Catalysts
·
2024
·Vol. 14
·期 11
·797
·
IF 3.8
Hanyang Zhang,Wen Liu,Jiale Hu,Qian Zhang,Zeguo Fang,Dong Li
An efficient method involving copper-catalyzed trifluoromethylthiolation and radical cyclization ofN-phenylpent-4-enamides using readily available and stable AgSCF3as the trifluoromethylthiolating reagent is described. The method enables the synthesis of a series of potential medicinally valuable trifluoromethylthio-substitutedγ-lactams and relative 2-oxazolidinone derivatives with broad functional group compatibility. Mechanistic investigations indicated that this reaction involved amidyl radical-initiated cascade5-exo-trigcyclization followed by trifluoromethylthiolation, resulting in the formation of new C-N and C-S bonds.
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Journal of Physical Chemistry Letters
·
2024
·
IF 4.8
Xue Zhou,Yueying Chu,Chao Wang,Qiang Wang,Min Hu,Jun Xu,Feng Deng
γ-Al2O3 is a crucial catalyst widely used in industrial alcohol dehydration processes. However, the specific nature of its active sites has remained unclear. In this study, we utilize two-dimensional heteronuclear correlation solid-state nuclear magnetic resonance and density functional theory calculations to uncover the active Al sites on the surface of γ-Al2O3 that facilitate ethanol dehydration. We show the formation of stable pentacoordinated AlV–ethanol complexes upon the adsorption of ethanol on the tetracoordinated AlIV sites. This interaction significantly enhances synergy with adjacent AlV–OH sites, resulting in a marked reduction of the activation energy barrier for ethene production. Furthermore, we reveal an interchange between AlIV and AlV–OH species, allowing hexacoordinated AlVI–OH sites to participate in the dehydration pathway through the migration of ethanol between these coordination sites.
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ACS Nano
·
2025
·
IF 16
Jingjing Cao,Wenji Zhan,Meng Ren,Yao Wang,Haifei Wang,Ni Zhang,Yuetian Chen,Tianfu Wang,Yanfeng Miao,Yixin Zhao
The application of promising perovskite light-emitting diodes (PeLEDs) faces a significant challenge known as efficiency roll-off, which refers to the decline in external quantum efficiency (EQE) at high current densities. This issue arises mainly from high trap densities in perovskite films and imbalanced carrier injection, which limit improvements in brightness and stability of PeLEDs. Here, we develop a green solvent strategy using γ-valerolactone (GVL) to suppress efficiency roll-off in PeLEDs. This strategy effectively slows down the crystallization kinetics, yielding cubic-phase formamidinium lead triiodide (α-FAPbI3) films with reduced trap states, enhanced charge carrier injection, and suppressed Auger recombination. As a result, we achieve a record radiance of 1411 W sr–1 m–2 for GVL-based PeLEDs. These PeLEDs exhibit a substantially reduced efficiency roll-off, maintaining an EQE above 20% even at a high current density of 900 mA cm–2. Our findings highlight the potential of the green solvent approach for developing high-brightness, high-efficiency PeLEDs for practical applications.
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DOI
PubMed
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Tingting Ma,Yijia Guan,Yanru Zhang,Jinlun Feng,Yue Yang,Junying Chen,Wenjie Guo,Jianguo Liao
Magnesium oxychloride cement (MOC) has the advantage of high early strength. However, it has the defect of poor water resistance. Considering this performance, we use γ-polyglutamic acid (γ-PGA) and chitosan (CS) to modify MOC. The effects of γ-PGA and CS such as strength, in vitro degradation and in vitro bioactivity of MOC were studied. Based on the preparation of γ-PGA and CS modified MOC (γ-PGA/CS-MOC) composite bone cement, the strontium ranelate (SrR) was loaded on. The results showed that the softening coefficient of γ-PGA/3 wt.% CS-MOC after soaking in SBF for 28 d reached 0.48, while that of control group (without CS and γ-PGA) was only 0.35; Cell experiments indicated that SrR could promote differentiation into osteoblasts. After the γ-PGA/CS-MOC composite bone cement containing SrR was implanted into the osteoporotic bone defect for 12 w, it was found that the material was gradually absorbed and the new bone tissue grew. The results showed that SrR/γ-PGA/CS-MOC composite bone cement had a potential application prospect in the repair of osteoporotic bone defects.
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PubMed
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2024
·
IF 5.4
Xiaowei Ding,Xuerong Luo,Imran Mahmood Khan,Lin Yue,Yin Zhang,Zhouping Wang
Geraniol (Ger) is an essential oil molecule with excellent biological activity. High hydrophobicity and volatility limit its practical application. Cyclodextrins (CDs) are water-soluble cyclic oligosaccharides with hydrophobic cavities. Physical encapsulation of CDs to improve the solubility and stability of essential oil molecules is not satisfactory. Therefore, this study synthesized the γ-CD derivative (γ-CD-Ger) by grafting Ger onto γ-CD using a bromide-mediated method. Compared to the inclusion complexes (γ-CD/Ger) formed by both, the derivatives exhibit better solubility and thermal stability. The derivative has better antibacterial activity when the ratio of γ-CD to Ger was 1:2. In addition, the derivatives did not exhibit cytotoxic and hemolytic properties. These results indicate that this research provides a water-soluble antibacterial agent with a wide range of promising applications and offers new ideas for the application of alcohol hydrophobic molecules in aqueous systems.
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PubMed
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JOURNAL OF FOOD PROCESSING AND PRESERVATION
·
2025
·Vol. 2025
·期 1
·7504108
·
IF 2.5
Xinyao Quan,Jiajia Ma,Lingxiang Sun,Guili Huang,Siyao Sui,Haocong Li,Qianshuo Shao,Su Yan,Yuning Wang,Xiaoqing Wang
To address the demand for sustainable postharvest preservation, this study developed a chitosan-based composite film integrated with γ -cyclodextrin ( γ -CD) microcapsules encapsulating proanthocyanidins and cinnamaldehyde. The primary objectives were to evaluate the film’s physicochemical properties and assess its efficacy in mitigating quality deterioration in citrus fruits during storage. Results demonstrated that the composite film significantly reduced weight loss (5.78%), maintained firmness (≥ 80% retention), and delayed changes in total soluble solids (TSSs) and pH compared to uncoated controls. Furthermore, it inhibited vitamin C degradation (≤ 35% loss) and extended shelf life to 40 days at 15°C by suppressing microbial growth and oxidative stress. The synergistic effects of chitosan’s film-forming capacity and the sustained release of bioactive compounds from γ -CD microcapsules, among which proanthocyanidins had good antioxidant function and cinnamaldehyde had good antibacterial property, played a key role in the preservation of citrus fruits.
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Discover Food
·
2025
·Vol. 5
·期 1
·428
·
IF 3.7
Gui Xinchen,Chen Yaozhong,Cao Shihai,Yu Yadong
To address the limitations of conventional packaging materials, this work synthesized the curcumin-loaded γ-cyclodextrin-metal-organic frameworks, Cur@CD-MOF, which was subsequently combined with the zein-chitosan (ZC) matrix to form the Cur@CD-MOF/ZC film. The structure, physiochemical property, curcumin release behavior, antibacterial/antioxidant activity and strawberry preservation performance of the Cur@CD-MOF/ZC film were investigated. Results confirmed that Cur@CD-MOF was successfully incorporated into the ZC matrix. The incorporation of Cur@CD-MOF made the Cur@CD-MOF/ZC films own smoother and denser microstructures, and have a lower water vapor permeability and light transmittance. The tensile strength of Cur@CD-MOF/ZC film (5.99 ± 0.55 MPa) was significantly higher than that of ZC film (3.37 ± 0.15 MPa). The release of curcumin from the Cur@CD-MOF/ZC film was delayed in humid environments, and interestingly, it became faster under acidic conditions compared to that under neutral conditions. Cur@CD-MOF significantly improved the antioxidant activity of Cur@CD-MOF/ZC film and its inhibitory effects against Escherichia coli and Staphylococcus aureus . Fruit preservation experiments showed that Cur@CD-MOF/ZC film effectively reduced the decay of strawberry. Moreover, Cur@CD-MOF/ZC film exhibited excellent preservation performances on other fruits and vegetables as well (winter jujube, broccoli, white mushroom, etc.), confirming their broad application potentials for the perishable produce preservation.
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JOURNAL OF MEDICINAL CHEMISTRY
·
2025
·
IF 6.8
Xinlin Zhu,Yi Dong,Ya Zhang,Chenghai Gao,Lijian Ding,Yonghong Liu,Zhiran Ju
Gouty arthritis, driven by monosodium urate (MSU) crystal deposition and dysregulated inflammation, remains a therapeutic challenge due to the limitations of current treatments. Here, we investigate Herdmanine D (HDD), a marine-derived alkaloid from the ascidian Herdmania momus. It was optimized via structure–activity relationship (SAR) studies and computational modeling to enhance its binding to peroxisome proliferator-activated receptor γ (PPAR-γ), which regulates the PPAR-γ/NF-κB signaling pathway in gout pathogenesis. The optimized HDD derivative 9a demonstrated potent PPAR-γ binding affinity and pharmacokinetic properties, effectively suppressing NF-κB-driven pro-inflammatory cytokines in vitro. In murine MSU-induced gouty arthritis models, 9a alleviated synovial inflammation and tissue damage. Mechanistically, 9a activated PPAR-γ to inhibit NF-κB and attenuate NLRP3 inflammasome assembly. This work highlights HDD as a unique marine scaffold for next-generation antigout therapeutics, merging marine natural product safety with rational design to address unmet clinical needs.
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PubMed
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MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Xinying Ma,Huiping Lv,Meifeng Chen,Hua Liu,Shouqing Xue,Qi Zhu,Xueliang Wang
Propyl gallate (PG), a common anti-oxidant used in food, has garnered extensive attention due to its possible harm to human health. Herein, a highly sensitive sensor for determination of PG in foodstuffs was fabricated by electropolymerizing γ-aminobutyric acid (GABA) and electrodepositing gold (Au) on a glassy carbon electrode (GCE). Scanning electron microscopic (SEM) images showed that the poly GABA formed a layer of uniform membrane, and the deposited Au was needle-like nanoclusters (AuNC). The electrochemical experiments showed that, under the optimal conditions, the modified electrode can be used for determination of PG in a wide concentration range from 0.06 to 3.6 μmol/L, with a correlation coefficient (R) of 0.9990 and a detection limit of 0.001 μmol/L (S/N = 3). The applicability of the sensor was verified by detecting PG in food samples, such as instant noodles, biscuits and edible oils, with excellent specificity and good recoveries (94.0–100.6 %), indicating that the sensor has application prospects in food safety control.
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WATER SCIENCE AND TECHNOLOGY
·
2017
·Vol. 75
·期 6
·1466-1473
·
IF 1.197
Li Shifeng,Qi Fang,Xiao Min,Fan Hongtao,Shen Yanming,Du Kaige,Zhang Zhigang,Li Wenxiu
Mg-Al layered double hydroxides (LDHs) adsorbent was synthesized in situ on γ -Al 2 O 3 for the removal of Cr(VI) from aqueous solution. The material was characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electronic microscopy and thermogravimetry and differential thermal analysis. Compared to the LDHs powder, the calcined LDHs sorbent prepared in situ on γ -Al 2 O 3 had higher specific surface area and was easy to recover and reuse. The adsorptive capacity for removing Cr(VI) from aqueous solution was resulting from the memory effect of LDHs based on the XRD results. Both the pseudo-second-order kinetic model and the Langmuir model fit the experimental data well. Furthermore, the adsorbent exhibits excellent sorption–regeneration performances.
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JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2020
·Vol. 167
·期 13
·132505
·
IF 3.721
Xiangyu Ren,Jie Tang,Cunying Xu,Shuxian Wang,Jianru Li,Jingling Lu,Yixin Hua,Qibo Zhang,Juanjian Ru
The electrodeposition behavior of Zn–Ni alloy on a Cu electrode has been studied in the choline chloride-urea-ethylene glycol (ChCl-urea-EG) based deep eutectic solvent (DES). The nickel and zinc sources are introduced into the solvent by the dissolution of nickel oxide (NiO) and zinc oxide (ZnO), respectively. Cyclic voltammetry indicates that the electroreduction of Ni(II) or Zn(II) species in the DES is a diffusion-controlled process and the diffusion coefficient of Zn(II) species is an order of magnitude larger than that of Ni(II) species. Under the examined condition, the anomalous codeposition of Zn–Ni alloy is observed, which is different from normal codeposition of Zn–Ni alloy in similar DESs using metal chlorides as precursor. The deposition potential is found to play an important role in controlling the composition and surface morphology of the resultant Ni-Zn alloys. The phase structure of the deposits depends on the Ni content, and changes from a mixture of η-phase and γ-phase to single γ-phase with (411) plane orientation. A mechanism for this electrodeposition process has been proposed on the basis of the formation of complex ions [NiO·urea·Cl]−, [ZnO∙urea·Cl]− and [ChCl·O·urea]2− in ChCl-urea-EG-ZnO-NiO electrolyte during the electrodeposition, emphasizing that the metal oxides were dissolve in DES by forming metal complex ions, the cathodic reduction of metal complex ions generates complex ions [ChCl·O·urea]2− with alloys (NixZny), and [ChCl·O·urea]2− is oxidized to release O2 at anode.
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ACS Applied Electronic Materials
·
2024
·
IF 4.3
Zihan Zhou,Silin Han,Yunwen Wu,Tao Hang,Huiqin Ling,Jie Guo,Su Wang,Ming Li
The SiO2 layers, as the dielectric in the multistack storage cells of 3D NAND, are detrimentally dissolved by phosphoric acid (PA) during the selective Si3N4 etching. The thinning of SiO2 layers leads to the failure of subsequent processes; thus, an etching inhibitor for SiO2 is crucial for 3D NAND fabrication. However, most inhibitors are currently limited to neutral or alkaline solutions. In this work, the γ-ureidopropyltriethoxysilane (UPTES), compatible with a hot-concentrated PA solution, was applied to the wet-etching process for the first time and exhibited an inhibitory effect on SiO2 etching by retarding the etch rate over 60% without affecting the Si3N4 etching. The saturation adsorption of UPTES on the SiO2 substrate is confirmed to occur around the critical concentration, according to the Langmuir–Freundlich adsorption isotherm. The adsorption behavior of UPTES exhibits a reliance on its concentration. Around the critical concentration, the UPTES molecules chemisorb on the SiO2 surface by Si–O–Si covalent bonds to form ordered UPTES-siloxane layers, avoiding contact between SiO2 and the etchant; whereas oversaturated UPTES polymers physisorb not only on SiO2 but also on Si3N4, impeding the Si3N4 etching. This work contributes to a step forward in the effective wet-etching process in high-density 3D NAND fabrication.
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