JOURNAL OF CONTROLLED RELEASE
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2026
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IF 12.4
Fenfang Li,Guipan Chen,Tiantian Xue,Yuhan Jiang,Yurong Chai,Ke Yi,Yanteng Xu,Yuanyuan Jin,Yixin Zhang,Yuechen Luo,Haixia Wang,Enguo Ju,Zhuanggui Chen,Xi Xie,Yanglong Hou,Xintao Shuai,Kai Li,Mingqiang Li,Yu Tao
Stem cell-derived hepatocyte therapy holds great potential for treating acute liver failure (ALF) by rapidly restoring liver function and stimulating regeneration. However, significant challenges remain in efficiently driving stem cells toward a hepatic lineage and ensuring transplanted cell survival and functionality in the hostile, injured liver microenvironment. To overcome these hurdles, we developed a novel ceria nanoparticle@microRNA complex that facilitates hepatic differentiation of mesenchymal stem cells. We show that ceria nanozymes synergize with microRNA-122 to enhance hepatic differentiation by maintaining redox homeostasis and boosting mitochondrial biogenesis via TCF7L2 suppression, providing direct evidence that ceria nanoparticles can promote stem cell hepatic lineage commitment. Furthermore, we coated the resulting induced hepatocyte-like cells with a cerium-tannic acid metal-phenolic network, which protected the cells from oxidative damage under liver failure conditions. In a carbon tetrachloride-induced acute liver failure mouse model, this integrated strategy significantly restored liver function and promoted tissue regeneration. Overall, this study establishes a new bio-nano approach for stem cell-based liver therapy and offers fundamental insights into how bioactive nanomaterials can orchestrate stem cell differentiation and microenvironment remodeling, highlighting a conceptually innovative strategy with translational potential.
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SENSORS AND ACTUATORS B-CHEMICAL
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2026
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IF 8.3
Wenjing Li,Bi Lin,Bixiao Li,Peifu Zhang,Ziyue Ju,Anees A. Ansari,Ruichan Lv
Nanorobots, with miniature size, wireless operation, and flexible mobility, can access narrow spaces and are widely used in biomedicine. High-precision transport is vital for targeted drug delivery, disease diagnosis, and treatment, yet current research has limitations like insufficient single-imaging diagnosis and active tumor targeting. In this research, a magnetic nanorobot platform is proposed, combining magnetic ferric oxide substrate with rare earth nanoparticles (RENPs). This magnetic nanorobot features multi-modal imaging including NIR II fluorescence, MRI, and PA with high moving target effect (<5 s). After conjugated with antibodies against MET and VEGF, this platform enables multi-molecular targeting. Under an external magnetic field, the dual-targeting (active and physical magnetic) allows in vitro and in vivo precise tumor cell targeting with tumor imaging. Moreover, its NIR II luminescence enables enhanced real-time temperature detection (Region: 24.6–41.5℃). Especially, the deep learning allows NIR II imaging to simultaneously perform increased fluorescence imaging for surgical boundary definition and temperature sensing display (R 2 = 0.973, RMSE = 1.50℃). With high penetration and spatial resolution, this proposed magnetic/rare earth hybrid nanorobots holds great promise for precision biomedicine.
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JOURNAL OF CONTROLLED RELEASE
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2026
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IF 12.4
Chongzheng Yan,Zhichao Kong,Yuxue Pan,Zhipeng Fu,Kun Han,Xiaotian Zhao,Jing Zhang,Longyu Bo,Weiyi Sun,Jinxin Gao,Xianghui Dong,Zuolin Zheng,Xiao Yue,Peng Sun,Xinyi Jiang,Chen Chen
Chimeric antigen receptor microglia (CAR-M)-mediated amyloid-β oligomers (AβO) phagocytosis shows great promise in Alzheimer's disease (AD) treatment, however, the limited AβO degradation of CAR-M compromises their anti-AβO potency. This work here reports an in situ engineered agonistic anti-C-type lectin domain containing 7 A (CLEC7A) nanobody to accelerate AβO degradation of CAR-M, augmenting their anti-AβO efficacy. Specifically, with the intranasal-delivered microglia-targeting lipid nanoparticles (LNP), this work generates an AβO-specific degradation-potentiated CAR-M by introducing dual mRNAs encoding AβO-specific CAR and anti-CLEC7A nanobody into the cerebral microglia. These data show that these engineered CAR-M exhibited superior phagocytic function and promoted intracellular AβO degradation via activating CLEC7A-spleen tyrosine kinase (SYK) signaling pathway through the local secretion of anti-CLEC7A nanobody. In the APP/PS1 mouse model of AD, these in situ reprogrammed CAR-M significantly reduced cerebral Aβ levels, suppressed neuroinflammation, and restored cognitive function. In sum, these findings demonstrate that potentiating AβO degradation within CAR-M effectively alleviates AD pathology, providing a promising therapeutic strategy for AD with broad application in other neurodegenerative diseases.
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
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2026
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IF 9.2
Jia Yuan,Chunyu Wang,Xinrui Yuan,Xin Wang,Xu Gao,Yuxuan He
Due to the excessive chemical-energy consumption, conventional treatments ( e.g. Fenton or catalytic ozonation) have faced great challenges when treating chemical wastewater containing tetrabromobisphenol S (TBBPS), a prevalent brominated flame retardant. This study proposes an electrocatalytic active atomic hydrogen (H*)-mediated electroreduction strategy, enabling enhanced degradation of TBBPS into intermediates with lower toxicity and higher biodegradability. A palladium-modified electrocatalytic microfiltration membrane (EMM) was developed to efficiently generate H*, which played a dominant role in the reductive debromination of TBBPS. By conducting quenching experiments, it was found that free H* and adsorbed H* co-dominate the TBBPS removal process. Under optimized conditions, the EMM achieved nearly complete removal (∼100%) of TBBPS (100 mg L −1 ) within 60 min, with a low energy consumption of 9.53 kWh/m 3 . The degradation pathway of TBBPS was proposed on the results of calculations and LC-MS analysis, and the evidence demonstrated the lower toxicity of the degradation intermediates. These findings emphasize the prospects of H*-mediated electroreduction strategy as a green and environmentally friendly treatment for industrial wastewater treatment.
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CHEMICAL ENGINEERING SCIENCE
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2026
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IF 5.1
Mengying Lin,Hanyue Lou,Zhaoyang Qi,Jie Chen,Changshen Ye,Ting Qiu
The development of highly active catalysts is crucial for oxidative desulfurization (ODS) to meet the growing demand for sulfur-free fuels. In this study, a defect-rich composite catalyst UiO-DAlaPW was successfully synthesized via mechanochemical grinding, wherein phosphotungstic acid (HPW) was encapsulated within a defect-engineered UiO-66 framework, utilizing D-alanine (DAla) as a bridging molecule. The synthesized catalyst, UiO-DAlaPW, significantly enhances the utilization efficiency of hydrogen peroxide (H 2 O 2 ). In the model oil ODS system, the material exhibited exceptional catalytic performance: achieving deep desulfurization at room temperature within merely 5 min under conditions of extremely low acetonitrile cosolvent usage and a low oxidant/sulfur (O/S) ratio, accompanied by remarkably high H 2 O 2 utilization efficiency. Moreover, the catalyst maintained high desulfurization efficiency even in the absence of acetonitrile. Characterization by XRD, FT-IR, TGA, and XPS confirmed the successful encapsulation of HPW within the UiO-66 framework. Mechanistic studies revealed a significant synergistic effect between UiO-66 and HPW. The effective cooperation of the two active sites, namely Zr in UiO-66 and PW, significantly enhances the catalytic performance, contributing to superior oxidative desulfurization activity.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Xingxing Li,Jianing Qi,Mingjing Shi,Yuan Yao,Yingying Cao,Xue Wang,Hui Wang
Artemisinin is primarily derived from Artemisia annua L. However, due to the complex composition of its leaf extract, the purification and separation of artemisinin remain a significant challenge. In this work, various poly(ionic liquid)s (PILs) containing polar ester groups and non-polar long-chain alkyl groups were synthesized through radical polymerization. Subsequently, these PILs were made into coatings with controllable pore sizes and adjustable hydrophobicity. The ethyl octadecanoate based PIL coating showed excellent capability to intensify this purification process. The product purity could reach 96.8% after one crystallization step under the optimal conditions, approximately 30.8% higher than the traditional method. And the product purity could reach 99.9% after three sequential separation processes. In addition, the adsorption kinetics of wax oil on the PIL coating were studied, and the results indicated that it followed a pseudo-first-order kinetic model with a maximum adsorption capacity of 226.33 mg/g. Mechanism analysis demonstrated that hydrogen bonding and van der Waals forces between the wax oil and PIL facilitated the adsorption of the wax oil, thereby increasing the purity of artemisinin.
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2026
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IF 3.5
Lifan Zhong,Xianchao Lv,Zhenyang Ling,Weerawut Chaiwat,Shasha Liu,Shu Zhang,Xingjie Lu,Miftahul Huda,Yong Huang,Jing-Pei Cao
The complex composition of bio-oil necessitates advanced separation strategies for its valorization. This work reports the application of biochar as a sustainable and structure-tunable stationary phase in column chromatography for the efficient fractionation of bio-oil. Biochars with distinctly different properties were engineered through pyrolysis of bamboo at 400 °C (bsC-400) and 700 °C (bsC-700). Comprehensive characterization confirmed that bsC-700 possessed a highly aromatized and hydrophobic surface with a well-developed porous network, while bsC-400 retained a polar and oxygen-functionalized surface. Their chromatographic performance revealed a fundamental structure-function relationship, as evidenced by the strong retention of sugars on the polar surface of bsC-400 via hydrogen-bonding interactions, which necessitated the use of aggressive solvents for elution. In contrast, bsC-700 exhibited exceptional affinity for phenolics via π-π stacking, while facilitating the early and efficient elution of sugars with moderately polar solvents due to its non-polar chemistry. This study establishes pyrolysis temperature as a critical design parameter for tailoring biochar selectivity, positioning it as a versatile stationary phase for targeting specific compound families within complex mixtures and advancing integrated biorefinery concepts.
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FUEL
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2026
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IF 7.8
Saiyi Song,Xiangyu Chen,Xiaojie Feng,Xiaoxiao Wei,Yinghua Sun,Shuqian Xia
The depletion of conventional light oil reserves and the escalating global energy crisis have intensified the strategic imperative to develop unconventional heavy oil resources. However, the efficient extraction and transportation of heavy oil are severely hampered by its inherent high viscosity, primarily caused by elevated contents of asphaltenes. In this work, an oil-soluble polymeric viscosity reducer (MPPMO) was pre-designed using molecular dynamics (MD) simulations and realized by grafting polyethylene glycol monomethyl ether (PGME) onto the PMO backbone to integrate polar functionalities with a long-chain structure. Performance evaluation demonstrated that MPPMO achieves a net viscosity-reduction efficiency of 42.51%, markedly outperforming PMO (35.54%) with a relative improvement of about 20% in high-viscosity crude oil (OIL A, 17951 mPa·s) at 50 °C, while maintaining an exceptional stability over 14 h. Molecular dynamics simulations illustrate that introducing polar groups (–COOH and –O–) enables MPPMO to interact more strongly with asphaltenes than PMO, leading to the breakdown of asphaltene aggregates and viscosity reduction, while the long-chain backbone of MPPMO further inhibits their re-aggregation through steric hindrance. Therefore, these findings support a molecular-design strategy that couples long-chain backbones with multiple polar functional groups to improve the dispersion of asphaltene aggregates and enhance heavy-oil flowability.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2026
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IF 9.2
Xintong Li,Zhichuan Yang,Shenglong Li,Min Gao,Yu Liu
Although remarkable progress has been achieved in electrocatalytic water splitting, the design of highly efficient bifunctional catalysts remains a significant challenge, mainly because of the slow kinetics of the oxygen evolution reaction (OER) and the limited stability of non-precious metal catalysts. This work presents a novel heterojunction catalyst consisting of Co–MnO nanocubes anchored on nitrogen-doped graphitic carbon derived from carbonized Ganoderma lucidum mycelium (CGLM), synthesized via an ion-exchange-coupled pyrolysis strategy. The unique fibrous entanglement morphology of CGLM offers ideal anchoring sites for catalytic centers, while preserving its intrinsic three-dimensional porous architecture to establish a continuous conductive network. This structural enhances electron transport efficiency and promotes stable immobilization of Co–MnO nanocubes (Co–MnO -2 /CGLM). Extensive experimental and theoretical investigations demonstrate that the Co–MnO -2 heterogeneous interface induces charge redistribution, synergistically optimizes the hydrogen adsorption free energy (Δ G H = −0.15 eV), and reduces the OER energy barrier, with a rate-determining step of Δ G 4 = 1.69 eV. The catalyst demonstrates remarkable bifunctional activity in alkaline media, exhibiting overpotentials of 105 mV for hydrogen evolution reaction (HER) at 10 mA cm −2 and 250 mV for OER at 50 mA cm −2 . Notably, the assembled electrolytic cell (Co–MnO -2 /CGLM||Co–MnO -2 /CGLM) achieves a voltage of only 1.61 V (50 mA cm −2 ) in overall water-splitting tests and maintains excellent durability, with negligible change in current density during prolonged operation. This study highlights the synergistic effect of heterogeneous structure engineering combined with biomass-derived carbon substrates in reducing reaction barriers and facilitating charge transfer, offering novel perspectives on the design of cost-effective electrocatalysts for sustainable energy conversion.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.6
Yi-Lin Liu,Changgui Guo,Ping Cao,Qingyan Zhang,Ling Wang,Qingyi Zeng
The rapid development of the nuclear industry has made the efficient treatment of uranium-containing wastewater a significant challenge in environmental radiochemistry. This study aimed to develop a high-performance adsorbent for the removal of UO 2 2+ from water. A series of MIL-125/Ti 3 C 2 nanocomposites were successfully constructed via an in-situ solvothermal method, by integrating two-dimensional Ti 3 C 2 MXene with rich surface functional groups and porous MIL-125(Ti) MOF. The composite material not only retained the regular pore structure of MIL-125 but also exposed a greater number of active sites, exhibiting optimal adsorption performance. Under neutral conditions (pH = 7), the adsorption of U(VI) onto MIL-125/Ti 3 C 2 –2 followed the pseudo-second-order kinetic model and reached equilibrium within 50 min, with a remarkable maximum adsorption capacity of 661.07 mg/g, clear superior to most reported adsorbents. The adsorption isotherm fitted the Langmuir model, indicating monolayer chemisorption. Furthermore, the material demonstrated excellent anti-interference ability and selectivity in the presence of various coexisting ions (except for Cu 2+ and Ca 2+ ) and humic acid, along with satisfactory regeneration performance (85.6% retention after 5 cycles). The adsorption mechanism involves strong coordination interactions between surface functional groups (-NH 2 , -OH) and UO 2 2+ , while the potential reducing ability of MXene also facilitates the partial reduction of U(VI) to the more stable U(IV), forming a dual fixation mechanism of ‘synergistic adsorption-reduction’. This work provides new insights and experimental evidence for designing efficient and stable MOF/MXene adsorbents for treating actual uranium-containing wastewater.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
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IF 6.2
Danni Zhang,Yiwen Zhu,Imre Blank,Ni Yang,Ian Fisk,Yumin Liu,Yanping L. Qian,Michael C. Qian,Shui Jiang,Yuan Liu
Cultivated pufferfish (Takifugu rubripes) is a valuable sustainable source of nutritious and tasty food. The Sensomics approach was applied to elucidate the impact of cooking on the aroma of steamed and roasted pufferfish (STR, RTR) by solvent-assisted flavor evaporation, identification, quantitation, aroma recombination, and omission studies. Thirty-five odor-active compounds were characterized by flavor dilution factors of 4 to 2048. The concentrations of selected odorants ranged from 0.06 to 95653 μg/kg. Trimethylamine, 2,3-pentanedione, acetoin, (Z)-4-heptenal, 2-acetyl-1-pyrroline, nonanal, 2-ethyl-3,5-dimethylpyrazine, 2,3-diethyl-5-methylpyrazine, (E)-2-nonenal, (E,Z)-2,6-nonadienal, 2-acetylthiazole, 2-acetyl-2-thiazoline, 4-hydroxy-2,5-dimethyl-3(2H)-furanone, and 4-hydroxy-5-methyl-3(2H)-furanone contributed to the aroma of STR and RTR, while 2- and 3-methylbutanal and dimethyl disulfide were more pronounced in the RTR aroma. Compared with STR, higher amounts of trimethylamine, (Z)-4-heptenal, and Maillard-derived odorants like 4-hydroxy-2,5-dimethyl-3(2H)-furanone and ethyl-substituted pyrazines contributed to the stronger fishy and caramel-like/roasted notes of RTR, respectively. Cooking at high temperatures and prolonged time could promote the generation of pleasant sensorial attributes of pufferfish.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Jiayi Song,Yijian Wu,Peipei Guan,Bin Zeng
Residues of tetracycline antibiotics (TCs) in aquaculture pose serious risks to environmental and human health. Although laccase-based enzymatic degradation offers a green and sustainable strategy for removing TCs from marine aquaculture wastewater, its application is often hindered by inefficient enzyme production and stability issues. In this study, we engineered Aspergillus oryzae , a Generally Recognized as Safe (GRAS) filamentous fungus with powerful secretory capabilities, for the homologous overexpression of laccase. After purification, the laccase was stably immobilized onto polycarboxylate-functionalized magnetic nanoparticles via covalent bonding. Compared with free laccase, the immobilized enzyme exhibited markedly enhanced performance under various conditions, including pH tolerance, thermostability, long-term storage stability, and reusability. This novel biocatalyst, exhibiting optimal activity under neutral to slightly alkaline conditions, was subsequently applied to degrade TCs in simulated aquaculture wastewater. The maximum removal efficiencies of tetracycline (TC) and oxytetracycline (OTC) (10 mg/L) by the immobilized laccase reached 82.9% and 87.84%, respectively. Based on the identification of intermediates, the pathways for TC removal involve dehydrogenation, demethylation, and ring-opening reactions, resulting in less toxic and readily biodegradable products. Overall, this system demonstrates strong potential for effective removal of TCs from aquaculture wastewater and for broader environmental remediation applications.
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