ELECTROCHIMICA ACTA
·
2018
·
IF 5.116
Min Yao,Yao Meng,Xiang Mao,Xingming Ning,Zhen Zhang,Duoliang Shan,Jing Chen,Xiaoquan Lu
The porphyrin aggregate is recognized as an attractive candidate for developing artificial light-harvesting systems. Using 5, 10, 15, 20-tetrakis-(4-carboxyphenyl) porphyrin (TCPP), the porphyrin aggregates with different morphologies (sphere, rod and flake) are controllably prepared by the surfactant-assisted self-assembly reaction, and then synthesize the ternary bionic-system (e.g. porphyrin composites). These composites are characterized by scanning-electron microscopy (SEM), atomic force microscope (AFM) and spectroscopic technology. The combinatorial technique consisted of ultraviolet–visible spectroscopy and scanning electrochemical microscopy (UV–vis/SECM) is used to record SECM approach curves of porphyrin photocatalysis under visible light illumination at the specific zones, where morphology-dependent porphyrin composite is recognized to be distributed evenly on ITO surface. Heterogeneous photoelectron transfer rates ( k eff ) are given by simulating SECM approach curves. It is suggested that rod-like porphyrin aggregate composite has highest photocatalytic efficiency with the kinetics rate to be 8.624 × 10 −2 cm s −1 , the largest k eff of which is obtained at the excitation wavelength of 469 nm. These findings are also proved by photocatalytic decomposition test of pollutants (methyl orange). It is indicated that one-dimensional nanostructure is advantageous for separation of electrons and holes and directional transmission of photoelectron.
研究领域:
化学
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材料科学
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环境科学
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DOI
高影响因子
Tungsten
·
2024
·
IF 5.6
Sun Xin-Ran,Yuan Hao-Ming,Zhang Guo-Da,Wang Chao,Sun Shu-Juan,Shi Peng-Fei
The combination of photodynamic therapy (PDT) and chemodynamic therapy (CDT) in tumor treatment has attracted considerable attention. However, tumor hypoxia and glutathione (GSH) overproduction in the tumor tissue restricted the progress of their applications. Herein, a Mn-porphyrinic metal–organic framework (Mn-TCPP) was constructed by the one-pot method and further used for immobilizing glucose oxidase (GOx) to obtain GOx@Mn-TCPP. GOx would rapidly exhaust endogenous glucose into hydrogen peroxide (H 2 O 2 ) and gluconic acid, thus shutting off the energy supply of tumor cells for starvation treatment. Mn-TCPP catalyzed H 2 O 2 to produce oxygen, regulating the hypoxic tumor microenvironment and in turn improving 1 O 2 generation under laser irradiation. Interestingly, Mn-TCPP can reduce reactive oxygen species consumption owing to the redox reaction between Mn 3+ and GSH, thus greatly enhancing PDT. Furthermore, benefiting from GOx-mediated starvation therapy, Mn 2+ produced by Mn 3+ reduction can react with sufficient intracellular H 2 O 2 to generate ·OH with high cytotoxicity through a Fenton-like reaction. After treatment by GOx@Mn-TCPP under laser irradiation in vitro, the cell viability of 4T1 and A549 tumor cells reached to 20%, reflecting GOx@Mn-TCPP could give full play to the advantages of PDT/CDT/starvation therapy. The results in vivo demonstrated that GOx@Mn-TCPP mediated synergistic cascade therapy could significantly inhibit tumor growth and improve the therapeutic effect.
研究领域:
肿瘤学
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生物医学工程
·
纳米医学
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DOI
高影响因子
Advanced Therapeutics
·
2023
·
IF 4.6
Lihua Wu,Yue Luo,Hu Wei,Shuilin Wu,Yufeng Zheng,Zhaoyang Li,Zhenduo Cui,Yanqin Liang,Shengli Zhu,Jie Shen,Xiangmei Liu
Bismuth metal–organic frameworks (MOFs) as catalysts are scarce. Herein, the first MOF comprising meso- tetra(4-carboxyphenyl) porphine (TCPP) as an organic ligand and Bi ion as a metal node, denoted as Bi-TCPP, is synthesized by a convenient one-step hydrothermal method. Compared to other 2D (Cu-TCPP) or 3D (PCN-222) MOFs with TCPP as a ligand, Bi-TCPP has ultrafast singlet oxygen generation ability and a high photothermal conversion efficiency of 49.5% under the irradiation of 660 nm light. This is due to Bi-TCPP's strong ligand-to-metal charge transfer (LMCT) events that form singlet oxygen ( 1 O 2 ). Further, when the electrons and holes above the bandgap relax to the band edge, the excess energy is converted into heat. In vitro and in vivo experiments show excellent antibacterial and repair effects. Hence, the synthesis of Bi-TCPP provides new ideas for the study of rare bismuth-based MOFs, and its excellent biocompatibility provides a possibility for further application.
研究领域:
材料科学
·
化学
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生物医学工程
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DOI
高影响因子
Nano Research
·
2020
·Vol. 14
·期 3
·660-666
·
IF 8.183
Hang Lifeng,Zhang Tao,Wen Hua,Liang Lianbao,Li Wuming,Ma Xiaofen,Jiang Guihua
Photodynamic therapy (PDT) is a widely-used technology for cancer therapy, but conventional photosensitizers still face some drawbacks, such as hydrophobicity, inadequate pharmacokinetics, low cell/tissue specificity, and uncontrollable photodynamic performance during the therapeutic process. Herein, we present a controllable photodynamic performance based on two-dimensional metal-organic frameworks (2D Zn-TCPP MOF) that displayed a week PDT effect under a neutral environment upon exposure to a 660 nm laser due to the degeneracy of Q bands of TCPP. However, the 2D Zn-TCPP MOF showed a significantly enhanced PDT effect in an acidic environment under irradiation with a 660 nm laser due to the released TCPP from decomposed MOF structure. From the in vitro outcomes, the 2D Zn-TCPP MOF showed controllable photodynamic performance from neutral to acidic environments. Due to the acidic tumor microenvironment, the 2D Zn-TCPP MOF presented the strongest antitumor effect in vivo under irradiation with a 660 nm laser. This work offers a promising strategy to develop a next-generation photosensitizer.
研究领域:
生物医学工程
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癌症治疗研究
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材料科学
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DOI
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2022
·Vol. 38
·期 6
·1356-1360
·
IF 2.726
Wang Yitong,Meng Fanchen,Su Ruifa,Sun Changrui,Han Qianqian,Zhang Weina,Zhang Suoying
Metal-organic frameworks(MOFs) have been widely regarded as promising carriers for enzyme immobilization owing to their advantages in improving loading and regulating interaction with enzymes. However, they are still suffering from the problems of slow mass transfer and compromising activity. In this paper, the active two-dimensional(2D) MOF of Cu-TCPP(Fe)[TCPP=tetrakis(4-carboxy-phenyl)porphyrin], which possesses the biomimetic architecture of peroxidase, was adopted to anchor cytochrome(Cyt c) for the enhancement of catalytic activity. The atomic/nanometer thickness and micrometer lateral dimension of 2D MOFs can ensure the full exposure of immobilized enzymes and a shorter diffusion distance for the reactant molecules. Besides, the active carrier can provide synergistic catalysis and activity compensation during the reaction. When tested in the decomposition reaction of H 2 O 2 , Cyt c/Cu-TCPP(Fe) exhibited nearly twice catalytic activity and an accelerated catalytic rate compared to free Cyt c.
研究领域:
生物化学
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材料科学
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Xinyi Guo,Mengmeng Wang,Danyang Qu,Hao Cui,Jiajing Gong,Qinglin Shen,Yang Han,Xingqi Pan,Zhenbao Liu,Meilin Shi
Sonodynamic therapy (SDT) offers a noninvasive strategy for tumor ablation through ultrasound-activated sonosensitizers that generate reactive oxygen species (ROS); however, its therapeutic efficacy is often limited by tumor hypoxia. Herein, we report the rational design of a multifunctional theranostic nanoplatform, HA-MnO2-TCPP nanoflowers, that integrates active tumor targeting, dual ROS amplification, and magnetic resonance imaging (MRI) guidance for synergistic sonodynamic and chemodynamic therapy. The MnO2 nanoflowers were loaded with the sonosensitizer 4-carboxyphenyl porphyrin (TCPP) and surface-modified with hyaluronic acid (HA). This design enables CD44 receptor-mediated tumor targeting and tumor microenvironment-responsive degradation. Upon exposure to the mildly acidic and reductive tumor microenvironment, MnO2 is reduced to Mn2+, leading to glutathione depletion, in situ oxygen generation, and alleviation of hypoxia, while the released Mn2+ catalyzes Fenton-like reactions to generate highly toxic hydroxyl radicals (•OH) and simultaneously serves as an efficient T1-weighted MRI contrast agent. Meanwhile, TCPP enhances singlet oxygen (1O2) generation upon ultrasound activation, enabling effective sonodynamic therapy. Through the coordinated activation of SDT and CDT under MRI guidance, HA-MnO2-TCPP nanoparticles achieve precise and efficient tumor suppression without reliance on photothermal mechanisms. This work provides a robust paradigm for tumor microenvironment-responsive nanotheranostics and highlights the potential of ultrasound-activated strategies for precision cancer therapy.
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DOI
PubMed
高影响因子
Advanced Composites and Hybrid Materials
·
2026
·Vol. 9
·期 4
·340
·
IF 15.5
Wang Yanrong,Chen Qiuling
The strategic integration of metal-organic frameworks (MOFs) with MXenes presents a promising avenue to overcome charge separation bottlenecks in photocatalysis. This study constructs a hierarchical S-scheme heterojunction by in-situ growing ultrafine Zinc–Tetrakis(4-carboxyphenyl) porphyrin (Cobalt-incorporated) Zn-TCPP(Co) MOF nanoparticles (15 nm) on two-dimensional functionalized MXene nanosheets. This unique “particle-on-lamella” architecture is engineered with molecular bridges, establishing a chemically bonded interface via C–Ti–O and N–Ti bonds that facilitate rapid charge transfer. The optimized heterostructure exhibits a narrow bandgap of 1.95 eV, a significantly prolonged charge carrier lifetime of 35.5 ns, and a high photocurrent density of 1.7 µA cm − 2 . By leveraging synergistic S-scheme charge separation, MXene’s metallic conductivity, and molecular single-atom Co sites, the composite achieves an exceptional hydrogen evolution rate of 24.3 mmol g − 1 h − 1 with an apparent quantum efficiency of 10.2% at 420 nm—representing a sixfold enhancement over pristine Zn-TCPP(Co). This performance surpasses many recently reported MOF- and MXene-based photocatalysts. Combined density functional theory calculations and experimental analyses confirm the critical role of the internal electric field in driving the S-scheme mechanism, which effectively preserves strong redox potentials. This work provides a definitive blueprint for high-performance photocatalytic systems through molecular-level interfacial engineering.
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高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Junying Peng,Shengjie Lu,Nan Su,Wenbei Situ,Xianliang Song
Caffeine, a central nervous system stimulant ubiquitously present in many plants such as coffee and tea, is conventionally quantified using chromatographic and electrophoretic techniques. Despite the advantages of rapid response, simple instrumentation, and low cost, photoelectrochemical (PEC) sensing remains underdeveloped for caffeine analysis. In this study, a novel PEC sensor was constructed by integrating BiVO 4 nanoparticles with Co-TCPP MOF on ITO (BiVO 4 /Co-TCPP MOF/ITO), with the aim of caffeine detection. A series of structural, morphological, optical and photoelectrochemical analyses were conducted on the BiVO 4 /Co-TCPP MOF/ITO electrode. The results demonstrated that the incorporation of Co-TCPP MOF significantly enhanced the photoelectrochemical performance of the material attributable to their extensive π-conjugated system, achieving a photocurrent density of 2.01 mA/cm 2 at 0.6 V (vs. Ag/AgCl), approximately 3.3-fold higher than pristine BiVO 4 (0.59 mA/cm 2 ). After optimization of key parameters including Co-TCPP MOF dosage, electrolyte, applied bias, the sensor exhibited a robust linear response to caffeine in the range of 0.5–120 μM, with a detection limit of 0.12 μM. Moreover, it displayed excellent selectivity, reproducibility (RSD < 3.5%), and long-term operational stability. Application to real tea and coffee samples achieved satisfactory recoveries (95.8–103.2%), with results consistent with HPLC-MS/MS, confirming its reliability. This work provides an efficient PEC caffeine sensing platform and new insights for designing MOF-semiconductor hybrids for advanced optoelectronic sensing.
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高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 3
·126
·
IF 5.4
Zhou Yu,Wu Runqiang,Fan Lingling,Qui Pengtao,Deng Xiaohua,Tan Xiaohong,Dong Shuaikang,Li Canru,Chen Jiejing,Liang Jintao,Li Guiyin
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide, and early diagnosis is crucial. Golgi protein 73 (GP73) has emerged as a promising serum biomarker for HCC. However, current detection methods often fail to meet routine screening requirements due to limitations in sensitivity and operational simplicity. To address these challenges, we have developed a novel fluorescent aptamer-based sensor for highly sensitive GP73 detection based on the fluorescence resonance energy transfer (FRET) mechanism between graphitic carbon nitride quantum dots (g-CNQDs) and a copper-based metal–organic framework (Cu-TCPP). g-CNQDs were covalently conjugated with a GP73-specific aptamer to serve as the fluorescent donor, while two-dimensional Cu-TCPP nanosheets acted as the efficient acceptors. Fluorescence was quenched upon donor–acceptor interaction via FRET. In the presence of GP73, aptamer–target binding disrupted FRET interaction, separating the donor from the acceptor and restoring fluorescence in a concentration-dependent manner. Under optimal conditions, the sensor exhibited excellent linearity over a concentration range 1.0–225.0 ng mL⁻¹, with a detection limit as low as 0.907 ng mL⁻¹. Recoveries for spiked human serum samples ranged from 95.96% to 103.85%, with relative standard deviations (RSDs) of 0.38%–5.48%. The developed aptamer sensor demonstrated excellent sensitivity, selectivity, and stability, providing a powerful tool for early HCC diagnosis and offering strong potential for real-time analytical applications. Graphical A novel fluorescent aptamer sensor for GP73 detection by leveraging the fluorescence resonance energy transfer (FRET) mechanism between graphite-phase carbon nitride quantum dots (g-CNQDs) and a copper-based organic framework (Cu-TCPP). This platform achieved a good linear relationship with GP73 concentration in the range of 1.0–225.0 ng mL -1 for GP73 concentration, and a detection limit of 0.907 ng mL -1 .
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PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Shabab Hussain,Xinsheng Peng
Metal organic frameworks (MOFs) based Nanofiltration (NF) membranes have promising advantages in the separation of dyes and salts to purify the industrial polluted water. Herein, we report the synthesis of porphyrinic, porous and ultra-fast photothermal sensitive iron tetrakis(4-carboxyphenyl)porphyrin) (Fe-TCPP) MOFs nanofibers and the corresponding thin film nanocomposite (TFN) membranes by facile interfacial polymerization (IP). The Fe-TCPP nanofibers based TFN membrane enhances the pure water permeance to 28.1 L·m −2 ·h −1 ·bar −1 ( i.e., 3.5-fold higher than thin film composite (TFC)) by providing continuous hydrophilic flow pathways to permeate. The Fe-TCPP nanofibers contribute to the surface of TFN membrane, resulting not only fast permeation, but also ultra-high rejection of dyes i.e., 97.2%, 98.3% and 99.1% for Indocyanine Green, Brilliant Blue-R and Direct Red-80, respectively. Additionally, the TFN membrane also demonstrates 23–43 % salts rejection. Due to the ultra-fast photothermal responsive nature of Fe-TCPP nanofibers (88.4 °C increased temperature in 2 sec photo exposure), the water permeation of TFN NF membrane increases 30 % with 0.5 min under visible light-irradiation. This photo-induced ON/OFF separation is switchable. The enhanced permeation, high dyes rejection and photo-modulated ON/OFF nano-separation opens a new avenue for TCPP-based MOFs in the water purification technologies.
研究领域:
材料科学
·
环境工程
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Shabab Hussain,Sher Bahadar,Guitu Wang,Liping Zhu,Zhizhen Ye,Xinsheng Peng
Synthesizing defects free, mechanically robust, thin polyamide (PA) selective layer with sufficient channels for boosted permeance/selectivity of the thin-film composite (TFC) nanofiltration (NF) membranes are the central issues which impede the lab-made nanoseparation membranes commercialization. In this work, a new approach is developed to synthesize thin PA layer by light-driven interfacial-polymerization (IP) via photothermal effect from Fe-TCPP metal organic frameworks (MOFs) nanofibers inter-layer. The Fe-TCPP nanofibers convert the illuminating visible light into heat (high local temperature) and provide to PA polymerization, ultimately synthesizing robust, thin, hydrophilic PA selective layer. After removing the Fe-TCPP nanofibers layer from the prepared thin PA film with Fe-TCPP nanofibers (TFN) NF membrane, the PA of the thin-film composite (TFC) NF membrane is enforced enough to sustain high pressure of 8 bars. The resulted TFC NF membrane shows boosted methanol and acetonitrile permeances of 120 and 160 L·m −2 ·h −1 ·bar −1 with 97% rejection to acid fuchsin dye. The nanofiltration membranes show stable separation performance in both organic and aqueous mediums and have potential for organic solvent nanofiltration (OSN) and dye-wasted water nanoseparation. This photothermal-driven interfacial-polymerization will open doors for typical TFC nanofiltration/reverse osmosis membranes.
研究领域:
材料科学
·
环境工程
·
化学工程
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DOI
高影响因子
Journal of Biological Engineering
·
2026
·Vol. 20
·期 1
·94
·
IF 6.3
Ye Gaobing,Liu Jing,Jin Yu,Hu Renren,Tian Tianli,Chen Peilei
Tumor hypoxia limits type-II photodynamic therapy (PDT) by restricting oxygen-dependent singlet oxygen production during irradiation. Here, we developed a pH-responsive ZnO 2 @ZIF-8/TCPP nanoplatform (PZZT) that integrates an acid-activated oxygen-generating core (ZnO 2 ), a ZIF-8 gatekeeper shell, and the photosensitizer TCPP, aiming to enhance PDT under hypoxic conditions. Under mildly acidic conditions, PZZT showed improved oxygen generation and enhanced DPBF consumption upon 660 nm irradiation, indicating elevated ¹O₂ production. In 4T1 cells, PZZT + laser induced stronger intracellular ROS signals and greater phototoxicity than free TCPP or control formulations. In 4T1 tumor-bearing mice, PZZT + laser achieved the most significant tumor growth inhibition without obvious systemic toxicity. Overall, PZZT provides a practical pH-activated self-oxygen-supplying strategy to improve PDT efficacy.
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PubMed
高影响因子
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