingbo Wen,Shuang Liu,Hongxia Liu,Huaili Zheng
A kind of starch-based flocculant (starch- graft -poly[(2-methacryloyloxyethyl) trimethyl ammonium chloride], denoted St-g-PDMC-LPUV) has been synthesized by low-pressure ultraviolet initiation and was employed to remove humic acid (HA) for water purification . The physicochemical characteristics of starch and St-g-PDMC-LPUV were characterized by FT-IR, 1 H NMR, XRD, TGA , SEM and BET to confirmed the successful grafting DMC onto starch. Effects of flocculant dosage, pH, the adding amount of Fe 3 O 4 , initial HA concentration and stirring speed were investigated systematically. The prepared St-g-PDMC-LPUV flocculant with non-toxic, biodegradability and environmental friendliness exhibited effective performance for removing HA from water in a wide pH range (5–10). The flocculation mechanism was attributed to the effective collision between function groups of the St-g-PDMC-LPUV flocculant and HA by charge neutralization, adsorption, bridging and patching.
研究领域:
环境科学
·
化学工程
·
材料科学
·
水处理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL PAPERS
·
2021
·Vol. 76
·期 2
·691-700
·
IF 2.097
Zhan Pei,Liang Shengyuan,Li Shi,Hu Jiwen,Lin Shudong,Gui Xuefeng,Liu Cailin
A novel type of poly(St–SSS–APEG) (SAS) copolymer was prepared by graft polymerization with corn starch (St) as the backbone chain and with sodium p -styrene sulfonate (SSS) and allyl polyethylene glycol (APEG-1000) as side chains in aqueous solution. This graft copolymer can serve as an effective dispersing agent for multi-walled carbon nanotubes (MWCNTs) and offers excellent dispersion performance. The primary focus of this investigation was the dispersing behavior of the graft copolymer and the optimization of the ratio between SAS and MWCNTs. For comparisons, poly(St–SSS) (SS) and poly(St–APEG) (SA) were, respectively, synthesized under the same conditions. The structures of SAS, SS, and SA were characterized via Fourier-transform infrared (FT-IR) spectroscopy. The morphologies of corn starch and modified corn starch were characterized by scanning electron microscopy (SEM), while the crystal form of the starch before and after this modification reaction was evaluated by X-ray diffraction (XRD). In addition, the morphology of the dispersed MWCNTs was observed by transmission electron microscopy (TEM). In addition, the dispersion properties and the optimum mass ratio between SAS and MWCNTs were analyzed by zeta potential measurements and ultraviolet–visible–near infrared (UV–Vis–NIR) spectroscopy. It was found that the SAS was more effective in decreasing the aggregative tendency of MWCNTs in water than SS and SA. Graphic abstract
Based on a simple graft polymerization reduction, we have successfully prepared a novel type of poly(St–SSS–APEG) (SAS) copolymer with corn starch (St) as the backbone chain and with sodium p-styrene sulfonate (SSS) and allyl polyethylene glycol (APEG-1000) as side chains in aqueous solution, which can serve as an effective dispersing agent for multi-walled carbon nanotubes (MWCNTs) and offer excellent dispersion performance. It was demonstrated that the dispersion ability of SAS is due to the synergic effects of electrostatic repulsion and steric hindrance.
研究领域:
材料科学
·
高分子化学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
THERMOCHIMICA ACTA
·
2017
·
IF 2.236
Xia Gao,Tianbo Zhao,Guan Luo,Baohui Zheng,Hui Huang,Xue Han,Yuqiao Chai
A facile method was developed for encapsulating paraffin wax with St-DVB-SiO 2 organic−inorganic hybrid shells through the combination of suspension emulsion polymerization and hydrolysis and condensation reaction. In this work, the influence of TEOS/MPS mass ratios on the morphology, particle size distribution (PSD), content of core materials, latent heat storage capacity, thermal conductivity and stability of these microcapsules has been studied. SEM and PSD analysis showed that the fabricated microcapsules had a bowl-like shape with concaves on the shell. Moreover, SEM and TGA results jointly illustrated that the higher amount of MPS incorporated into the experimental process, the more SiO 2 particles bonded on the shell of microcapsules. DSC measurements revealed that the microcapsules had a melting temperature range of 44.36–55.03 °C and latent heat storage capacities of 38.90–95.67 J/g. It was suggested that microencapsulated paraffin wax with St-DVB-SiO 2 hybrid shells has been synthesized successfully.
研究领域:
材料科学
·
化学工程
·
热能存储
✓ 已验证
产品关联
DOI
高影响因子
POWDER TECHNOLOGY
·
2023
·
IF 5.2
Xuan Liu,Jie Gong,Kai Jiang,Xiaojuan Lai,Yu Tian,Kang Zhang
In order to reduce the apparent viscosity of lignite coal water slurries (CWSs) and improve its static stability, a series of three-arm amphiphilic block copolymers have been prepared through RAFT polymerization by using poly(ethylene glycol) methyl ether acrylate (PEGMA) and sodium 4-vinylbenzenesulfonate (SSNa) as hydrophilic monomers and styrene (St) as hydrophobic monomer. The chemical structure of the copolymers has been investigated, and the impact of relative molecular weight, hydrophilic/hydrophobic ratio, and ionic group content on the pulping performance of three-arm amphiphilic block copolymers has been examined. The lignite coal water slurries (CWSs) prepared from the block copolymer tri -P(St 50 - s -SSNa 50 ) 10K - b -PPEGMA 10K exhibit a remarkably low apparent viscosity of 395 mPa·s and excellent static stability when the coal content is at 55 wt% and dispersant content is at 0.5 wt%. Moreover, these CWSs can achieve a maximum pulping concentration of up to 59 wt%. Additionally, the thermogravimetric test reveals insights into the water occurrence in CWSs, indicating that higher levels of free water content correspond to lower apparent viscosities. Suitable hydrophobicity facilitates the removal of internal water from lignite by dispersants, disrupting its flocculation structure and promoting CWSs formation. Meanwhile, the presence of ionic groups enhances the static stability of the resulting CWSs. Furthermore, the adsorption behavior of the three-arm amphiphilic block copolymer dispersant in lignite has been analyzed through XPS testing to elucidate its dispersion mechanism. The use of three-arm amphiphilic block copolymers in preparing lignite CWSs results in lower apparent viscosity and improved static stability, attributed to the amphiphilic and steric hindrance effects of dispersants. This not only expands the application range of lignite CWSs but also highlights the significant potential of this type of dispersant.
研究领域:
聚合物化学
·
材料科学
·
能源工程
·
化工工程
✓ 已验证
DOI
高影响因子
RSC Advances
·
2024
·Vol. 14
·期 25
·17547-17556
·
IF 3.9
Shilei Tang,Shaobin Huang,Pengfei Chen,Zhipeng Wu,Tianyu Zhao
Dredged sediment poses significant challenges for transportation and subsequent treatment due to its high water content and large volume. Coagulation, a common method of dewatering, can significantly enhance the dewatering performance of dredged sediment. This study synthesized a cationic starch-based flocculant [starch-3-chloro-2-hydroxypropyl trimethylammonium chloride (St-CTA)] through etherification for the flocculation dewatering of dredged sediment. The effectiveness and mechanism of St-CTA as a dewatering flocculant for dredged sediment were investigated. The results demonstrated that when the dosage of St-CTA was 12 mg g−1 TSS (total suspended solids), the dehydration property of dredged sediment substantially improved, with the specific resistance to filtration (SRF) decreasing by 93.3%, the capillary suction time (CST) by 93.5%, and the water content of the filter cake (WC) by 9.7%. The removal rate of turbidity of the supernatant from the conditioned dredged sediment reached 99.6%, accelerating the settling speed and effectively capturing and separating fine particles from the sediment. St-CTA significantly increased the median particle size (D50), altered the microstructure and extracellular polymeric substances (EPS) of the flocs, and increased the fractal dimension of the flocs, making them more compact and conducive to the formation of drainage channels. These findings confirm the feasibility of using potentially environmentally friendly St-CTA as a rapid dewatering conditioning agent for sediment.
研究领域:
环境工程
·
水处理
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PHYSICA E-LOW-DIMENSIONAL SYSTEMS & NANOSTRUCTURES
·
2022
·
IF 3.369
Shuai Li,Yuanshu Xiao,Guohua Shan,Xinlei Fan,Mengru Wang,Rui Liu,Lixia Jia
Biomimetic structural colors have demonstrated significant practical promise in eco-friendly coloring. However, the development of novel, simple, and effective methods for the fabrication of photonic crystal structural colors remains an enormous challenge, particularly for flexible substrates . In this work, we prepared structural color coatings with bright, full-color, and low angle dependence on flexible textile substrates via simple vacuum-assisted filtration self-assembly (VAFS). The resultant photonic crystals were polycrystalline structures containing both face-centered cubic (FCC), simple cubic (SC), and amorphous structures (APS), resulting in structural color coatings with bright and low angle dependence. The precise regulation of different hues of structural colors can be achieved by changing the size of microspheres or mixing of microspheres with different sizes. Furthermore, various microspheres (e. g., SiO 2 , SiO 2 @PDA or P (St-MMA-AA)) and fabrics (cotton, linen, silk or wool fabric) can be utilized as self-assembly materials to create structural color coatings, demonstrating the simplicity, low-cost, and great compatibility. Meanwhile, this method may also be applied to the preparation of structural color coatings on substrates with pores, expanding the application of structural colors in various fields.
研究领域:
材料科学
·
纺织工程
·
光学
·
纳米技术
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Wendong Hu,Yingrui Nie,Yang Wang,Pengcheng Gao,Yong Jiang
A facile synthetic route to composite particles with raspberry-like structure was reported, and further led to superhydrophobic and superlipophilic surface by the usage of these composite particles. In this approach, the poly(styrene-co-3-methacryloxypropyl trimethoxysilane) (P(St-MPS)) particles were fabricated by one-step dispersion polymerization . Then, the P(St-MPS)@SiO 2 composite particles with raspberry-like structure were obtained by hydrolysis of tetraethoxysilane (TEOS) with (P(St-MPS)) particles under alkaline conditions. The morphology of the (P(St-MPS))@SiO 2 composite particles could be controlled by adjusting the ratio of the initial reactants 3-methacryloxypropyl trimethoxysilane (MPS) and styrene (St). A possible mechanism of the morphology changes was also discussed, the reactive siloxane groups of the (P(St-MPS)) particles induce the growth of silica generated by the hydrolysis of tetraethoxysilane (TEOS) on its surface to form raspberry-like structure. In addition, the water contact angle (WCA) of the coating was 152° ± 2°, and the oil contact angle (OCA) of the coating was close to 0°, which demonstrated a superhydrophobic and superlipophilic properties by a rational surface modification of this P(St-MPS)@SiO 2 composite particles with raspberry-like structure. Hydrophobic properties could be adjusted by varying the surface morphology of the P(St-MPS)@SiO 2 composite particles. The coatings could be used in applications such as self-cleaning and oil-water separation and whole process was carried out under mild conditions and did not involve complex steps.
研究领域:
材料科学
·
表面化学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）