DYES AND PIGMENTS
·
2021
·
IF 4.889
Kun Yan,Lancheng Wang,Huimin Zhou,Zhendong Hua,Peng Xu,Hui Xu,Youmei Wang,Bin Di,Chi Hu
Typical AIE luminogens with extensive π-electron conjugation are limited in use on account of their complex synthesis, high cost and environmental concerns. To this end, we report here a novel host-guest inclusion complex that is assembled from nonemissive ligands, and surprisingly exhibits notable AIE features in aqueous solution while maintaining good sensitivity for ketamine (KET) detection. Isothermal titration studies confirm that palmatine (PAL) binds to cucurbit[8]uril (Q8) in a 2:1 ratio with an equilibrium association constant of 1.75 × 10 11 M −2 , suggesting that the unconventional AIE effects can be attributed to the stacking of two PAL moieties inside a single Q8 cavity. Geometric constraints of the macrocycle result in dimeric coupling of PAL in the ground state with significant bathochromic shifts in absorption and emission, which can be readily excited to exhibit enhanced photoluminescence . The unusual upfield perturbation and broadening of Q8 signals in the 1 H NMR spectrum upon binding with PAL convey decisive information that Q8 not only serves as a molecular container, but also participates in the electron delocalization during the AIE events. Upon addition of KET, fluorescence was switched off through guest exchange to generate [email protected] as well as free PAL. The significant AIE characteristics of 2* [email protected] in combination with its specific molecular recognition towards KET gives rise to 5.0 ng/mL limit of detection with linear range from 16.8 to 500 ng/mL, and a pronounced selectivity over possible interfering substances in biological matrices. We demonstrate the first example of Q8-mediated AIE effects, where the photoluminescence of virtually nonemissive or feebly emissive ligands is remarkably intensified through clustering inside a macrocyclic host molecule, therefore offering great promise for further development into dedicated AIE-based sensors.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF MULTIPHASE FLOW
·
2021
·
IF 3.186
Ju Wang,Zhaomiao Liu,Yan Pang,Mengqi Li
ABSTRACT The significant relationship between performance parameters of compound droplets and their geometries makes accurate control of the breakup of compound jets particularly critical. The physical mechanism behind the earlier and easier loss of stability in compound jets caused by inner dispersive interfaces is still not fully known, which constrains accurate prediction of the conditions that result in the breakup of compound jets. In the present study, three perturbation modes—namely, block-off, squeeze-through, and slip-through—are found to form between an inner sphere and a liquid jet. The conditions for the occurrence of block-off are accurately predicted by solving for the radius of the liquid jets. According to analyses of the velocity profiles of liquid jets, the key reason for the loss of stability in a quasi-steady jet interface caused by the entry of a sphere smaller in size than the jet cross-section is the degradation of tracking characteristics of the sphere due to viscous shear on the sphere. These findings provide a new explanation for the long-standing question that how the inner dispersive interface triggers jet instability and can help improve the accurate control of the breakup of compound jets containing inner dispersive interface.
✓ 已验证
产品关联
DOI
高影响因子
INORGANIC CHEMISTRY
·
2021
·
IF 5.165
Quwei Ni,Zhibin Mei,Chunxia Li,Jieying Li,Jiachun Liu,Wanqiang Liu,Jiansheng Huo,Qianming Wang
The influence of temperature on a variety of physiological or chemical processes has generated considerable interest, and recently noninvasive lanthanide-incorporated optical thermometers have been considered as promising candidates for monitoring its changes at different scales. Herein, a novel Bi3+-activated Sr3–xGdxGaO4+xF1–x phosphor with tunable color has been constructed by a cooperative cation–anion substitution strategy with to the replacement of [Sr2+–F–] by [Gd3+–O2–]. When x = 0, the sample Sr3GaO4F/Bi3+ possesses a peak wavelength at 438 nm, and this value will shift to 470 nm if x is equal to 1 (Sr2GdGaO5/Bi3+). In addition, photoluminescence tuning from blue to red has been realized successfully by an efficient Bi3+ → Eu3+ energy migration model in Sr2.6Gd0.4GaO4.4F0.6 samples. The specific Bi3+ → Eu3+ energy transfer has been explained by dipole–dipole interactions derived from a model of the Dexter pathway. Intriguingly, the two dopants (a blue signal from Bi3+ and a red signal from Eu3+) possess different thermal responses to increasing temperature. Accordingly, the intensity ratio values are sensitive to the temperature changes. The energy level cross relaxation causes the quenching effect of Bi3+, and the multi-phonon de-excitation mode leads to the thermal quenching of Eu3+. At room temperature (298 K), the determined maximum relative sensitivity (Sr) is 1.27% K–1. Moreover, the absolute sensitivity (Sa) is 0.067 K–1 since the temperature is elevated to 523 K. The collected results are superior to most of the reported optical thermometry materials.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Ying Quan,Qinfu Liu,Kuo Li,Hao Zhang,Liang Yuan
Due to the fine granularity of CG with the dissemination of non-graphite minerals, highly efficient purification of natural coaly graphite (CG) by low-cost, low-energy consumption and low-pollution methods remains a challenge. In this study, a novel and efficient electrochemical method is demonstrated for purifying natural CG. The electrochemical purification is carried out in a mixed electrolyte containing 0.5 M (NH 4 ) 2 SO 4 and 10% HF with an optimum potential sequence starting at + 2.5 V for a few minutes followed by a short burst of + 5 V. The CG purification mechanism is proposed based on the experimental results. There are three main factors, namely, the type of the graphite anode, the electrolyte and the applied voltage are critical for effectively electrochemical purification. It is interesting to find that the main purified products are graphene mixed with graphite aggregates at a yield of 68%. Raman analysis indicates that the purified CG has fewer structural defects than the natural CG after removing the non-graphite minerals. Moreover, the XPS and FTIR analysis demonstrate that no other functional groups are grafted onto the parent graphite during this purification process. In comparison with the electrolyte only containing HF, the adding of 0.5 M (NH 4 ) 2 SO 4 in the HF electrolyte could reduce the amount of HF by more than 50%, which cuts the cost and alleviates the impact on the environment.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Yi Zheng,Wenping Ma,Zhibo Yang,Hongjian Zhang,Jingge Ma,Tian Li,Huicong Niu,Yanling Zhou,Qingqiang Yao,Jiang Chang,Yufang Zhu,Chengtie Wu
Rapid hemostasis and wound healing for emergency trauma is the key to ensure the survival of patients with massive hemorrhage. However, it is still a challenge to develop hemostatic materials with both excellent hemostatic activity and wound healing function. Herein, we propose to fabricate an inorganic hemostatic aerogel mainly based on biocompatible inorganic ultralong hydroxyapatite (HAP) nanowires with polyvinyl alcohol (PVA) as organic binder, and the hemostatic aerogel is prepared by using freeze-drying technology to construct three-dimensional (3D) porous structure, which possesses good plasticity and flexibility. When the content of ultralong HAP nanowires reaches 80 wt%, the W-8HAP-2PVA aerogel (aerogel consists of 80 wt% ultralong HAP nanowires and 20 wt% PVA) exhibits super-hydrophilicity/super-hematophilicity, and its in vitro blood clotting index is only 3.81 ± 0.71 %, which is much lower than that of medical gauze. When applied in hemostasis of rat liver and rabbit femoral artery, the hemostatic time and blood loss amount of the W-8HAP-2PVA aerogel are 26.59 ± 7.46 s, 0.18 ± 0.05 g and 174.00 ± 16.57 s, 2.18 ± 1.56 g, respectively. Benefiting from its excellent hydrophilicity and high porosity structure, W-8HAP-2PVA aerogel can quickly absorb water from blood to concentrate blood cells and platelets and accelerate hemostasis. Notably, it shows good hemocompatibility and cytocompatibility, and is able to promote skin wound healing. Hence, W-8HAP-2PVA aerogel has great potential in rapid hemostasis and wound healing for clinical settings.
✓ 已验证
产品关联
DOI
高影响因子
Horticulture Research
·
2021
·
IF 6.793
Dang Qingyuan,Sha Haiyun,Nie Jiyun,Wang Yongzhang,Yuan Yongbing,Jia Dongjie
Color is an important trait for horticultural crops. Carotenoids are one of the main pigments for coloration and have important implications for photosynthesis in plants and benefits for human health. Here, we identified an APETALA2 (AP2)/ETHYLENE RESPONSE FACTOR (ERF) transcription factor named MdAP2-34 in apple (Malus domestica Borkh.). MdAP2-34 expression exhibited a close correlation with carotenoid content in ‘Benin Shogun’ and ‘Yanfu 3’ fruit flesh. MdAP2-34 promotes carotenoid accumulation in MdAP2-34-OVX transgenic apple calli and fruits by participating in the carotenoid biosynthesis pathway. The major carotenoid contents of phytoene and β-carotene were much higher in overexpressing MdAP2-34 transgenic calli and fruit skin, yet the predominant compound of lutein showed no obvious difference, indicating that MdAP2-34 regulates phytoene and β-carotene accumulation but not lutein. MdPSY2-1 (phytoene synthase 2) is a major gene in the carotenoid biosynthesis pathway in apple fruit, and the MdPSY2-1 gene is directly bound and transcriptionally activated by MdAP2-34. In addition, overexpressing MdPSY2-1 in apple calli mainly increases phytoene and total carotenoid contents. Our findings will advance and extend our understanding of the complex molecular mechanisms of carotenoid biosynthesis in apple, and this research is valuable for accelerating the apple breeding process.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymers
·
2021
·Vol. 13
·期 19
·3341
·
IF 4.329
Xiuhua Yuan,Yeling Liu,Hui Yuan,Bingxin Liu,Tianyu Guo,Huawei Zhou,Xia Li
While the CuBi2O4-based photocathode has emerged as an ideal candidate for photoelectrochemical water splitting, it is still far from its theoretical values due to poor charge carrier transport, poor electron–hole separation, and instability caused by self-photoelectric-corrosion with electrolytes. Establishing synthesis methods to produce a CuBi2O4photocathode with sufficient cocatalyst sites would be highly beneficial for water splitting. Here, the platinum-enriched porous CuBi2O4nanofiber (CuBi2O4/Pt) with uniform coverage and high surface area was prepared as a photocathode through an electrospinning and electrodeposition process for water splitting. The prepared photocathode material was composed of a CuBi2O4nanofiber array, which has a freestanding porous structure, and the Pt nanoparticle is firmly embedded on the rough surface. The highly porous nanofiber structures allow the cocatalyst (Pt) better alignment on the surface of CuBi2O4, which can effectively suppress the electron–hole recombination at the electrolyte interface. The as-fabricated CuBi2O4nanofiber has a tetragonal crystal structure, and its band gap was determined to be 1.8 eV. The self-supporting porous structure and electrocatalytic activity of Pt can effectively promote the separation of electron–hole pairs, thus obtaining high photocurrent density (0.21 mA/cm2at 0.6 V vs. RHE) and incident photon-to-current conversion efficiency (IPCE, 4% at 380 nm). This work shows a new view for integrating an amount of Pt nanoparticles with CuBi2O4nanofibers and demonstrates the synergistic effect of cocatalysts for future solar water splitting.Keywords:electrospinning;CuBi2O4nanofiber;photocathode;water splitting
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Chemical Neuroscience
·
2021
·
IF 4.418
Yishuai Yang,Yao Tan,Dongting Zhangsun,Xiaopeng Zhu,Sulan Luo
Nicotinic acetylcholine receptors (nAChRs) are essential pentameric ligand-gated ion channels that are distributed throughout the central and peripheral nervous systems and non-neuronal tissues in mammalian species that play critical roles in a variety of neural and mental activities. The α3β2 nAChR subtype participates in pain, addiction to nicotine, and other neurophysiological and pathological activities. Owing to the lack of highly selective pharmacological tools targeting α3β2, related research on its tissue distribution and function has been hindered. α-Conotoxin (α-CTx) LtIA, discovered from Conus literatus in our lab, potently and selectively blocks α3β2 nAChR, providing an important molecular probe to study the α3β2 nAChR structure and function. We used the fluorescent molecule 5-carboxytetramethylrhodamine succinimidyl ester, which can react with the N-terminus of LtIA, to obtain a novel fluorescent analogue of LtIA (LtIA-F). The potency and selectivity of LtIA-F were tested using a two-electrode voltage clamp recording on various nAChRs expressed in Xenopus laevis oocytes. LtIA-F potently inhibited ACh-evoked currents at the α3β2 nAChR, with an IC50 value of 90.66 nM, displaying a ∼4-fold decrease in potency compared with native LtIA without a change in selectivity. The serum stability results indicated that LtIA-F exhibited stability similar to that of native LtIA. This study on an α-CTx LtIA fluorescent analogue provides a wealth of pharmacological tools to explore the structure–function relationship, distribution, and ligand binding domain of the α3β2 nAChR subtype.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Min Zou,Jing-Yan Li,Meng-Jia Zhang,Jun-Hui Li,Jun-Tao Huang,Pei-Dan You,Shu-Wen Liu,Chun-Qiong Zhou
At present, there are still no anti-Zika virus (ZIKV) drugs or vaccines approved by FDA with accurate targets and antiviral mechanisms. Considering the RNA G-quadruplex sequences in ZIKV genome, it is very meaningful to develop G-quadruplex binders as potential anti-ZIKV drugs with novel and accurate targets. In this paper, five classical G-quadruplex binders including Ber , Braco 19 , NiL , 360A and PDS have been chosen to discuss their interaction with ZIKV RNA G-quadruplexes. PDS shows higher binding affinity and thermal stability than the other G-quadruplex binders. This property is further evidenced in cells by immunofluorescence microscopy. And PDS shows higher anti-ZIKV activity (EC 50 = 4.2 ± 0.4 μM) than the other G-quadruplex binders as well as the positive control ribavirin, with a low cytotoxicity. By time-of-addition assay, PDS exerts antiviral activity at the post-entry process of ZIKV replication cycle, thus inhibiting ZIKV mRNA replication and protein expression. Furthermore, PDS combines with ZIKV NS2B-NS3 protease and reduces its catalytic activity. This study suggests that G-quadruplex binder PDS is an effective multi-target ZIKV inhibitor, which provides more guidance to design some novel anti-ZIKV drugs targeting ZIKV RNA G-quadruplexes.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
HIGH PERFORMANCE POLYMERS
·
2021
·
IF 2.161
Oussama Mehelli,Mehdi Derradji,Abdelmalek Habes,Nour Elislem Leblalta,Raouf Belgacemi,Slimane Abdous,Yasmine Izri,Wenbin Liu
The design of lightweight neutrons shields has been restricted for quite some time to the use of the epoxy thermosets as the main building blocks. Meanwhile, the recent developments in the field of polymers suggest otherwise. Indeed, benzoxazine resins have taken the lead over the traditional thermosets in many exigent applications. Therefore, in a vision to introduce newer matrices with better performances and to further expand the applications of the benzoxazine resins into the nuclear field, the neutron shielding efficiency along with the thermal and thermomechanical performances of the neat benzoxazine polymer and its subsequent B4C-reinforced composites were investigated. The neutron shielding measurements were performed using an optimized experimental setup at NUR research reactor, Algiers. The neat benzoxazine polymer displayed almost similar thermal neutrons screening performances than the epoxy with a macroscopic cross-section (Σ) of a 0.724 cm−1 equivalent to a mean free path (λ) of 0.957 cm. The effect of the particle amount was also studied to maximize the shielding ability of the developed materials. For instance, the benzoxazine composite containing 20 wt.% of B4C displayed the outstanding screening ratio of about 96% for a sample thickness of 13 mm. Finally, the remarkable findings were put into context by providing multifaceted comparisons with the available shielding materials.
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2021
·
IF 4.527
Kepi Chen,Jinxu Ma,Chuanxi Tan,Cuiwei Li,Linan An
In this paper, we explored the possibility of forming single-phase high-entropy fluorite oxides (HEFOs) in the (Ce 0.2 Zr 0.2 Ti 0.2 Sn 0.2 M 0.2 )O 2-δ (M = Mg, Y, Yb, and Ca) system. The result showed that single-phase high-entropy fluorite can only be obtained from (Ce 0.2 Zr 0.2 Ti 0.2 Sn 0.2 Ca 0.2 )O 2-δ . Compared with other reported anion-deficient HEFOs, this material has the lowest rare earth element content, the smallest average cationic radius and the lowest theoretical density. The effects of cation radius and starting materials on the formation of single-phase HEFOs are discussed.
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2021
·
IF 6.4
Yarong Wang,Xueling Yan,Qiming Kou,Qi Sun,Yuexin Wang,Ping Wu,Lulan Yang,Jiaming Tang,Tao Le
Purpose Sulfamethazine (SMZ) exposed in the environment can enter the human body through the food chain and pose a serious threat to human health. Therefore, it is important to develop a rapid and sensitive method for detecting SMZ in environmental samples. In order to fastly and quantitatively detect SMZ in environmental samples, we developed a label-free fluorescent aptasensor based on specific aptamer (SMZ1S) and fluorescence resonance energy transfer (FRET) between gold nanoparticles (AuNPs) and rhodamine B (RhoB).Methods In the absence of SMZ, SMZ1S was adsorbed on the surface of AuNPs, which led to dispersion of the AuNPs in high concentration saline solution, thus effectively quenching the fluorescence of RhoB. With the increase of the SMZ concentration, the specific binding of SMZ1S and SMZ led to the aggregation of AuNPs in the presence of NaCl, which reduced the quenching of RhoB fluorescence and increased the fluorescence intensity. The sensitivity and linearity curve of the label-free fluorescent aptasensor were determined with different concentrations of sulfamethazine standard solutions. The specificity of this fluorescent aptasensor was determined by replacing sulfamethazine with different antibiotics. In addition, the actual water and soil samples were spiked and recovered.Results Under optimized conditions, the proposed fluorescent aptasensor demonstrated a good linear detection of SMZ in binding buffer from 1.25 ng mL−1 to 40 ng mL−1 and the limit of detection was 0.82 ng mL−1. The spiked recoveries for SMZ were 94.4% to 108.8% with a relative standard deviation of 1.8–10.3% in water and soil samples, respectively.Conclusion The label-free fluorescent aptasensor investigated in the current study is a promising tool to detect and quantify SMZ in water and soil samples.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）