查找使用阿拉丁产品的科研文献

Cationic Complex Polymer Separator Confined Anionic [Zn(OH)4]2‒ Reduction for Stable Alkaline Batteries

Zhihao Sun,Lin Liu,Junwei Zhang,Yuhang Liu,Yifeng Wang,Ying Wan,Fanxing Bu,Bao Zhang,Wanhai Zhou,Dongyuan Zhao,Dongliang Chao

Unlike neutral aqueous batteries with cationic Zn 2+ as the charge carrier, alkaline batteries with anionic [Zn(OH) 4 ] 2‒ and OH ‒ are actually commercially feasible and thermodynamically stable thanks to their ability to suppress hydrogen evolution. Whereas commercial separators in alkaline batteries, without ion regulation capability, fail to suppress severe dendrite and passivation of anionic [Zn(OH) 4 ] 2‒ and accelerate ion transport of anionic OH ‒ . Herein, we tailor the coordination structures of alkali-stable cationic complexes in polymer separators (CCPS) to construct anionic OH ‒ selective transfer channels. Synchrotron spectroscopic characterizations and theoretical calculations reveal that the low-coordination cationic complexes expose more positive charge density, electrostatically attracting more negative charge from [Zn(OH) 4 ] 2‒ . In situ electrochemical digital holography technology and time-of-flight secondary ion mass spectrometry analyses further confirm the homogeneous [Zn(OH) 4 ] 2‒ distribution at the CCPS-electrode interface, oriented Zn deposition, and impeded passivation. As a result, CCPS enables alkaline Zn||Cu cells to operate over 5500 cycles at 1 mA cm ‒2 with a high coulombic efficiency of 99.99%. Alkaline Ni–Zn batteries exhibit ultrastable cycling over 1000 cycles at 6 C and maintain 86.17% of their maximum capacity at 10 C. Our work may provide practical and effective separator strategies to accelerate the commercialization of alkaline batteries.

Synthesis of 4-(Diethylamino)salicylaldehyde Derivatives and Research on Their Antifungal Mechanism against Rhizoctonia solani

He Yaofeng,Shi Zhengyang,Liu Xiaokang,Zeeshan Muhammad,Zhang Guoqiang,Han Xiaoqiang,Ma Ting

To enhance the antifungal activity of 4-(diethylamino)salicylaldehyde (DSA), 20 salicylaldehyde Schiff base compounds (L1–L20), including nine novel derivatives, were synthesized and characterized by MS, 1 H NMR, and 13 C NMR. In vitro assays identified compound L5 as the most active agent, with an EC 50 of 10.797 μg/mL (2-fold higher than DSA), and pot experiments confirmed its efficacy against cotton damping-off disease. Mechanistic investigations via electron microscopy, transcriptomics, physiological assays and molecular docking suggest that L5 may target fatty acid synthase (FAS) to interfere with fungal lipid biosynthesis, disrupt energy homeostasis, and induce oxidative stress, which triggers synergistic membrane impairment and oxidative damage and ultimately causes hyphal death. With a novel target and a distinctive single-target, multieffect mode of action, L5 is a promising candidate for new fungicide development.

High-Pressure Synthesis of K4N6 with All Nitrogen Atoms Forming Aromatic Hexazine [N6]4– Anions

Jie Zhang,Tingting Ye,Guo Chen,Deyuan Yao,Xin Zhang,Chuanguo Zhang,Jing Zhao,Pei Wang,Junfeng Ding,Zhi Zeng,Xianlong Wang

Realizing compounds entirely composed of aromatic hexazine N6 rings with high stability is a long-term challenge. Existing high-pressure synthesized compounds contain a maximum of 5.36% N atoms, forming aromatic [N6]4– rings. We predict that all N atoms contribute to aromatic [N6]4– rings in K4N6, which become stable at 60 GPa and can stably exist up to 600 K at 0 GPa. Furthermore, K and KN3 are suggested as precursors for the synthesis of K4N6. Following this approach, based on the diamond anvil cell, K4N6 with 100% nitrogen atoms forming aromatic hexazine [N6]4– rings is synthesized at 45 GPa after laser heating and identified by synchrotron X-ray diffraction and Raman spectroscopy. Our results bring us closer to achieving aromatic N6 rings at ambient condition.

High Glass Transition and Optical Transparency of Novel Organosoluble Polyamides Containing 4-tert--Butyltoluene Moiety

Chenyi Wang,Xiaoyan Zhao,Guang Li,Jianming Jiang

A series of novel polyamides 3a – 3d containing 4- tert- butyltoluene moiety, were prepared using the phosphorylation polycondensation technique. FT-IR and 1 H NMR techniques were used to investigate the chemical structures of 3a–3d . The results confirmed that they agreed with the proposed structures for 3a – 3d completely. The 3a – 3d had inherent viscosities ranging from 0.71 to 1.67 dL·g −1 . All the polyamides showed excellent solubility, with the dissolvability at a concentration of 10 wt% in most amide polar solvents. Flexible and tough polyamide films could be prepared by casting from DMAc ( N , N -dimethylacetamide) solvent. Their films were nearly colorless and exhibited high optical transparency, with the UV cutoff wavelength in the range of 346–363 nm and transmittance higher than 80% at 450 nm. They also exhibited high glass transition temperatures in the range of 310–343°C and the onset decomposition temperatures in the range of 435–462°C in nitrogen atmosphere. Meanwhile, these polyamide films possess good mechanical properties with tensile strengths of 76.4–86.1 MPa and elongations at break of 11.2%–27.3%. Due to those properties, these polyamides could be considered as photoelectric and microelectronic materials.

Discovery of N-hydroxy-4-(1H-indol-3-yl)butanamide as a histone deacetylase inhibitor

Jiang Bian,Yepeng luan,Chunbo Wang,Lei Zhang

Formation and molecular dynamics simulation of inclusion complex of large-ring cyclodextrin and 4-terpineol

Chuan Cao,Changyue Deng,Jinwei Hu,Yibin Zhou

In the present study, the formation and structure of the inclusion compound of large-ring cyclodextrin and 4-terpineol were obtained through different experiments and molecular dynamics (MD) simulation. The analysis of FTIR, 1 H-NMR, and thermodynamic results confirmed the formation of clathrates. Analysis of molecular structure (root-mean-square deviation and radius of gyration), solubility, and interaction energy (Coul, H bond) based on MD simulations further clarified the nature of the clathrate and the conformational changes caused by guest molecules as well as inclusion complexes process trends. The inclusion complex reportedly has a new crystal structure with improved thermal stability. Practical Application This is the first work to demonstrate the complex formation between 4-terpineol and large-ring cyclodextrin by molecular dynamics simulation. Molecular dynamics simulation confirmed the formation of inclusion complexes theoretically. Conformational changes of the molecules and the formation of complexes with improved thermal stability were observed. Complexing with large-ring cyclodextrin can be used as an effective means to encapsulate the aroma/flavor compounds.

4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to promote cuproptosis in colorectal cancer

Wenchang Yang,Yaxin Wang,Yongzhou Huang,Jiaxian Yu,Tao Wang,Chengguo Li,Lei Yang,Peng Zhang,Liang Shi,Yuping Yin,Kaixiong Tao,Ruidong Li

Cuproptosis, a novel copper-induced cell death pathway, is linked to mitochondrial respiration and mediated by protein lipoylation. The discovery of cuproptosis unfolds new areas of investigation, particularly in cancers. The present study aimed to explore the role of cuproptosis in colorectal cancer progression. The genetic alterations of cuproptosis in colon cancer were evaluated using a database. MTT assays, colony formation, and flow cytometry were used to examine the effect of elesclomol-Cu and 4-Octyl itaconate (4-OI) on colorectal cancer cell and oxaliplatin-resistant cell viability. The anti-tumor effect of elesclomol with 4-OI was verified in vivo assay. The results showed that FDX1, SDHB, DLAT, and DLST genes were more highly expressed in normal tissues than those in primary tumor tissues. Patients with high expressions of these genes in tumor tissues had a better prognosis. Using MTT assay and colony formation analysis, elesclomol-Cu pulse treatment showed significant inhibition of cell viability in HCT116, LoVo, and HCT116-R cells. In addition, flow cytometry revealed elesclomol-Cu significantly promoted apoptosis. Tetrathiomolybdate, a copper chelator, markedly inhibited cuproptosis. Subsequently, we found 2-deoxy- D -glucose, a glucose metabolism inhibitor, sensitized cuproptosis. Furthermore, galactose further promoted cuproptosis. Interestingly, 4-OI significantly enhanced cuproptosis which was irrelevant to ROS production, apoptosis, necroptosis, or pyroptosis pathways. Aerobic glycolysis was inhibited by 4-OI through GAPDH, one of the key enzymes of glycolysis, sensitizing cuproptosis. Meanwhile, FDX1 knockdown weakened the ability of 4-OI to promote cuproptosis. In vivo experiments, 4-OI with elesclomol-Cu showed better anti-tumor effects. These results indicated that elesclomol-Cu rapidly halted cell growth in colorectal cancer cells and oxaliplatin-resistant cell line. Importantly, we revealed that 4-OI inhibited aerobic glycolysis by targeting GAPDH to promote cuproptosis.

Highly Stable Europium(III) Tetrahedral (Eu4L4)(phen)4 Cage: Structure, Luminescence Properties, and Cellular Imaging

Feng Guo,Duo-Fu Li,Fang Gao,Kai Xu,Jun Zhang,Xiu-Guang Yi,Dong-Ping Li,Yong-Xiu Li

Luminescent lanthanide cages have many potential applications in guest recognition, sensing, magnetic resonance imaging (MRI), and bioimaging. However, these polynuclear lanthanide assemblies’ poor stability, dispersity, and luminescence properties have significantly constrained their practical applications. Furthermore, it is still a huge challenge to simultaneously synthesize and design lanthanide organic polyhedra with high stability and quantum yield. Herein, we demonstrate a simple and robust strategy to improve the rigidity, chemical stability, and luminescence of an Eu(III) tetrahedral cage by introducing the conjugated planar auxiliary phen ligand. The self-assembled tetrahedral cage, (Eu4L4)(phen)4 [L = (4,4′,4″-tris(4,4,4-trifluoro-1,3-dioxobutyl)-triphenylamine), phen = 1,10-phenanthroline], exhibited characteristic luminescence of Eu3+ ions with high quantum yield (41%) and long lifetime (131 μs) in toluene (1.0 × 10–6 M). Moreover, the Eu(III) cage was stable in water and even in an aqueous solution with a pH range of 1–14. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and cellular imaging revealed that the Pluronic F127-coated hybrid material, (Eu4L4)(phen)4@F127, exhibited low cytotoxicity, good biocompatibility, and cellular imaging ability, which may inspire more insights into the development of lanthanide organic polyhedra (LOPs) for potential biomedical applications.

Efficient elimination of nonylphenol and 4-tert-octylphenol by weak electrical stimulated anaerobic microbial processes

Cuicui Wang,Jierong Zheng,Sufang Wang,Aijuan Zhou,Xin Kong,Bowei Zhao,Houfen Li,Xiuping Yue

The investigation into the degradation of alkylphenol pollutants (APs) has become a hotspot due to their harmful effects on the environment and human health. In this study, microbial electrolysis cells (MECs) were used to degrade nonylphenol (NP) and 4- tert -octylphenol (4- tert -OP). The study found that the degradation rates of NP and 4- tert -OP for a 6-day period were 83.6% and 96.3%, respectively, which were 30.53% and 26.7% higher than those of the group without applied voltage. The double layer area in the degradation of 4- tert -OP was larger than that of NP, and the resistance exhibited by 4- tert -OP (87.47 Ω) in MEC was lower than that of NP (99.42 Ω). Meanwhile, NP had a greater effect on the bioenzyme activity than 4- tert -OP. GC-MS analysis showed that the degradation pathways of both pollutants mainly included oxidation and hydroxylation reactions. Furthermore, the microbial community analysis indicated that the main functional bacteria in NP degradation were Citrobacter , Desulfovibrio and Advenella , and those in 4- tert -OP degradation were Stenotrophomonas , Chryseobacterium , Dokdonella , and the key microbiomes underlying the cooperative relationship. The biotoxicity test indicated that the toxicity of residual substances was significantly reduced. Therefore, the MEC system is efficient and environmentally friendly and has broad application prospects in phenol refractory organics.

Efficient Electrocatalytic Oxidation of 5-Hydroxymethylfurfural Coupled with 4-Nitrophenol Hydrogenation in a Water System

Xuliang Pang,Hongye Bai,Huaiquan Zhao,Weiqiang Fan,Weidong Shi

Electrocatalytic conversion of biomass-derived 5-hydroxymethylfurfural (HMF) to value-added 2,5-furandicarboxylic acid (FDCA) is of great significance for sustainable chemical production. The key challenge is to establish an electrocatalytic system with a wide potential window, which can selectively oxidize HMF to FDCA without causing water oxidation. In this study, Cu foam decorated with Cu(OH)2 (CF-Cu(OH)2) was successfully fabricated as an efficient catalyst, and CuOOH active species generated by electrochemistry were demonstrated as the main catalytic sites for HMF oxidation. As a result, the current density of CF-Cu(OH)2 reached up to 198.2 mA/cm2 (100 mM HMF, 1.0 M KOH, 0.8 V vs Ag/AgCl), and a high faradic efficiency close to 100% for FDCA production (yield: 98.7%) was realized. Moreover, we reveal the mechanism for the electro-oxidation of HMF to FDCA and further provide an insight into the oxidation pathway for HMF. A paired electrochemical system exhibits superior catalytic performance of synergetic reactions (HMF oxidation and 4-NP reduction). Therefore, this work proposes a strategy to simultaneously produce two types of value-added chemicals at both electrodes, which can be applied in other electrocatalytic systems for the green synthesis of organic compounds.

Asymmetric total synthesis of (+)-(2R,4′R,8′R)-α-tocopherol enabled by enzymatic desymmetrization

Haidi Yang,Jinyao Liu,Pan Hu,Liang Gao,Zedu Huang,Fener Chen

A new and highly stereoselective synthesis of chiral diol (S)-14, the common synthetic intermediate to (+)-(2R,4′R,8′R)-α-tocopherol (1), was accomplished in seven steps with 13.8% overall yield. This developed route featured a lipase-catalyzed desymmetric hydrolysis of prochiral diester 39a, which was prepared through a challenging Heck coupling, to chiral quaternary carbon-containing monoester (R)-37a of the correct configuration in 81% yield and 96.7% ee, to the best of our knowledge, leading to the most efficient enzymatic desymmetric synthesis of the chiral chroman skeleton of vitamin E members reported to date. Coupled with the modified preparation of the phytol-derived side chain, the chemoenzymatic total synthesis of 1 was completed in 15 longest linear steps with 3.1% overall yield.

Insights into the mode of action of 2-(4-methoxyphenyl)ethyl isothiocyanate on Aspergillus niger

Tian-Lin Wu,Yong-Mei Hu,Yu Sun,Zhi-Jun Zhang,Zheng-Rong Wu,Wen-Bin Zhao,Chen Tang,Sha-Sha Du,Ying-Hui He,Yue Ma,Cheng-Jie Yang,Ying-Qian Liu

Isothiocyanates had attracted attention for many years due to their antimicrobial properties. In this study, the antifungal efficiency of eighteen isothiocyanate compounds were evaluated against six plant pathogenic fungi and two molds in vitro . Among them, 2-(4-methoxyphenyl)ethyl isothiocyanate displayed the highest antifungal activity against Aspergillus niger (EC 50  = 4.19 μg/mL). The further studies of its mode of action showed that it may damage the cell morphology and membrane integrity in a dose dependent manner by morphological observation, propyl iodide staining and the release of cellular contents. On the other hand, the decrease of related enzyme activities in tricarboxylic acid cycle suggested that 2-(4-methoxyphenyl)ethyl isothiocyanate may effected energy metabolism. Besides, reactive oxygen species, the content of malondialdehyde, the total antioxidant capacity , the content of glutathione and the kinase of oxidative reactive were changed in fungi treated with 2-(4-methoxyphenyl)ethyl isothiocyanate, compared with those in untreated fungi, which all indicated that 2-(4-methoxyphenyl)ethyl isothiocyanate exhibited antifungal activity against A.niger by inducing oxidative stress.