COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
·
IF 5.518
Youmei Bao,Yong Zhao,Guangjiong Qin,Jinling Wang,Kuan Li,Xiaolan Zhu
In this study, a magnetic dendritic mesoporous silica nanoparticle material (MDMS@MAH-Cd-IIP) was prepared via surface ion-imprinted technique for selective removal of Cd(Ⅱ) from aqueous solution. The material was based on an ion-imprinted copolymers of 4-vinyl pyridine (4-VP) and N-methacryloyl- L -histidine (MAH), a synthesized ligand monomer to complex with cadmium ions as ion recognition layer. The obtained polymer was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and magnetic measurement system. The adsorption experiments exhibited MDMS@MAH-Cd-IIP showed fast (within 35 min) and selective capture of Cd(Ⅱ) with maximum uptake capacity of 21.04 mg g −1 . The adsorption process followed pseudo-second order kinetic and Langmuir adsorption isotherm models, indicating monolayer chemisorption on homogeneous sites was the rate-limiting step. Meanwhile, the MDMS@MAH-Cd-IIP also showed a specificity recognition ability for Cd(Ⅱ) using analogues Co(Ⅱ), Pb(Ⅱ), Zn(Ⅱ) and Ni(Ⅱ) as interference. Moreover, the MDMS@MAH-Cd-IIP based magnetic SPE can extract approximately 90.0–102.0% of Cd (Ⅱ) in real water samples with a RSD of 3.34–8.23%, which indicated the polymer had the high stability and reproducibility and presented itself a promising material for the Cd(Ⅱ) adsorption and detection from aqueous solution.
研究领域:
环境科学
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材料科学
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化学工程
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DOI
高影响因子
LANGMUIR
·
2021
·
IF 3.882
Yang Wang,Yingying Wei,Qianrui Xu,Shimin Shao,Hong Man,Yingrui Nie,Zhifei Wang,Yong Jiang
Magnetic materials perform well in the purification of histidine-rich proteins (His-proteins). In this work, a facile fabrication of yolk–shell magnetic Fe3O4@NiSiO3/Ni microspheres for the efficient purification of His-proteins has been reported. Yolk–shell Fe3O4@NiSiO3 microspheres were prepared via hydrothermal reaction. Then Ni nanoparticles (NPs) were loaded on Fe3O4@NiSiO3 microspheres after the adsorption and in situ reduction of nickel acetylacetonate. The yolk–shell Fe3O4@NiSiO3/Ni microspheres had a hierarchical flower-like structure and large cavities. The size of the cavity depended on the reaction time. This indicated that the microspheres had a large specific surface area for loading of more Ni NPs, which was crucial to the high His-protein adsorption capacity of Fe3O4@NiSiO3/Ni microspheres. Fe3O4@NiSiO3/Ni microspheres had a high adsorption capacity for bovine hemoglobin (BHb, 2822 mg/g), which was better than the values of other His-protein adsorbents. Fe3O4@NiSiO3/Ni microspheres still had a high BHb separation efficiency after seven separation cycles, indicating its good reusability and stability. Therefore, the as-prepared bifunctional yolk–shell Fe3O4@NiSiO3/Ni microspheres exhibited great practical application value for His-protein purification.
研究领域:
生物化学
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材料科学
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高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2021
·Vol. 22
·期 21
·11436
·
IF 5.924
Zhiyuan Chen,Bin Wang,Jiali Dong,Yuan Li,Shuqin Zhang,Xiaozhou Zeng,Huiwen Xiao,Saijun Fan,Ming Cui
Radiation-induced cardiopulmonary injuries are the most common and intractable side effects that are entwined with radiotherapy for thorax cancers. However, the therapeutic options for such complications have yielded disappointing results in clinical applications. Here, we reported that gut microbiota-derivedl-Histidine and its secondary metabolite imidazole propionate (ImP) fought against radiation-induced cardiopulmonary injury in an entiric flora-dependent manner in mouse models. Local chest irradiation decreased the level ofl-Histidine in fecal pellets, which was increased following fecal microbiota transplantation.l-Histidine replenishment via an oral route retarded the pathological process of lung and heart tissues and improved lung respiratory and heart systolic function following radiation exposure.l-Histidine preserved the gut bacterial taxonomic proportions shifted by total chest irradiation but failed to perform radioprotection in gut microbiota-deleted mice. ImP, the downstream metabolite ofl-Histidine, accumulated in peripheral blood and lung tissues followingl-Histidine replenishment and protected against radiation-induced lung and heart toxicity. Orally gavaged ImP could not enter into the circulatory system in mice through an antibiotic cocktail treatment. Importantly, ImP inhibited pyroptosis to nudge lung cell proliferation after radiation challenge. Together, our findings pave a novel method of protection against cardiopulmonary complications intertwined with radiotherapy in pre-clinical settings and underpin the idea that gut microbiota-producedl-Histidine and ImP are promising radioprotective agents.Keywords:radiation-induced cardiopulmonary injury;gut microbiota metabolites;imidazole propionate;pyroptosis;l-histidine
研究领域:
肿瘤学
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药理学
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微生物学
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心血管科学
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肺科学
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DOI
PubMed
高影响因子
BIOMACROMOLECULES
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2023
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IF 6.2
Qizhen Zheng,Jinhan Sheng,Ji Liu,Xianghan Chen,Ming Wang
Biomineralization of metal–organic frameworks (MOFs) provides a powerful approach for intracellular protein delivery, enabling the study of biological function and therapeutic potential of proteins. However, the potency of this approach is largely challenged by the low efficiency of current strategies for interfacing proteins with MOFs for biomineralization and intracellular delivery. Here, we report a versatile and convenient biomineralization strategy for the rapid encapsulation and enhanced delivery of proteins using MOFs, accelerated by histidine-rich proteins. We demonstrate that the histidine-rich green fluorescent protein (H39GFP) can accelerate the biomineralization of MOFs by promoting the coordination between proteins and metal ions, leading to enhanced protein delivery efficiency up to 15-fold. Moreover, we show that the delivery of H39GFP-fused cytotoxic ribonuclease and bacterial-derived RAS protease can effectively inhibit tumor cell growth. The strategy of promoting the biomineralization of MOFs via histidine-rich proteins for enhanced intracellular delivery could be expanded to other biomacromolecules, advancing their therapeutic potential and the biomedical scope of MOFs.
研究领域:
生物医学工程
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材料科学
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生物化学
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癌症研究
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DOI
PubMed
高影响因子
ACS Omega
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2022
·
IF 4.132
Qingxin Liu,Yinglan Wu,Min Feng,Wanmin Chen,Zhiping Zheng
Silver complexes with proteinogenic amino acid ligands are of interest for biomedical and antimicrobial applications. In this work, we obtained {[Ag7(l-his)4](NO3)3·3H2O}0.2{[Ag8(l-his)4(H2O)2](NO3)4·3H2O}0.8 (1) and {[Ag7(d-his)4](NO3)3·3H2O}0.2{[Ag8(d-his)4(H2O)2](NO3)4·3H2O}0.8 (2), which represent the first example of any Ag-exclusive complex featuring a cluster-type core motif and with only proteinogenic amino acid ligands. Upon immersion into acetonitrile, an interesting single-crystal-to-single-crystal transformation occurred to produce a new cluster complex of the formula [Ag8(l-his)4(NO3)(H2O)](NO3)3 (3). Using a racemic mixture of histidine, the reaction under otherwise identical conditions led to the production of the second example of a three-dimensional (3D) network structured Ag-exclusive complex with only a proteinogenic amino acid ligand. Compared with other Ag–histidine complexes in the literature, the significance of reaction conditions, particularly the Ag/histidine ratio and pH of the reaction mixture, is revealed. Temperature-dependent emission of 1 and 2 at 440 nm characteristic of silver–philophilic interactions was also observed.
研究领域:
无机化学
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生物医学
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材料科学
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DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
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2026
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IF 7.1
Xinjie Wang,Jinzhou Lu,Dan Yu,Shiyin Tao,Yang Zhang,Jiayou Li,Jianxing Yu
This study aims to evaluate the inhibitory effect and molecular mechanism of orange peel (OP) and its fermented product (FOP) by Rhizopus stolonifer JP1118 on the accumulation of biogenic amines (BAs) in Chinese rice wine (Huangjiu). UHPLC-Q-TOF-MS/MS technology was utilized to analyze the differences in metabolites between OP and FOP. Huangjiu fermentation experiments were conducted to compare the effects of different OP/FOP concentrations on BAs formation, and molecular docking was used to verify the interaction between flavonoid components and BAs synthesis-related decarboxylases. The results indicated that the content of 13 flavonoid compounds in FOP was more than double that in OP. The 4 g/L FOP treatment group demonstrated the most inhibition of BAs formation, and the inhibition on histamine was particularly significant. Molecular docking results confirmed that 11 flavonoids in FOP could stably bind to histidine decarboxylase (HDC), and 10 flavonoids could stably bind to tyrosine decarboxylase (TDC). They occupy the active sites of the enzymes via hydrogen bonding and hydrophobic interactions, thereby impeding substrate binding and inhibiting the synthesis of histamine and tyramine. This research offers a technical solution for low-amine Huangjiu, references for BAs control in other fermented foods and agricultural by-product recycling, with academic and industrial significance.
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高影响因子
CHEMICAL PAPERS
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2022
·Vol. 76
·期 12
·7855-7863
·
IF 2.146
Zhang Shen,Jin Mei-ling,Gao Ya-xi,Li Wen-qin,Wang Xin-yu,Li Xin-xin,Qiao Jia-qi,Peng Yang
Herein, histidine, as a protective agent, was applied for the synthesis of copper nanoclusters (histidine-Cu NCs) by using ascorbic acid as an efficient reducing agent. The as-fabricated fluorescent histidine-Cu NCs displayed blue-green emission wavelength at 492 nm with the excitation of 410 nm. Using histidine-Cu NCs as a novel nanoprobe, the fluorescent “turn-off” mechanism was developed for the determination of furaltadone accompanying linear attenuation of fluorescence at 492 nm. Furaltadone acted as a quencher and ln ( F 0 / F ) value of histidine-Cu NCs had an excellent linear relationship of furaltadone concentrations (0.5–500 μM) (the F 0 and F are referred to the fluorescence intensity of probe without and with furaltadone), along with the detection limit and linear fit constant of 0.085 μM and 0.9948, respectively. The fluorescence quenching of histidine-Cu NCs demonstrated good selectivity for furaltadone over other potential control substances. The quenching mechanism might be assumed to be static quenching. This system was proved to be an appropriate detection pattern for furaltadone sensing in real medical samples.
研究领域:
分析化学
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生物医学工程
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DOI
高影响因子
APPLIED SURFACE SCIENCE
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2022
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IF 7.392
Qinglei Wu,Chenyang Shen,Chang-jun Liu
Suppressing the excessive hydrogenation capacity of palladium has great significance for selective hydrogenation of acetylene. Herein, an amino acid (histidine or His in abbreviation) modified Pd/SiO 2 catalyst (Pd-His/SiO 2 ) for selective hydrogenation of acetylene was prepared by incipient wetness impregnation, followed by hydrogen reduction at 240 °C. The intense interaction between Pd and histidine greatly affects the structure and properties of Pd-His/SiO 2 . The Pd nanoparticles are highly dispersed on the support with an average diameter of 1.0 nm and positively charged. The use of histidine weakens the adsorption of acetylene and ethylene on the metal. Especially, the adsorption of di-σ-bonded ethylene is significantly impaired on the catalyst, which is beneficial to improve the ethylene selectivity. The conversion of acetylene is up to 100.0 % at 160 °C on Pd-His/SiO 2 while the ethylene selectivity reaches 81.5 %. A 50-hour test at 160 °C confirms the good stability of Pd-His/SiO 2 .
研究领域:
催化化学
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材料科学
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DOI
高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
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2019
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IF 2.291
Wenpei Zhang,Haohua Ma,Jiahui Hua,Wenqi Zhang,Cheng Guo,Jianqiang Wang
pH-responsive drug delivery material based on histidine periodic mesoporous organosilica (His-PMO) was constructed by the condensation of histidine bissilylated organosilica precursor (His-BOP) and TEOS in acidic medium under the template P123. The organosilica precursor His-BOP was prepared by selecting histidine as the main reactant via multi-step reactions. Histidine is first introduced as the skeletal constituents of PMO to improve flexibility of the robust framework and sensitivity of pH response. The materials His-PMO maintain ordered meso-structure and facilitate entrance or exit of compounds during application process. Paclitaxel (PTX) is used as the cargo molecules to observe drug delivery in vitro . The results indicate that the maximum loading amounts of drugs are up to 28 mg/g on the material His-PMO-10% under the same conditions. In the release experiments, the different release percentage and speed of PTX are observed with the variation of pH values (pH 5.2, 6.8 and 7.4), which exhibits nonlinear over the time. Rapid accumulation of drugs at low pH are maybe helpful for improving the performance of conquering cancer.
研究领域:
材料科学
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药学
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生物医学工程
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DOI
高影响因子
Gels
·
2022
·Vol. 8
·期 9
·570
·
IF 4.432
Qingrong Wu,Yu Fu,Wanying Yang,Shouxin Liu
Hydrogel is a good drug carrier, widely used in the sustained-release aspect of tumor drugs, which can achieve the continuous release of drugs to the tumor sites. In this study, diethylene glycol monomethyl ether methacrylate (MEO2MA) and poly (ethylene glycol) methyl ether methacrylate (OEGMA) are temperature-sensitive monomers. N-Methacryloyl-L-Histidine (Mist) is pH sensitive monomer and ligand for metal coordination bond. The temperature-sensitive monomers and pH sensitive monomer with stereocomplex of modified polylactic acid (HEMA-PLLA30/PDLA30) were mixed, under 2,2’-azobis (2-methylpropionitrile) (AIBN) as radical initiator, polymer was formed by free-radical polymerization. The polymer was then immersed in ZnSO4solution, the imidazole group of Mist monomer forms a tridentate metal coordination bond with Zn2+, temperature/pH double-responsive and physical double-crosslinked hydrogel was finally obtained. Comparing the hydrogen bond hydrogel, hydrogen bond and metal coordination bond double crosslinking hydrogel, metal coordination bond hydrogel, testing thermal stability, viscoelasticity, swelling, and morphology of three hydrogels. In addition, using UV-Visible spectroscopy (UV-Vis) to test the sustained release of the hydrophobic drug doxorubicin hydrochloride (DOX-HCl) in the human tumor environment (37 °C, pH = 5). We found that the temperature/pH double-responsive and physical double-crosslinked hydrogel had the most potential for the sustained drug release.
研究领域:
材料科学
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药学
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生物医学工程
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DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2026
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IF 2.4
Vladimir B. Motalov,Mikhail A. Korobov,Andrey S. Kaplin,Anatoliy M. Dunaev,Elena Yu. Tyunina,Vitaly V. Kolobov,Lev S. Kudin
Special mild conditions (temperature range and duration) were selected for Knudsen effusion mass spectrometric thermodynamic studies of low-volatility amino acids l-histidine and l-aspartic acid, which made it possible to avoid any significant degradation of the starting materials, as evidenced by IR spectroscopy and visual observation. The saturated vapor pressure data in the studied temperature range are described by a linear equation ln(p/Pa) = −(21983 ± 485)/T + (42.411 ± 1.029) for l-histidine (448–480 K) and ln(p/Pa) = −(22350 ± 600)/T + (43.757 ± 1.351) for l-aspartic acid (420–450 K); the overall uncertainty that follows the ± sign includes statistical (expanded standard uncertainty with k = 2) and systematic components. The pressures of these two compounds are of the same order, but l-histidine is most likely slightly less volatile. The enthalpy of sublimation was determined by the methods of the second and third laws of thermodynamics; the recommended values are 183.5 ± 4.2 kJ·mol–1 for l-histidine and 183.2 ± 3.6 kJ·mol–1 for l-aspartic acid. The enthalpy of formation of the gaseous amino acids was found to be −283.2 ± 5.0 kJ·mol–1 for l-histidine and −791.1 ± 4.6 kJ·mol–1 for l-aspartic acid.
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高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 8
·506
·
IF 5.4
Jiang Xue,Zheng Yuxin,Arkin Kamile,Xu Yuting,Li Kexin,Shang Qingkun
Blue fluorescent carbon dots (Soy-His CDs) with high fluorescence quantum yield were synthesized via a hydrothermal method using biowaste soybean straw and L-histidine as precursors. A ratiometric fluorescence probe (Soy-His CDs@PEp-PEI) was subsequently constructed for the visual detection of epinephrine (Ep). Upon the continuous formation of the PEp-PEI copolymer, the green fluorescence of the Soy-His CDs@PEp-PEI probe at 515 nm gradually intensified, while the blue fluorescence at 420 nm was progressively quenched. This allows for the rapid and sensitive detection of Ep by monitoring the variation in the I 515 /I 420 ratio. The limit of detection (LOD) was determined to be 0.025 µmol/L in the linear range 0.1–20 µmol/L. The response mechanism is attributed to the inner filter effect (IFE) between the Soy-His CDs and the polyepinephrine-polyethyleneimine (PEp-PEI) copolymer. The proposed method was successfully applied to detect Ep in human urine samples, yielding recoveries ranging from 95.82% to 102.01%. Furthermore, portable visual and intelligent detection of Ep was achieved using a smartphone equipped with RGB analysis software based on the Soy-His CDs@PEp-PEI probe system, with recoveries ranging from 94.65% to 108.33%. A good linear relationship was obtained in the range 0–10 µmol/L, with a limit of detection (LOD) of 0.14 µmol/L. Graphical
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高影响因子
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