JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·Vol. 24
·期 1
·653
·
IF 15
Zhou Tao,Lin Yajing,Wang Ying,Lin Lin,Li Jingtong,Tang Ning,Mao Yingji,Zhou Pinghui
Immune dysregulation and scar tissue formation following traumatic spinal cord injury (SCI) result in the generation of a microenvironment that significantly inhibits nerve regeneration and functional recovery. Continuous drug delivery across the dura, with minimal damage, and modulation of this inhibitory microenvironment pose substantial challenges in SCI treatment. This study fabricated a pH-responsive immunomodulatory microneedle (MN) patch by incorporating zeolitic imidazolate framework-8 (Zif-8) nanoparticles loaded with chondroitinase ABC (ChABC) into a gelatin methacrylate (GelMA) hydrogel (Z@C-MN). As the patch progressively degraded, this system continuously released Zn 2+ and ChABC in a pH-responsive manner to facilitate in situ SCI repair. In vitro, Z@C-MN can down-regulate macrophage inflammatory responses, promote axon extension, and differentiate neural stem cells into neurons. In vivo, Z@C-MN reduced the inflammatory microenvironment in an injury model and promoted angiogenesis in a rat SCI model. In addition, it promoted axonal regeneration and neurogenesis by inhibiting nerve scar formation and regulating CD4 + T cell transformation. These effects contributed to the recovery of motor and neurological functions. Thus, this drug delivery system offers a highly efficient, transdural, and continuous-release multifunctional platform for patients with SCI. Graphical
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International Journal of Minerals Metallurgy and Materials
·
2026
·Vol. 33
·期 6
·1886-1899
·
IF 8.8
Zeng Yong,Che Xiyuan,Zhang Lei,Chen Peng,Song Shaoxian,Wang Deshou,Jia Feifei
Thiosulfate gold extraction technology has gained considerable interest owing to its environmental compatibility and broad applicability to diverse ore types. However, the lack of efficient methods to recover Au(S 2 O 3 )
3− 2
from leaching solutions has hindered its industrial implementation. To address this challenge, this study used a thiosulfate leaching solution from quartz-type gold ores to design an activated carbon-coated titanium electrode (Ti@AC) with a porous surface structure. This electrode facilitated the direct reduction of low-concentration Au(S 2 O 3 )
3− 2
to metallic gold (Au 0 ) in solution, achieving a gold recovery of 99.58%, surpassing other recovery methods from the leaching solution by 30%–80%. After ten consecutive 200 L pilot-scale tests, the Ti@AC electrode demonstrated remarkable stability, consistently maintaining a recovery >98% and yielding 20.23 g of gold. The porous architecture of the activated carbon (AC) promoted the adsorption of low-concentration Au(S 2 O 3 )
3− 2
, while its low charge transfer resistance facilitated the efficient conversion of Au(S 2 O 3 )
3− 2
to Au 0 . Moreover, the reduction reaction generated a concentration gradient near the cathode, promoting the diffusion of Au(S 2 O 3 )
3− 2
toward the electrode and ensuring an efficient recovery process. This study provides a feasible strategy for the direct reduction of low-concentration precious metal ions to monomers with high recovery and low costs, which is promising for industrial applications.
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Frontiers of Materials Science
·
2026
·Vol. 20
·期 3
·260775
·
IF 2.3
Chen Chen,Chang Jie,Wang Tao,Fatima Areeje,He Min,Huang Jiarui
It is of practical significance to develop gas sensors with high sensitivity and high selectivity. In this study, ZnO nanoflakes were synthesized by hydrothermal synthesis, and Au/ZnO, Pd/ZnO, and Pt/ZnO nanoflakes were fabricated by uniformly loading small-sized Au, Pd, and Pt nanoparticles using an ultraviolet-assisted reduction. Gas-sensing performance tests revealed that Au/ZnO nanoflakes exhibited a higher response to isopropanol compared to Pd/ZnO, Pt/ZnO, and ZnO nanoflake sensors. At the working temperature of 225 °C, it demonstrated response of 132.2 to 100 ppm isopropanol, with 8 s response time and 12 s recovery time, and showed high selectivity, repeatability, and stability. Hydrogen sensing performance of Au/ZnO nanoflakes was also evaluated at the optimal operating temperature, yielding a response of 13.5 to 100 ppm hydrogen, with response time and recovery time of 17 and 21 s, respectively, and exhibiting a high concentration-dependent response. The material’s enhanced gas sensing performance is due to a synergistic effect. This effect combines abundant active sites on nanoflakes with inherent catalytic properties of gold nanoparticles.
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JOURNAL OF SOILS AND SEDIMENTS
·
2026
·Vol. 26
·期 7
·252
·
IF 3.3
He Ye,Zhong Jiawen,Wei Xiaoli,Wang Jinjin,Xu Huijuan,Zhang Yulong,Li Wenyan
Purpose Polycyclic aromatic compounds (PACs) and heavy metals (HMs) frequently coexist in the soil of industrial areas, posing significant ecological risks. This study investigated the distribution and influencing factors of PACs and HMs in soil aggregates under co-contamination, as well as their interactive adsorption behavior and mechanisms with soil, with a focus on lead (Pb), phenanthrene (Phe), and 1-acenaphthenone (1-ACE). Methods Soil samples were collected from an industrial area and fractionated into four aggregate sizes. soil properties and the contents of PACs and HMs in different aggregates were determined. Single and co-adsorption behaviors of Pb, Phe, and 1-ACE were examined through batch adsorption experiments, with isotherms modeled using Freundlich, Langmuir, and Linear models. Adsorption mechanisms were further explored by X-ray photoelectron spectroscopy (XPS) analysis. Results Most PACs and HMs mainly accumulated in the < 0.002 mm aggregates, with HMs influenced by multiple soil properties and PACs primarily influenced by soil organic matter (SOM). The Freundlich parameters (K F and 1/n) indicated that Pb exhibited heterogeneous multilayer adsorption, while Phe and 1-ACE exhibited homogeneous adsorption. The presence of Phe inhibited Pb adsorption by 7.94–19.28%, whereas 1-ACE enhanced it by 3.28–12.65%. Conversely, Pb coexistence increased the adsorption of Phe (17.29–27.26%) and 1-ACE (40.10–60.03%). XPS revealed that Phe competed with Pb for C=O groups, weakening Pb’s complexation and ion exchange, while 1-ACE promoted Pb adsorption by increasing C=O proportions. Pb enhanced Phe adsorption via increased surface hydrophobicity and π-π interactions, while it promoted 1-ACE adsorption through strengthened complexation and iron oxides interactions. Conclusions The results demonstrated that the interaction between co-contaminants and soil can alter the adsorption behaviors of pollutants, thereby deepening our understanding of their environmental fates. These findings provide crucial insights for assessing environmental risks and developing remediation strategies for co-contaminated soils.
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Nature Communications
·
2026
·Vol. 17
·期 1
·4508
·
IF 18.1
Li Shuying,Wang Yonghong,Liu Yuan,Cao Qing,Chen Gaojie,Fan Xiaolong,Li Qinyi,Zhang Peng,Hu Renzhi,Tham Yee Jun,He Xu-Cheng,Chu Biwu,Ma Qingxin,Chen Jinsheng,He Hong
Chlorine atoms (·Cl) exhibit high reactivity and exert a substantial influence on the atmospheric oxidation capacity and chlorine cycle in the troposphere. The photolysis of molecular chlorine (Cl 2 ) is a crucial source of ·Cl. However, the daytime peaks of Cl 2 concentration cannot be entirely accounted for by the currently known pathways. Here we show that the photolytic oxidation of ammonium chloride (NH 4 Cl), a ubiquitous component of atmospheric aerosol, serves as an important daytime source of Cl 2 . Laboratory experiments demonstrate that oxygen, water vapour, and acidity are indispensable for Cl 2 generation and release, and that Cl 2 production is enhanced in the presence of black carbon aerosol. Field observation combined with model simulation demonstrates that the mechanism explains 12-55% of daytime Cl 2 concentration. These results reveal a photoactivation pathway for chlorine production that depends only on chlorine salts and solar radiation, with significant implications in regions with abundant chloride salts.
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Translational Psychiatry
·
2026
·
IF 7.5
Liu Chang,Zhang Ting,E Er-Deng,Xu Tian-Yang,Yang Fei-Ran,Li Jia-Wen,Shang Qing,Zhang Zhong-Yu,Shen Hao-Wei,Zhang Xiao-Qin
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder characterized by progressive cognitive decline, and increasing evidence indicates that systemic inflammation can accelerate disease progression. Maraviroc, a CCR5 antagonist approved for the treatment of human immunodeficiency virus (HIV) infection, has shown neuroprotective effects in several neurological contexts, but its role in AD-related pathology remains unclear. In this study, cognitive performance was assessed in 5 × FAD mice using the Y-maze, novel object recognition, novel location recognition, and social discrimination tests. Amyloid-related changes were evaluated by hippocampal APP/Aβ immunoblotting and plaque staining using 6E10 and Thioflavin S. Glial responses were examined by IBA1 and GFAP immunostaining, and inflammatory cytokines were quantified by ELISA. We found that 5 × FAD mice exhibited age-dependent cognitive impairments, with detectable deficits emerging at 3 months of age. Systemic administration of lipopolysaccharide (LPS) further exacerbated cognitive dysfunction, amyloid-related alterations, and neuroinflammatory responses in young 5 × FAD mice. Maraviroc treatment attenuated LPS-associated cognitive impairments, reduced amyloid-related measures, and dampened pro-inflammatory cytokine responses, with a trend toward reduced microglial cell density. Collectively, these findings demonstrate that systemic inflammation accelerates Alzheimer’s-like pathology and cognitive decline, and suggest that pharmacological modulation of neuroinflammatory signaling by maraviroc may mitigate inflammation-driven disease exacerbation at early stages. Schematic diagram illustrating the effects of maraviroc on LPS-induced cognitive deficits in 3-month-old 5 × FAD mice. In this model, maraviroc is associated with modulation of glial inflammatory responses, reduced pro-inflammatory cytokine levels, and alleviation of amyloid pathology in the hippocampus, which together coincide with improved cognitive performance. Figure created with BioRender.com.
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PubMed
高影响因子
Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·431
·
IF 38.5
Wang Dongdong,Dou Shuo,Huang Qiongying,Li Jiaying,Xu Mi,Li Jingshuai,Guo Zhendong,Qin Siqi,Wang Tieyan,Yu Haipeng,Dou Haozhen,Chen Zhongwei
A loose selective interface (LSI) is in situ constructed by self-assembly of porous organic cages for aqueous Zn metal batteries.
The porous LSI enables fast Zn 2+ transport, dynamic self-repairing capability and dendrite-free Zn deposition.
Ah-level aqueous Zn pouch cells deliver 1 Ah capacity with stable cycling performance.
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PubMed
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Advanced Composites and Hybrid Materials
·
2026
·Vol. 9
·期 4
·297
·
IF 15.5
Lv Ze,Fang Yu,Gao Yang,Li Hongwei,Yan Pengkun,Zhang Zheng,Wang Lei,Li Fengyu,Ma Yingjian,Zhao Rui,Guo Xinyu,Wu Xuemin,Xu Yong
Sustainable management of plant bacterial diseases calls for delivery systems that minimize reliance on conventional synthetic pesticides while improving deposition efficiency, on-demand release, and environmental compatibility. This study employs a coordination-driven hollowing strategy to construct interface-optimized hollow metal–phenolic nanocarrier (NaSA@PDA@ZIF-8), achieving synergistic loading of sodium salicylate and Zn 2+ . PDA-induced etching of ZIF-8 generates a well-defined hollow architecture while enhancing hydrophilicity and colloidal stability. The optimized nanocarrier, obtained via Box–Behnken response surface design, achieves a NaSA loading content of 23.90%. Regarding interfacial performance, the carrier exhibits significantly optimized wetting behavior with a contact angle reduced to 51.15°, enhanced dynamic spreading speed, and outstanding leaf adhesion and rain-wash resistance, ensuring effective retention and utilization in complex field environments. Under simulated bacterial wilt conditions in tobacco (acidic pH 5.0 and elevated temperature of 35 °C), the system exhibited enhanced release behavior. The cumulative release of NaSA reached 81.72% and 83.40%, while Zn 2+ release reached 23.19% and 18.72%, indicating good responsiveness to disease-relevant microenvironmental conditions. Its antibacterial activity (EC 50 = 17.80 mg·L -1 ) is likely associated with multiple contributing factors, including Zn 2+ release, potential ROS generation mediated by PDA, and NaSA-related activation of plant defense responses. This work demonstrates a hollow metal–phenolic nanoplatform that integrates interfacial adhesion, stimuli-responsive co-delivery, and biosafety, providing a multifunctional reference model for green plant protection. Graphical abstract
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CELLULAR & MOLECULAR BIOLOGY LETTERS
·
2026
·
IF 12.2
Zhou Daqian,Wang Liquan,Zhou Yang,Lv Jiale,Song Chao,Mei Yongliang,Liu Tao,Wu Taotao,Yu Fei,Liu Zongchao
Intervertebral disc degeneration (IVDD) is a common and challenging chronic condition in orthopedics, primarily characterized by the aging of nucleus pulposus cells (NPC). Current treatment strategies for IVDD, particularly those targeting NPC senescence, remain underdeveloped. Research has shown that NPC senescence is closely associated with mitochondrial damage, leading to the accumulation of cytoplasmic reactive oxygen species (ROS) and mitochondrial DNA (mtDNA). Mitochondrial autophagy, as a key mechanism of mitochondrial quality control, regulates ROS and mtDNA levels by eliminating dysfunctional and damaged mitochondria, thereby delaying cellular aging. Notably, mitophagy signaling associated with Sirtuin 6 (SIRT6) and PTEN-induced kinase 1 (PINK1)/Parkin has been implicated in this process. Traditional Chinese Medicine (TCM), with its holistic approach and unique theoretical system of syndrome differentiation and treatment, offers significant advantages in preventing and treating degenerative diseases such as IVDD. However, research into TCM formulations aimed at NPC senescence remains limited. In preliminary studies, we observed that Nodakenin, the primary active compound from the TCM formula Duhuo Jisheng decoction (DHJSD), exerts protective effects in a SIRT6-associated manner and appears to be associated with activation of PINK1/Parkin-related mitophagy signaling. In this study, we used single-cell analysis to construct human NPC senescence and rat IVDD models, assessing mitochondrial morphology, mitochondrial membrane potential, cell senescence, and autophagy-related gene expression. We further evaluated the effects of Nodakenin (Nod) on H 2 O 2 -induced NPC senescence and determined the optimal intervention concentration, followed by assessment of mitochondrial phenotypes and SIRT6- and PINK1/Parkin-associated markers. These findings provide new theoretical support for the clinical application of TCM in the treatment of IVDD.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Wu Youyi,Wu Jingyi,Lu Xingyu,Wang Yuanjie,Gao Shiqian,Zhao Yang,Zhu Qionghui,Wang Xuedong
This study presented a new method of dispersive liquid–liquid microextraction based on Fe 3 O 4 nanoparticles-enhanced hydrophobic magnetic deep eutectic solvent (NPE-MDES-DLLME) for the simultaneous enrichment of six estrogens and bisphenols in water samples. The enriched analytes were then detected by ultra-performance liquid chromatography-fluorescence detection (UPLC-FLD). The innovations of the proposed method lie in two aspects: synthesis of a new hydrophobic MDES extractant composed of bis(2-ethylhexyl) phosphate, 1-hexanol, and nickel chloride, and addition of Fe 3 O 4 nanoparticles to enhance the extraction efficiency as well as speed up phase separation. Key parameters affecting extraction efficiency, including MDES composition, sample volume, extraction time, and elution conditions, were systematically optimized. Consequently, the method exhibited excellent analytical performance, characterized by good linearity (0.070–500 µg·L −1 , R 2 > 0.99), high enrichment factors (543–640), and low limits of detection (0.021–0.096 µg·L −1 ). When applied to real water samples, the proposed method yielded spiked recoveries ranging from 90.1% to 112.0% with relative standard deviations (RSDs) below 8.0%. Furthermore, greenness assessments using the ComplexAPI and AGREE metrics confirmed the method’s eco-friendliness. The developed NPE-MDES-DLLME/UPLC-FLD method provided a reliable, sensitive, and cost-effective approach for determining ultra-trace levels of estrogenic and bisphenol pollutants in the aquatic environment. Graphical
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COLLOID AND POLYMER SCIENCE
·
2026
·
IF 2.9
Xing Youmei,Hu Tao,Ying Ting,Zhang Zhijun,Wang Chen,Liu Jiani,Liu Zining,Hu Bin,Deng Chengwen,Xu Wen,Fang Weihua,Yin Yunjian,Jiang Huier,Wu Zhen,Wang Guojie
High-soluble nonionic Gemini surfactants are critically important in applications such as industrial cleaning. Herein, four nonionic Gemini surfactants with varying polyoxyethylene (EO) chain lengths, denoted as S1 ( n = 2), S2 ( n = 4), S3 ( n = 5), and S4 ( n = 7), are synthesized using 2,5-dimethyl-3-hexyne-2,5-diol and ethylene oxide as the raw materials. The structures of S1-S4 are confirmed by infrared spectroscopy and nuclear magnetic resonance spectroscopy. The S1-S4 surfactants exhibit a high solubility in both acidic and alkaline solutions and a high cloud point above 65 ℃, demonstrating good high-temperature stability. The surfactant with the shortest EO chain (S1) achieves the highest surface activity, reducing the surface tension to 47.21 mN/m (at 0.1 mol/L), while the surfactant with the longest EO chain (S4) exhibits the optimal cleaning performance with an impressive oil removal efficiency of 80.2%. Meanwhile, we systematically investigate the influence of EO chain length on surface tension, wettability, water solubility, and foaming performance. The results indicate that shorter EO chains contribute to higher surface activity, enhanced wetting performance, and reduced foam stability. In addition, the S1-S4 surfactants possess strong cleaning capabilities. This study provides a theoretical basis for the molecular design and screening of surfactants tailored for different application scenarios such as high-temperature stability, wettability optimization, and oil stain removal. Graphical
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Nature Communications
·
2026
·Vol. 17
·期 1
·5836
·
IF 18.1
Tursumamat Nafisa,Liu Qiannan,Lu Jihong,Guo Shuhong,Du Shuangshuang,Liu Shengyang,Wu Shuye,Li Heming,Wu Peng,Li Bin,Wei Juan
High-sensitivity glycomic analysis is essential for advancing both basic and translational biomedical research, yet remains methodologically challenging for limited-quantity samples, primarily due to complex workflows and reliance on specialized instrumentation. Here, we introduce solution-enhanced glycan reduction and permethylation (seGRAP), a streamlined, accessible, and high-sensitive method that enables glycan profiling from sub-nanogram protein inputs and picoliter-scale human plasma using widely available mass spectrometry (MS) platforms. seGRAP-MS demonstrates consistently robust and reproducible glycomic performance and enables comprehensive N -glycome characterization of human oocytes at single-cell resolution. Our single-oocyte analysis uncovers a highly conserved N -glycome across both individuals and developmental stages, revealing a previously uncharacterized layer of molecular stability in human reproduction. By significantly lowering technical and logistical barriers, seGRAP-MS redefines the benchmark for high-sensitive glycomics, expanding accessibility and empowering broader applications in fundamental biology, clinical research, and precision medicine.
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