Polymers
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2026
·Vol. 18
·期 8
·908
·
IF 5.8
Xinyu Zhang,Chu Gong,Yujie Liu,Jun Wang,Zhizhou Yang,Jun-Li Yang
Biopolymer-based packaging films possess outstanding performances and are being developed as the alternatives to traditional petroleum-based plastic packaging films with many non-ignorable shortcomings. In this study, chitosan, succinylated pullulan (SP), and berberine (BBR) were combined to fabricate novel biopolymer-based composite films (CSSPB) via the layer-by-layer assembly method. The effects of the incorporation of BBR on the physicochemical properties of the film were investigated. It was found that after BBR was added, the tensile strength (TS), elongation at break (EAB), hydrophobicity, and antioxidant capacities of the film were enhanced. The chemical bonding, crystalline properties, elemental composition, and thermal stability of the films were also characterized by Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA), respectively. The in vitro antifungal tests revealed the antifungal activities of the films with a relatively high BBR content againstColletotrichum gloeosporioides(CG). In the preservation experiments, the CSSPB films exhibited preservation effects on fresh-cut apples, which manifested as delaying browning, weight loss, an increase in the soluble solids content, and a decrease in hardness. The new CSSPB composite films were opined to hold application potential in the field of food packaging.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Jie Liu,Ao Cao,Yanchun Liu,Xuejing Zheng,Keyong Tang
Soluble soybean polysaccharide (SSPS)/pullulan (PUL) blend films enriched with lavender essential oil (LEO) or clove essential oil (CEO) were prepared using the solution casting method. The structural, optical, mechanical, barrier, thermal, antioxidant, and antibacterial properties of the SSPS/PUL/LEO and SSPS/PUL/CEO films were investigated and compared. Scanning electron microscopy micrographs revealed randomly distributed micropores within the SSPS/PUL matrix after enrichment with essential oils (EOs). The addition of EOs significantly improved the UV-blocking performance, elongation at break (EAB), water resistance, antioxidant activity and hydrophobicity of the films. The results showed that the SSPS/PUL/CEO films exhibited nearly 100 % UV-blocking efficiency in the wavelength range of 190–290 nm, while achieving a maximum EAB of 90.6 ± 5.3 %. However, the tensile strength of the films decreased from 10.8 MPa to 5.6 MPa or 4.8 MPa upon the addition of 15 % LEO or CEO, respectively. Thermogravimetric analysis indicated that the addition of EOs had little effect on the thermal properties of the SSPS/PUL films. Both SSPS/PUL/LEO and SSPS/PUL/CEO films exhibited good antioxidant and antibacterial properties, with the SSPS/PUL/CEO film showing superior performance in both aspects. The results preliminarily suggest that the SSPS/PUL/EOs films have great potential to be used as active food packaging materials.
研究领域:
食品科学
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材料科学
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高影响因子
Journal of Radiation Research and Applied Sciences
·
2025
·
IF 2.5
Lan Tang,Xin Zhang,Ye Huang,Depeng Kong,Yiwen Yan,Zhimin Ou,Mulan Zhu,Yi Li,Jianwei Wang
Objective This study aimed to enhance the solubility and dispersion of poorly water-soluble dexamethasone (DEX) in oral films by developing a novel pullulan-vitamin E succinate (PUL-VES) coupling compound (designated PUVS3) as the film matrix. Methods The amphiphilic coupling compound PUVS3 was synthesized, characterized and evaluated. Using PUVS3 as a solubilizing/suspension agent, and PUL as the film-forming material, a dexamethasone-fast dissolving oral film (DEX-FDOF) was prepared by solvent casting method. The film was evaluated for appearance, microstructure, mechanical properties, weight variation, content uniformity, disintegration time and in vitro dissolution. Results The DEX-FDOF formulation exhibited a smooth surface with no observable drug precipitation and demonstrated excellent transparency. Both weight variation and content uniformity complied with the pharmacopoeial standards. The film displayed rapid disintegration (<15s) and favorable mechanical properties with an elastic modulus of 35–45 MPa and elongation at break of 17%–20%. Notably, in vitro dissolution reached approximately 47 % within 10 min, representing a significant improvement over the pure drug. This enhancement was achieved through the use of a self-synthesized PUL-VES coupling compound as the film matrix. This innovative approach enabled homogeneous dispersion of the poorly water-soluble DEX within the water-soluble oral film while simultaneously improving its solubility characteristics. Conclusion The DEX-FDOF, fabricated using the self-synthesized PUL-VES coupling compound as the matrix, exhibited excellent uniformity, mechanical strength, rapid disintegration (<15 s), and notably enhanced dissolution (47 % in 10 min), demonstrating its potential as an effective delivery system for poorly soluble drugs such as DEX.
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Qian Xiao,Yanqian Gong,Hui Zhou,Yuming Zhang,Qingwu Shen,Xiaohong Sun
Inspired by the high-density hydrogen bonds in spider silk and the mussel adhesive mechanism, pullulan-tannic acid (TA) hydrogels with high stretchability, toughness, adhesiveness, and rapid self-healing capabilities were successfully fabricated via a hydrogen-bond-driven co-assembly strategy combined with controlled evaporation. Infrared spectroscopy confirmed the presence of hydrogen bonds between pullulan and TA, while scanning electron microscopy revealed the porous network structure of the hydrogels. The tensile strength (TS), Young's modulus (YM), and toughness values of PulTA5 hydrogels were 0.48 MPa, 19.17 MPa, and 268.10 MJ/m 3 , respectively, reflecting increases of 433.3 %, 1538.5 %, and 76.7 % compared to PulTA1 hydrogels. The self-healed PulTA5 hydrogels exhibited the highest TS and toughness, along with the lowest elongation at break (EAB) values among all tested hydrogels. Furthermore, PulTA5 hydrogels demonstrated the highest adhesion strength to glass, paperboard, and metal surfaces. These improvements are attributed to the formation of abundant hydrogen bonds and van der Waals forces in the PulTA5 system, as confirmed by molecular dynamics (MD) simulations, which enhance the cohesion of the hydrogel and contribute to its compact structure. This novel strategy for designing pullulan-based hydrogels that combine high toughness and self-healing properties holds promise for the development of biobased materials for food packaging applications.
研究领域:
材料科学
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生物仿生学
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食品包装
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MACROMOLECULAR BIOSCIENCE
·
2024
·
IF 4.4
Ying Li,Yajing Xiang,Yuxi Chen,Yingying Wang,Wei Dong,Yan Liu,Xiaoliang Qi,Jianliang Shen
Existing methods for treating diabetic oral ulcers often fall short in clinical environments due to potential bacterial contamination, oxidative harm, and hindered angiogenesis throughout the healing process. Here, a hydrogel patch (HYG2) have been developed for local in situ application. HYG2 comprises oxidized pullulan, quaternized chitosan, and eumelanin nanoparticles derived from cuttlefish ink. These components work together to efficiently heal wounds associated with diabetic oral ulcers. Application begins with a simple local injection that quickly forms a protective barrier over the mucosa, effectively stopping bleeding and counteracting inflammatory agents. HYG2 is distinguished by its strong antibacterial properties and capacity to eliminate reactive oxygen species, promoting bacteria clearance and managing oxidative stress, which accelerates the healing phase from inflammation to tissue regeneration. Additionally, HYG2's 3D structure, incorporating elements from natural sources, offers exemplary support for structural and nutritional cell needs. This enhancement fosters cell adhesion, migration, and proliferation, along with further angiogenesis during mucosal remodeling. Ultimately, HYG2 is fully absorbed by the body after serving its therapeutic functions. Evidence from in vitro and in vivo studies shows that HYG2 hydrogel markedly accelerates mucosal wound repair, making it a promising treatment for diabetic oral ulcers.
研究领域:
生物医学工程
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材料科学
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药剂学
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组织工程
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2017
·
IF 3.671
Ping Shao,Ben Niu,Hangjun Chen,Peilong Sun
Edible packaging films using polymer for food preservation have been developed for a long time. In this study, the effects of different concentrations (0.5%, 1%, 1.5%, w/v) of tea polyphenols incorporated into pullulan-Carboxymethylcellulose sodium (Pul-CMC) solutions on electrospun nanofiber films were evaluated. The fiber size distribution was characterized by scanning electron microscopy. The morphological features of nanofibers were modulated through adjusting process parameters (e.g. concentration of polymer solution, applied voltage and feeding rate). Increasing the applied voltage from 19 to 21 kV and the feed rate from 0.36 to 0.6 mL/h leads to a reduction in mean fiber diameter. Fruit packaging potential was evaluated using strawberry. The pullulan-CMC-TP nanofibers significantly decreased weight loss and maintained the firmness of the strawberries, and improved the quality of the fruit during storage. The findings demonstrate a facile packaging route to improve food sustainability and reduce waste.
研究领域:
食品科学
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材料科学
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高分子化学
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农产品贮藏与加工
·
功能食品
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2020
·
IF 5.162
Ting Su,Wei Zhao,Lipeng Wu,Wei Dong,Xiaoliang Qi
With the rapid development of biomedicine applications, more flexible and efficient fabrication strategies are required for drug delivery vehicles. Naturally resourced polymers have gained considerable attention for construction of drug carriers. Here, biocompatible hydrogel reservoir system (named PHG-PDA) based on pullulan and polydopamine (PDA) are designed and fabricated by one-pot incorporation of PDA fibers into pullulan hydrogel (PHG). The structure and performance of the PHG-PDAs can be nicely adjusted by regulating the content of PDA fibers in precursor hydrogel solutions. Crystal violet is used as a drug prototype and introduced into hydrogels via swelling-diffusion approach. We found that the drug loading process followed the pseudo-second-order model and Langmuir isotherm model, while the drug releasing process was pH-responsive, and the cumulative release reached 60.3% and 87% at pH 7.4 and 5.0, respectively. In vitro cytotoxicity studies on L929 cells demonstrated that our hydrogels were nontoxic even in a high concentration (3.4 mg/mL). In sum, these biocompatible PHG-PDAs with tunable physicochemical properties are promising systems for drug delivery.
研究领域:
生物医学工程
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材料科学
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药剂学
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Food Biophysics
·
2021
·Vol. 16
·期 4
·460-473
·
IF 3.114
Zhang Xiuling,Li Zhen,Ji Run,Li Kun,Zhang Wentao
Biodegradable composite films based on pullulan/carboxymethyl cellulose/nano-TiO 2 were prepared using a solution casting method. In this study, the composite films were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM), and their physical, mechanical and antimicrobial properties were investigated. FTIR and XRD results confirmed that the presence of nano-TiO 2 could enhance the interaction between the film matrix. SEM analysis revealed that the composite films had a homogeneous network structure, and good particle dispersion could be obtained when the nano-TiO 2 particle content was low. DSC results indicated that the composite films possessed good thermal stability. The incorporation of nano-TiO 2 increased the thickness and contact angle while significantly decreasing the water solubility ( p < 0.05). As the content of nano-TiO 2 increased, the water vapor and ultraviolet visible (UV–Vis) light barrier properties of composite films were significantly improved ( p < 0.05). Mechanical analysis demonstrated that the tensile strength of the composite films first increased and then decreased, whereas the elongation at break decreased significantly ( p < 0.05). In addition, the composite films exhibited excellent activity against Escherichia coli and Staphylococcus aureus mainly due to the inactivation of bacteria by nano-TiO 2 photocatalysis. Preservation experiments showed that the composite films could decrease the weight loss significantly and maintain the firmness, titratable acidity, vitamin c and skin color of strawberries, thereby improving the overall quality of strawberries and extending their shelf life. This finding suggested that pullulan/carboxymethyl cellulose/nano-TiO 2 composite films possessed excellent potential for application in food packaging.
研究领域:
材料科学
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食品科学
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生物技术
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化学
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农业工程
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Xihao Pan,Siyao Cheng,Cheng Zhang,Yingzhi Jiao,Xiangpeng Lin,Wei Dong,Xiaoliang Qi
Magnetic hydrogels are fascinating materials that can be used as Fenton-like catalysts to remove antibiotics from biomedical wastewater. However, the poor distribution of magnetic nanoparticles in hydrogel matrix and weak mechanical properties severely confine their applications from lab to industrial scale. Here, we presented for the first time the facile fabrication of mussel-inspired magnetic pullulan ( MMP ) hydrogels using polydopamine as a bridge to build a relationship between Fe 3 O 4 and pullulan matrix, which could solve the common problems of magnetic hydrogels and enhance catalytic degradation of tetracycline (TC) simultaneously. Degradation results proved that our catalytic system ( MMP4 ) showed superior TC degradation efficiency (86.32% within 60 min). Theoretical studies verified that TC could act as an electron donor and the produced electrons from TC were transferred via polydopamine to the iron species through π-Fe interactions. Besides, MMP4 exhibited excellent reusability and stability that no apparent decrease in degradation efficiency was observed after 5 cycles. Altogether, our findings provide a simple but effective strategy to design magnetic hydrogel catalysts for enhancing antibiotic degradation from biomedical wastewater.
研究领域:
环境科学
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材料科学
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生物医学工程
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DOI
高影响因子
CARBOHYDRATE POLYMERS
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2022
·
IF 10.723
Tian Wang,Boya Hao,Shilin Xu,Jie Meng,Tao Wen,Jian Liu,Haiyan Xu
RNA interference is a very useful tool for clinical treatment as well as mechanistic studies of leukemia. However, leukemia cells are known as hard-to-transfected by non-virus carriers. The low capacity of endocytosis and lysosomal escape of synthetic carriers are two obstacles for successful RNAi in leukemia cells. In this work, we established a universal powerful strategy for mediating effective RNAi in different types of leukemia cells by sequentially using spermine-modified pullulan (PS) as siRNA carrier and desloratadine (DL) to promote the lysosomal escape. It was shown that the complex of PS and siRNA could be largely internalized by human T-cell acute lymphoblastic leukemia cells, acute myeloid leukemia cells and chronic myeloid leukemia cells in serum-containing media, and the internalized complex was able to escape from the lysosomes by the aid of DL, resulting in effective RNAi against the key genes for the different leukemia cells.
研究领域:
肿瘤学
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分子生物学
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药学
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MOLECULES
·
2014
·Vol. 19
·期 9
·13305-13318
·
IF 2.095
Roufen Yuan,Fuchun Zheng,Shuping Zhong,Xiaojun Tao,Yanmei Zhang,Fenfei Gao,Fen Yao,Jiaxiong Chen,Yicun Chen,Ganggang Shi
Glycyrrhetic acid (GA)-modified pullulan nanoparticles (GAP NPs) were synthesized as a novel carrier of curcumin (CUR) with a degree of substitution (DS) of GA moieties within the range of 1.2–6.2 groups per hundred glucose units. In the present study, we investigated the physicochemical characteristics, release behavior,in vitrocytotoxicity and cellular uptake of the particles. Self-assembled GAP NPs with spherical shapes could readily improve the water solubility and stability of CUR. The CUR release was sustained and pH-dependent. The cellular uptake of CUR-GAP NPs was confirmed by green fluorescence in the cells. An MTT study showed CUR-GAP NPs with higher cytotoxicity in HepG2 cells than free CUR, but GAP NPs had no significant cytotoxicity. GAP is thus an excellent carrier for the solubilization, stabilization, and controlled delivery of CUR.Keywords:pullulan;glycyrrhetic acid;self-aggregated nanoparticle;curcumin;drug delivery
研究领域:
药剂学
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生物医学工程
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材料科学
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Chaoyi Shen,Zian Deng,Jingshan Rao,Zhichao Yang,Yonghui Li,Di Wu,Kunsong Chen
In this work, multi-fluid mixing solution blow spinning was applied to develop gelatin/pullulan composite nanofibers, and then the nanofibers were glycated to enhance the physical properties. The results show that the grafting degree of the nanofibers increased significantly from 17.5 % to 36.0 % as the glycation time increased, and the morphology results indicated that 72 h of glycation did not destroy the structure of the nanofibers. FTIR results show that the glycation consumed the the–NH 2 groups, cleaved sugar units of polysaccharide, and affected the secondary structure of the protein. The glycation enhanced the thermal stability and improved the rigidity of the nanofibers. Besides, after 120 h of glycation, the water contact angle of nanofibers increased from 0° to 79.1°, and the water vapor transmission rates decreased from 12.49 to 8.97 g mm/m 2 h kPa, indicating the enhanced hydrophobicity and barrier properties. In addition, the glycation improved the water stability of the nanofibers, which increased the applicability of the gelatin/pullulan nanofibers in food packaging. The present work provides a green and efficient method for improving the physical properties of gelatin/pullulan nanofibers.
研究领域:
材料科学
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纳米技术
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生物技术
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食品科学
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PubMed
高影响因子
危险品化学品经营许可证（带存储）