MOLECULES
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2020
·Vol. 25
·期 8
·1772
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IF 3.267
Hui Lu,Xia Zhou,Lei Wang,Linhong Jin
A series of newN-phenylacetamide derivatives containing 4-arylthiazole moieties was designed and synthesized by introducing the thiazole moiety into the amide scaffold. The structures of the target compounds were confirmed by1H-NMR,13C-NMR and HRMS. Their in vitro antibacterial activities were evaluated against three kinds of bacteria—Xanthomonas oryzaepv.Oryzae(Xoo),Xanthomonas axonopodispv.Citri(Xac) andX.oryzaepv. oryzicola(Xoc)—showing promising results. The minimum 50% effective concentration (EC50) value ofN-(4-((4-(4-fluoro-phenyl)thiazol-2-yl)amino)phenyl)acetamide (A1) is 156.7 µM, which is superior to bismerthiazol (230.5 µM) and thiodiazole copper (545.2 µM). A scanning electron microscopy (SEM) investigation has confirmed that compoundA1could cause cell membrane rupture ofXoo. In addition, the nematicidal activity of the compounds againstMeloidogyne incognita(M. incognita) was also tested, and compoundA23displayed excellent nematicidal activity, with mortality of 100% and 53.2% at 500 μg/mL and 100 μg/mL after 24 h of treatment, respectively. The preliminary structure-activity relationship (SAR) studies of these compounds are also briefly described. These results demonstrated that phenylacetamide derivatives may be considered as potential leads in the design of antibacterial agents.Keywords:synthesis;thiazole;nematicidal activity;antibacterial activity;structure-activity relationship
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JOURNAL OF MOLECULAR LIQUIDS
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2020
·
IF 5.065
Jinbo Ouyang,Jian Chen,Haiqing Huang,Limin Zhou,Xin Huang
Solubility of 4-Methylumbelliferon in different pure solvents, including polar and apolar solvents, were firstly measured at varied temperatures under 0.1 MPa by a gravimetric method. Results showed that solubility in all solvents increase with rising of temperature, and 4-Methylumbelliferon is most soluble in acetone, followed by 1-butanol, isopropanol, 1-propanol, isobutanol , ethyl acetate , ethanol, methanol, methyl acetate , acetonitrile , butyl acetate and water. The experimental solubility data were correlated by several thermodynamic models, including modified Apelblat model, NRTL model and Wilson model. The accuracy of these models is determined by calculation of mean relative deviation ( MRD ). Moreover, dissolution thermodynamics i.e. dissolution enthalpy, dissolution Gibbs energy and dissolution entropy, were calculated by using Wilson equations.
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APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Gaosheng Ren,Zhihui Su,Yu Tang,Weichen Du,Nan Xu,Chengyi Dai,Xiaoxun Ma
It is very important to design model catalysts to control the site distribution and develop methods to improve their electronic environment and thus promote the catalyst’s performance in the electrochemical reduction of CO 2 (CO 2 RR). In this work, a strategy of in-situ synthesis and anchoring of nanoparticles (SSAN) was developed. Using this strategy, a “jujube-cake” type catalyst was designed, referred to as Ag@4-MBA. In this catalyst, Ag nanoparticles (NPs) act as “jujube”, which are embedded in 4-mercaptobenzoic acid (4-MBA) acting as “cake”. A Pointer-shaped Ag@4-MBA material was prepared that achieved high loading of Ag species (∼24.0 wt%), high dispersion (5–10 nm), high CO mass activity (93.7 A g Ag −1 ), high CO faradaic efficiency (94.0%) and high CO production (2.0 mol g Ag −1 h −1 ), showing a superior performance to that of the recently reported Ag-based catalysts. Density functional theory (DFT) calculations and X-ray photoelectron spectroscopy (XPS) characterization showed that a high degree of electron delocalization of the Ag–S–aromatic ring and reconstructing the electronic environment of the metal sites were achievied, it is beneficial to stabilize the reaction intermediate COOH*. This work provides a new approach for the design of metal nanoparticle model catalysts with more sustainable CO 2 RR.
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CHEMOSPHERE
·
2022
·
IF 8.943
Ang Ma,Weiye Yang,Kunpeng Gao,Junqi Tang
Anisotropic gold nanostructures have attracted great attention in different fields including catalysis. Thermodynamically driven selective surface growth offers a reliable and reproducible method for anisotropic gold nanoparticle synthesis with specific morphologies. Herein, monocrystalline concave gold nano-arrows (AuCNAs) are prepared by the over-growth method using Au nanorods (AuNRs) as seeds. The as-prepared AuCNAs consist of a biconical head and four concave structures. Interestingly, silver ions (Ag + ) concentration significantly affects the product morphology by tuning the peak positions of surface plasmon resonance (SPR), aspect ratio, arrow, and concave morphology of AuCNAs. The position of longitudinal SPR peaks is observed at 810, 805 and 782 nm at [Ag + ]/[Au 3+ ] molar ratios of 1:2, 1:1, and 2:1, respectively. Diameters and lengths of AuCNAs varied from 25 nm to 36 nm; 104 nm, 78 nm, and 120 nm, respectively. Additionally, the AuCNAs are applied for the catalytic reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) in presence of excess NaBH 4 . Compared to gold nanorods (AuNRs), the prepared AuCNAs catalyst shows excellent catalytic activity , demonstrating that concave structures and sharp corners significantly enhance the catalytic activity. The value of pseudo-first-order reaction kinetic constants (k app ) increased from 0.0051 to 0.0195 s −1 with increasing catalyst valume from 7.5 to 37.5 μL. The highest normalized reaction rate constant (K nor ) and turnover frequency (TOF) reach 5.84 × 10 4 min −1 mmol −1 and 443.47 h −1 , respectively, at [Ag + ]/[Au 3+ ] ratio of 1:1 in AuCNAs catalyst. This study expands catalytic applications of anisotropic gold nanostructures and widens their potential application areas, such as surface plasmon exciton photonics , biomedical photonics, and photocatalysis .
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Journal of Energetic Materials
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2023
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IF 2.1
Jin-Qiang Zhou,Yi-Ming Wang,Hua Fang,Peng Deng,Jian-Xin Nie,Xue-Yong Guo,Rui Liu
The design and preparation of new high-energy composite DAP-4/Al is very important for the study of composite solid propellants. In this work, the combustion properties and reaction mechanism of DAP-4/Al composites doped with WO3 nanoparticles were studied. DAP-4/Al composites were prepared by different mass ratios. The combustion state, combustion time, pressure, pressurization rate and flame temperature of DAP-4/Al/WO3 with different mass ratios were monitored. The results show that the combustion performance of DAP-4/Al can be significantly improved under the catalysis of WO3. Compared with DAP-4/Al-5, the average combustion time of DAP-4/Al/W-4 is significantly reduced by ~ 70 ms, the average combustion pressure is increased by 654 KPa, and the average pressurization rate is increased by 0.22 MPa·s−1. Under the catalysis of WO3, the activated substances can react rapidly with H2dabco2+ and NH+ to produce CO2, CO, N2 and H2O. When the mass ratio is 20:80:2, the average maximum combustion heat of DAP-4/Al/W-4 is 8474 J/g, which is higher than 493 J/g of DAP-4/Al-5. The reaction mechanism of WO3 catalyzed DAP-4/Al system was further analyzed by TG-MS and XPS. This work provides a new idea for the future application of DAP-4/Al composites in solid propellants.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2023
·Vol. 140
·期 29
·e54063
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IF 3
Huan Wang,Zhengzai Cheng,Lesly Dasilva Wandji Djouonkep,Linfeng Wang,Shuanpu Cai,Mario Gauthier
A novel biphenyl monomer, diethyl 6,6′-dimethoxy-[1,1′-bipheny]-3,3′-dicarboxylate (DDBD), was synthesized from 4-hydroxybenzaldehyde, a phenolic compound derived from lignin. A series of polyesters were prepared by polycondensation of the biphenyl monomer with hydroquinone bis(2-hydroxyethyl) ether and aliphatic diacids via a two-step melt polycondensation method. It was shown that the properties of the polyesters can be tuned by varying the length and the structure of the spacer in the aliphatic diacid monomers. Structure–property relations for these materials were investigated by Fourier-transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, gel permeation chromatography (GPC), differential scanning calorimetry, thermogravimetric analysis, and dynamic mechanical analysis. GPC analysis showed that the weight-average molecular weight ( M w ) of the samples varied from 4.2–5.0 × 10 4 g/mol, while thermal analysis yielded T g values of 51–120°C, and 5% decomposition temperatures ( T d,5% ) of 327–389°C. All the samples exhibited a high yield strength (56–87 MPa). After 30 weeks of degradation in soil, the copolyesters had mass losses of up to 4.4%, and an investigation of the ecotoxicity of the copolyesters with Eisenia fetida yielded a survival rate of over 80% after 14 days for the different copolyesters, suggesting low toxicity in the environment. Overall, these copolyesters have good properties and would be suitable to replace petroleum-based commercial poly(ethylene terephthalate) packaging materials.
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International Journal of Electrochemical Science
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2023
·
IF 1.5
Chengyi Zhu,Jianxiong Liu,Xiaohua Yu,Yingjie Zhang,Xiaodong Jiang,Peng Dong,Yannan Zhang
4-Bromoanisole (4BA) is recommended for LiNi0.6Co0.2Mn0.2O2 (NCM 622) cathode materials as a safety electrolyte additive. The effect of anti-overcharge on NCM 622 cathodes are analyzed by cyclic voltammetry, constant current charge and discharge, AC impedance and scanning electron microscopy (SEM) measurement. The overcharge test results show that 4BA can be effectively electropolymerized at 4.45 V (vs. Li/Li + ), which can consume the overcharge current and protect the working electrode from voltage runaway. The time for the voltage rising to the overcharge state is availably delayed from about 16 hours to about 37 hours. The strategy can block off further oxidation of the active material and electrolyte, and finally promote the overcharge tolerance of the Li-ion batteries. Moreover, it is also found that the use of 4BA as a safety electrolyte additive does not obviously effect the electrochemical performance of NCM 622 and can effectively improve its cycle stability at high cut-off voltage (4.7 V).
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ENVIRONMENTAL MONITORING AND ASSESSMENT
·
2023
·Vol. 195
·期 6
·1-15
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IF 3
Wang Yan,Han Xue,Zhang Jie,Zhou Meng-Xuan,Liu Ai-Lin
Biological effect-based monitoring is essential for predicting or alerting to a possible deterioration in drinking water quality. In the present study, a reporter gene assay based on oxidative stress–mediated Pgst-4::GFP induction in the Caenorhabditis elegans strain VP596 (VP596 assay) was assessed for its applicability in evaluating drinking water safety and quality. This assay was used to measure the oxidative stress response in VP596 worms exposed to six ubiquitous components (As 3+ , Al 3+ , F − , NO 3 − -N, CHCl 3 , and residual chlorine) in drinking water, eight mixtures of these six components designed through orthogonal design, ninety-six unconcentrated water samples from source to tap water in two supply systems, and organic extracts (OEs) of twenty-five selected water samples. Pgst-4::GFP fluorescence was not induced by Al 3+ , F − , NO 3 − -N, and CHCl 3 , and was significantly enhanced by As 3+ and residual chlorine only at concentrations higher than their respective drinking water guideline levels. Pgst-4::GFP induction was not detected in any of the six-component mixtures. Induction of Pgst-4::GFP was observed in 9.4% (3/32) of the source water samples but not in the drinking water samples. However, a notable induction effect was revealed in the three OEs of drinking water, with a relative enrichment factor of 200. These results suggest that the VP596 assay has limited utility for screening drinking water safety by testing unconcentrated water samples; however, it offers a supplemental in vivo tool for prioritizing water samples for an enhanced quality assessment, monitoring pollutant removal performance by drinking water treatment plants, and evaluating water quality in water supplies.
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Micromachines
·
2023
·Vol. 14
·期 4
·739
·
IF 3.4
Mingjie Han,Yong Xie,Ri Wang,Yang Li,Chao Bian,Shanhong Xia
As a highly toxic heavy metal ion, mercury ion (Hg2+) pollution has caused serious harm to the environment and human health. In this paper, 4-mercaptopyridine (4-MPY) was selected as the sensing material and decorated on the surface of a gold electrode. Trace Hg2+could be detected by both differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) methods. The proposed sensor displayed a wide detection range from 0.01 μg/L to 500 μg/L with a low limit of detection (LOD) of 0.002 μg/L by EIS measurements. Combined with molecular simulations and electrochemical analyses, the chelating mechanism between Hg2+and 4-MPY was explored. Through the analysis of binding energy (BE) values and stability constants, 4-MPY showed an excellent selectivity for Hg2+. In the presence of Hg2+, the coordination of Hg2+with the pyridine nitrogen of 4-MPY was generated at the sensing region, which caused a change in the electrochemical activity of the electrode surface. Due to the strong specific binding capability, the proposed sensor featured excellent selectivity and an anti-interference capability. Furthermore, the practicality of the sensor for Hg2+detection was validated with the samples of tap water and pond water, which demonstrated its potential application for on-site environmental detection.
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ELECTROCHIMICA ACTA
·
2018
·
IF 5.116
Yinghua Xu,Tingjie Ge,Hongxing Ma,Xufen Ding,Xiaoyong Zhang,Qi Liu
Hydrodefluorination (HDF) is the key step in fluoroaromatic pollutant (FAP) degradation, making the search for efficient HDF catalysts and the determination of the corresponding mechanism a matter of great importance. In this study, we developed an efficient HDF catalyst (a Rh-Pd alloy) and investigated the underlying catalytic reaction mechanism , using 4-fluorophenol (4-FP) as a model FAP. Specifically, the rapid aqueous-phase HDF of 4-FP at pH 3 was achieved on a Rh-Pd alloy-modified Ni foam electrode, which was followed by ring hydrogenation (RH) of the HDF product (phenol) to afford cyclohexanone and cyclohexanol . Inductively coupled plasma optical emission spectrometer (ICP-OES) and thermodynamic analyses showed that, in addition to those supplied by the applied current, the electrons involved in the HDF of 4-FP and the RH of phenol were largely provided by the oxidative dissolution of the Ni foam support. Hydrogenation and cyclic voltammetry experiments indicated that the HDF of 4-FP probably follows an indirect mechanism (featuring adsorbed H atoms as the direct reductant) and that the strength of 4-FP adsorption onto the surface of the catalyst significantly influences its HDF activity.
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NEW JOURNAL OF CHEMISTRY
·
2018
·Vol. 42
·期 14
·12205-12211
·
IF 3.201
Qin Wang,Jianling Zhang,Yuyan Yu,Yi Dan,Long Jiang
Aiming to develop a visible-light-driven polymeric photocatalyst that can be fabricated by an easy-to-scale-up polymerization method, a porous polyimide (PPI) with a specific surface area (SBET) of 79.3 m2 g−1 was synthesized by a facile polycondensation of 3,3′,4,4′-benzophenonetetracarboxylic dianhydride (BTDA) with 4,4′,4′′-triaminotriphenylamine (TPA). UV-vis diffused reflection spectroscopy (DRS), electrochemical analysis, valence band X-ray photoelectron spectroscopy (XPS), and density functional theory (DFT) calculation results reveal that the prepared PPI possesses a narrow band gap (2.04 eV) with the valence band (VB) located at 1.26 V (vs. NHE) and the conduction band (CB) edge at −0.78 V (vs. NHE), clearly indicating the visible light activity of PPI. The photocatalytic performance for the degradation of methylene blue (MB) in water was studied, and the results demonstrate that PPI possesses excellent photocatalytic activity under visible light irradiation. Electron paramagnetic resonance (EPR) and photo-current analyses were used to study the photocatalytic mechanism, which show that PPI has a lot of single electron trapped oxygen and more light-generated electrons. This work may provide a cost-effective, potentially scalable strategy to design and develop a polymeric photocatalyst with continuously tunable photoelectrical properties.
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TISSUE & CELL
·
2024
·
IF 2.7
Lei Zhu,Qingxin Cai,Gang Li,Xiaoming Zou
Objective Gastric precancerous lesions (GPL), characterized by intestinal metaplasia and dysplasia, marks a pivotal juncture in the transformation from gastritis to gastric cancer. Research on GPL could offer fresh perspectives on preventing cancer occurrence. Methods This study employed 1-methyl-3-nitro-1-nitrosoguanidine (MNNG) to establish GPL rat models and knocked BRD4 down in vivo to assess its impact on the lesions and macrophage morphology. Following that, the impacts of BRD4 knockdown on the malignant phenotypes of human gastric epithelial GES-1 cells were determined. Moreover, conditioned medium from macrophage was gathered and used for GES-1 cell culture. The involvement of macrophage polarization in the BRD4 regulatory mechanism in GES-1 cells was assessed. Results This study elucidated that MNNG induced an increase level of BRD4 in the rat models. BRD4 knockdown reduced lesions based on pathological sections and immunohistochemistry to detect proliferative antigens. Western blotting and immunofluorescence showed that BRD4 knockdown suppressed epithelial-mesenchymal transition and macrophage M2 polarization. In in vitro experiments, BRD4 knockdown inhibited the malignant phenotype of GES-1 cells and the differentiation of THP-1 cells into M2 macrophages, respectively. The conditioned medium from M2 macrophages with BRD4 knockdown was co-incubated with GES-1 cells, which attenuated the malignant phenotypes compared with the medium from M2 macrophages. Conclusion: Through in vivo and in vitro experiments, BRD4 upregulation was found to already occur during GPL, affecting macrophage polarization and epithelial cell cancerization. This finding provides an experimental basis for strategies targeting BRD4 inhibition at this critical stage.
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