NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 43
·期 41
·16164-16168
·
IF 3.069
Shangqing Chen,Zheng Wang,Jiayin Hu,Yafei Guo,Tianlong Deng
The readily available ZnI2/NEt3 system was used firstly to catalyze the transformation of CO2 and 2-aminobenzonitriles into quinazoline-2,4(1H,3H)-diones at room temperature and low CO2 pressure in high yields. Further experiments indicated that this ZnI2/NEt3 system has excellent effects on activating both amino and cyano groups.
研究领域:
有机化学
·
催化化学
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DOI
高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2019
·
IF 4.833
Wen-Jing Zhu,Ben-Wen Cui,Hui Min Wang,Ji-Xing Nan,Hu-Ri Piao,Li-Hua Lian,Cheng Hua Jin
Six series of 4-(benzo[ c ][1,2,5]thiadiazol-5-yl)-3(5)-(6-methylpyridin-2-yl)- pyrazoles 18a – d , 19a – d , 22a – d and 3(5)-(6-methylpyridin-2-yl)-4-(thieno[3,2,- c ]- pyridin-2-yl)pyrazoles 20a – d , 21a – d , 23c , 23d have been synthesized and evaluated for their activin receptor-like kinase 5 (ALK5) and p38α mitogen activated protein (MAP) kinase inhibitory activities in enzymatic assays. Among these compounds, the most active compound, 22c , inhibited ALK5 phosphorylation with an IC 50 value of 0.030 μM in the enzymatic assay. Compound 22c showed four-fold more potent activity against ALK5 kinase than the clinical candidate, compound LY-2157299 . The selectivity index of 22c against p38α MAP kinase is 235, which is much higher than that of LY-2157299 (4) and equally selective to that of EW-7197 (218). Compound 22c effectively suppressed protein and mRNA expression of collagen I and α-SMA in TGF-β-induced LX-2 human hepatic stellate cell (HSC), this result shows that compound 22c has the ability to inhibit the activation of HSC. Compound 22c is expected to be a preclinical candidate for the treatment of hepatic fibrosis .
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DOI
PubMed
高影响因子
KEY ENGINEERING MATERIALS
·
2021
·
IF 0
Yang Yi Chen,Wen Jing Wen,Zhi Qin Su,Qi Huan,Chu Yang Zhang
Thermo-responsive random copolymer poly (2-(2-methoxyethoxy) ethoxyethyl methacrylate-co-poly (ethylene glycol) methyl ether methacrylate), abbreviated as P(MEO2MA-co-OEGMA300) was synthesized by 2-(2-methoxyethoxy) ethoxyethyl methacrylate (MEO2MA) and poly (ethylene glycol) methyl ether methacrylate (OEGMA300) with a molar ratio of 1:1 via atom transfer radical polymerization (ATRP). The structure of P(MEO2MA-co-OEGMA300) was confirmed by 1H NMR and GPC. The transition behaviors of P(MEO2MA-co-OEGMA300) in aqueous solution were investigated by UV-Vis and DLS. While the transition behaviors of P(MEO2MA-co-OEGMA300) thin films were probed by white light interferometry. Compared to the P(MEO2MA-co-OEGMA300) in solution, it shows a much broader transition region, which is a promising candidate for the slow release of drug in the field of medicine.
研究领域:
材料科学
·
生物医学工程
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DOI
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Yingxia Wei,Zhangwei Li,Farhat Nosheen,Xueyan Wu,Rui Xue,Xingyun Li,Yan Lv,Jixi Guo,Dianzeng Jia
Direct seawater electrolysis for hydrogen production faces significant challenges, particularly regarding stability due to chlorine corrosion and oxidation. Herein, we present an earth-abundant alkaline seawater oxidation electrocatalyst (CO 3 2− -Co(OH) 2 @FeOOH) capable of sustained electrolysis for 5000 h without a significant attenuation at 1 A cm −2 , achieving 100% oxygen Faradaic efficiency. This multilayer electrode, featuring an amorphous FeOOH coating on crystalline cobalt carbonate hydroxide, not only generates a CoFe (oxy)hydroxide active layer but also effectively inhibits the release of CO 3 2− into the electrolyte during the reconstruction process. The synergistic effect of CO 3 2− and the distinct structure contributes to the catalyst's high activity, selectivity, and corrosion resistance. The constructed Pt/C/NF||CO 3 2− -Co(OH) 2 @FeOOH electrochemical cell achieves seawater electrolysis of 500 mA cm −2 at 1.80 V cell voltage, resulting in a power consumption of only 4.30 (kWh m −3 H 2 ). The voltage of the anion exchange membrane electrolyzer remains stable after 600 h of continuous operation at 500 mA cm −2 . The calculated gasoline-equivalent (GGE) per gallon of H 2 is as low as $0.96. This work emphasizes the synergistic effect of multilayer electrodes and anions. and provides a potential catalyst for commercialization.
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DOI
高影响因子
POLYMER COMPOSITES
·
2025
·
IF 4.7
Yifeng Lai,Jun Liu,Xiaowei Hu,Yiju Zhu,Yuting Yang,Xuan Yang,Guowen Peng,Songbo Tan
The development of efficient gamma-ray shielding materials is crucial for addressing increasingly complex radiation environments. In this study, (BiO) 4 CO 3 (OH) 2 (BCH) and (BiO) 4 CO 3 (OH) 2 @Gd 2 O(CO 3 ) 2 ·H 2 O (BG) fillers were synthesized via a hydrothermal method. After being dispersed into epoxy resin by mechanical stirring, the mixtures were molded using a vacuum-assisted thermal curing process. Under 59.5 keV gamma irradiation, the linear attenuation coefficient (LAC) of BG/EP-50 reached 5.8 cm −1 , representing an 84% increase compared to BCH/EP-50 (3.15 cm −1 ) and about 33 times that of pure EP (0.17 cm −1 ). In addition, the temperature at 50% weight loss (T 50% ) of BG/EP-50 increased to 637.9〬C, which is 60.9% higher than that of the epoxy matrix, indicating improved thermal stability. The BG filler, constructed through a simple two-step hydrothermal route, demonstrated a synergistic effect between Bi and Gd components, which not only compensated for the limitations of Bi in the low-energy region but also enhanced the gamma shielding capability of the epoxy resin at higher energies. Compared to several shielding materials reported in recent years, BG/EP-50 shows superior performance and offers a promising strategy for lightweight and environmentally friendly polymer-based gamma shielding materials.
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产品关联
DOI
高影响因子
INORGANICA CHIMICA ACTA
·
2024
·
IF 2.7
Hou Cong Li,Ye Fan Zheng,Ming Zhu Wang,Chen Chen Geng,Min Hou,Chang Qing Liu,Wen Ge Li
Two new ligands, 2-(5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazolin-6-yl)phenol (H 2 L1′) and 2-(5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazolin-6-yl)-4-fluorophenol (H 2 L2′) were synthesized by 2-(2-aminophenyl)benzimidazole with salicylaldehyde and 5-fluorosalicylaldehyde, respectively. While the two ligands (H 2 L1′ and H 2 L2′) were coordinated with nickel (II) and cobalt (II) ions and represented open-chain Schiff base structures (H 2 L1 and H 2 L2). Their metal complexes: [Ni 2 (HL1) 2 (C 2 H 5 OH) 2 Cl 2 ]‧2C 2 H 5 OH (complex 1), [Co (HL1) (L1)] (complex 2), [Ni 2 (HL2) 2 (C 2 H 5 OH) 2 Cl 2 ]‧2C 2 H 5 OH (complex 3) and [Co (HL2) (L2)] (complex 4) were obtained by solvothermal reaction. The four Schiff base complexes were characterized by infrared spectroscopy, elemental analysis, thermal stability analysis, X-ray powder diffraction, single-crystal X-ray diffraction, and lipophilicity assay. Single crystal X-ray analysis reveals that complexes 1 and 3 crystallize in a monoclinic system with space group P 21/n, while complexes 2 and 4 crystallize in a trigonal system with space group R -3. The lipophilicity assay (Log P) showed that the introduction of fluorine atoms enhanced the lipophilicity of ligands and complexes. The MTT method was used to determine the IC 50 values of complexes, ligands, and cisplatin against four different tumor cells (A-549, SMMC-7721, MDA-MB-231, and CNE-2Z) and one normal cell (IOSE 80). The results indicated that the four complexes exhibited stronger anticancer efficacy than ligands, among which the fluorine-substituted Co (III) complex (complex 4) displayed greater cytotoxicity compared with cisplatin in inhibiting SMMC-7721, MDA-MB-231 cells and A-549 cells, respectively. In addition, complex 4 can increase intracellular reactive oxygen species levels, arrest cells in the G0/G1 phase, upregulate Bax levels, and downregulate Bcl-2 levels, inducing MDA-MB-231 cell apoptosis in a dose-dependent manner.
研究领域:
化学
·
医学
·
肿瘤学
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DOI
高影响因子
JOURNAL OF CHEMICAL CRYSTALLOGRAPHY
·
2026
·Vol. 56
·期 1
·27
·
IF 0.7
Ni Yingjia,Jin Shouwen,Hong Ruyu,Hong Huiling,Gao Rui,Wang Daqi
The hydrothermal reaction of the Cd( O Ac) 2 with the 2-methylimidazole (mim) in the presence of the monocarboxylic acids produced five unpublished mim-derived coordination compounds of Cd(mim) 2 (ibu) 2 (1) (Hibu = ibuprofen), Cd(mim) 2 (sal) 2 (2) (Hsal = salicylic acid), Cd(mim) 2 (pba) 2 (3) (Hpba = 3-phenoxybenzoic acid), Cd(mim) 2 (tba) 2 (4) (Htba = 2,4,6-trichlorobenzoic acid), and Cd(mim) 2 (tmba) 2 (5) (Htmba = 2,4,6-trimethoxybenzoic acid) and they are structurally characterized by the EA, IR spectra, TG and SCXRD analysis. The X-ray investigations declared that all these coordination compounds demonstrated the mononuclear graphs with the pseudo-tetrahedral/octahedral/square-pyramidal geometries around the Cd 2+ . The mim molecules take the coordination mode of the monodentate by only using its imidazole ring N atoms. The CO 2 − coordinated to the Cd 2+ ion in monodentate, and chelating bidentate types. The intricate intra- and intermolecular traditional H-bonds are uncovered by the X-ray crystallographic studies, which mediate the discrete systems into the 1D–2D supramolecules. Graphical Five mononuclear Cd 2+ complexes with the pseudo-tetrahedral/octahedral/square-pyramidal coordination geometries have been synthesized and characterized, the intricate intra- and intermolecular traditional H-bonds mediate the discrete systems into the 1D-2D supramolecules.
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产品关联
DOI
高影响因子
INORGANIC CHEMISTRY
·
2021
·
IF 5.165
Xiao-Bao Li,Chun-Li Hu,Fang Kong,Jiang-Gao Mao
Two new antimonous phosphates, namely Ba3Sb2(PO4)4 and Cd3Sb2(PO4)4(H2O)2, have been successfully prepared through mild hydrothermal reactions. Ba3Sb2(PO4)4 features a 1D [Sb(PO4)2]3– chain structure separated by Ba2+ cations while Cd3Sb2(PO4)4(H2O)2 presents a 2D [Sb(PO4)2]3– layered structure with Cd2+ located at the interlayer space. The [Sb(PO4)2]3– chain in Ba3Sb2(PO4)4 is the first example of 1D antimonous phosphate structure, and Cd3Sb2(PO4)4(H2O)2 represents the first d10 transition metal antimonous phosphate. Based on UV–vis–NIR spectra, both Ba3Sb2(PO4)4 and Cd3Sb2(PO4)4(H2O)2 can display large optical band gaps (4.30 and 4.36 eV, respectively). But their transparent ranges are quite different because of the coordination water of Cd3Sb2(PO4)4(H2O)2 (500–2000 and 500–1300 nm for Ba and Cd compounds). The anhydrous Ba3Sb2(PO4)4 shows high thermal stability in the nitrogen atmosphere (900 °C). Because of the incorporation of the lone pair cation of Sb(III), the birefringence of Ba3Sb2(PO4)4 and Cd3Sb2(PO4)4(H2O)2 has been enhanced to 0.086 and 0.053 at 532 nm, respectively.
研究领域:
无机化学
·
材料科学
·
光学材料
·
晶体学
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DOI
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2023
·
IF 3.6
Yuhang Xue,Chengjun Wu,Haiwen Li,Cunde Wang
Acetic acid-catalyzed (3 + 2) cyclization reaction of substituted 2-aroyl-3-aryl-1,1-dicyanocyclopropanes with arylhydrazines was investigated for the efficient synthesis of 4-dicyanomethyl-1,3,5-triaryl-4,5-dihydropyrazoles in good yields, in which 4,5-double substituents are predominantly trans selective. This approach included the consecutive condensation, ring opening, and double nucleophilic cyclization reaction.
研究领域:
有机化学
·
合成方法学
·
杂环化学
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DOI
高影响因子
Journal of CO2 Utilization
·
2018
·
IF 5.503
Xue-Dong Li,Yu Cao,Ran Ma,Liang-Nian He
Efficient CuI/1,10-phen-catalyzed three-component cascade reaction of propargylic alcohols, CO 2 , and 2-aminoethanols has been firstly developed for the thermodynamically favourable preparation of 2-oxazolidinones. In the presence of commercially available CuI, 1,10-phen (1,10-phenanthroline) and t -BuOK, the cascade reaction afforded the desired products in good to excellent yields with a broad substrate scope (14 examples). The predicted copper complex Cu 2 I 2 (phen) 2 in situ formed from CuI and 1,10-phen could activate the triple bond through coordination. The isolation of α-alkylidene cyclic carbonate as the reaction intermediate suggests that the carboxylative cyclization of propargylic alcohol with CO 2 , followed by ring-opening reaction, is involved in the one-pot three-component cascade reaction.
研究领域:
有机化学
·
催化
·
二氧化碳利用
·
合成方法学
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DOI
高影响因子
ENERGY
·
2023
·
IF 9
Xiaobin Zhou,Chao Liu,Jie Zhang,Yinming Fan,Yinian Zhu,Lihao Zhang,Shen Tang,Shengpeng Mo,Hongxiang Zhu,Zongqiang Zhu
Biphasic solvents are regarded as promising candidates for CO 2 capture but still suffer from the deficiency of inferior regenerability, which negatively affects their energy-saving potential. 2-Amino-2-methyl-1-propanol (AMP)-based absorbents have superior regenerability but poor phase-change performance. In this study, an effective strategy that using tetraethylenepentamine (TEPA) to regulate the phase change behavior of an AMP-pentamethyldiethylenetriamine (PMDETA) aqueous solution was proposed, aiming to develop a novel AMP-PMDETA-TEPA (A-P-T) biphasic solvent with good regenerability and excellent phase separation performance. The A-P-T biphasic solvent could realize a high CO 2 loading of 0.73 mol mol −1 and a high desorption efficiency of 75.3%. Its sensible heat requirement significantly decreased to 0.14 GJ·ton −1 CO 2 , 78.1% less than the monoethanolamine solution. The 13 C NMR characterization and quantum chemistry calculations indicated that with the introduction of TEPA, high polar TEPA-associated products were generated, which broke the original assimilation state of the A-P-T system and drove it to undergo phase change. Since the TEPA-associated products had a strong affinity to other CO 2 -captured products and H 2 O, they gathered together to form the CO 2 -rich phase. In contrast, less polar PMDETA showed a relatively weak affinity to the TEPA-associated products and was solely separated from the solution to form the CO 2 -lean phase.
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产品关联
DOI
高影响因子
Journal of CO2 Utilization
·
2022
·
IF 8.321
Mengmeng Ma,Yuchen Liu,Yuli Chen,Guohua Jing,Bihong Lv,Zuoming Zhou,Shihan Zhang
The large-scale deployment of non-aqueous amine solution for carbon dioxide (CO 2 ) capture is mainly limited by its high viscosity, even insoluble substances in saturated solution, which may result in equipment fouling and pipeline blockage. To avoid this problem, the polyamine 1,5-diamino-2-methyl-pentane (DA2MP) was screened as the main absorbent to ensure the high absorption load. While 2-amino-2-methyl-1-propanol (AMP) was used as the regulator to reduce the viscosity and eliminate insoluble substances, which dissolved in n-propanol (PrOH) to from the novel non-aqueous absorbent for CO 2 capture. The CO 2 absorption load of the novel absorbent was 0.95 mol·mol −1 , and the viscosity of saturated solution was only 15.00 mPa·s, remarkably lower than that of the solution without AMP regulation. The solution maintained 97% of its initial CO 2 absorption capacity after fourth regeneration cycle. The regulation mechanism was investigated using 13 C nuclear magnetic resonance (NMR) and quantum chemical calculations. It was proved that a strong and dense hydrogen bond network between DA2MP-carbamates was formed due to the self-deprotonation process, leading to insoluble products in the saturated DA2MP/PrOH solution. Through AMP regulation, there was another type of DA2MP-carbamates deprotonated by AMP formed in the solution with less hydrogen bond network, which could further react with PrOH to produce alkyl carbonates, achieving the elimination of insoluble products and reducing viscosity. Overall, the total regeneration energy consumption was 1.86 GJ·ton −1 CO 2 , only 50.27% of that of the benchmark monoethanolamine (MEA)-based solution, which would be a promising candidate for CO 2 capture.
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产品关联
DOI
高影响因子
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