CHINESE JOURNAL OF CHEMISTRY
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2019
·Vol. 37
·期 6
·581-587
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IF 2.376
Xinyu Bian,Bing Zhao,Bo Pang,Zhong Zheng,Shu Liu,Zhiqiang Liu,Fengrui Song
Summary of main observation and conclusion Two catechin epimers and their non-covalent complexes with γ-cyclodextrin were studied by using ion mobility coupled with mass spectrometry (IM-MS). Rapid separation of complexes was achieved with the peak-to-peak resolution reaching 0.86 after optimization of IM condition. Collision cross section (CCS) was measured to explore the structural difference of complexes. A gap of 11.75 Å 2 between two complexes was found. Molecular modeling and theoretical CCS calculation were adopted to explain the measurement results. Two binding ways of both complexes were found and the calculated CCS corresponds accurately to the measured CCS. Quantification of catechins in mixtures was performed and the relative error was less than 15%, indicating the effectiveness of quantification by IM-MS.
研究领域:
分析化学
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生物化学
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理论计算
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高影响因子
FOOD CHEMISTRY
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2015
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IF 3.391
Shan Hong,Songbai Liu
The reactivity profile of all the hydroxyl groups in (+)-catechin towards acylation and their respective contribution to radical scavenging activity were systematically explored in this work. Selective acylation of the hydroxyls on different rings was carried out employing either a basic or acidic activation strategy. Monoacylation of B ring was achieved effectively with the aid of dimethyltin dichloride. Monoacylation of A ring was accomplished by sequential protection and deprotection of B and C rings. Based on specific acylation of all the individual hydroxyls of (+)-catechins, the structure radical scavenging activity relationship of each hydroxyl of (+)-catechin was established. It was demonstrated that the vicinal phenolic hydroxyls on B ring played the most important role in the ABTS radical scavenging activity and those on A and C rings made a much smaller contribution. This study has laid solid groundwork for further modification of the catechins and improvement of their properties.
研究领域:
植物化学
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天然产物化学
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药物化学
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PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2023
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IF 4.4
Yiran Wang,Xinyu Yang,Xueting Lu,Xiaonian Cao,Ling Ao,Lele Ma,Caihong Shen,Yongqian Fu,Yaqiong Yang
A low-cost and simple boron-dipyrromethene (BODIPY)-labeled aptasensor (B-aptamer) was designed for rapid, sensitive and turn-on catechin detection. B-aptamer as signal indicator and recognition element initially stacked on the surface of multi-walled carbon nanotubes (MWCNTs) via π-π conjugation, resulting in efficient quenching of the fluorescence of the aptasensor. Upon addition of catechin, catechin was adsorbed to B-aptamer, thereby undergoing a conformational change to form B-aptamer/catechin complex, which prompted the release of the signaling probe from the surface of MWCNTs. Hence, the fluorescence intensity (FL) of the B-aptamer was increasing with the increase of catechin concentrations with the limit of detection (LOD) of 5 ng/mL. Furthermore, the method was used to analyze catechin in food samples with the recovery rate of 92.7–107.1 %. This method provided a proper analysis method for clinical analysis and pharmaceutical quality control.
研究领域:
分析化学
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纳米技术
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食品科学
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药学
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PubMed
高影响因子
RSC Advances
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2022
·Vol. 12
·期 33
·21135-21144
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IF 4.036
Yirong Xia,Wei Ni,Xintong Wang,Yanyan Wang,Ximing Huang
The health benefits of drinking tea stem from it being rich in polyphenols and other physiologically-active substances. Thus, exploring the synergistic effect between polyphenols and a variety of physiologically-active substances can contribute to our understanding of how tea benefits health. In this work, we have studied the interactions between catechin and theanine, exploring the synergetic antioxidant mechanism of the two molecules. Electrochemical characterization results showed that the oxidation peak current of catechin decreased gradually with the concentration of theanine, which is due to theanine spontaneously binding to catechin through intermolecular hydrogen bonds and forming molecular clusters via two hydrogen bonds. The binding constant is 4.75 at room temperature. The molecular clusters reduce the diffusion coefficient of catechin in solution, leading to the slow release of its antioxidant capacity (ability to effectively inhibit free radical oxidation reactions). Density functional theory calculations were also performed and verified the binding behavior. In identifying the synergistic effect between catechin and theanine on the antioxidant capacity of tea, this study adds to our understanding of the efficacy of tea polyphenols.
研究领域:
食品科学
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生物化学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Fang Kou,Weihao Wang,Sangguan You,Xuetuan Wei,Xian Wu
A novel encapsulation system was designed, utilizing sodium alginate (SA) polysaccharide as the matrix and easily absorbed Fe 2+ as the metal-organic framework, to construct microbead scaffolds with both high catechins (CA) and vitamin C (Vc) loading and antioxidant properties. The structure of microbead hydrocolloids was investigated using SEM, XPS, FTIR, XRD and thermogravimetry, and the antioxidant activity , in vitro digestion and the release of CA and Vc were evaluated. These results revealed that the microbead hydrocolloids SA-CA-Fe and SA-CA-Vc-Fe exhibited denser and stronger cross-linking structures, and the formation of inter- and intramolecular hydrogen and coordination bonds improved thermal stability . Moreover, SA-CA-Fe (44.9 % DPPH and 47.8 % ABTS) and SA-CA-Vc-Fe (89.9 % DPPH and 89.3 % ABTS) displayed strong antioxidant activity . Importantly, they were non-toxic in Caco2 cells. The SA-CA-Fe and SA-CA-Vc-Fe achieved significantly higher CA (56.9 and 62.7 %, respectively) and Vc (42.2 %) encapsulation efficiency while maintaining higher CA and Vc release in small intestinal environment. These results suggested that SA polysaccharide-based encapsulation system using Fe 2+ framework as scaffold had greater potential for delivery and controlled release of CA and Vc than conventional hydrocolloids, which could provide new insights into the construction of high loading, safe, targeted polyphenol delivery system.
研究领域:
食品科学
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材料科学
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生物医学工程
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DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
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2025
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IF 6.6
Rourou Wen,Xianghua Chai,Pingping Wang,Kegang Wu,Xuejuan Duan,Jiasi Chen,Xiumei Li
In this study, the effect of hydroxyl and galloyl groups structure of catechin monomers on the inhibitory activity of α-amylase were studied by substrate depletion, inhibition kinetics, fluorescence quenching, circular dichroism analysis, molecular docking, and molecular dynamics methods. The catechin monomers of EGCG and ECG with more phenolic hydroxyl groups and specific gallate esters showed the stronger inhibitor effect, higher fluorescence quenching effects and more intense structural disruption on α-amylase than EGC and EC. Molecular simulation further elucidated that EGCG and ECG, due to their specific gallate esters and more phenolic hydroxyl groups, interact more favorably with amino acid residues in the α-amylase active site compared to EGC and EC. These findings reveal the mechanism of α-amylase inhibition by catechin monomers with different structures and provide the theoretical basis for the role of catechins as anti-glycemic components in the dietary management of diabetes.
研究领域:
生物化学
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营养学
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药物化学
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高影响因子
Algal Research-Biomass Biofuels and Bioproducts
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2026
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IF 5
Jikang Sui,Jinku Zhang,Xiangning Lu,Kangning Wang,Mingkai Bai,Adewale Olusegun Obadina,Shiyang Li,Guangxin Feng,Haohao Wu
Microalgae are a sustainable and nutrient-dense food source, but their strong off-flavors significantly limit broader consumption. This study evaluates the effectiveness of a laccase-catechin mediator in improving the odor profiles of Spirulina, Chlorella, and Chlamydomonas reinhardtii . Mediators were applied ex situ (pre-formed) or in situ (generated within the suspension). Ex-situ mediators, optimized at 40 °C for 2 h, achieved better deodorization compared to in-situ mediators, with optimal catechin dosages of 28, 16, and 8 mg/g biomass for Spirulina, Chlorella, and C. reinhardtii , respectively. Sensory evaluation showed reduced grassy, earthy, and fatty odors, and enhanced floral and fruity notes, with the ex-situ approach leading to higher overall acceptability. GC–MS analysis confirmed that mediators decreased the diversity and abundance of key odor-active volatiles in three microalgae species. Laccase-catalyzed quinone-type mediators effectively neutralize undesirable compounds, offering a promising enzymatic strategy for improving the sensory quality of microalgae-based foods, especially for sustainable food applications.
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高影响因子
JOURNAL OF FOOD SCIENCE
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2019
·Vol. 84
·期 8
·2042-2049
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IF 2.081
Lipeng Han,Qingna Lin,Guoqin Liu,Dongxue Han,Li Niu,Dongxiao Su
It is important to inhibit the food-derived, potentially hazardous chemical glycated lipids by natural products. A model system was established and the products are identified to study the inhibitory mechanism of four types of catechin, resveratrol (RES), and the synthetic antioxidants butylated hydroxylanisole (BHA) and tert-butylhydroquinone (TBHQ) on the formation of carboxymethyl 1,2-dipalmitoyl-sn-glycero-3-phosphatidylethanolamine (CM-DPPE) by determining hydroxyl radical (OH·), Amadori-1,2-dipalmitoyl-sn-glycero-3-phosphatidylethanolamine (Amadori-DPPE) and glyoxal (GO). The results show that the inhibitory rates of catechin and RES on the content of CM-DPPE in the model system are higher than those of BHA and TBHQ. There are at least two inhibitory mechanisms of antioxidants on CM-DPPE. (1) Antioxidants scavenge OH·, which blocks the process of Amadori-DPPE oxidation to form CM-DPPE. (2) Antioxidants trap GO, which blocks the reaction between GO and DPPE to form CM-DPPE. This research will reveal the inhibitory mechanisms of natural antioxidants on glycated lipids from the aspect of scavenging OH· and trapping GO. Practical Application Food manufacturers should pay attention on the production of glycated lipids in food processing. This study will provide the theoretical basis for the use of natural products to inhibit the formation of food-derived glycated lipids. Natural products, such as catechin and resveratrol, can substitute chemical synthesis antioxidants, such as butylated hydroxylanisole and tert-butylhydroquinone, in food processing, which inhibit the formation of glycated lipids.
研究领域:
食品科学
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生物化学
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DOI
PubMed
高影响因子
POLYMER INTERNATIONAL
·
2017
·Vol. 67
·期 3
·322-329
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IF 2.07
Yu Qi,Zhihuan Weng,Jinyan Wang,Shouhai Zhang,Lishuai Zong,Cheng Liu,Xigao Jian
The development of bio-based thermosetting resins with good thermal stability can potentially afford sustainable polymers as replacements for petroleum-based polymers. We report a practical route to a novel catechin-based phthalonitrile resin precursor (CA-Ph), which contains free phenolic hydroxyl groups that result in ‘self-curing’ at elevated temperatures to afford a thermostable polymer. Comparison of the performance of this CA-Ph resin with that of a conventional petroleum-based bisphenol A phthalonitrile resin (BPA-Ph; containing 5 wt% of the curing agent 4,4′-diaminodiphenylsulfone) revealed that CA-Ph exhibits a lower melting point and curing temperature. Cured CA-Ph resin retains 95% of its weight at 520 °C under a nitrogen atmosphere, which compares favorably with results obtained for BPA-Ph resin that retains 95% of its weight at a lower temperature of 484 °C. Kinetic results indicated that the curing reactions of both CA-Ph and BPA-Ph systems follow an autocatalytic mechanism. These results suggest that catechin is a useful bio-based feedstock for the preparation of self-curing and thermally stable phthalonitrile resins for advanced technological applications. © 2017 Society of Chemical Industry
研究领域:
材料科学
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有机化学
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2023
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IF 8.6
Qixian Zhang,Qingyong Sun,Xulin Duan,Yuanlong Chi,Bi Shi
Previous research had proved that collagen fiber can be used as separation material for removing caffeine from tea polyphenol extract effectively. But the recovery rate of catechin compounds from collagen fiber column was quite low by using water and ethanol as eluent because of excessively strong hydrogen bond interaction between collagen fiber and polyphenols. To solve the problem, collagen fiber was hydrophobically modified in this work by using silane coupling agents with alkyl chains (butyl, octyl, dodecyl and octadecyl). FT-IR, DSC, SEM and EDS Mapping proved the successful grafting of alkyl chains on collagen fiber, leading to the significantly enhanced hydrophobicity of collagen fiber. Static adsorption showed that the adsorption capacity of EGCG decreased when the grafted alkyl chain length increased mainly relying on the weakened hydrogen bond interaction. Dynamic adsorption and elution behavior also indicated less retention capacity of EGCG on collagen fiber with higher hydrophobicity. In column separation of simulated tea polyphenol extract containing caffeine and catechin compounds, the collagen fiber grafted with octadecyls (CF(C18)) presented excellent separation efficiency for caffeine and catechin compounds, and simultaneously the catechin compounds were highly recovered. The recovery rates of EGC and EGCG were 2–7 times higher than those separated by pristine collagen fiber column and glutaradehyde crosslinked collagen fiber column developed in our previous work. In the reusing round of CF(C18) column, the chromatogram was almost the same as the first round, showing excellent reusability. In fact, the separation performance of CF(C18) to caffeine and catechin compounds was comprehensively superior to Sephadex LH-20, presenting great practical application potential in effectively removing caffeine from tea polyphenol extract and recovering catechin compounds.
研究领域:
化学工程
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材料科学
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食品科学
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高影响因子
FOOD HYDROCOLLOIDS
·
2022
·
IF 11.504
Yuanyuan Liu,Yifan Zhang,Meiyang Zhen,Yuangen Wu,Meihu Ma,Yuxin Cheng,Yongguo Jin
The catechin and tannins as crosslinking and antioxidant compounds were added into sodium alginate/gelatin/poly(vinyl alcohol) (SA/GEL/PVA) blend film with 0.5%, 2%, and 5% (based on the total mass of polymers), respectively. This study aims to investigate the effect of different polyphenols on the structural and functional properties of food packaging film. Molecular interactions among polyphenols and polymers in film-forming solution (FFS) were analyzed based on the rheological behavior, low field nuclear magnetic resonance (LF-NMR), and the changes in structural characteristic of modified films were analyzed through Fourier transform infrared spectra (FTIR), Scanning electron mcroscopy (SEM) and X-ray diffraction (XRD) analysis. The results indicated that the crosslinking degree of the polymer network in FFSs modified by tannins was higher than that of catechin. The mechanical properties, water insolubility, water vapor barrier performance and antioxidant activity of the blend film were improved by polyphenols addition. The film modified by 2% tannins showed the highest tensile strength and elongation at break in comparing with catechin modified films. This study demonstrated that the tannins have a great potentiality in enhancing the structure and function of SA/GEL/PVA blend film.
研究领域:
材料科学
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食品科学
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高分子化学
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生物技术
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高影响因子
Bioactive Carbohydrates and Dietary Fibre
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2025
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IF 3.6
Dima Atehli,Tianyu Qi,Rui Liu,Wan Wang,Qiaomei Zhu,Yuanlin Sun,Qingbin Guo,Ji Kang
Both arabinoxylan (AX) and catechin (CA) have shown promising therapeutic potential for inflammatory bowel disease (IBD). However, the efficacy of their covalent (S, CP) and non-covalent (PM) complexes against IBD remains largely unexplored. This study evaluated the therapeutic effects of AX, CA, and their respective complexes in a Drosophila melanogaster model of dextran sodium sulfate (DSS)-induced colitis. Results demonstrated that covalent AX-CA complexes generated by ultrasonic treatment provided the greatest therapeutic benefits, followed by those produced using cold plasma treatment. These complexes significantly improved survival rates, restored locomotor activity, enhanced metabolic rate, improved intestinal barrier function, markedly reduced the expression of genes associated with JAK/STAT signaling pathway, and concurrently upregulated the expression of genes within the Nrf2/Keap1 pathway.
研究领域:
分子生物学
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营养生物化学
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炎症研究
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食品科学
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果蝇遗传学
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高影响因子
危险品化学品经营许可证（带存储）