SENSORS AND ACTUATORS B-CHEMICAL
·
2020
·
IF 7.1
Xueqing Gao,Jia Liu,Xuming Zhuang,Chunyuan Tian,Feng Luan,Huitao Liu,Yuan Xiong
Based on the encapsulation of copper nanoclusters (CuNCs) mixed with Al 3+ into a zeolitic imidazole framework-90 (ZIF-90) to form CuNCs-Al 3+ /ZIF-90 composites, a novel, simple and sensitive fluorescent sensor was developed to detect adenosine triphosphate (ATP) and then evaluate the freshness of aquatic products by determining the changes in the level of ATP. Encapsulated CuNCs could be released from the ZIF-90 after their addition to ATP, resulting in the fluorescence quenching of this system. Based on this phenomenon, the sensitive detection of ATP was realized with a detection limit of 0.67 μM, and a good linear relationship was observed between the fluorescence quenching ratios of the CuNCs-Al 3+ /ZIF-90 composites and ATP in the concentration range from 1 to 2000 μM. Moreover, satisfactory results were obtained when the proposed ATP detection method was applied to real samples to evaluate the freshness of aquatic products.
研究领域:
生物化学
·
食品科学
·
材料科学
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Xinran Shi,Liang Ji,Yuanyuan Hu,Jinyu Gu,Liming Wang,Wenwen Lu,Jiali Meng,Yan Du,Lingzhong Huang,Dongxia Nie,Yanyan Yu
Since adenosine triphosphate (ATP) and reactive oxygen species (ROS) are closely related to neuron functions and the pathogenesis of Alzheimer's disease , herein, the first example of using a dual-responsive zeolitic imidazolate framework-90 (ZIF-90) to fabricate a single fluorescent probe , CuNCs/ [email protected] /ZIF, was reported, which specifically and sensitively responded to intracellular level fluctuations of ATP and ROS both in neuronal and tumor cells without obvious cross-talking. Through a stepwise in situ growth method, ROS-responsive glutathione-stabilized copper nanoclusters (GSH-CuNCs) and double tagged ATP aptamer hybrid chain (P1-P2) were prepared and respectively encapsulated into the inner and outer ZIF-90. The obtained CuNCs/ [email protected] /ZIF probe as a tandem system could firstly respond to ATP in an “off-to-on” mode, in which, the quenched fluorescence of FAM by BHQ1 attached on P2 was recovered through the competitive displacement between ATP and ZIF-90, leading to the release of FAM from ZIF-90. Upon collapse of the outer ZIF-90, the strong emission of CuNCs enclosed in the inner ZIF-90 was subsequently quenched in the presence of ROS. Accompanied with high sensitivity, selectivity and accuracy, the resultant fluorescent probe exhibited good performance and properties for tracking the level variations of ATP and ROS in SH-SY5Y and Hela cells under different stimulations. This strategy highlighted the potential of the ZIF-90 based nanocomposite for multi-targets detection, and also provided a value tool for the early diagnosis of diseases.
研究领域:
生物化学
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医学诊断
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材料科学
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产品关联
DOI
高影响因子
Emergent Materials
·
2023
·
IF 3.8
Shen Yuxin,Zhang Yao,Gao Xiyue,Shang Mengdi,Cai Yanfei,Yang Zhaoqi
The most prevalent malignant neoplasm identified in females is breast cancer. Multidrug resistance is a significant obstacle for breast cancer chemotherapy, despite the availability of several therapies. This article describes the development of a nanocomposite based on ZIF-90 to reduce multidrug resistance in breast cancer cells. Synthesized ZIF-90 is utilized to transport MiR-489 and Adriamycin into drug-resistant cancer cells. The epithelial-mesenchymal transition that is initiated by TGF-β is dependent on Smad3, and MiR-489 may target Smad3. MiR-489 ultimately suppresses the epithelial-mesenchymal transition pathway, hence increasing the efficacy of Adriamycin therapy. The results of Western blot analysis indicated that the Smad3 is effectively reduced by MiR-489. The cell viability assay showed that the IC 50 of nanocomposite to the drug-resistant breast cancer cells (1.032 μg/mL) was nearly 40 times lower than the IC 50 of ADM to the same cells (39.87 μg/mL), and was closer to the IC 50 of nanocomposite to the non-drug-resistant cells (0.49 μg/mL). These findings conclusively shown that our developed nanocomposite has ameliorated the multidrug resistance issue.
研究领域:
肿瘤学
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纳米技术
·
分子生物学
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产品关联
DOI
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2026
·Vol. 49
·期 4
·e70420
·
IF 3.6
Wen-Zhi Chen,Hao-Nan Chen,Zheng Zhang
This work addresses the challenge of imparting molecular selectivity to metal-organic frameworks (MOFs) by developing a molecularly imprinted polymer based on ZIF-90 (MI-ZIF). Starch was used as a green and multifunctional auxiliary polymer during a room-temperature preparation of MI-ZIF with baicalin as the template. This strategy leverages the hydroxyl groups of starch to orchestrate the formation of specific recognition cavities within the ZIF-90 framework. The well prepared MI-ZIF exhibited high adsorption capacity and good specificity, with an imprinting factor (IF) of 4.1. The MI-ZIF was used to enrich baicalin from complex matrices such as plant extracts and serum samples. It achieved a high adsorption rate of 93.2% for baicalin from a Scutellaria baicalensis Georgi (SBG) root extract, increasing the baicalin purity from 19.7% to 71.3%. As a solid-phase extraction sorbent for the analysis of serum samples, this method showed high sensitivity with a detection limit of 0.9 ng mL −1 and recoveries in the range of 78.2%–97.2%. The results indicate that the MI-ZIF can significantly improve the enrichment efficiency and detection sensitivity of baicalin, providing an efficient and reliable technical means to solve the problems of enrichment, separation, and trace detection of flavonoid compounds in complex samples.
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DOI
PubMed
高影响因子
ANALYST
·
2015
·Vol. 140
·期 9
·3107-3112
·
IF 4.107
Ye-Yu Wu,Cheng-Xiong Yang,Xiu-Ping Yan
The unique properties of metal–organic frameworks, such as diversity in structures and pore sizes, high surface area, shape selectivity and available to functionality make them as potential materials of the stationary phase for gas chromatography. Here we show an in situ growth approach to the fabrication of zeolite imidazolate framework-90 (ZIF-90) bonded capillary column for gas chromatography separation. ZIF-90 was directly grown onto the inner wall of the carboxyl modified capillary via the coordination between Zn(II) and carboxyl group. The fabricated ZIF-90 bonded capillary column acted as a weak polar stationary phase. It not only exhibits high capacity in the separation of linear molecules, but also offers excellent features for the separation of 2- and 3-substituted ketones.
研究领域:
化学
·
分析化学
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产品关联
DOI
PubMed
高影响因子
TALANTA
·
2024
·
IF 5.6
Ning Ding,Ruoqing Liu,Bo Zhang,Ningru Yang,Mingwei Qin,Yin Zhang,Zhouping Wang
In this study, a novel fluorescent nanoprobe (ZIF-90@FSS) was constructed using a zeolite imidazolium ester skeleton (ZIF-90) incorporating sodium fluorescein within its porous structure. Notably, this nanoprobe exhibited regular fluorescence “off” detection performance of Fe 3+ in actual samples and living cells. The concentration range of 0–150 ng/mL exhibited a lowest detection limit of 0.26 ng/mL. A nanofiber paper-based platform (VL78/ZIF-90@FSS) was further developed by coupling the prepared nanoprobe to a multi-dimensional fiber paper via C N bonds, enabling rapid visual white light colorimetric and fluorescence imaging of Fe 3+ within 2 min. The constructed nanoprobe and its paper-based detection platforms demonstrated a stable recovery range in tap water, beer, and soy sauce samples during spiking-recovery assessments. The recovery rates ranged from 98.46 % to 108.24 % for the nanoprobe and from 91.75 % to 108.71 % for the nanofiber paper-based platform. Therefore, the developed nano-fluorescent sensor and paper-based nanofiber sensing platform offer a promising strategy for the visual detection of Fe 3+ , while also presenting novel and valuable methods to investigate the regulatory mechanisms of Fe 3+ in living cells.
研究领域:
分析化学
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生物医学工程
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材料科学
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产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 2
·1-9
·
IF 5.833
Li Wenjun,Chen Siyu,Yang Yue,Song Yiju,Ma Chaoyun,Qiao Xiuwen,Hong Chenglin
A GOx/HRP@ZIF-90 nanomaterial is proposed by coating GOx and HRP in ZIF-90 using a bio-simulated mineralization method to improve the tolerance of the enzyme to the external environment. In the detection process, the ZIF-90 is turned on under mild conditions by the competitive reaction of ATP with Zn 2+ and imidazole-2-carboxaldehyde (2-ICA), and the electrical signal of the system is amplified by the enzyme cascade reaction of GOx and HRP. Finally, based on the signal amplification strategy of the competitive reaction between Zn 2+ and ATP to construct a “signal on” mode, electrochemical immunosensor of GOx-HRP enzyme–linked cascade reaction was prepared. The proposed electrochemical immunosensor shows an excellent analytical performance when detecting CA-125, with good selectivity and stability, with a detection range of 0.1 pg mL −1 –40 ng mL −1 and a detection limit of 0.05 pg mL −1 . The test has been performed using chronoamperometry under a constant voltage of −0.4 V. The immunosensor also shows an excellent performance when analysing human blood samples. The recovery of the immunosensor is 97.94–101.8%, with a relative standard deviation of 3.7–6.1%. The proposed sensor provides a novel idea for clinical use of GOx and HRP enzymes and a new method for the clinical detection of tumor markers. Graphical abstract
研究领域:
生物医学工程
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分析化学
·
肿瘤标志物检测
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2014
·
IF 4.258
Li-Qing Yu,Cheng-Xiong Yang,Xiu-Ping Yan
Metal–organic frameworks (MOFs) are attractive as porous stationary phase for open-tubular capillary electrochromatography (OT-CEC) due to their fascinating structures and unusual properties. Here we report a directly covalent bonding approach to prepare uniform and dense MOF film on the inner wall of fused silica capillary at room temperature for OT-CEC. Zeolitic imidazolate framework-90 (ZIF-90) as a model MOF because it not only possesses large surface area and high stability but also provides the free aldehyde groups to bond to the inner surface of capillary via covalent bond. X-ray diffraction, scan electron microscopy, and UV–vis spectrophotometry were used to confirm the bonding of the ZIF-90 to the inner wall of the silica capillary. The ZIF-90 coating not only increased the phase ratio of open-tubular column, but also improved the interactions of tested analytes and the coating. Owing to the porous structure of ZIF-90 and hydrophobic interactions between the analytes and the organic ligands of ZIF-90, three groups of isomers, neutral and basic compounds and nonsteroidal anti-inflammatory drugs were well separated on the ZIF-90 bonded column. The precisions (relative standard deviation, RSD) of retention time, half peak width and peak area for three consecutive runs were 0.3–1.2%, 1.3–6.0% and 1.5–5.2%, respectively. The run-to-run, day-to-day, and column-to-column precisions (RSDs) for the electroosmotic flow of the ZIF-90 bonded column were 0.2%, 0.4%, and 1.9%, respectively. Moreover, the ZIF-90 bonded column could stand more than 230 runs without observable change in the separation efficiency.
研究领域:
分析化学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL BIOCHEMISTRY
·
2026
·
IF 3.1
Jiayi Zhou,Luodan Di,Yinghui Song,Baojun Yang,Ying Ma,Yang Lu
GOx@ZIF-90@CuCo-MOF composite was synthesized via synergistic self-assembly. • Bimetallic sites and ZIF-90 shell significantly enhanced nanozyme activity. • The GOx@ZIF-90@CuCo-MOF paper-based nanozyme sensor was fabricated for rapid and noninvasive glucose detection in saliva. • The sensor achieved a 13.5 μM detection limit within a 20-min reaction. Glucose biosensors are pivotal to diabetes management; however, traditional fingerstick blood collection methods are often challenging due to their invasiveness, pain, high cost, and inability to provide continuous monitoring. Here, we constructed a paper-based colorimetric sensing platform using a multifunctional metal–organic framework (MOF) composite system to enable rapid, noninvasive detection of glucose in saliva. This platform utilized a CuCo-MOF framework, loaded with glucose oxidase (GOx) and ZIF-90 via a synergistic self-assembly mechanism, to catalyze the colorimetric reaction of H 2 O 2 and tetramethylbenzidine (TMB). The synergistic effect of the composite significantly enhanced the overall catalytic efficiency, enabling a sensitive response to glucose levels in saliva. Using ImageJ, color images captured with a smartphone were analyzed using RGB color channels to quantitatively determine glucose levels in saliva. The detection time was 20 min, with a detection limit (LOD) of 13.5 μM and a linear range of 50–2000 μM. This platform offered advantages with the absence of blood sample collection, ease of operation, and visual response. It provided new material strategies and design ideas for developing portable, non-invasive blood glucose monitoring technology. Download: Download high-res image (367KB) Download: Download full-size image
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DOI
高影响因子
Journal of Materials Chemistry A
·
2025
·
IF 9.5
Jianfeng Hu,Huiya Cheng
A challenge in metal protection is developing anti-corrosion materials that possess both high adsorption capacity and intelligent responsiveness. To overcome the limitations of traditional corrosion inhibitors, a novel pH-responsive corrosion inhibitor (PDT@ZIF-90) was developed through a multi-step strategy. Specifically, the catechol-modified polymer–TiO2 hybrid (PDT) was synthesized through Schiff base reactions, which demonstrated dense adsorption on Q235 carbon steel through Fe–N/O coordination. Subsequent ZIF-90-mediated in situ encapsulation enabled precise payload integration of the PDT corrosion inhibitor. UV-vis characterization confirmed that the PDT@ZIF-90 composite system enables pH-triggered intelligent release of the active corrosion inhibitor component under acidic conditions (pH < 6). Electrochemical tests revealed a 95.2% inhibition efficiency for 200 ppm PDT@ZIF-90 in 3.5 wt% NaCl. This dual-functional strategy offers a scalable paradigm for self-adaptive anticorrosion materials suitable for Q235 carbon steel in marine and energy infrastructure applications.
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Ebenezer Kobina Sam,Yang Ge,Jun Liu,Xiaomeng Lv
Oil/water emulsion separation to this day is a worldwide problem and the discharge of large amounts of waste oil and oil spills have caused more harm to human health and the environment as a whole. It is therefore important to have the necessary materials in case the need arises to handle such problems. Superhydrophobic coatings have shown promise in dealing with these issues but their poor durability limits their application. To overcome this situation, superhydrophobic coatings endowed with a self-healing ability can work as a potential solution. In this work, a modified fabric is prepared via dip-coating of Polydimethylsiloxane (PDMS), ZIF-90 and fluoroalkyl silane (FAS) on linen fabric. PDMS, a known organosilicon and hydrophobic in nature was first coated on the fabric to serve as the underlying hydrophobic that would migrate to the surface to restore hydrophobicity in case it is lost. ZIF-90 was then coated on the fabric via hydrothermal treatment to provide nanoscale roughness which was then modified with FAS to improve the hydrophobicity . The modified fabric was superhydrophobic with a water contact angle (WCA) of 151°. It also showed good separation capability for several oil/water emulsions, reaching a maximum of 99.5% efficiency and flux of 1213 L m −2 h −1 . The modified fabric exhibited excellent recyclability for 10 cycles and also showed good stability towards mechanical durability and chemical stability tests and could self-heal at room temperature and also by heat treatment. The self-healing mechanism was then explained. The separation efficiency and flux after the tests were also promising, suggesting its potential application in real oil/water emulsion separation.
研究领域:
材料科学
·
环境科学
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2022
·
IF 10.53
Guozhen Li,Zhihao Si,Shuai Yang,Yan Zhuang,Siyu Pang,Yuhui Cui,Jan Baeyens,Peiyong Qin
Mixed-matrix membranes (MMMs), consisting of nanoparticles and a polymeric matrix, have been proven high-efficiency separation media for gas separations. The interface engineering between the particles and polymeric matrixes is the key-point for MMMs to display an excellent separation performance. Herein, an amine modified ZIF-90 (ZIF-90-NH 2 ) is dispersed in 6FDA-Durene to prepare MMMs, the modified amino groups can form the hydrogen bonding with 6FDA-Durene to enhance the compatibility of ZIF-90-NH 2 and 6FDA-Durene. A 45 wt% ZIF-90-NH 2 /6FDA-Durene MMM demonstrated a high separation performance, surpassing the 2008 Robeson permeability-selectivity upper bounds. This satisfactory gas separation performance can be due to the intimate interactions between the 6FDA-Durene polymer and ZIF-90-NH 2 nanoparticles via abundant hydrogen bonding. Furthermore, the covalent linkage of ZIF-90-NH 2 with 6FDA-Durene can be driven by the tris(2-aminoethyl) amine (TAEA) vapor thermal modification method to realize the ring opening reaction, which further enhances the particles-polymer connection in the ZIF-90-NH 2 /6FDA-Durene-TAEA MMMs. Results show that the 45 wt% ZIF-90-NH 2 /6FDA-Durene-TAEA MMM exhibits a remarkably enhanced H 2 permeability of 487.0 Barrer with a H 2 /CO 2 selectivity of 35.8, which is 6.8 times higher than that of ZIF-90/6FDA-Durene-TAEA MMM. This strategy offers new prospects for membrane materials and opens a new way for the precise interface engineering of MMMs, and the resulting high performance for energy-efficient gas separations.
研究领域:
材料科学
·
化学工程
·
膜技术
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）