ANALYST
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2018
·Vol. 144
·期 2
·656-662
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IF 3.864
Shujuan Zhuo,Yuanyuan Guan,Hui Li,Jing Fang,Ping Zhang,Jinyan Du,Changqing Zhu
In this paper, we have presented a novel strategy to fabricate Fe-doped carbon quantum dots (Fe-CQDs) for dopamine sensing applications. The Fe-CQDs are obtained by one step hydrothermal carbonization, using ethylenediamine tetraacetic acid salts and ferric nitrate as the carbon and iron source, which simultaneously incorporates Fe (dopamine-bonding site) and luminescent carbon quantum dots (fluorophores). The added dopamine containing catechol groups might form complexes with Fe ions (doped in CQDs) due to coordination. Subsequently, dopamine was oxidized to generate dopamine-quinone (a known potent electron acceptor) species by ambient O2. Thus, the coordination induced dopamine in proximity to the CQDs, which provided favourable electron acceptors in close proximity to the CQDs and produced high quenching efficiencies. Such fluorescence responses can be used for well quantifying dopamine in the range of 0.01–50 μM with a detection limit of 5 nM (S/N = 3). The proposed sensing system has been successfully used for the assay of dopamine in human urine samples. Preliminary cell image study indicates that the obtained Fe-CQDs possess high photostability and low cytotoxicity, which make them promising for biological applications.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2018
·
IF 3.235
Meiling Wang,Mingzhu Cui,Weifeng Liu,Xuguang Liu
Conductive polymer hydrogels (CPHs) have exhibited great potential as advanced material for sensing. Here, a facile approach to 3D networked polypyrrole (PPy) hydrogel is reported. This strategy relies on the doping of the azo dye molecule Tartrazine during the synthesis of nanostructured conductive PPy hydrogel. The prepared PPy hydrogel can be highly dispersible in the mixed solvent of isopropanol/H 2 O (4/1). The unique 3D network nanostructure endow PPy hydrogels with high electric conductivity and effective interface area for enhanced sensing performance towards the simultaneous determination of ascorbic acid , dopamine and uric acid with respective lower detection limits of 1.283, 0.044 and 0.046 μmol L −1 . The as-designed electrochemical sensor also exhibited excellent stability and reproducibility.
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Journal of Inorganic and Organometallic Polymers and Materials
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2018
·Vol. 29
·期 2
·423-428
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IF 1.754
Liu Jian-Ping,Zhang Han-Yu,Wang Jun
We developed a seepage method for fabricating a non-enzymatic glucose sensor based on a hybrid of polypyrrole (PPy), silver amalgam (AgHg) and natural biomineralization hydroxyapatite (BioHAP). The fabricated sensor (PPy/BioHAP/AgHg) with unique structure presents a synergistic effect of the hybrid for glucose sensing. Many active sites on BioHAP help to adsorb glucose molecules. AgHg is used as the source of Ag for electrocatalyzing glucose oxidation. PPy forms a wonderful tubular array in BioHAP, improving its conductivity. The sensitivity and the limit of detection reach 2.21 µA M cm −2 and 0.27 mM for glucose ( S / N = 3), respectively. It also shows a good selectivity to ascorbic acid, uric acid and dopamine.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Ting Yin,Sheng Zhang,Mengxuan Li,Carl Redshaw,Xin-Long Ni
Supramolecular p K a shifts, have attracted much attention in catalytic and biomimetic studies because of their excellent property to modify the acidity or basicity of the substrate in aqueous media by host-guest inclusion. Here, Fluorescence indicator displacement based on cucurbit[8]uril encapsulation of the dye acridine leads to the recognition of the peptide drug octreotide in aqueous solution via distinctive pH signals was expolited. This is thought to be a result of competitive host-guest interactions involving a supramolecular p K a shift.
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MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 10
·1-9
·
IF 5.705
Wang Yanying,Yang Li,Liu Yaqin,Zhao Qingbiao,Ding Fang,Zou Ping,Rao Hanbing,Wang Xianxiang
A composite consisting of NiCo 2 S 4 and reduced graphene oxide (rGO) was prepared via a hydrothermal process. Compared to individual NiCo 2 S 4 nanomaterials or reduced graphene oxide, the composite exhibits enhanced oxidase-like activity. It is found that dopamine (DA) inhibits the ability of NiCo 2 S 4 -rGO to oxidize the substrate 3,3′,5′,5′-tetramethylbenzidine (TMB) to form blue colored ox-TMB. Based on these findings, a colorimetric method for determination of DA was worked out. The absorption, best measured at 652 nm, increases linearly in the 0.5–100 μM DA concentration range, and the limit of detection is 0.42 μM. This method was successfully applied to the detection of DA in spiked human serum samples.
A hierarchical NiCo 2 S 4 -rGO composite was prepared through two-step hydrothermal process. It exhibits enhanced oxidase-like activity which, however, is inhibited by dopamine (DA). Hence, less blue colored ox-TMB is formed by oxidation of 3,3′,5,5′-tetramethylbenzidine in the presence of dopamine.
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Nanoscale
·
2018
·Vol. 10
·期 34
·15932-15937
·
IF 7.233
Feng Wang,Jian Lin,Hongye Wang,Shansheng Yu,Xiaoqiang Cui,Asghar Ali,Tao Wu,Yang Liu
Herein, the ECL behaviors of precise mono-Cu+ ion doped Cd–In–S supertetrahedral chalcogenide nanoclusters (Cu@CdInS NCs) were investigated, and the effect of mono-Cu+ ions at the vacancy site of NCs on ECL emission performance was also elucidated. Precise mono-Cu+ ion doping not only induced new ECL emission at 596 nm with enhanced efficiency as high as 21.72% relative to [Ru(bpy)3]2+, but also improved acid tolerance of the ECL performances of NCs. In addition, a simple, fast and label-free dopamine ECL sensor with excellent selectivity was achieved.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Chen Li,Xuejuan Chen,Zhe Zhang,Jilin Tang,Bailin Zhang
Aptamer-based microcantilever (ML) array sensor is a recently development method for the analysis of various molecules with free-label, high sensitivity and selectivity. Since its signal-transducing principle is the changes of surface stress or resonance frequency caused by molecules binding on the surface, there have difficulties in determining some low molecular weight substances. Herein, a novel detecting dopamine (DA) method based on aptamers functionalized-ML array using gold nanoparticle (NP)-DNA conjugates as the signal-amplifying strategy was developed. In this method, thiolated DA aptamers were self-assembled on the surface of ML array and then Au NP-DNA conjugates which contained a stretch of complementary sequences for DA aptamers were hybridized to DA aptamers. When DA sample interacted with its aptamer and replaced the Au NP-DNA conjugates, the surface stress of ML array was enhanced about fifteen times and resulted in much more deflection. The deflection was linearly proportional to DA concentration in the range from 0.5 to 4 μM with a lowest limit of detection 77.3 nM ( R 2 = 0.993). Some structural and functional DA analogues did not cause interference for the detection of DA. These results proved that the functionalized-ML array sensor based on Au NP-DNA conjugates could be used as a promising tool to detect low-weight molecules with high sensitivity and selectivity.
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Nanomaterials
·
2018
·Vol. 8
·期 12
·993
·
IF 3.504
Baoyan Wu,Shihua Hou,Yongyong Xue,Zhan Chen
The study reports a facile and eco-friendly approach for nanomaterial synthesis and enzyme immobilization. A corresponding glucose biosensor was fabricated by immobilizing the gold nanoparticles (AuNPs) and glucose oxidase (GOD) multilayer films onto the polypyrrole (PPy)/reduced graphene oxide (RGO) modified glassy carbon electrode (GCE) via the electrodeposition and self-assembly. PPy and graphene oxide were first coated on the surface of a bare GCE by the electrodeposition. Then, AuNPs and GOD were alternately immobilized onto PPy-RGO/GCE electrode using the electrodeposition of AuNPs and self-assembly of GOD to obtain AuNPs-GOD multilayer films. The resulting PPy-RGO-(AuNPs-GOD)n/GCE biosensors were used to characterize and assess their electrocatalytic activity toward glucose using cyclic voltammetry and amperometry. The response current increased with the increased number of AuNPs-GOD layers, and the biosensor based on four layers of AuNPs-GOD showed the best performance. The PPy-RGO-(AuNPs-GOD)4/GCE electrode can detect glucose in a linear range from 0.2 mM to 8 mM with a good sensitivity of 0.89 μA/mM, and a detection limit of 5.6 μM (S/N = 3). This study presents a promising eco-friendly biosensor platform with advantages of electrodeposition and self-assembly, and would be helpful for the future design of more complex electrochemical detection systems.Keywords:polypyrrole;graphene;gold nanoparticles;electrodeposition;self-assembly;biosensor
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ACS Sensors
·
2018
·
IF 5.711
Jia-Dong Zhang,Lei Lu,Xiu-Fang Zhu,Li-Jing Zhang,Shan Yun,Chuan-Song Duanmu,Lei He
In this work, we developed an innovative closed bipolar electrode (BPE)-electrochemiluminescence (ECL) sensing strategy with generality for target detection. Based on charge balance and 100% current efficiency between the closed BPE poles and the driving electrodes, one of the driving electrodes in one cell of the closed BPE system was employed as ECL sensing surface to reflect the target on the BPE pole in the opposite cell. Compared with traditional BPE-ECL sensing method, which in general adopted the anodic ECL reagents such as Ru(bpy)32+ and its coreactant on one pole (anode) to reflect the target (occurring reduction reaction) on the other pole (cathode), the difference was that the targets occurring oxidation reaction could be detected by the anodic ECL reagents based on this strategy. To verify the feasibility of this strategy, the detection principle was stated first, and Fe(CN)64– as model target at anodic BPE pole were detected by anodic ECL reagents (Ru(bpy)32+ and TprA) on the driving electrode first. The ECL signals showed good performance for target detection. By changing the size and the material of the BPE pole where the targets were located, the detection of l-ascorbic acid (AA), uric acid (UA), and dopamine (DA) as other model targets with higher detection limit were accomplished. Visual and high-throughput detection of AA, UA, and DA were also successfully realized by an array of the closed BPE system. This closed BPE (array) system is an effective supplement of traditional BPE-ECL sensing and could greatly expand the scope of the detection target.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Di Zhu,Dongxuan Guo,Lulu Zhang,Lichao Tan,Haijun Pang,Huiyuan Ma,Mo Zhai
Heteropolyacids (PMo 6 W 6 ) and ferrocene (Fc) were assembled on the glassy carbon electrode for the first time by electrodepositon method, and further combined with reduced graphene oxide (RGO) through the layer-by-layer self-assembly technology, developing a novel non-enzymatic nanocomposite for xanthine (XA) detection. The detection signal of XA was greatly amplified on the Fc-PMo 6 W 6 /RGO nanocomposite modified electrode due to coexist of these three active components. As ferrocene and PMo 6 W 6 all have relatively good electrochemical reversibility, fast electron transfer ability and generation of stable redox forms, meanwhile RGO can enlarge the active surface area of the electrode, increase the conductivity and load of ferrocene and PMo 6 W 6 . Under the optimized conditions, the developed nanocomposite modified electrode displayed superb sensing property towards xanthine with a widely linear range from 5.00 × 10 −8 ∼ 2.03 × 10 -3 M, along with a relatively low detection limit of 1.01 × 10 -8 M. The modified electrode has good stability as it is prepared by the smart combination electrodeposition and layer-by-layer self-assembly. Additionally, the nanocomposite was applied in detecting xanthine in actual samples with acceptable results, demonstrating the feasibility of Fc-PMo 6 W 6 /RGO nanocomposite in routine testing xanthine to some extent.
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MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 10
·1-11
·
IF 5.705
Tang Jing,Jiang Sixun,Liu Yu,Zheng Shengbiao,Bai Lei,Guo Jiahao,Wang Jianfei
A composite was prepared from a Co(II)-based zeolitic imidazolate framework (ZIF-67) and graphene oxide (GO) by an in situ growth method. The material was electrodeposited on a glassy carbon electrode (GCE). The modified GCE was used for the simultaneous voltammetric determination of dopamine (DA) and uric acid (UA), typically at working potentials of 0.11 and 0.25 V (vs. SCE). The morphology and structure of the nanocomposite were characterized by scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy and X-ray diffraction. The modified electrode exhibits excellent electroanalytical performance for DA and UA owing to the synergistic effect of the high electrical conductivity of GO and the porosity of ZIF-67. By applying differential pulse voltammetry, a linear response is found for DA in the 0.2 to 80 μM concentration range, and for UA between 0.8 and 200 μM, with detection limits of 50 and 100 nM (at S/ N = 3), respectively. Further studies were performed on the effect of potential interferents, and on electrode stability and reproducibility. The modified GCE was applied to the simultaneous detection of DA and UA in spiked human urine and gave satisfying recoveries.
Schematic of the preparation procedure of GO-ZIF67 and electrochemical reaction mechanisms of UA and DA at the GO-ZIF67-modified glassy carbon electrode (GCE). GO: graphene oxide; ZIF-67: Co(II)-based zeolitic imidazolate framework.
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MOLECULES
·
2018
·Vol. 23
·期 10
·2518
·
IF 3.098
Xuan Zheng,Hongwei Wang,Peng Zhang,Lin Gao,Ning Yan,Panpan Li,Xinmin Liu,Yongmei Du,Guoming Shen
Chaenomeles speciosa(Sweet) Nakai is a medicinal plant. Until date, there are no studies focusing on comparing the chemical profiles, antioxidant activity andα-glucosidase inhibitory activity of the dried fruits ofC. speciosafrom different production regions. In the study, we investigated the chemical components of dried fruits ofC. speciosafrom Yunnan, Chongqing, Zhejiang and Anhui provinces in China in relation to the antioxidant activity andα-glucosidase inhibitory activity.C. speciosafrom Yunnan had higher total flavonoid (47.92 ± 3.79 mg/g), total polyphenol (29.15 ± 0.29 mg/g) and polysaccharide (27.60 ± 1.56 mg/g) contents than plants from other production areas. Samples from Yunnan, Zhejiang and Anhui (all > 3200 mg/kg) had higher free amino acid contents than those from Chongqing (2286.66 mg/kg). Oleanolic acid and ursolic acid levels were highest in samples from Zhejiang (555.98 ± 20.88 μg/g) and Anhui (321.06 ± 14.64 μg/g), respectively.C. speciosafrom Chongqing had low total flavonoid, total polyphenol, polysaccharide, free amino acid, oleanolic acid and ursolic acid contents but high levels of palmitic acid (12.04 ± 0.02 mg/g) and stearic acid (2.23 ± 0.08 mg/g). Among four production areas, Yunnan represented the highest antioxidant activity andα-glucosidase inhibitory activity. In addition, correlation analysis revealed that total flavonoid, total polyphenol, polysaccharide and ursolic acid were the major components responsible for the antioxidant activity ofC. speciosa, while total flavonoid and polysaccharide were the main contributors forα-glucosidase inhibitory activity of the plant. These results would be helpful for evaluating the quality ofC. speciosain the different production areas.Keywords:Chaenomeles speciosa;chemical composition;antioxidant activity;α-glucosidase inhibitory activity
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