ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2026
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IF 6.6
Yiwen Tang,Chen Li,Mingliang Liu,Na Li,Beibei Liu,Dongmei Li,Lei Huang
Paired blood and urinary Pb/Cd biomarkers showed distinct renal association profiles. • A multi-matrix, multi-outcome framework captured complementary Pb–Cd renal signals. • Outcome-oriented networks recurrently prioritized IL1B and IL6 across renal modules. • Shared inflammatory hubs coexisted with outcome-related peripheral network organization. • Targeted cellular assays supported the exposure responsiveness of prioritized targets. Background Lead (Pb) and cadmium (Cd) remain widespread environmental toxicants, and the kidney is a major target organ. However, reliance on a single biomarker matrix or renal endpoint may incompletely characterize Pb–Cd-associated renal abnormalities. Whether blood- and urine-based Pb/Cd biomarkers exhibit differential association profiles across renal outcomes, and whether outcome-oriented networks converge on shared candidate pathways, remains unclear. Methods We analyzed NHANES 2011–2018 data from 5049 adults. Blood and urinary Pb and Cd biomarkers were evaluated in relation to estimated glomerular filtration rate (eGFR), albuminuria [log(UACR)], and a CKD-compatible phenotype using survey-weighted regression, whereas Pb–Cd mixtures were examined using case-weighted quantile g-computation and generalized weighted quantile sum regression. Effect modification by age, sex, BMI, diabetes, and hypertension was evaluated using formal interaction tests with false-discovery-rate correction. An outcome-oriented network toxicology framework was constructed using CKD-, albuminuria-, and broad renal injury-oriented disease modules. HEK293T cells were used for targeted cellular assessment of cytotoxicity, intracellular metal accumulation, redox and inflammatory responses, and transcriptional changes in genes prioritized by network analysis following Pb, Cd, or combined exposure. Exploratory molecular docking was performed to examine potential metal–protein interaction sites. Results Individual-biomarker and mixture analyses showed that the observed associations varied across biomarker matrices and renal outcomes. Urinary Pb was positively associated with eGFR; urinary Cd and blood Pb were associated with higher log(UACR); and blood Pb and blood Cd were associated with higher odds of the CKD-compatible phenotype. The urinary Pb–Cd mixture was positively associated with eGFR and log(UACR), whereas the blood mixture was associated with higher log(UACR) and higher odds of the CKD-compatible phenotype. Formal interaction analyses identified age-related heterogeneity in selected blood-based associations, while inverse associations of blood Pb, blood Cd, and urinary Cd with eGFR were stronger among participants with diabetes. Outcome-oriented network analysis consistently prioritized IL1B and IL6 as shared inflammatory hubs, while peripheral network architecture differed across renal modules. In HEK293T cells, combined Pb–Cd exposure increased intracellular metal burden and cytotoxicity, reduced antioxidant capacity, and altered the expression of IL1B, IL6, and selected stress-response genes. Conclusion Blood- and urine-based Pb and Cd biomarkers exhibited distinct association profiles across renal outcomes, indicating that a single biomarker matrix or endpoint may incompletely characterize Pb–Cd-associated renal abnormalities. Outcome-oriented networks converged on IL1B and IL6 as shared inflammatory hubs within distinct peripheral architectures, with targeted cellular evidence supporting the responsiveness of prioritized targets. These findings establish an integrative, multi-matrix and multi-outcome framework for the mechanistic interpretation and risk assessment of Pb–Cd co-exposure. Download: Download high-res image (271KB) Download: Download full-size image
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高影响因子
Journal of Environmental Chemical Engineering
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2023
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IF 7.7
Zulqarnain Haider Khan,Zhongyang Li,Minling Gao,Md. Shafiqul Islam,Ling Xiao,Weiwen Qiu,Zhengguo Song
As(III) and Cd(II) co-existence results in co-contamination in soil and water. It is still a great challenge for As(III) and Cd(II) simultaneous removal in the aqueous medium due to their contrasting chemical behaviour. Herein, we prepared a novel magnesium-manganese modified biochar composite (Mg/Mn@BC) for simultaneous Cd(II) and As(III) elimination from contaminated water . The synergistic effect of Mg/Mn@BC composite on synchronous Cd( II ) and As(I II ) removal was confirmed. In the mixed sorption system, the Langmuir sorption capacity of Mg/Mn@BC for As(III) and Cd( II ) was 164 and 316 mg g −1 , respectively, which was more than that in the single adsorption system (75 and 295 mg g −1 ). In the single sorption system, the Mg/Mn@BC sorption efficiency was > 61% and 100% for As( III ) and Cd( II ), respectively, while > 87% and 100% in the mixed adsorption system. The characterization results revealed that synergistic adsorption was mainly attributed to anion-bridging (Mn/MgO–As–Cd) and cation-bridging (Mn/MgO–Cd–As). The ion exchange, precipitation, Cd–π binding and inner-sphere surface complexation with functional groups were predominant in the sorption process, while hydrogen bonding force and ternary complexation were the primary pathways in mixed adsorption system to eliminate Cd(II) and As(III). The results suggested that Mg/Mn@BC composite can be a potential material for wastewater treatment .
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Journal of the Taiwan Institute of Chemical Engineers
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2023
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IF 5.7
Yaru Li,Yanyan Liu,Caiying Liu,Li Feng,Shuao Yang,Yuxue Shan,Fei Xiao
Background Toxic metals such as Pb(II) and Cd(II) have thrown great threat to human health. Adsorption has been drawn more attention due to its low-cost, easy process and extensive raw materials. However, high efficient and environmental-friendly adsorbents are still in great need. Furthermore, the quantitatively adsorption mechanisms of Pb(II) and Cd(II) remain unclear. MgO-loaded lotus stem biochar was proposed as a highly efficient adsorbent to removal aqueous Pb(II) and Cd(II). Methods MgO-loaded biochar was prepared by using lotus stalk as a precursor to be pyrolyzed with MgCl 2 impregnation. Adsorption isotherms , kinetics, thermodynamics experiments were carried out. SEM, XRD, FTIR, XPS, etc. were employed to characterize the adsorbent before and after adsorption. Significant findings The adsorption capacities of MgO-loaded biochar for Pb(II) and Cd(II) reached 1379.54 mg/g and 404.04 mg/g, respectively, which were 5 and 20 times higher than that of the original biochar. The adsorption kinetics and thermodynamics indicated that the adsorption process was a chemisorption-based heat absorption reaction, and the characterization results showed the main adsorption mechanisms were ascribed to ion-exchange, precipitation, surface complexation between biochar and Pb(II)/Cd(II) ions, in which the ion exchange mechanism was quantitatively confirmed. Finally, MgO-loaded biochar has been proved to be an efficient adsorbent.
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MOLECULES
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2023
·Vol. 28
·期 17
·6344
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IF 4.6
Shuanghui Wang,Chuhong Chen,Yan Lu
Cadmium (Cd), a harmful heavy metal that has no biological purpose, can harm healthy fetal and child development. Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol in tea, has been shown to increase cell viability under Cd exposure and ameliorate Cd-induced kidney injury in adult male rats. Using theCaenorhabditis elegans(C. elegans) model, we demonstrated that EGCG mitigated Cd-induced body size developmental toxicity through a mechanism that did not involve chelation with EGCG and was not associated with Cd accumulation and efflux. Our research indicated that the beneficial effects of EGCG on Cd-induced body size developmental toxicity were associated with the mitigation of endoplasmic reticulum stress. Furthermore, our observations indicate that EGCG reduced Cd-induced developmental toxicity inC. elegansvia the PEK-1/eIF-2α/ATF-4 pathway. Our results provide important evidence for the potential benefits of consuming tea as a detoxification agent.Keywords:tea;EGCG;cadmium;Caenorhabditis elegans;developmental toxicity;endoplasmic reticulum stress
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高影响因子
ENVIRONMENTAL TOXICOLOGY
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2023
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IF 4.5
Jie Tang,Nenghua Zhang,Shipiao Chen,Kewei Hu,Yintao Li,Yipeng Fang,Zhenqiang Wu,Yi Zhang,Long Xu
Environmental pollution is complex, and co-exposure can accurately reflect the true environmental conditions that are important for assessment of human health. Cadmium (Cd) is a widespread toxicant that can cause acute kidney injury (AKI), while its combined effect with 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) is not fully understood. Thus, we used an in vivo model where C57BL/6J mice were treated with low dietary intake of Cd (5 mg/kg/day) and/or BDE-47 (1 mg/kg/day) for 28 days to examine AKI, and in vitro experiments to investigate the possible mechanism. Results showed that Cd or BDE-47 caused pathological kidney damage, accompanied by elevated urea nitrogen (BUN) and urinary creatinine, as well as increased interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), and reduced IL-10 in kidney tissues. In vitro Cd or BDE-47 exposure decreased cell viability and induced cell swelling and blebbing of human embryonic kidney 293 (HEK-293) and renal tubular epithelial cell lines (HKCs), and changes in co-exposure was larger than that in Cd and BDE-47 treatment. Oxidative stress indicators of the reactive oxygen species (ROS) and malondialdehyde (MDA) were elevated, while the antioxidant superoxide dismutase (SOD) was decreased. Necrosis occurred with increased lactate dehydrogenase (LDH) release and propidium iodide (PI) staining, which was attenuated by the ROS scavenger N-acetyl-L-cysteine (NAC). Furthermore, necroptotic genes of receptor-interacting protein kinase-3 (RIPK3), classical mixed lineage kinase domain-like protein-dependent (MLKL), IL-1β and TNF-α were up-regulated, whereas RIPK1 was down-regulated, which was attenuated by the RIPK3 inhibitor GSK872. These findings demonstrate that Cd or BDE-47 alone produces kidney toxicities, and co-exposure poses an additive effect, resulting in AKI via inducing oxidative stress and regulating RIPK3-dependent necroptosis, which offers a further mechanistic understanding for kidney damage, and the combined effect of environmental pollutants should be noticed.
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Surfaces and Interfaces
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2022
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IF 6.137
Xueqiang Liu,Diandi Li,Jiguang Li,Jianle Wang,Shujie Liang,Hong Deng
Heavy metal ion pollution (e.g., Hg, Pb, Cr, Cd) that has a great threat to human health is a global concern, because of their great toxicity (e.g., carcinogenicity and mutagenicity). Therefore, it is necessary to find an economical and efficient technology to remove metal. In recent years, modified biochar plays an important role in the removal of heavy metal. However, most of the biochar modification methods rely on high temperature and long time, which limits their application in practical engineering. In this study, we firstly synthesized HMBC (MnO X -OBC, peanut shells as raw materials) using H 2 O 2 -NaOH method, where the materials only need to be modified for 10 min at ambient temperature to obtain high adsorption performance. The maximum Pb(Ⅱ) and Cd(Ⅱ) adsorption capacities of HMBC were 164.59 mg g − 1 and 36.77 mg g − 1 , respectively, which were 7.2 times and 5.6 times that of the unmodified PBC (peanut shells derived biochar ) , and the main adsorption mechanisms were complexation, ion exchange, cation-π interaction and precipitation. The adsorption process of lead and cadmium by HMBC was more consistent with the Freundlich model and Pseudo-second-order adsorption kinetics . HMBC had high selectivity for lead and cadmium, and the adsorption performance of HMBC was basically not reduced after five cycles. The above experimental results show that the newly prepared HMBC has the potential to treat lead and cadmium industrial wastewater.
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JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
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2022
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IF 2.042
Abdullah Akhdhar,Amr A. Yakout
Heavy metals sequestration from industrial discharges has aroused increasing attention worldwide to cleaner and sustainable water production by developing fast, effective eco-friendly nanosorbents. This study aimed to design a robust and fast nanocomposite to remove heavy metal ions, mainly Pb(II) and Cd(II). To this end, poly-(2-aminothiophenol); PATP was incorporated into graphene oxide; GO to fabricate PATP@GO nanocomposite. The structure and morphology of the novel nanocomposite were evaluated by FTIR, TEM, XRD, Raman, EDX, and TGA. Integrating PATP improved the adsorption efficiency of the GO from 61.3% to 98.6% for Pb(II) and 34.6% to 87.3% for Cd(II). Furthermore, the impact of pH, the mass of nanocomposite, metal ions concentrations, and coexisting ions were thoroughly investigated and optimized. The potential efficiency and adsorption capacity of PATP@GO nanocomposite toward Pb(II) was 98.6.00%, 142.9 mg.g-1 for Pb(II) at pH 5 and 87.3%, 125.0 mg.g-1 for Cd(II) at pH 7 within 25 minutes, respectively. This behavior was explained in terms of strong complex formation with the thiol groups of PATP, as well as the hydroxyl and carboxyl groups in GO. Kinetic studies were based on pseudo-second order (R2 > 0.99) and the adsorption data are best fitted with the Langmuir model. The excellent stability of PATP@GO nanocomposite enabled effective extractions for seven successive runs (98.6%-95.3% for Pb(II) and 87.3–85.1% for Cd(II)). The developed PATP@GO nanocomposite is believed to show fast and high potential in detoxifying of heavy metal ions from different environmental samples in aquatic life.
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RSC Advances
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2022
·Vol. 12
·期 28
·18004-18011
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IF 4.036
Lingling Xu,Chuan Zhou,Fan Wang,Huiqin Liu,Guangyuan Dong,Siyi Zhang,Tao Liu
In this study, a drug delivery system was prepared by grafting the targeting molecule arginine-glycine-aspartic acid (RGD) onto hyperbranched polyglycerol (HPG)-modified β-cyclodextrin (β-CD-HPG) for the targeted inhibition of nasopharyngeal carcinoma (NPC) cells. The obtained β-CD-HPG-RGD with a relatively small size and low surface charge delivered docetaxel (Doc) effectively and displayed a targeting effect to human NPC HNE-1 cells, as confirmed by confocal laser scanning microscopy and flow cytometry. The in vitro drug release analysis exhibited the controlled drug release kinetics of the β-CD-HPG-RGD/Doc nanomedicine. β-CD-HPG-RGD/Doc effectively inhibited the proliferation of HNE-1 cells and promoted apoptosis. Moreover, its biocompatibility in vitro and in vivo was assessed. The results indicate that the β-CD-HPG-RGD/Doc nanomedicine has potential application in NPC targeting therapy.
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高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
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2022
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IF 10.753
Dezheng Sun,Fayong Li,Junwei Jin,Sangar Khan,Kamel Mohamed Eltohamy,Miaomiao He,Xinqiang Liang
Developing effective modification methods and obtaining a comprehensive understanding of adsorption mechanisms are essential for the practical application of biochars for the removal of heavy metals from solutions. In this study, rice straw was impregnated with sodium phytate and pyrolyzed at 350 °C, 450 °C, and 550 °C to synthesize modified biochars (i.e., MBC350, MBC450, and MBC550). The Cd(II) adsorption capacities and contributions of different mechanisms, including the effects of biochar-derived dissolved organic matter (BDOM), were investigated using batch sorption experiments and characterization analyses. The modification of sodium phytate promoted the pyrolysis of biomass, thereby increasing the BDOM content and aromatic structures at low and high pyrolysis temperatures, respectively. Moreover, the modification also increased the exchangeable Na + and carbonate contents in the modified biochars. Compared with the raw biochars, the Cd(II) adsorption capacities of modified biochars increased by 3.3–4.3 times, and MBC550 had the highest Cd(II) adsorption capacity (126.5 mg/g), of which precipitation with minerals and interaction with π-electrons contributed 41.7% and 45.8%, respectively. However, at a lower pyrolysis temperature, the Cd(II) adsorption attributed to ion exchange and co-deposition with BDOM significantly increased, especially on MBC350 (33.9 and 12.6 mg/g, respectively). These results indicate that modification by sodium phytate effectively enhanced various adsorption mechanisms, thereby increasing the Cd(II) adsorption capacity. In addition, the contribution of co-deposition with BDOM to adsorption was unneglectable for the biochars pyrolyzed at low temperatures.
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SCIENCE OF THE TOTAL ENVIRONMENT
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2023
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IF 9.8
Hui Huang,Yuwei Lv,Kunkun Tian,Yu Shen,Yongli Zhu,Haiying Lu,Ronghua Li,Jiangang Han
As a toxic heavy metal, cadmium (Cd) easily enters into rice while rice grains greatly contribute to the dietary Cd intake in the populations consuming rice as a staple food . The availability of Cd in paddy soil determines the accumulation of grain Cd. Soil drainage leads to the remobilization of Cd, increasing bioavailability of Cd. In contrast, soil flooding results in little contribution of soil Cd to grain Cd, which is generally attributed to sulfate reduction induced by sulfate-reducing bacteria (SRB) in paddy soils. However, effects of SRB cultured from the paddy soil on the solubility and redox behavior of Cd have been seldom investigated before. Here, we used SRB enrichment cultures to investigate the temporal dynamics of Cd 2+ . The results showed that SRB enrichment cultures efficiently reduced solution redox potential (Eh) to less than −100 mV and gradually increased pH to neutral, demonstrating their ability to create a good anaerobic environment. The solubility of Cd obviously decreased in the anaerobic phase and Cd 2+ was transformed into poorly dissolved CdS near the SRB cell wall edge. The addition of Zn 2+ and/or Fe 2+ further improved the decrease in Cd solubility and facilitated the formation of polymetallic sulfides as a consequence of promoting the production of S 0 and dissolved sulfides (S 2− /HS − ) and the transformation of S 0 into S 2− /HS − . Little of Cd was detected in the media upon reoxidation, which was probably due to the high pH and the interaction between CdS and ZnS/FeS. Conclusively, these results demonstrate the detailed dynamic processes that explain the essential role of SRB in regulating the redox dynamics of chalcophile heavy metals and their bioavailability in paddy soils.
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高影响因子
Journal of Fungi
·
2021
·Vol. 8
·期 1
·10
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IF 5.816
Dyaaaldin Abdalmegeed,Gan Zhao,Pengfei Cheng,Javaid A. Bhat,Wajid Ali Khattak,Mostafa G. Ali,Fawze Alnadari,Ilyas Ali,Qurban Ali,Sameh A. Korma,Yehia A.-G. Mahmoud,Manar K. Abd Elnabi,Weiti Cui,Wenbiao Shen
Whether or not hydrogen gas (H2) can reduce cadmium (Cd) toxicity inGanoderma lucidumhas remained largely unknown. Here, we report that Cd-induced growth inhibition inG. lucidumwas significantly alleviated by H2fumigation or hydrogen-rich water (HRW), evaluated by lower oxidative damage and Cd accumulation. Moreover, the amelioration effects of H2fumigation were better than of HRW in an optimum concentration of H2under our experimental conditions. Further results showed that H2-alleviated growth inhibition inG. lucidumwas accompanied by increased nitric oxide (NO) level and nitrate reductase (NR) activity under Cd stress. On the other hand, the mitigation effects were reversed after removing endogenous NO with its scavenger cPTIO or inhibiting H2-induced NR activity with sodium tungstate. The role of NO in H2-alleviated growth inhibition under Cd stress was proved to be achieved through a restoration of redox balance, an increase in cysteine and proline contents, and a reduction in Cd accumulation. In summary, these results clearly revealed that NR-dependent NO might be involved in the H2-alleviated Cd toxicity inG. lucidumthrough rebuilding redox homeostasis, increasing cysteine and proline levels, and reducing Cd accumulation. These findings may open a new window for H2application in Cd-stressed economically important fungi.Keywords:hydrogen fumigation;nitric oxide;hydrogen-rich water;stress alleviation;cysteine;proline;Ganoderma lucidum
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高影响因子
Journal of Environmental Chemical Engineering
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2023
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IF 7.7
Jiajia Li,Yi Li,Manhua Chen,Xi Tang,Nianwen Zhu,Wenxuan Li,Qiong Mei,Shijun Yue,Yuping Tang,Qizhao Wang
The exploitation of magnetic recyclable and effective degradation photocatalysts with wide-pH-range response was essential to the practical application in the photo-Fenton process. In this study, Cd/CdS coupling with CuO/Fe 2 O 3 /CuFe 2 O 4 (CF) was employed to prepare an efficient and recyclable photocatalyst Cd/CdS-CuO/Fe 2 O 3 /CuFe 2 O 4 (CCCF). The obtained CCCF was utilized to activate H 2 O 2 for the photo-Fenton degradation of tetracycline after verifying optical properties and energy band structures. The photo-Fenton degradation performance of CCCF on tetracycline was researched in the effects of photocatalyst concentration, initial pH and H 2 O 2 volume. The photo-Fenton removal efficiency of CCCF+H 2 O 2 was capable of achieving 82.43 % under the optimal reaction condition, which was apparently higher than that of Cd/CdS and CF. The enhanced degradation efficiency could be owned to the effective carriers separation thanks to the p-n heterojunction . The development of such photocatalysts offers a new approach to degrading organic pollutants from industrial wastewater , making it a valuable tool for contaminants degradation.
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高影响因子
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