JOURNAL OF CHEMICAL RESEARCH
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2020
·
IF 0.593
Mingguang Zhang,Zhongbao Bi,Yunyun Wang,Yuxun Zhao,Yang Yang,Yongqiang Zhu,Shifa Wang
A new and practical synthesis of 3-chloro-2,4-difluoro-5-hydroxybenzoic acid, a key intermediate for preparing antimicrobial 3-quinolinecarboxylic acid drugs, is synthesized from 2,4-difluoro-3-chlororobenzoic acid. The protocol involves nitration, esterification, reduction of NO2, diazotization, and hydrolysis with a 70% overall yield. The structures of the synthesized compounds are determined by infrared spectroscopy, nuclear magnetic resonance spectroscopy, and high-resolution electrospray ionization mass spectrometry. The advantages of this developed synthetic strategy include an improved overall yield and readily controllable reaction conditions.
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PLANT PHYSIOLOGY AND BIOCHEMISTRY
·
2021
·
IF 4.27
Xuqiu He,Ronghao Huang,Lipeng Liu,Yingying Li,Wenzhao Wang,Qingshan Xu,Youben Yu,Tianshan Zhou
Anthocyanins are a group of natural water-soluble pigments in plants that contribute to the pink-purple color of a range of tissues. Because anthocyanins have various biological activities in human health, there is great research interest in the development of anthocyanin-rich foods and beverages, including purple shoot tea. Anthocyanidin 3- O -galactosides have been identified as one of the main anthocyanin components in purple shoot tea, but the enzyme responsible for their biosynthesis remains unclear. UDP-galactose anthocyanidin 3- O -galactosyltransferase (UA3GalT) is presumed to catalyze the galactosylation of anthocyanidin. Therefore, we assayed the UA3GalT activity in five tea samples with varying degrees of purple color and found that its activity was strongly positively correlated (r = 0.929, p < 0.05) with anthocyanin content. Phylogenetic analysis and sequence alignment suggested that CsUGT78A15 encoded a UA3GalT enzyme. Enzymatic assays indicated that r Cs UGT78A15 could catalyze the synthesis of cyanidin 3- O -galactoside and delphinidin 3- O -galactoside using UDP-galactose as a sugar donor, and it showed higher catalytic efficiency towards delphinidin than cyanidin. These results indicate that Cs UGT78A15 acts as a UA3GalT in vitro . Subcellular localization showed that Cs UGT78A15 was located in the endoplasmic reticulum (ER) and nucleus, consistent with the location of anthocyanin synthesis. Transient overexpression of CsUGT78A15 in the fruit of mature ‘Granny Smith’ apples showed that the upregulation of CsUGT78A15 promoted cyanidin 3- O -galactoside accumulation in apple skins. These results suggested that Cs UGT78A15 could catalyze galactosylation of anthocyanidins in planta . Our findings provide insight into the biosynthesis of anthocyanins in tea plants .
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2020
·Vol. 31
·期 3
·2360-2369
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IF 2.22
Yu Bin,Jia Dongling,Miao Yuqing
Herein, the Nd(OH) 3 -NiTe 2 nanoparticles were synthesized by hydrothermal synthesis. The crystal structure, morphology and surface element composition were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction and X-ray photoelectron spectroscopy. At the same time, the electrocatalytic performance of Nd(OH) 3 -NiTe 2 for glucose oxidation in alkaline electrolyte was determined by cyclic voltammetry, chronoamperometry and electrochemical impedance spectroscopy (EIS). It exhibits a high peak current density of about 21.09 mA/cm 2 for glucose oxidation. The low semicircle diameter of 8000 Ω means fast electron transfer of Nd(OH) 3 -NiTe 2 . The oxidation signal of glucose at 0.5 V tends to be constant within 36000 s. Electrochemical experiments show that Nd(OH) 3 -NiTe 2 nanoparticles exhibit good electrocatalytic activity and stability for the oxidation of glucose, which proves their potential application in the field of fuel cells.
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OPTICS EXPRESS
·
2018
·Vol. 26
·期 13
·17056-17065
·
IF 3.356
X. X. Zeng,R. Wang,X. Q. Xi,B. Li,J. Zhou
Terahertz (THz) radiation excites electronic and optical modes of many materials, and controlling interaction of these materials with THz pulses provides a fascinating avenue to achieve unprecedented functionalities in return. Here, woodpile-structured rare-earth orthoferrite metamaterials built with 3-D direct ink writing technology are proposed and experimentally demonstrated. Polarization-independent THz refraction and switching of resonances by varying the number of layers in the structure, as well as the structural parameters and specimen support angle are achieved. Such all-rare-earth-orthoferrite dielectric metamaterials are easy to fabricate and can be very promising in developing efficient and low cost THz functional metadevices.
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APPLIED CLAY SCIENCE
·
2019
·
IF 3.89
Hui-Ran Jin,Xin-Yu Zhou,Yong Zhu,Guo-Fan Sun,Shi-Jie Ding,Jing Chen
In this paper, non-aqueous Fe(OH) 3 /palygorskite dispersion was prepared and its liquid crystal phase behavior was investigated. Positively charged Fe(OH) 3 colloidal particles were put in to non-aqueous and organically modified palygorskite dispersion. The effects of organically treated palygorskite and Fe(OH) 3 on the preparation of stable palygorskite dispersion were characterized with FT-IR, XRD , Contact Angle measurement , Zeta potential detection, Settlement measurement and SEM , respectively. The addition of Fe(OH) 3 particles shifted the concentrations of the coexisting isotropic and nematic phases to higher values while at the same time markedly accelerated the phase separation. The influence of Fe(OH) 3 particles on the dispersion in magnetic field was also discussed.
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Journal of Environmental Sciences
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2015
·
IF 2.002
Xiaolong Li,Congcong Ding,Jiali Liao,Liang Du,Qun Sun,Jijun Yang,Yuanyou Yang,Dong Zhang,Jun Tang,Ning Liu
The biosorption mechanisms of uranium on an aerobic bacterial strain Streptomyces sporoverrucosus dwc-3, isolated from a potential disposal site for (ultra-)low uraniferous radioactive waste in Southwest China, were evaluated by using transmission electron microscopy (TEM), energy dispersive X-ray (EDX) analysis, Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), proton induced X-ray emission (PIXE) and enhanced proton backscattering spectrometry (EPBS). Approximately 60% of total uranium at an initial concentration of 10 mg/L uranium nitrate solution could be absorbed on 100 mg S. sporoverrucosus dwc-3 with an adsorption capacity of more than 3.0 mg/g (wet weight) after 12 hr at room temperature at pH 3.0. The dynamic biosorption process of S. sporoverrucosus dwc-3 for uranyl ions was well described by a pseudo second-order model. S. sporoverrucosus dwc-3 could accumulate uranium on cell walls and within the cell, as revealed by SEM and TEM analysis as well as EDX spectra. XPS and FT-IR analysis further suggested that the absorbed uranium was bound to amino, phosphate and carboxyl groups of the cells. Additionally, PIXE and EPBS results confirmed that ion exchange also contributed to the adsorption process of uranium.
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ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
·
2014
·
IF 1.251
Fengting Chen,Jiachang Zhao,Jingli Xu,Yuandong Wu
The hetero-bimetallic polyanionic compound BiCu 2 (TeO 3 )(SO 4 )(OH) 3 was synthesized using hydrothermal techniques. Single-crystal X-ray diffraction analysis revealed that title compound crystallizes in the monoclinic space group P 2 1 / n (No. 14) with lattice parameters a = 9.5513(15), b = 6.3022(10), c = 13.955(2) Å, β = 102.845(3)°, and Z = 4. The structure of title compound is a three-dimensional tunnel framework consisting of edge-sharing two-dimensional [Cu 3 O 10 ] 14– layers linked by BiO 8 bicapped trigonal prisms, TeO 3 2– trigonal pyramids and SO 4 2– tetrahedra. Along [010], each Cu(1)O 6 octahedron shares two edges with adjacent Cu(1)O 6 units to form infinite one-dimensional zigzag chains, which are connected by double inverted Cu(2)O 6 octahedral units via edge sharing (O9 ··· O8). The suitability of crystal for optical applications was investigated by UV/Vis/NIR spectroscopy. Raman and FTIR spectra were used to confirm the presence of various functional groups such as TeO 3 2– , SO 4 2– , OH – in the crystals.
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INSTRUMENTATION SCIENCE & TECHNOLOGY
·
2017
·
IF 0.874
Shuyan Niu,Yajie Fang,Kun Zhang,Juan Sun,Jun Wan
A facile and sensitive fluorescent strategy for the determination of dopamine is reported using 2, 3-diaminophenazine. Dopamine caused autooxidation in the presence of oxygen with catalysis by Mn2+ and formed 2, 3-dihydro-1H-indole-5,6-dione. 2, 3-Diaminophenazine provided relatively strong fluorescence. 2, 3-Diaminophenazine in aqueous solution caused fluorescence quenching when the aminochrome condensed with 2, 3-diaminophenazine to allow the determination of dopamine. Under the optimized conditions, the linear dynamic range for dopamine was from 2.0 × 10−6 mol · L−1 to 6.1 × 10−5 mol · L−1 with a detection limit of 1.76 × 10−6 mol · L−1.
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JOURNAL OF MATERIALS SCIENCE
·
2016
·Vol. 51
·期 24
·10849-10862
·
IF 2.302
Zhang Man,Li Chuan,Gao Huiqi,Fu Wei,Li Yingying,Tang Liwei,Zhou Zhiming
Twelve salts of 3-nitro-1,2,4-triazol-5-one (NTO) (ammonium, hydrazinium, guanidinium, aminoguanidinium, diaminoguanidinium, triaminoguanidinium, N -carbamoylguanidinium, semicarbazidium, 1,5-diamino-1,2,4-tetrazolium, 3,4,5- triamino-1,2,4-triazolium, 3,6,7-triamino-7H-[1, 2, 4]triazolo[5,1-c][1,2,4]triazol-2- ium, and 4,4′,5,5′-tetraamino-3,3′-bi-1,2,4-triazolium) were synthesized. The new salts were fully characterized by 1 H and 13 C NMR spectroscopy, infrared spectroscopy, and elemental analysis. The crystal structures of salts 10 and 11 were determined by single-crystal X-ray diffraction. All energetic salts except salt 6 exhibit excellent thermal stabilities with decomposition temperatures ranging from 203 to 270 °C. The densities of salts ranged from 1.65 to 1.88 g cm −1 as measured by a gas pycnometer. Theoretical performance calculations (Gaussian 03 and EXPLO5 v6.01) yielded detonation pressures and detonation velocities for the energetic salts, ranging from 24.4 to 38.1 GPa and 8136 to 9575 m s −1 , respectively. In particular, salt 2 has an outstanding detonation performance ( P
cj = 38.1 GPa, v
D = 9575 m s −1 ) with a satisfactory acidity compared to that of NTO ( pK
a = 5.63 versus pK
a = 2.37). Furthermore, the particles of salt 2 form two-dimensional blades of submicron size, as determined by scanning electron microscopy analysis. Meanwhile, salt 2 was compatible with TNAZ, TATB, TKX-50, Al, NH 4 ClO 4 , CL-20, TNT, and F2603 fluororubber, as determined by differential scanning calorimetry or vacuum stability tests.
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ChemistrySelect
·
2024
·Vol. 9
·期 3
·e202304182
·
IF 1.9
Yiguo He,Mengxiang Li,Liming Peng,Tong Yang,Dong Zhang,Yadong Zhang
Graphical Atorvastatin calcium is a pivotal pharmaceutical for the treatment of primary hypercholesterolemia, with the reaction between isobutyl acetate and aniline being a crucial step. By employing continuous flow synthesis technology, we achieved a yield of 94 % within a residence time of 15 minutes. Simultaneously, kinetic studies and CFD calculations were conducted. Subsequently, we conducted further reaction investigations and designed a continuous system. 4-methyl-3-oxo-n-phenyl-pentanamide, as a crucial component of atorvastatin calcium, often generates a large amount of by-products in conventional synthesis. Here, we first developed a continuous microflow system for the continuous flow synthesis of 4-methyl-3-oxo-n-phenyl-pentanamide. Compared to traditional batch reactors, the reaction time was reduced by 1/12 in the microreactor. Using this device, the kinetic parameters of the reaction were determined, and a reaction kinetics model was established to investigate the effects of channel geometry and material inlet velocity on the entire reaction system. Furthermore, we studied the subsequent reactions and successfully established a fully continuous synthesis device, where the two-step continuous flow chemical reactions were achieved at 40 minutes and a total yield of 32 %.
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Cell Metabolism
·
2025
·
IF 30.9
Jie Jiang,Yuqing Gao,Jiang Wang,Yan Huang,Rong Yang,Yongxin Zhang,Yuandi Ma,Yingquan Wen,Gongkai Luo,Shurui Zhang,Yutang Cao,Minjun Yu,Qinxue Wang,Shulei Hu,Kanglong Wang,Xiaozhen Guo,Frank J. Gonzalez,Yameng Liu,Hong Liu,Qing Xie,Cen Xie
Metabolic-dysfunction-associated steatohepatitis (MASH) remains a major health challenge. Herein, we identify sphingomyelin phosphodiesterase 3 (SMPD3) as a key driver of hepatic ceramide accumulation through increasing sphingomyelin hydrolysis at the cell membrane. Hepatocyte-specific Smpd3 gene disruption or pharmacological inhibition of SMPD3 alleviates MASH, whereas reintroducing SMPD3 reverses the resolution of MASH. Although healthy livers express low-level SMPD3, lipotoxicity-induced DNA damage suppresses sirtuin 1 (SIRT1), triggering an upregulation of SMPD3 during MASH. This disrupts membrane sphingomyelin-ceramide balance and promotes disease progression by enhancing caveolae-dependent lipid uptake and extracellular vesicle secretion from steatotic hepatocytes to exacerbate inflammation and fibrosis. Consequently, SMPD3 acts as a central hub integrating key MASH hallmarks. Notably, we discovered a bifunctional agent that simultaneously activates SIRT1 and inhibits SMPD3, which shows significant therapeutic potential in MASH treatment. These findings suggest that inhibition of hepatic SMPD3 restores membrane sphingolipid metabolism and holds great promise for developing novel MASH therapies.
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CRYSTENGCOMM
·
2024
·Vol. 26
·期 29
·3948-3953
·
IF 2.6
Xinyue Wang,Dandan Wang,Yujie Liu,Jinhui Wang
Cyanurate or isocyanurate compounds containing plane π-conjugated groups usually have giant optical anisotropy, which are promising candidates for optoelectronic functional materials. In this work, a new alkali-metal isocyanurate was successfully synthesized by a hydrothermal method, namely Cs3(H2C3N3O3)3(H3C3N3O3)·3H2O, belonging to the triclinic crystal and P space group. The compound has two-dimensional layers constructed with (H2C3N3O3)− and (H3C3N3O3) six-membered rings extending along the ab plane. The characterization results show that it exhibits a wide band gap (5.03 eV) and a large birefringence (0.23 at 1064 nm). In addition, in order to evaluate the relationship between the crystal structure and its optical properties, the first-principles calculation was also carried out. This work provided a possible candidate for anisotropic optical crystals applied in the ultraviolet region.
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危险品化学品经营许可证（带存储）