COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2023
·
IF 5.2
Asim Mushtaq,Xuehua Ma,Jabeen Farheen,Xiaoqing Lin,Muhammad Tayyab,M. Zubair Iqbal,Xiangdong Kong
Magnetic hydroxyapatite nanocomposites are promising candidates for various biomedical applications. However, the uncontrolled growth with the unfavorable size limits their widespread utilization in real-time applications. Herein, a facile method was utilized to fabricate uniform spherical-shaped nanocomposites of manganese oxide combined hydroxyapatite (Mn 3 O 4 -HAp) with an average size of about 28 nm. The structural characterization reveals the presence of Mn 3 O 4 in the crystalline phase, confined by HAp to give a composite structure. The biocompatibility and drug loading capability of Mn 3 O 4 -HAp nanocomposites are improved by surface modification using Food and Drug Administration-approved triblock copolymer Pluronic® F-127, followed by folic acid (FA) for targeting ability. Taking advantage of the surface properties of the polymer and the drug delivery potential of HAp, metformin was encapsulated in the prepared nanocomposites with a loading capacity of 98 %. The prepared nanocomposites indicate promising cell viability up to 87 % and an excellent drug release profile in an acidic atmosphere. Moreover, the magnetic component Mn 3 O 4 presents auspicious T 1 -Magnetic resonance imaging with notable r 1 relaxivity of 2.166 mM −1 s −1 . Further, the Mn 3 O 4 [email protected] nanocomposites demonstrate good cellular uptake and excellent reactive oxygen species (ROS) production under low-intensity UV irradiation , resulting in a remarkable photodynamic therapeutic effect. The results showed that the designed Mn 3 O 4 -HAp nanocomposites are promising targeted chemo-theranostic agents.
研究领域:
生物医学工程
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纳米技术
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材料科学
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癌症治疗
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医学影像
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产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2020
·
IF 0
Chen Bai,Pengcheng Hu,Nianlong Liu,Guodong Feng,Di Liu,Yi Chen,Ming Ma,Ning Gu,Yu Zhang
To elevate the accurate diagnosis of tumors, nanomaterial-based magnetic resonance imaging (MRI) contrast agents are being rapidly developed. In this paper, we report the large-scale synthetic method of Fe3O4 nanoparticles by high-temperature thermal decomposition and their application as time-dependent T1–T2 dual-modal MRI contrast agents in rabbit hepatic tumors. The Fe3O4 nanoparticles are modified with bull serum albumin (BSA), which provides excellent biocompatibility and colloidal stability. These nanoparticles also exhibit a high r1 value of 6.99 mM–1 s–1 and a low r2 value of 24.11 mM–1 s–1 at a clinically relevant magnetic field (3.0 T). In in vivo experiments, after intravenous administration with these nanoparticles, the rapid T2-weighted effect can be acquired within 5 min and the slow T1 contrast enhancement at the tumor site appears at 90 min. The explanation of this phenomenon is possibly due to the different accumulation rates and states of the nanoparticles in different tissues. In normal liver tissue, the nanoparticles can be quickly phagocytosed by a reticuloendothelial system and accumulated in the liver. These accumulated nanoparticles aggregate, improving the T2-weighted effect and reducing the T1-weighted effect. However, because of an enhanced permeation and retention effect, the nanoparticles are delivered into tumor tissue gradually and dispersedly, which takes a longer time to generate the T1-weighted effect at the tumor site. In summary, these Fe3O4 nanoparticles have significant potential to improve the diagnostic accuracy and sensitivity in MRI.
研究领域:
纳米技术
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医学成像
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生物医学工程
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癌症研究
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药理学
✓ 已验证
产品关联
DOI
Journal of Materials Chemistry B
·
2016
·Vol. 5
·期 5
·1108-1116
·
IF 4.872
Zhe Yang,Jinghua Ren,Zhilan Ye,Wei Zhu,Liji Xiao,Li Zhang,Qianyuan He,Zushun Xu,Haibo Xu
Polypyrrole nanoparticle (PPy) based theranostic agents for magnetic resonance imaging (MRI) guided photothermal therapy (PTT) have received increasing attention in recent years. However, the limitations of cost and biocompability still offer us opportunities to improve these agents. Considering the versatile character of polydopamine (PDA), PEGylated PPy@Fe3+-chelated PDA nanocomposites (PPDEs) were designed and prepared in an easy way. PPDE with a uniform core–shell structure could be obtained by adjusting the ratio of dopamine and PPys. In this nanocomplex, the shells confer the nanoparticles with good biocompability and MRI signal enhancing ability. Moreover, the PPy cores play a role in photothermal ablation of tumors. Compared with pure PDA nanoparticles, the PPDEs have higher NIR absorbance and better photothermal capability benefitting from the high photothermal conversion of the cores. Additionally, the obtained PPDEs provide significant MRI signal enhancement for both in vitro and in vivo imaging with high longitudinal relaxivity (r1 = 5.055 mM−1 s−1). After intravenous injection, the PPDEs exhibited valid tumor accumulation, as revealed by MRI and verified by biodistribution analysis. Under NIR irradiation, the PPDEs showed highly effective photothermal ablation of 4T1 cells. Notably, excellent biocompability of the PPDEs was confirmed by a relevant MTT assay and histologic analysis. This work achieved an example of exploiting the inherent advantages of PPy and PDA within a single unit and exploring its potential for T1 MRI-guided PTT.
研究领域:
材料科学
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生物医学工程
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纳米技术
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癌症治疗
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磁共振成像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2022
·
IF 10.753
Tao Zhang,Shuang-yan Xu,Hui Lin,Jian Yang,Zhuo-qun Zhao,Damià Barceló,Hua-bao Zheng
Tylosin is widely used in livestock; however, the release of tylosin through animal manure can cause serious environmental problems. In this study, a new tylosin-degrading strain, TYL-T1, was isolated. Its phylogenetic similarity to Klebsiella oxytoca was found to be 99.17 %. TYL-T1 maintained good growth at 40 °C over a broad pH range (4.0–10). TYL-T1 degraded 99.34 % of tylosin in 36 h under optimal conditions (tylosin initial concentration: 25 mg/L, pH: 7.0, and temperature: 35 °C). After LC-MS-MS analysis, a new degradation pathway for tylosin was proposed, including ester bond breaking of the macrolide lactone ring, redox reaction, and loss of mycinose and mycarose. Based on a transcriptome analysis, 164 genes essential for degradation were upregulated through hydrolysis and redox of tylosin. Among various transferases, lipopolysaccharide methyltransferase, glycogen glucosyltransferase, and fructotransferase were responsible for tylosin degradation. The present study revealed the degradation mechanism of tylosin and highlighted the potential of Klebsiella oxytoca TYL-T1 to remove tylosin from the environment.
研究领域:
环境科学
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微生物学
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药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL MICROBIOLOGY
·
2025
·
IF 2.3
Ma Yujun,Wang Jihong,Leng Su
The microbial degradation of tetracycline (TC) represents an effective bioremediation method. An effective TC-degrading strain of Cladosporium colombiae T1 was isolated from chicken manure using enrichment techniques. Response surface methodology was employed to ascertain the optimal conditions for removing TC by strain T1, identified as a temperature of 40.00 °C, solution pH of 6.92, TC concentration of 42.99 mg/L, and inoculum dose of 1.98%. The inhibitory effect of TC degradation products on Escherichia coli was investigated using the paper diffusion method. The results demonstrated that the toxicity of TC degradation products by T1 was lower than that of the parent compound. The shake-flask batch experiments showed that the biodegradation of TC was a synergistic effect of intra- and extracellular enzymes, with intracellular enzymes exhibiting greater efficacy in TC degradation (48.56%). LC–MS analysis identified ten potential biodegradation products, and biodegradation pathways were proposed. This study offers a theoretical foundation for the characterization and mechanistic investigation of TC degradation in the environment by Cladosporium colombiae T1. Graphical
研究领域:
环境科学
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微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Bio Materials
·
2023
·
IF 4.7
Dan Zhao,Shibo Peng,Hanzhang Xiao,Qilong Li,Yahong Chai,Hongxia Sun,Ruping Liu,Li Yao,Lin Ma
Iron oxide nanoparticles (IONPs) have been developed as contrast agents for T1- or T2-weighted magnetic resonance imaging (MRI) on account of their excellent physicochemical and biological properties. However, general strategies to improve longitudinal relaxivity (r1) often decrease transverse relaxivity (r2), thus synchronously strengthening the T1 and T2 enhancement effect of IONPs remains a challenge. Here, we report interface regulation and size tailoring of a group of FePt@Fe3O4 core–shell nanoparticles (NPs), which possess high r1 and r2 relaxivities. The increase of r1 and r2 is due to the enhancement of the saturation magnetization (Ms), which is a result of the strengthened exchange coupling across the core–shell interface. In vivo subcutaneous tumor study and brain glioma imaging revealed that FePt@Fe3O4 NPs can serve as a favorable T1–T2 dual-modal contrast agent. We envision that the core–shell NPs, through interface engineering, have great potential in preclinical and clinical MRI applications.
研究领域:
生物医学工程
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材料科学
·
影像医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2023
·Vol. 11
·期 12
·4359-4369
·
IF 6.6
Yuting Jiang,Haojie Gu,Zhongyuan Cai,Shengxiang Fu,Yingzi Cao,Lingling Jiang,Changqiang Wu,Wei Chen,Chunchao Xia,Su Lui,Bin Song,Qiyong Gong,Hua Ai
Gadolinium (Gd)-based contrast agents (CAs) for clinical magnetic resonance imaging are facing the problems of low longitudinal relaxivity (r1) and toxicity caused by gadolinium deposition. Manganese-based small molecule complexes and manganese oxide nanoparticles (MONs) are considered as potential alternatives to Gd-based CAs due to their better biocompatibility, but their relatively low r1 values and complicated synthesis routes slow down their clinical translation. Herein, we presented a facile one-step co-precipitation method to prepare MONs using poly(acrylic acid) (PAA) as a coating agent (MnO2/PAA NPs), which exhibited good biocompatibility and high r1 values. A series of MnO2/PAA NPs with different particle sizes were prepared and the relationship between the particle size and r1 was studied, revealing that the MnO2/PAA NPs with a particle size of 4.9 nm exhibited higher r1. The finally obtained MnO2/PAA NPs had a high r1 value (29.0 Mn mM−1 s−1) and a low r2/r1 ratio (1.8) at 1.5 T, resulting in a strong T1 contrast enhancement. In vivo magnetic resonance angiography with Sprague-Dawley (SD) rats further proved that the MnO2/PAA NPs showed better angiographic performance at low-dosage administration than commercial Gadovist® (Gd-DO3A-Butrol). Moreover, the MnO2/PAA NPs could be rapidly cleared out after imaging, which effectively minimized the toxic side effects. The MnO2/PAA NPs are promising candidates for MR imaging of vascular diseases.
研究领域:
医学影像学
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纳米医学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL RESEARCH
·
2023
·
IF 8.3
Liao Qiuling,Yu Qilin,Yu Cheng,Zhang Minping,Wang Kangning,Xiao Enhua
The use of multiparametric magnetic resonance imaging (MRI) to distinguish complex histopathological changes in liver fibrosis has not yet been systematically established. The purpose of this study is to gauge the efficacy of a cutting-edge MRI platform for evaluating ecotoxicologically hazardous carbon tetrachloride (CCl 4 ) induced liver fibrosis, while also scrutinizing the relationship between MRI and its histopathological features. Thirty-six mice were randomly divided into 6 groups, each with 6 mice. Control mice received an intraperitoneal injection of olive oil, while the experimental mice received different doses of intraperitoneal injection of CCl 4 . Both sets underwent this process twice per week over a duration of 5 weeks. MRI measurements encompassed T1WI, T2WI, T1 mapping, T2 mapping, T2* mapping. Liver fibrosis and inflammation were assessed and classified using Metavir and activity scoring systems. CCl 4 successfully induced liver fibrosis in mice, showing an increasing extent of liver fibrosis and liver function damage with the increasing dosage of CCl 4 . Compared with the control group, T1, ΔT1, and T2 in the experimental group were considerably elevated (P < 0.05) than those in the control group. Spearman's correlation showed that the correlation of Native T1 and △T1 with fibrosis (r = 0.712, 0.678) was better than with inflammation (r = 0.688, 0.536). T2 correlation with inflammation (r = 0.803) was superior to fibrosis (r = 0.568). ROC analysis showed that the AUC of Native T1 was highest (0.906), followed by ΔT1 (0.852), while the AUC increased to 0.945 when all relevant MRI parameters were combined. T1 is the most potent MRI parameter for evaluating CCl 4 -induced liver fibrosis, followed by ΔT1. Meanwhile, T2 may not be suitable for evaluating liver fibrosis but is more suitable for evaluating liver inflammation.
研究领域:
医学影像学
·
毒理学
·
肝脏病学
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Chuyao Chen,Cong Huang,Jiamin Liu,Jia Tao,Yuying Chen,Kan Deng,Yikai Xu,Bingquan Lin,Peng Zhao
The imaging resolution of magnetic resonance imaging (MRI) is influenced by many factors. The development of more effective MRI contrast agents (CAs) is significant for early tumor detection and radical treatment, albeit challenging. In this work, the Hofmeister effect of Fe2O3 nanoparticles within the tumor microenvironment was confirmed for the first time. Based on this discovery, we designed a nanocomposite (FePN) by loading Fe2O3 nanoparticles on black phosphorus nanosheets. After reacting with glutathione, the FePN will undergo two stages in the tumor microenvironment, resulting in the robust enhancement of r1 and r2 based on the Hofmeister effect in the commonly used magnetic field (3.0 T). The glutathione-activated MRI signal of FePN was higher than most of the activatable MRI CAs, enabling a more robust visualization of tumors. Furthermore, benefiting from the long circulation time of FePN in the blood and retention time in tumors, the synergistic therapy of FePN exhibited an outstanding inhibition toward tumors. The FePN with good biosafety and biocompatibility will not only pave a new way for designing a common magnetic field-tailored T1–T2 dual-mode MRI CA but also offer a novel pattern for the accurate clinical diagnosis and therapy of tumors.
研究领域:
医学影像学
·
纳米医学
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2026
·
IF 5.9
Manman Xie,Yusong Peng,Cong Zhang,Jiahui Xu,Buhui Liu,Christopher J. Butch,Yiqing Wang
Magnetic resonance imaging (MRI) is crucial for visualizing soft tissues and organs. Although gadolinium-based contrast agents (Magnevist, Gd-DTPA), which are commonly used in clinical MRI, their safety and resolution are still limited in practical applications. Herein, we present the preparation of exceedingly small amorphous iron oxide nanoclusters (ES-AIONCs) with properties characteristic of amorphous, exhibiting enhanced T 1 MRI contrast (r 1 = 8.1 mM −1 s −1 ) than that of Gd-DTPA (r 1 = 3.9 mM −1 s −1 ) under the 7 T magnetic field. The high r 1 value of ES-AIONCs enables them to increase the T 1 -weighted MRI signal in the murine model of xenograft tumors by 64.7%, which is even a little higher than the value of Gd-DTPA (52.3%) at 7 T MRI instrument. Additionally, the stability of the ES-AIONCs towards biodegradation, is significantly reduced, leading to rapid breakdown and clearance when administered intravenously. This combination of properties directly addresses two outstanding needs in T 1 magnetic resonance imaging: the need for increased MRI resolution and the need to avoid bioaccumulation of imaging nanoparticles for reasons related to both patient safety and quality of future images.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2021
·Vol. 56
·期 12
·7386-7396
·
IF 4.22
Zhou Weixiu,Shen Jiyun,Lin Jiaomin,An Miao,An Lu,Tian Qiwei,Yang Shiping
Gd–chelate magnetic resonance imaging (MRI) contrast agents used in conventional clinical medicine still have some shortcomings, such as their low relaxation rates and poor imaging sensitivity. In this work, a Gd–chelate (Gd–DTPA), with a comparison made to the commercial contrast agent Magnevist was loaded into a zeolitic imidazolate framework (ZIF-8) to construct the efficient T 1 MRI contrast agent Gd–DTPA@ZIF-8. At 0.5 T, the longitudinal relaxivity value ( r 1 ) of Gd–DTPA@ZIF-8 reaches 29.60 mM −1 s −1 , which is about 6 times higher than that of Gd–DTPA. In terms of the retention of Gd–DTPA in ZIF-8, no obvious Gd 3+ ions are released in water and complete culture solution over a long time period. Haemolysis and cytotoxicity experiments revealed that Gd–DTPA@ZIF-8 has good biocompatibility. In addition, the in vivo MRI results prove that Gd–DTPA@ZIF-8 can significantly enhance the T 1 -weighted MRI contrast effect of the tumour site. These advantages make Gd–DTPA@ZIF-8 a potential candidate for biomedical applications.
研究领域:
医学影像学
·
材料科学
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
Materials
·
2021
·Vol. 14
·期 9
·2238
·
IF 3.623
Xiaoming Cao,Liyuan Gu,Shike Hu,Aiman Mukhtar,Kaiming Wu
A lot of nanomaterials are using T1-T2dual mode magnetic resonance (MR) contrast agents (CAs), but multilayer nanowire (NW) with iron (Fe) and manganese (Mn) as T1-T2dual modal CAs has not been reported yet. Herein, we synthesized a Fe/Mn multilayer NW with an adjustable Fe layer, as T1-T2dual-mode CAs. The relaxation performance of Fe/Mn multilayer NW was studied at 1.5 T. Results show that, when the length of the Fe layer is about 10 nm and the Mn is about 5 nm, the r1value (21.8 mM−1s−1) and r2value (74.8 mM−1s−1) of the Fe/Mn multilayer NW are higher than that of Mn NW (3.7 mM−1s−1) and Fe NW (59.3 mM−1s−1), respectively. We predict that our Fe/Mn multilayer NW could be used as T1-T2dual mode MRI CAs in the near future.Keywords:dual modal;MRI;CAs;nanowire;relaxation
研究领域:
医学影像学
·
材料科学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）