CHINESE JOURNAL OF CHEMISTRY
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2014
·Vol. 32
·期 8
·771-776
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IF 1.04
Mo Sun,Hengyi Zhang,Xinyue Hu,Bowen Liu,Yu Liu
A hyperbranched supramolecular polymer (HSP) is constructed based on the intermolecular inclusion complexation of bridged tris(permethyl- β -cyclodextrin) with Mn III -porphyrin bearing poly(ethylene glycol) (PEG) side chains (Mn III -TPP), and characterized by UV/vis absorption spectroscopy, isothermal titration calorimetry (ITC), NMR, dynamic light scattering (DLS), atomic force microscopy (AFM) and transmission electron microscopy (TEM), respectively. The presence of permethyl- β -cyclodextrin can stabilize the low-valent Mn II -TPP. In vitro cell experiment indicates that this HSP has no remarkable cellular toxicity against NIH 3T3 cells. In vitro MR imaging experiment indicates a slightly increased T 1 relaxivity for this HSP compared to that for the linear supramolecular polymer.
研究领域:
生物化学
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材料科学
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医学影像学
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DOI
高影响因子
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
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2015
·
IF 2.084
Xian-Hua Chen,Li Ma,Yi-Xiang Hu,Dan-Xian Wang,Li Fang,Xue-Lai Li,Jin-Chuan Zhao,Hai-Rong Yu,Hua-Zhong Ying,Chen-Huan Yu
Tris (2-ethylhexyl) trimellitate (TOTM) is commonly used as an alternative plasticizer for medical devices. But very little information was available on its biological effects. In this study, we investigated toxicity effects of TOTM on hepatic differential gene expression analyzed by using high-throughput sequencing analysis for over-represented functions and phenotypically anchored to complementary histopathologic, and biochemical data in the liver of mice. Among 1668 candidate genes, 694 genes were up-regulated and 974 genes were down-regulated after TOTM exposure. Using Gene Ontology analysis, TOTM affected three processes: the cell cycle, metabolic process and oxidative activity. Furthermore, 11 key genes involved in the above processes were validated by real time PCR. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that these genes were involved in the cell cycle pathway, lipid metabolism and oxidative process. It revealed the transcriptome gene expression response to TOTM exposure in mouse, and these data could contribute to provide a clearer understanding of the molecular mechanisms of TOTM-induced hepatotoxicity in human.
研究领域:
毒理学
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基因组学
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分子生物学
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DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2016
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IF 2.567
Changqing Miao,Donghai Yu,Lina Huang,Shengmao Zhang,Laigui Yu,Pingyu Zhang
1,3,5-Tris(phenylamino) benzene and a series of its substitution derivatives were synthesized. The structure of the as-synthesized products was confirmed by nuclear magnetic resonance spectroscopy and high resolution mass spectra. Moreover, the antioxidation behavior of 1,3,5-tris(phenylamino) benzene and its substitution derivatives as antioxidants in several ester oils was evaluated by a rotary oxygen bomb test and pressurized differential scanning calorimetry, while theoretical calculations were conducted to examine their antioxidation mechanism. It was found that 1,3,5-tris(phenylamino) benzene exhibits better antioxidation ability at elevated temperature (150 and 210 °C) than commonly used commercial antioxidant diphenylamine. In the meantime, the substitution groups exhibit significant effects on the antioxidation behavior of 1,3,5-tris(phenylamino) benzene and its derivatives. This is because the substituents result in changes in the molecular structure and electronic effect of the as-synthesized products, thereby causing s change in their antioxidation behavior.
研究领域:
有机化学
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材料科学
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物理化学
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DOI
高影响因子
POLYHEDRON
·
2019
·
IF 2.284
Qingchun Zhang,Bo Jin,Shufan Feng,Tian Zheng,Xiaofang Wang,Zhicheng Guo,Rufang Peng
There is a growing interest in the development of new iron ligands as novel promising therapeutic strategies for neurodegenerative disorders. In the article, a new tripodal hexadentate tris(dopamine) ligand, containing three dopamine chelate moieties which were attached to a cyanuric chloride molecular scaffold, has been synthesized and fully characterized by NMR, FTIR and MS. The solution thermodynamic stability of the ligand with Fe III , Mg II and Zn II ions was investigated. The results demonstrated that the ligand exhibited effective binding ability and improved selectivity for Fe III ion. The high affinity could be attributed to the favorable geometric arrangement between the ligand and Fe III ion coordination preference. The ligand also exhibited high antioxidant activity. Hence, the ligand could be used as potential chelating agent for iron overload situations.
研究领域:
生物化学
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药物化学
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医学
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DOI
高影响因子
MICROCHIMICA ACTA
·
2022
·Vol. 189
·期 11
·1-10
·
IF 6.408
Wang Xin,Li Longwen,Li Lihua,Bu Tong,Yang Kairong,Xia Junfang,Sun Xinyu,Jiang Hong,Wang Li
A novel ratiometric fluorescence probe was designed for the determination of Al 3+ by self-assembling of NH 2 -MIL-101(Fe) and [Ru(bpy) 3 ] 2+ . Under the excitation wavelength of 360 nm, the NH 2 -MIL-101(Fe)@[Ru(bpy) 3 ] 2+ presented a dual-emitting luminescent property at 440 and 605 nm, respectively. In the presence of Al 3+ , the blue fluorescence of NH 2 -MIL-101(Fe)@[Ru(bpy) 3 ] 2+ at 440 nm was enhanced remarkably, while the red emission at 605 nm was almost not influenced. Therefore, taking the fluorescence at 440 nm as the report signal and 605 nm as the reference signal, quantitative determination was achieved for Al 3+ concentration in the ranges 0.2–25 μM and 25–250 μM. The limit of detection (LOD) and limit of quantification (LOQ) were calculated to be 73 nM and 244 nM, respectively. The sensing mechanisms were studied by theoretical calculation and optical spectra. The analysis of real food samples confirmed the suitability of the proposed method. More importantly, portable fluorescent test papers were successfully manufactured to provide a strategy for visual, rapid, and on-site detection of Al 3+ . Graphical abstract
研究领域:
分析化学
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材料科学
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环境科学
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食品科学
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产品关联
DOI
PubMed
高影响因子
WATER AIR AND SOIL POLLUTION
·
2021
·Vol. 232
·期 9
·1-13
·
IF 2.52
Li Qiuyue,Huang Kaibo,Duan Xingchun,Liang Jiahao,Chen Xinran,Tao Xueqin,Lu Guining
In this research, the feasibility of UV/Fe(III) photocatalytic technology for the degradation of tris (2-chloroethyl) phosphate (TCEP) was investigated. Experimental results showed that TCEP had a significant removal efficiency in UV/Fe(III) ([TCEP] 0 = 10 ppm, [Fe 2 (SO 4 ) 3 ] 0 = 0.5 mM, near-100% degradation rate after 90 min). A free radical scavenging experiment and EPR detection indicated that the formation of ·OH by the Fe(III) under ultraviolet light played a major role. Experiments on influencing factors revealed that oxygen accelerated the degradation of TCEP by accelerating the Fe(II)/Fe(III) cycle, but Cl − and PO 4 3− inhibited TCEP degradation. Three intermediate products were generated, including C 4 H 9 Cl 2 O 4 P (product A, m/z 222.9690), C 6 H 13 Cl 2 O 5 P (product B, m/z 266.9954), and C 2 H 6 ClO 4 P (product C, m/z 160.9762). Moreover, the degradation pathways primarily involved the C–Cl bond and phosphoric center being attacked. Escherichia coli toxicity test revealed that UV/Fe(III) treatment reduced environmental risk of TCEP. Therefore, UV/Fe(III) photocatalysis is a promising technique for TCEP control in wastewater treatment. Graphical abstract
研究领域:
环境科学
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化学工程
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毒理学
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DOI
高影响因子
Advanced Science
·
2024
·
IF 14.3
Kang Chen,Keyuan Pan,Shang He,Rui Liu,Zhe Zhou,Duoyi Zhu,Zhengdong Liu,Zixi He,Hongchao Sun,Min Wang,Kaili Wang,Minghua Tang,Juqing Liu
Ionic memristors can emulate brain-like functions of biological synapses for neuromorphic technologies. Apart from the widely studied excitatory-excitatory and excitatory-inhibitory synapses, reports on memristors with the inhibitory-inhibitory synaptic behaviors remain a challenge. Here, the first biaxially inhibited artificial synapse is demonstrated, consisting of a solid electrolyte and conjugated microporous polymers bilayer as neurotransmitter, with the former serving as an ion reservoir and the latter acting as a confined transport. Due to the migration, trapping, and de-trapping of ions within the nanoslits, the device poses inhibitory synaptic plasticity under both positive and negative stimuli. Remarkably, the artificial synapse is able to maintain a low level of stable nonvolatile memory over a long period of time (≈60 min) after multiple stimuli, with feature-inferencing/-training capabilities of neural node in neuromorphic computing. This work paves a reliable strategy for constructing nanochannel ionic memristive materials toward fully inhibitory synaptic devices.
研究领域:
神经科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Islam M. Mostafa,Abubakar Abdussalam,Hongzhan Liu,Zhiyong Dong,Shiyu Xia,Ala’a Mhmoued Abdllh Alboull,Baohua Lou,Guobao Xu
Dopamine (DA) is a very imperative neurotransmitter in our body, since it contributes to several physiological processes in our body, for example, memory, feeling, cognition, cardiovascular diseases, and hormone secretion. Meanwhile, tyrosinase is a critical biomarker for several dangerous skin diseases, including vitiligo and melanoma cancer. Most of the reported chemiluminescent (CL) methods for monitoring DA and tyrosinase are signal-off biosensors. Herein, we introduce a new chemiluminescent “signal-on” system, lucigenin-tris(hydroxypropyl)phosphine (THPP), for the selective determination of DA and tyrosinase. THPP is well known as a versatile and highly water–soluble sulfhydryl-reducing compound that is more highly stable against air oxidation than common disulfide reductants. By employing THPP for the first time as an efficient lucigenin coreactant, the lucigenin-THPP system has shown a high CL response (approximately 16-fold) compared to the lucigenin-H2O2 classical CL system. Surprisingly, DA can remarkably boost the CL intensity of the lucigenin-THPP CL system. Additionally, tyrosinase can efficiently catalyze the conversion of tyramine to DA. Therefore, lucigenin-THPP was employed as an ultrasensitive and selective signal-on CL system for the quantification of DA, tyrosinase, and THPP. The linear ranges for the quantification of DA, tyrosinase, and THPP were 50–1000 nM, 0.2–50 μg/mL, and 0.1–800 μM, respectively. LODs for DA and tyrosinase were estimated to be 24 nM and 0.18 μg/mL, respectively. Additionally, the CL system has been successfully employed for the detection of tyrosinase in human serum samples and the assay of DA in human serum samples as well as in dopamine injection ampules with excellent obtained recoveries.
研究领域:
分析化学
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生物医学
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神经科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2025
·
IF 5.2
Shanqin Ge,Long Chen,Wei Li,Qingzhao Cai,Genxiang Gong,Junhao Wu,Jinhong Yu,Kazuhito Nishimura,Nan Jiang,Tao Cai
Molecular additives have garnered widespread attention in the fields of lubrication and corrosion protection due to their designable interfacial film-forming efficiency. Herein, three protic ionic liquids (PILs) with the same cation but different anions have been designed and synthesized. Their physicochemical properties, tribological properties and anti-corrosion properties were systematically investigated. Results demonstrated that under dynamic steel-on-steel friction conditions, the PILs can maximally reduce the running-in period, friction coefficient, and wear rate by 90 %, 40 %, and 97 %, respectively, compared to the commercial ionic liquid, BMIMPF 6 . Under static copper corrosion conditions, the PILs efficiently adsorb onto the copper surface and formed a dense oxide layer on its surface, thus achieving excellent corrosion protection for the copper substrates. Molecular dynamics (MD) simulation results indicate that the exceptional lubricity of PILs is due to its ability to rapidly adsorb onto the metal surface through multiple interaction sites on both its anionic and cationic components, thereby reducing the running-in period and swiftly establishing a lubricating film. This study provides insights into the development of molecular additives featuring multiple adsorption sites, with potential applications in the fields of tribology and corrosion engineering.
研究领域:
材料科学
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润滑工程
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腐蚀防护
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产品关联
DOI
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2026
·
IF 4.6
Fathimath Abbas,Solomon Sime Tessema,Tadele Eticha,Xiaote Zhou,Saima Hanif,Yiran Guan,Guobao Xu
ECL of lithium bis(oxalate)borate was studied for the first time. • It exhibits strong Ru(bpy)₃²⁺ ECL. • It is sensitively detected by Ru(bpy)₃²⁺ ECL. • The present method holds promise for lithium bis(oxalate)borate detection in energy storage devices. Electrochemiluminescence (ECL) based on tris(2,2′-bipyridine)ruthenium II [Ru(bpy) 3 2+ ] is widely used in bioanalytical applications, but commonly relies on tripropylamine (TPrA) as a co-reactant. However, the toxicity, volatility, and solvent limitations of TPrA motivate the development of alternative co-reactants. In this work, lithium bis(oxalate)borate (LiBOB) was employed for the first time as a co-reactant for the Ru(bpy) 3 2+ ECL systems on a glassy carbon electrode (GCE). The ECL behavior of the Ru(bpy) 3 2+ /LiBOB system was investigated and compared with those of the conventional co-reactants, TPrA and sodium oxalate. The relative ECL efficiency of LiBOB ( φ ECL = 0.054) was nearly two-fold higher than that of sodium oxalate ( φ ECL = 0.028), suggesting its potential as a co-reactant for aqueous Ru(bpy) 3 2+ ECL systems. The ECL intensity exhibited a linear relationship with LiBOB concentration over the range of 0.001 to 0.9 mM, with a limit of detection of 0.5 μM. LiBOB enhanced the Ru(bpy) 3 2+ ECL signal and demonstrated favorable electrochemical characteristics. Its good solvent compatibility, thermal and chemical stability, and ability to generate reactive intermediates make LiBOB an attractive alternative co-reactant for Ru(bpy) 3 2+ -based ECL systems. These findings provide a foundation for the development of more robust and versatile ECL analytical platforms.
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高影响因子
DRUG AND CHEMICAL TOXICOLOGY
·
2025
·
IF 1.9
Yongxiao Huang,Caina Jiang,Fangyao Li,Xianli Ma
As a commonly used flame retardant in numerous products, it is inevitable that tris(2-chloroethyl)phosphate (TCEP) is released into the surrounding environment during its use. This process gives rise to potential environmental concerns that must be addressed. In recent years, there has been significant interest in the role of TCEP in the development of hyperuricemia (HUA). However, the specific mechanisms by which TCEP contributes to this condition remain to be fully elucidated. In this study, we have employed a combination of network toxicology and in vitro experiments to investigate the potential effects of TCEP on HUA and its mechanism of action. Through systematic analysis of GeneCards, OMIM, Swiss Target Prediction, and CHEMBL databases, a total of 242 TCEP-induced HUA targets were identified. Utilizing the STRING and DAVID databases further elucidated the core targets and associated signaling pathways of TCEP in relation to HUA. The molecular docking assay results demonstrated that TCEP exhibits binding activity with the selected targets. In vitro, our findings revealed that TCEP exacerbates HUA by amplifying the inflammatory response and upregulating the mRNA expression levels of GLUT9 and URAT1. The present study provides a new perspective and theoretical basis for the in-depth understanding of the molecular mechanism of TCEP affecting HUA, and helps to further understand the pathogenesis of HUA and the role of environmental factors.
研究领域:
环境毒理学
·
分子生物学
·
药理学
·
生物信息学
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产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2021
·
IF 4.527
Qingqing Chen,Daxin Li,Zhihua Yang,Dechang Jia,Yu Zhou,Ralf Riedel
Tris(dichloromethylsilylethyl)borane is a compound containing a B–C bond and Cl and H elements. Herein, we propose a novel method to synthesize polyborosilazanes using tris(dichloromethylsilylethyl)borane and boron trichlorosilane as boron sources and hexamethyldisilazane as a nitrogen source. The microstructure and chemical composition of the as-synthesized polyborosilazanes and as-annealed SiBCN ceramics were investigated using Fourier transform infrared spectroscopy , nuclear magnetic resonance spectroscopy , Raman spectroscopy , scanning electron microscope, and transmission electron microscope methods. The organic precursors were converted entirely into inorganic ceramics at 800 °C, and the ceramic yield of the polyborosilazanes was 88% at 1000 °C. SiBCN ceramics with irregular shapes contained chemical bonds of B–N, Si–N, and Si–C at 1500 °C and retained an amorphous structure below 1600 °C. After the first cycle, the fabricated SiBCN ceramic anodes exhibited a reversible capacity of 261.3 mA h/g, which was 2.6 times that reported in the literature (101 mA h/g). The discharge capacity decreased to 157.6 mA h/g after 30 cycles. The satisfactory electrochemical performance of the resulting SiBCN ceramic anodes can be attributed to the formation of conductive carbon species favoring the transport properties of lithium ion .
研究领域:
材料科学
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能源科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）