CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
·
2015
·Vol. 34
·期 4
·789-794
·
IF 0.657
Chang Zhiqiang,Liu Fei,Lian Chun’ang,Zhai Qianqian,Li Jian
The pharmacokinetic profiles and sulfamethoxazole (SMX) acetylation process in turbot reared at 18°C were investigated. Either SMX (parent drug) or its acetylized metabolite, N 4 -acetylsulfamethoxazole (AcSMX), was administered intravascularly to turbot at a dosage of 50 mg/kg BW. Serum concentrations of the parent drug and its metabolite were both measured by HPLC, and the changes in concentration over time were analyzed in two- and non-compartment models because SMX treatment produced multiple peaks. The results demonstrated that the elimination half-life of the parent drugs, SMX and AcSMX, were 159.2 and 5.9 h, respectively. The apparent volume of distribution was 0.2 and 0.8 L/kg, and the clearance was 0.038 and 0.222 L/(h·kg), for SMX and AcSMX, respectively. SMX acetylation in turbot was 2.8%, and the deacetylation of AcSMX was 0.2%. These findings may be useful in optimizing SMX dosage regimens in turbot aquaculture.
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Environmental Technology & Innovation
·
2025
·
IF 7.1
Xiao Tan,Gang Pan,Wenxue Che,Ying Man,Liyi Wang,Jinting Li,Hui Zhao
Microalgal-bacterial consortia provide a sustainable, low-cost solution for antibiotic-contaminated wastewater remediation. Microalgae cultivation typically involves natural symbiotic bacteria, which are often overlooked. To fill this gap, this study evaluated the adaptive response of Dunaliella sp. and its natural symbiotic bacteria to sulfamethoxazole (SMX) through cultivation experiments and 16S rDNA sequencing. The results demonstrated strong SMX tolerance but limited removal efficiency by the consortium. The adaptive responses were characterized by increased bacterial diversity and connectivity, with quorum sensing bacteria-driven community changes and biofilm formation playing a critical role in this process. Dunaliella sp. exhibited strong antioxidant capacity (with catalase playing a key role) and increased extracellular polymeric substances secretion, which not only contributed to its tolerance but also promoted microalgae-bacteria interactions, enhancing consortium adaptability. These findings strengthen our understanding of the responses of natural symbiotic bacteria to antibiotics and advance the development of microalgae-bacteria symbiosis technology for wastewater treatment.
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APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
·
2017
·Vol. 102
·期 1
·425-432
·
IF 3.42
Wang Shizong,Wang Jianlong
In this study, a novel strain capable of degrading sulfamethoxazole (SMX) was isolated and identified as Acinetobacter sp. The effect of influencing factors, such as initial SMX concentration (5–240 mg/L), temperature (15–35 °C), and pH (5–7), on SMX degradation was investigated. The results showed that when the initial SMX concentration was in the range of 5–240, the removal efficiency was 100%. The optimal condition for SMX biodegradation and microbial growth was determined to be 25 °C and pH = 7.0 in terms of the removal efficiencies of SMX and total organic carbon (TOC). Four metabolite compounds were detected during the process of SMX biodegradation, and the degradation pathways were tentatively proposed. In summary, Acinetobacter sp. was highly efficient in mineralizing SMX, which has the potential to be used for degrading SMX in water and wastewater.
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PubMed
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CHEMOSPHERE
·
2024
·
IF 8.1
Yuexinxi Wang,Shizong Wang,Yong Liu,Jianlong Wang
Heterogeneous activation of peroxomonosulfate (PMS) has been extensively studied for the degradation of antibiotics. The cobalt ferrite spinel exhibits good activity in the PMS activation, but suffers from the disadvantage of low PMS utilization efficiency. Herein, the nanocomposites including FeS, CoS 2 , CoFe 2 O 4 and Fe 2 O 3 were synthesized by hydrothermal method and used for the first time to activate PMS for the removal of sulfamethoxazole (SMX). The nanocomposites showed superior catalytic activity in which the SMX could be completely removed at 40 min, 0.1 g L −1 nanocomposites and 0.4 mM PMS with the first order kinetic constant of 0.2739 min −1 . The PMS utilization efficiency was increased by 29.4% compared to CoFe 2 O 4 . Both radicals and non-radicals contributed to the SMX degradation in which high-valent metal oxo dominated. The mechanism analysis indicated that sulfur modification, on one hand, enhanced the adsorption of nanocomposites for PMS, and promoted the redox cycles of Fe 2+ /Fe 3+ and Co 2+ /Co 3+ on the other hand. This study provides new way to enhance the catalytic activity and PMS utilization efficiency of spinel cobalt ferrite.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Tingzhe Shen,Danni Zeng,Ze Liu,Yadong Hu,Yaxi Tian,Jun Song,Tao Yang,Rongfeng Guan,Changjian Zhou
Improving the efficiency of photogenerated carrier separation by designing heterojunction photocatalysts remains an important challenge. In this study, TiO 2 nanofibers were prepared by electrospinning, Bi/Bi 2 WO 6 /TiO 2 heterojunctions were constructed by hydrothermal method, and verified by characterization techniques. The heterojunction had good photodegradation activity to sulfamethoxazole (SMX) under ultraviolet and visible light irradiation (96.4 % within 60 min). The enhanced photodegradation activity of Bi/Bi 2 WO 6 /TiO 2 nanocomposites can be attributed to the synergistic effect of S-Scheme mechanism and Bi metal plasma action. In addition, Bi metals can generate a large number of electron-hole pairs under the action of surface plasmon resonance (SPR). In addition, the influence factors such as pH, SMX concentration and catalyst loading were studied. According to the detected intermediates, the photocatalytic degradation pathway of SMX was studied. The results of free radical capture experiment and ESR show that ·O 2 – and h + free radicals play an important role in the decomposition of SMX. The cyclic experiments show that Bi/Bi 2 WO 6 /TiO 2 nanocomposites have excellent stability and reuse characteristics. Finally, the mechanism of photocatalytic degradation of SMX was described. This study provides a promising perspective for the preparation and development of S-Scheme heterojunction photocatalysts based on Bi 2 WO 6 .
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JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Zhenguo Qi,Xin Huang,Min Wang,Chunfeng Lv,Baoyou Shi
Activated carbon (AC) filtration is an effective technique to remove emerging contaminants in drinking water treatment plants. Adsorption onto AC and biodegradation by biofilm are two main mechanisms for the removal of emerging contaminants such as antibiotics. However, the effects of highly bioaccumulative and toxic poly- and perfluoroalkyl substances (PFAS) on antibiotic removal by AC filtration have not been well-understood. In this work, two AC columns were built and operated for 434 days to study the effects of ng-level PFAS on the removal of sulfamethoxazole (SMX). The results showed that 100 ng/L PFAS significantly decreased the removal rate of 1 μg/L SMX from 78.8% to 71.7%. Trace PFAS decreased the abundances of ammonia monooxygenase and nitrite-oxidizing bacteria, thus repressing nitrification co-metabolism process. Meanwhile, trace PFAS inhibited tricarboxylic acid (TCA) cycle by preventing pyruvate from generating acetyl-CoA, reducing energy supply for co-metabolism process. On the other hand, inhibiting TCA cycle led to a redirection of carbon from growth into polysaccharide intercellular adhesin biosynthesis. Trace PFAS also increased glutamate synthase and glutamine synthetase abundances, which promoted biofilm formation and then hindered SMX adsorption by AC. This study provides new insights into the adverse role of PFAS in antibiotic removal by AC filtration.
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JOURNAL OF HAZARDOUS MATERIALS
·
2022
·
IF 14.224
Yulong Yang,Wanyi Fu,Xixi Chen,Li Chen,Congyu Hou,Tianhao Tang,Xihui Zhang
Catalytic ceramic nanofiber membranes (Mn@CNMs) were prepared by anchoring Mn 2 O 3 nanoparticles on the pits of attapulgite (APT) nanofibers via an impregnation and in-situ precipitation method. An integrated catalytic ozonation/membrane filtration process applying Mn@CNM was employed to degrade sulfamethoxazole (SMX) and the removal achieved up to 81.3% during a 7-h continuous filtration. The reactive oxygen species (ROS) quenching and radical detection experiments were conducted to determine the contribution of 1 O 2 , ·OH and O 2 ·- towards the catalytic degradation of SMX. Moreover, Mn@CNM exhibited wide applicability for real water matrix and the total removal of various kinds of emerging contaminants in real hospital wastewater reached up to 98.5%. The excellent performances of Mn@CNM were attributed to the nano-confinement effect in the membrane layer. First, anchoring Mn 2 O 3 nanoparticles on the pits of the APT surface suppressed the growth and aggregation of nanosized Mn 2 O 3 , providing abundant reactive sites for catalytic ozonation . Second, the interlaced APT nanofibers formed nano-sized network structures, where ROS and SMX were confined in close vicinity and ROS have more chances to attack SMX. This work provides a promising strategy for the preparation of catalytic ceramic membrane with high catalytic efficiency for degradation of emerging contaminants in water.
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Journal of Environmental Chemical Engineering
·
2022
·
IF 7.968
Gaofeng Zhou,Runyu Zhou,Yiqing Liu,Li Zhang,Linyue Zhang,Yongsheng Fu
A novel heterogeneous peracetic acid (PAA)-based advanced oxidation process (AOP), viz. zero-valent cobalt activated PAA (ZVCo/PAA), was developed to remove sulfamethoxazole (SMX) in this study. About 99% SMX could be removed by ZVCo/PAA under neutral condition in 5 min. According to the characterization results of ZVCo before and after reaction by scanning electron microscopy (SEM), ZVCo was corroded to provide Co 2+ which was primarily responsible for the activation of PAA. The X-ray photoelectron spectroscopy (XPS) analysis of fresh and used ZVCo suggested that heterogeneous catalysis also occurred on the surface of ZVCo. Radical scavenging experiments indicated that organic radicals (i.e., CH 3 C(O)O • and CH 3 C(O)OO • ) were the dominant reactive species for SMX degradation in ZVCo/PAA system. SMX could be degraded well in a wide pH range especially at near-neutral pH. Increasing PAA or ZVCo dosage could enhance SMX removal, while excess ZVCo inhibited its degradation. The addition of SO 4 2− , NO 3 − or Cl − had a negligible effect on SMX degradation, while an obvious inhibition was observed in the presence of HCO 3 − or natural organic matter (NOM). ZVCo still presented an excellent activation ability for PAA to degrade SMX after 4 cycles, indicating its good stability and reusability. The probable reaction sites in SMX molecular structure were predicted by density functional theory (DFT) calculation and wave function analysis. Combining the results of DFT calculation and five identified transformation products , four possible degradation pathways of SMX in ZVCo/PAA system were proposed, including nitration , cleavage of S-N bond, coupling reaction and hydroxylation.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2022
·
IF 24.319
Chi Ma,Zhigang Yu,Jingjing Wei,Chang Tan,Xu Yang,Tantan Wang,Guanlong Yu,Chang Zhang,Xin Li
Traditional Fenton reaction takes place at a low pH and generates waste. Additionally, the storage and transportation of liquid H 2 O 2 may pose safety risks. To overcome these disadvantages, an eco-friendly, efficient advanced oxidation process was established with ultrathin-C 3 N 5 photocatalyst coupling sodium percarbonate (SPC). Under visible light irradiation, up to 93.97% of SMZ was removed within 120 min. Such efficient removal was attributed to the high carriers separation efficiency of U-C 3 N 5 , which was certified by DFT calculations and characterization methods. All the factors (various anions, pH values, fulvic acid, light sources, and water matrices) had a slight influence on SMZ degradation. Moreover, the toxicities of SMZ and its intermediates were reduced after degradation. Finally, a gelatin aerogel/U-C 3 N 5 composite was obtained to facilitate the recycling of U-C 3 N 5 . This work highlights the combination of metal-free photocatalysis with SPC to degrade sulfonamide antibiotics and furthers the development of advanced oxidation process for micropollutant removal.
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Journal of Environmental Sciences
·
2025
·
IF 6.3
Jia-Wei Song,Ju-Xiang Chen,Wen-Hai Chu,Yu-Qiong Gao,Nai-Yun Gao
Conventional treatment methods struggle to effectively eliminate sulfamethoxazole (SMX) from wastewater due to its persistent aromatic structure and sulfonamide moiety, while existing advanced oxidation processes often suffer from high energy consumption and inadequate degradation pathway control. This study demonstrates an advanced approach for SMX degradation in aqueous systems through dielectric barrier discharge (DBD) plasma technology synergistically integrated with COMSOL multiphysics simulation and particle swarm optimization-support vector machine (PSO-SVM) modeling. Computational simulations revealed that the DBD plasma generates a diffuse arc (D-A) mode electric field with Penning ionization effects, where primary reactive species formation predominantly occurs within the sheath layer. Under optimized operational parameters (input power: 50 W, pH 7, conductivity: 3.16 μS/cm, initial concentration: 10 mg/L, the carrier gas: air), the system achieved an exceptional SMX removal efficiency of 99.82 %, corresponding to a constant reaction rate of 0.3087 min −1 . The machine learning-optimized process simultaneously enhanced energy yield by 18.11 mg/kW·h and improved energy utilization efficiency by 15.11%. Notably, the system maintained robust performance (>75% SMX removal) in the presence of competing inorganic anions (NO 3 − , HCO 3 − and Cl − ). Mechanistic investigations combining DFT, EPR and UPLC-MS/MS elucidated that •OH, O 2 •− , 1 O 2 , •NO 2 and ONOOH preferentially attack the electrophilic N(4), N(7), and N(17) sites, initiating sequential diazotization and nitration pathways. Practical validation using hospital wastewater demonstrated significant removal of COD (56.17 %) and TOC (40.16 %), while effectively suppressing antimicrobial resistance genes. This work establishes PSO-SVM optimized DBD plasma as a sustainable and intelligent solution for pharmaceutical wastewater remediation.
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Surfaces and Interfaces
·
2026
·
IF 6.3
Jianle Wang,Hong Deng,Jiaxin Lv,Li Ma
To overcome mass-transfer limitations in solid–liquid catalytic reactions, a microwave-assisted system was developed based on bimetallic CuFe 2 O 4 spinel for peroxymonosulfate (PMS) activation. The catalyst achieved efficient sulfamethoxazole (SMX) degradation with a remarkable rate constant of 0.36 min −1 , representing an approximately 72 times faster rate than the non-microwave CuFe 2 O 4 /PMS system and superior to most reported analogues. Additionally, the microwave-assisted CuFe 2 O 4 /PMS system demonstrated higher efficiency than the PMS-only, Fe 3 O 4 /PMS, and CoFe 2 O 4 /PMS systems, which confirms the crucial role of Cu in the spinel structure. Quenching tests confirmed that superoxide radicals ( • O 2 − ) generated at the catalyst-solution interface played a dominant role. The system exhibited excellent stability and strong anti-interference ability across a wide pH range (3.0–9.0) and against common inorganic anions (Cl − , SO 4 2− , and HCO 3 − ). Under optimized conditions (1 g ·L −1 catalyst dosage and 700 W microwave power), nearly complete SMX removal was achieved within 20 min. XRD and XPS characterization confirmed that the crystal phase and chemical state of the CuFe 2 O 4 catalyst remained stable before and after the reaction. This study presents an efficient, stable approach for removing antibiotics from water and underscores the potential of microwave-enhanced interface catalysis in advanced oxidation processes.
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WATER AIR AND SOIL POLLUTION
·
2026
·Vol. 237
·期 17
·1016
·
IF 3.5
Xie Qingsong,Yang Qiang,Meng Lingyuan,Liang Jilin,Song Tiehong,Gao Yanjiao
The global contamination of aquatic environments by pharmaceutical residues presents new challenges for water treatment due to their recalcitrant nature. The periodate advanced oxidation process offers a novel research direction for removing such recalcitrant contaminants. This study investigated the treatment of sulfamethoxazole (SMX), a typical antibiotic pharmaceutical in water, using ultraviolet (UV)-activated periodate (PI) oxidation. The effects of UV intensity, pH, and PI concentration on SMX degradation were first examined. Subsequently, the reaction mechanism and degradation pathways of SMX were analyzed using a combination of chemical probe techniques, electron paramagnetic resonance (EPR) spectroscopy, and liquid chromatography-mass spectrometry (LC–MS). Additionally, the Fukui function was applied to predict the reactive sites of SMX, and ECOSAR software was used to assess the ecological safety of SMX degradation products. Finally, the degradation efficacy of the UV/PI process on other recalcitrant organic compounds was evaluated. The results showed that under optimal reaction conditions (UV intensity = 9.94 mW/cm 2 , pH = 5, PI = 2.5 mM, t = 60 min), 94.7% of SMX was removed. This was caused by several reactive species, including iodate radicals (IO₃•), superoxide radicals (O₂•⁻), hydroxyl radicals (•OH), and singlet oxygen ( 1 O₂), among which IO₃• played a major role. According to f⁰ values, C1, N4, C9, O10, C14, N17, S8, and H28 of SMX were identified as major reactive sites. SMX was degraded via four pathways into low-toxicity intermediates. Furthermore, the UV/PI could efficiently remove tetracycline, acetaminophen, oxytetracycline, and norfloxacin within 30 min. This study provides valuable references for related research on PI-based advanced oxidation processes.
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