INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Yuqing He,Wei Gao,Zhijun Zhang,Zhonghe Wang,Shucheng Zhang,Xuemin Kang,Yue Cheng,Bo Cui
Herein, we developed a versatile composite hydrogel by combining two dietary fibres, polydextrose (PDX) and sodium alginate (SA), at varying mass ratios (from 9:1 to 6:4). The microstructure of the prepared hydrogels evolved from an irregular macroporous network to a highly ordered honeycomb-like structure with increasing SA content. Fourier transform infrared spectroscopy and X-ray diffraction analysis revealed that PDX-SA composite hydrogels were formed through ionic cross-linking and hydrogen bonding. The incorporation of SA significantly enhanced the swelling capacity, colloidal stability (indicated by a high negative zeta potential), and water retention capacity (indicated by low syneresis) of the hydrogels while reducing their initial gel strength. The composite hydrogel with a PDX:SA ratio of 6:4 (PDX-SA-4) exhibited optimal overall properties, including a uniform microstructure, high swelling ratio (38.32% at 8 h), and excellent suspension stability (zeta potential: −33.92 mV). Furthermore, anthocyanins (ACNs) were effectively loaded into PDX-SA-4, exhibiting a concentration-dependent release profile in vitro . Notably, in vitro digestion experiments revealed that PDX-SA-ACNs synergistic lipid-regulating hydrogel effectively inhibited lipid digestion. These findings indicate that PDX-SA composite hydrogels, with tunable physicochemical properties, can be used to develop functional foods and delivery systems capable of modulating satiety and inhibiting lipid absorption.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Junzheng Chen,Xue Lv,Xikun Zhang,Huiwen Jia,Yanmin Ma,Wang Xu,Xiaoning Yang,Di Fang,Shurui Yi
Conductive hydrogels are valued for their flexibility and sensitivity for flexible wearable sensors, but they typically focus on strain sensing and lack features such as fast temperature response. In addition, discarded sensors can cause environmental problems. Based on this, we developed a novel G 2 B 3 M 4 hydrogel using NIPAAm, AM, PDA@BN, MXene, and SA to achieve dual response to temperature and strain as well as reuse after disposal. The addition of the copolymerized hydrophilic monomer AM successfully changed the lowest critical solution temperature (LCST) of G 2 B 3 M 4 to approach the normal body temperature. In addition, the excellent dispersion of PDA@BN in the G 2 B 3 M 4 hydrogel not only improved its temperature sensitivity (TCR = −1.953 %/°C) but also resulted in a high stress (730.38 kPa), strain (6994.18 %), elasticity (49.14 kPa) and toughness (2644.17 KJ/m 3 ). In addition, the abundant catechol groups, amino groups and carboxyl groups in G 2 B 3 M 4 hydrogel not only make it have good adhesion to various substrates but also can be used as a template to reduce Ag + to Ag NPs to serve as a catalyst for the efficient degradation of dye wastewater. The hydrogel has good application prospects in the field of flexible sensors.
研究领域:
材料科学
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环境科学
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生物医学工程
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高影响因子
ELECTROCHIMICA ACTA
·
2025
·
IF 5.6
Dianhao Zhao,Ao Wang,Ziyi Wang,Yuchao Wang,Shi Chen,Shiqing Zeng,Min Zhang,Ping Zong
In traditional Si-based anodes, bio-based binders can partially address the inherent drawbacks of silicon anodes. However, plenty of inactive materials hinder the improvement of the electrochemical performance of traditional Si-based anodes. To settle the issues above, sodium alginate (SA)/chitosan (CS) double-network is constructed to design a free-standing Si anode. The two physically cross-linked networks, reinforced by carbon nanotubes (CNTs), form a 3D-structured electrode that firmly anchors Si nanoparticles via forming dynamic hydrogen bonds. Furthermore, the in-situ -reduced copper particles act as the point-like conductive agent, CNTs function as the connecting conductive networks, and SA/CS aerogel sheets serve as the conductive plane, synergistically forming a three-dimensional conductive network (points-lines-planes) around Si particles. This double-network structure effectively alleviates Si volume expansion and endows the free-standing electrode with a high capacity of 1194 mAh/g (based on the whole weight of the electrode) and an excellent capacity retention rate of 85.1% after 100 cycles at 0.5 A/g. This strategy is anticipated to produce high-performance free-standing silicon anodes, therefore supporting lightweight and high-capacity electronics.
研究领域:
材料科学
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电化学
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纳米技术
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DOI
高影响因子
Materials Today Bio
·
2025
·
IF 10.2
Yue Fei,Xiao Wang,Zhichen Ling,Yuran Jiang,Ting Jiang,Lingyan Cao,Jun Wang
Angiogenesis remains a key challenge in pulp regeneration due to the ischemic and hypoxic root canal environment. Apoptotic vesicles (ApoVs) offer unique advantages as a breakthrough strategy due to their stability in hypoxic environments, resistance to immune clearance, and high yield. However, a critical gap persists in biomaterials capable of spatiotemporal ApoVs delivery for pulp regeneration. To address this, an ApoVs-laden silk fibroin/sodium alginate (SF/SA/ApoVs) hydrogel with tunable release kinetics was fabricated. This hydrogel exhibited superior shapeability, injectability, and self-healing properties. SF/SA/ApoVs hydrogel improved angiogenesis by enhancing paracrine functions of dental pulp stem cells (DPSCs), and promoting capillary lumen formation of human umbilical vein endothelial cells via the focal adhesion signaling pathway. It also effectively created an odontogenic and neurogenic inductive micro-environment for pulp-dentin complex formation. Furthermore, in-vivo studies showed that semi-orthotopic transplantation of SF/SA/ApoVs hydrogel accelerated micro-vessels formation, and orthotopic transplantation further confirmed its capacity in generating full-length vascularized pulp tissue with aligned odontoblast-like cells and neuronal extension. Our study pioneers an ApoVs-functionalized hydrogel system with advanced angiogenic potential for promoting pulp regeneration.
研究领域:
生物材料学
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组织工程
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再生医学
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牙体牙髓病学
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生物医学工程
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PubMed
高影响因子
Coatings
·
2025
·Vol. 15
·期 8
·893
·
IF 2.8
Lingling Cui,Yifan Lu,Jun Wang,Haiqin Ding,Guodong Jia,Zhiwei Li,Guang Ji,Dangsheng Xiong
Hydrogels, especially Polyvinyl alcohols, have received extensive attention as alternative materials for articular cartilage. Aiming at the problems such as low strength and poor toughness of polyvinyl alcohol hydrogels in practical applications, an enhancement and modification strategy is proposed. Sodium alginate fibers were introduced into polyvinyl alcohol hydrogel network through physical blending and freezing/thawing methods. The prepared composite hydrogels exhibited a three-dimensional porous network structure similar to that of human articular cartilage. The mechanical and tribological properties of hydrogels have been significantly improved, due to the multiple hydrogen bonding interaction between sodium alginate fibers and polyvinyl alcohol. Most importantly, under a load of 2 N, the friction coefficient of the PVA/0.4SA hydrogel can remain stable at 0.02 when lubricated in PBS buffer for 1 h. This work provides a novel design strategy for the development of high-performance polyvinyl alcohol hydrogels.
研究领域:
生物医学材料
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高分子科学
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组织工程
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材料科学
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机械工程
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Danyang Wang,Yuming Zhou,Xiaoting Wang,Xiaopu Ji,Yiying Wei,Shengdi Tong,Jinghui Hu,Haiqing Song,Zonglei Mou,Guofeng Zhang,Bo Cong,Wan Ru Sun,Pingyu Wang,Yuqiang Zhang,Shuyang Xie,Ranran Wang
Natural conductive hydrogels are regarded as desirable materials for motion monitoring owing to their outstanding biocompatibility and degradability. It has been reported that the occurrence rate of injuries in the final 30 % of the activity is closely associated with fatigue-induced changes in neuromuscular control. However, most hydrogels are designed solely for motion state and electromyography (EMG) detection and do not provide the capability to alleviate muscle fatigue. The development of conductive hydrogels that integrate motion monitoring with fatigue alleviation could enable simultaneous fatigue detection and on-demand fatigue relief, thereby reducing the risk of sports-related injuries. Photothermal therapy has been proven to be an effective method for relieving muscle fatigue. In this study, a double-network hydrogel composed of chitosan and sodium alginate was prepared, which incorporates lignin‑silver nanoparticles (NPs) and melanin NPs to achieve effective motion monitoring and photothermal therapy. A physical cross-linking network formed via electrostatic interactions between chitosan and sodium alginate was reinforced with a Genipin-mediated chemical cross-linking network. The addition of lignin‑silver NPs enhanced the hydrogel's conductivity and mechanical integrity, whereas melanin NPs improved adhesion and conferred photothermal responsiveness. The resulting hydrogel enabled reliable motion monitoring and real-time identification of exercise-induced fatigue through EMG. Upon fatigue detection, the photothermal properties of the hydrogel facilitated rapid fatigue alleviation.
研究领域:
生物材料
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生物医学工程
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可穿戴传感器
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纳米医学
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运动医学
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高分子科学
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FOOD CHEMISTRY
·
2024
·
IF 8.5
Mengyu Liu,Peiying Zhang,Yanwen Wu,Jie Ouyang
To address the challenge of preserving fresh chestnuts, chitosan (CS), hydroxypropyl methylcellulose (HPMC), nisin (N), and sodium alginate (SA) were utilized in the preparation of a bilayer edible film named CS-HPMC-N/SA, which was compared to the monolayer films CS-HPMC and CS-HPMC-N. In comparison to the CS-HPMC film, the CS-HPMC-N and CS-HPMC-N/SA films exhibited increased water vapor permeability (WVP), oxygen permeability, and thickness, while transparency, tensile strength (TS), and elongation at break (EAB) were reduced. The bilayer film CS-HPMC-N/SA showed higher WVP, transparency, thickness, and EAB, but lower TS than the monolayer film CS-HPMC-N. The chestnuts coated with CS-HPMC-N/SA showed lower respiratory intensity and decay rate compared to those coated with CS-HPMC and CS-HPMC-N. These results suggested that the bilayer film CS-HPMC-N/SA, containing nisin, has potential as an edible material for preserving fresh chestnuts.
研究领域:
食品科学
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材料科学
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农业工程
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CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Gangrong Wang,Zhuo Chen,Xin Jing,Xijian Yi,Jian Zou,Peiyong Feng,Hailiang Zhang,Yuejun Liu
Although conductive hydrogels have been widely developed currently, their low sensitivity and poor stability severely limited their practical application in flexible wearable devices. Herein, a green “stencil” anchoring strategy was proposed in this study to engineer an ultra-stable and supersensitive hydrogel by virtue of polydopamine decorating sodium alginate molecular chains as “stencil” to anchor polyaniline as conductive component. The dispersion of polyaniline was significantly improved by the sodium alginate “stencil” in the conductive hydrogel. The developed conductive hydrogel exhibited outstanding properties that outperformed most conventional ones, including extraordinary sensitivity with a gauge factor of 38.2 and excellent stability with negligible shifting upon long-term cyclic stretching. Moreover, the conductive hydrogel displayed great self-adhesion and reliable self-healing performance endowed by its abundant catechol groups, hydrogen bondings and π-π stackings, respectively. Furthermore, the prepared hydrogel was also assembled as flexible strain and self-powered sensors, which displayed excellent sensing performance, indicating great potential in human-machine interactions, information transmission and road transportation.
研究领域:
材料科学
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生物医学工程
·
柔性电子
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PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Nan Wang,Jie Tian,Linlin Wang,Chen Song,Chengrong Wen,Yinghuan Fu,Shuang Song
Developing sodium alginate (SA)/chito-oligosaccharide (COS) beads with antibacterial properties is highly appealing for food industrial applications. Herein, in this paper, the different viscosity-average molecular weight of SA/COS polyelectrolyte (SCP) gel beads were prepared by adding a low concentration of calcium ions (Ca 2+ ) as crosslinker and their size, mechanical property, microscopic morphology, elemental composition, and thermal stability of the gel beads were characterized. Furthermore, the morphological changes of gel beads in in vitro simulated digestion were investigated. A time-dependent co-culture assay was used to explore the antibacterial effect of gel beads on Staphylococcus aureus and Escherichia coli . The results showed that as the viscosity-average molecular weight (M v ) of SA decreased, the bursting strength faded, the thermal stability decreased, and the swelling index increased. Similarly, increasing the Ca 2+ content could also regulate the characteristics of the gel beads, such as diminishing size, increasing the bursting strength, making the surfaces rough, and producing the network structure in the cross-section. In addition, Ca 2+ competes with COS in cross-linking with the carboxyl groups of SA, which leads to a decrease in the content of N element on the surfaces of the gel beads and to a weakening of the antibacterial effect. After the addition of COS, the gel beads obtained antimicrobial effects and a denser cross-sectional structure. The present study could provide a theoretical basis for the design and development of novel gel foods in the food industry.
研究领域:
食品科学
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材料科学
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生物技术
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DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Lingxiao He,Ning Ma,Zhengyun Liang,Sidan Zhao,Jiaming Yan,Hanchen Lin,Chaoqun You,Lingchao Cai,Fei Wang
Matrine is a type of alkaloid found in plants, exhibiting a wide range of biological and pharmacological activities. The process of separating and purifying matrine poses challenges due to its low concentration and frequent presence in mixtures during raw extraction. This work aims at synthesizing suitable adsorbents for efficient separation and purification of matrine from plant materials. The sulfonated cellulose nanocrystals/sodium alginate beads (SCNCs/SA) were synthesized by the ionic gelation method, characterized and investigated for the adsorption of matrine from water. The equilibrium adsorption capacity of SCNCs/SA beads for matrine at 298 K was approximately 55.66 mg/g. The adsorption enthalpy, entropy, and free energy of matrine on the SCNCs/SA beads were evaluated, indicating that the adsorption process was spontaneous, exothermic, and primarily driven by physisorption. 95 % of the adsorption equilibrium could be achieved within 60 min, and approximately 20 bed volumes of an 80 % (v/v) ethanol aqueous solution for effective recovery. The adsorption isotherms are analyzed using both Langmuir and Freundlich models, the kinetic of adsorption using the pseudo-first-order and pseudo-second-order models, and the breakthrough curves using four breakthrough models. These results suggested that the rapid adsorption and effortless regeneration render SCNCs/SA beads as promising adsorbents for the efficient adsorption and separation of matrine from plants.
研究领域:
材料科学
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药学
·
植物化学
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DOI
高影响因子
Food Chemistry-X
·
2024
·
IF 6.5
Qian Zhang,Yu-Qiao Wang,Lin Li,Hao-Lin Song,Hai-Tao Wu,Bei-Wei Zhu
Salidroside (Sal), the main bioactive substance in Rhodiola rosea , is a promising functional food component with a wide range of pharmacological effects, but its biological activity is challenging to sustain due to its short half-life, low oral bioavailability, and susceptibility to environmental factors. The aim of this study was to investigate the effect of sodium alginate (SA) concentration on the construction of W/O/W emulsion in the protection of Sal. With the escalation of SA concentrations, the range of droplet size distribution was smaller and the droplets were more uniform. When the concentration of SA was 2 %, the average droplet size reached 9.1 ± 0.1 μm, and the encapsulation efficiency of Sal was 77.8 ± 1.8 %. Moreover, the double emulsion with 2 % SA was the most stable for 28 days at 4 °C since the oil droplets were embedded in the network structure of SA.
研究领域:
药学
·
食品科学
·
材料科学
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Ruihao Wang,Qian Li,Xiyan Sun,Xinyu Jia,Shuxian Li,Li Wei,Xitong Sun
In this work, a new biomass boron adsorbent of N -methyl-D-glucosamine embedded sodium alginate/polyethyleneimine/polysiloxane composite aerogel (SKPN) was reported. Relevant characterization proved that the aerogel exhibited 3D porous structure with plenty of hydroxyl and amino functional groups, which was beneficial to the diffusion of boron and the chelation between boron and SKPN. Various parameters affecting the adsorption performance including pH value, contact time initial concentration, temperature and reusability were investigated. The maximum adsorption capacity was found at pH 8.0, and the adsorption capacity reached equilibrium within 3.75–5.75 h. Adsorption kinetics were more in line with the pseudo-second order kinetic model, suggesting the predominance of chemisorption. The adsorption isotherm was more in line with the Langmuir model, and the maximum adsorption capacities were calculated up to 38.41–49.39 mg/g (3.55–4.57 mmol/g) within the temperature range of 298 to 318 K, which were higher than most of the previous works. In addition, SKPN still showed good resistance to external ion interference and good reusability. The adsorption mechanism proved that the chelation interactions between boron and cis-diol and amino groups were the main driving forces. These results instructed that the adsorbent exhibited a good application prospect for boron adsorption, with the advantages of high adsorption performance, simple preparation process and environmental friendliness.
研究领域:
环境科学
·
材料科学
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高影响因子
危险品化学品经营许可证（带存储）