ACS Applied Materials & Interfaces
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2019
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IF 8.456
Qi Huang,Liping Guo,Ning Wang,Xiang Zhu,Shangbin Jin,Bien Tan
Conjugated microporous polymers (CMPs) with high surface areas, tunable building blocks, and fully conjugated structures have found important applications in optoelectronics. Here, we report a new series of CMPs with tunable band gaps by introducing thiazolo[5,4-d] thiazole as the linkage. Because they are synthetic polymers, the geometries and structures could be rationally designed. Their intrinsic wide visible-light absorption properties and layered architectures endow them with a promising photocatalytic performance. The role of geometries, surface areas, and morphologies of the CMPs in photocatalysis abilities is examined and discussed. The results indicate that geometries have a direct impact on the surface areas and morphologies of the CMPs and thus exert great influence on photocatalysis.
研究领域:
材料化学
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物理化学
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高分子科学
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光催化
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纳米材料
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能源化学
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Advanced Healthcare Materials
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2025
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IF 9.6
Wenhui Hu,Zhicheng Cao,Mengtao Wang,Zhiwen Dong,Yufeng Wang,Xin Zhang,Yan Xu,Liming Wang,Changyan Ma,Cheng Tang
Endogenous regenerative strategy for osteochondral defect (OCD) repair remains challenging, largely due to the need to regulate the local inflammatory and metabolic microenvironment while preserving the stemness of bone marrow mesenchymal stem cells (BMSCs). Here, D-mannose we identify as a potent immunometabolic modulator that enhances BMSC-mediated osteochondral repair. Through in vitro experiments, we determined the optimal concentration of D-mannose and evaluated its ability to preserve the osteogenic and chondrogenic differentiation potential of BMSCs under inflammatory microenvironment. Transcriptomic analysis demonstrated that D-mannose contributed to the amelioration of inflammation by downregulating the NLRP3 inflammasome pathway. The metabolomic analysis further revealed that D-mannose treatment alleviated inflammation-induced dysregulation of the tricarboxylic acid cycle and facilitated the maintenance of glycolytic metabolic state in BMSCs. Furthermore, we fabricated a multifunctional GelMA-based hydrogel incorporating D-mannose (DM@GelMA). Macroscopic observation, micro-CT analysis and histological evaluation confirmed that DM@GelMA hydrogel effectively promoted osteochondral tissue remodeling and integration in the OCD model of rats. These findings suggested that the multifunctional D-mannose-loaded composite hydrogel is a promising biomaterial for enhanced osteochondral regeneration.
研究领域:
生物医学工程
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再生医学
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免疫代谢
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组织工程
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生物材料
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Nano Today
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2025
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IF 10.9
Wei Hu,Jiaxi Xu,Mingchen Lv,Min Sun,Zhen Fan,Jianzhong Du
Immunotherapy offers enduring cancer treatment by activating the immune system to eliminate cancer cells, but faces challenges like tumor immune evasion and low immunogenicity. Chirality, crucial in biological interactions, remains underexplored for immune modulation. Inspired by the metal-binding domain of manganese superoxide dismutase, we develop a cyclic D/L peptide for chirality-driven immune activation. The cyclic L -Tyr- D -His- L -Asp- D -His (YhDh) peptide coordinates with Mn 2+ to self-assemble into nanoparticles, cloak with tumor cell membranes for homologous targeting. Compared to all-L or all-D peptides, YhDh nanoparticles promote costimulatory molecule expression on dendritic cells (DCs). Upon intravenous administration, they are oxidized at melanoma sites with tyrosinase overexpression, enabling photothermal-induced immunogenic cell death (ICD). Chiral peptides synergize with Mn 2+ -mediated cGAS-STING activation and ICD, enhancing DC maturation and T cell infiltration (4.36- and 2.88-fold), suppressing tumor metastasis while establishing immune memory. Such chiral cyclic peptides offer a novel strategy for immune activation by regulating peptide chirality.
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Nano Energy
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2020
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IF 16.602
Zheng Zhou,Xiangxin Du,Zhao Zhang,Jikui Luo,Shaoyu Niu,Da Shen,Yuanyu Wang,Hui Yang,Qilong Zhang,Shurong Dong
Flexible piezoelectric nanogenerator (PENG) has been regarded as one of the promising solutions to harvesting mechanical energy, as a sustainable energy source for wearable devices , etc. Here, a universal strategy of carbon coating modulation is proposed to synthesis carbon coated 0-D piezoceramics nanoparticles (NPs). Owing to the good electric conductivity of carbon shell, the redistribution and accumulation of mobile charges in carbon layer gives rise to reinforcement of electric field, results in the much-enhanced piezoelectric effect. Polydimethylsiloxane (PDMS) composites with those 0-D piezoceramics NPs are used to fabricate PENGs. The peak power density of BT@C, PZT@C and KNN@C based PENGs reaches up to 45.4 μW/cm 2 , 59.8 μW/cm 2 and 9.9 μW/cm 2 , that are 20, 20.4 and 13.4 times larger than those of control PENGs incorporated with bare 0-D piezoceramic NPs, respectively. A theoretical model based on Lewis diffusion theory is constructed to reveal the mechanism of piezoelectric enhancement in the poling process. This research provides a new strategy for synthesis of high piezoelectric characteristic composites by embedding carbon coated 0-D piezoceramic NPs.
研究领域:
材料科学
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能源技术
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Frontiers in Endocrinology
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2023
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IF 5.2
Tingwan Du,Lian Xiang,Jingjing Zhang,Chunmei Yang,Wenxin Zhao,Jialu Li,Yong Zhou,Ling Ma
Introduction The study aimed to explore the association of serum 25(OH)D 3 and hepatic steatosis in non-alcoholic fatty liver disease (NAFLD) patients and to determine whether the effect of vitamin D (VD) is mediated by activation of the peroxisome proliferator-activated receptor α (PPARα) pathway. Methods The study contained a case-control study, in vivo and in vitro experiments. A case-control study was conducted to compare serum parameters between NAFLD patients and controls and to evaluate the association of 25(OH)D 3 and NAFLD. In vivo study, male Wistar rats were randomly divided into control and model groups, fed a standard chow diet and a high-fat diet (HFD), respectively, for 7 weeks to generate an NAFLD model. Then, the rats were treated with VD and a PPARα antagonist (MK886) for 7 weeks. Tissue and serum were collected and assessed by biochemical assays, morphological analysis, histological analysis, and western blot analysis. In vitro , HepG2 cells were incubated with oleic acid (OA) to induce steatosis, which was evaluated by staining. HepG2 cells were pretreated with MK886 followed by calcitriol treatment, and differences in lipid metabolism-related proteins were detected by western blot. Results NAFLD patients were characterized by impaired liver function, dyslipidemia, and insulin resistance. Serum 25(OH)D 3 was negatively associated with alanine aminotransferase (ALT) in NAFLD. VD deficiency was a risk factor for patients with no advanced fibrosis. Adequate VD status (25(OH)D 3 >20 ng/mL) had a protective effect in patients after adjustment for confounding variables. NAFLD rats showed hyperlipidemia with severe hepatic steatosis, systematic inflammation, and lower serum 25(OH)D 3 . VD treatment ameliorated hepatic steatosis both in NAFLD rats and OA-induced HepG2 cells. Further, MK886 inhibited the anti-steatosis effect of VD. Conclusion The study revealed that an adequate VD level may act as a protective factor in NAFLD and that VD may alleviate hepatic steatosis via the PPARα signaling pathway.
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JOURNAL OF MEMBRANE SCIENCE
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2023
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IF 9.5
Ruijun Zhang,Wenqian Zhu,Jiayu Tian,Shanshan Gao,Bart Van der Bruggen
Reverse osmosis is an effective seawater desalination way extending the available sources of fresh water, but challenged by the gypsum scaling. Herein, D (+)-glucosamine (DGA) was rationally selected and utilized to prepare a novel polyesteramide (PEA) NF membrane that can reject SO 4 2− but release Ca 2+ . Then it was employed in the pretreatment of seawater reverse osmosis to spatially isolate SO 4 2− and Ca 2+ , thus removing the “foundation” for forming gypsum. Compared to the referenced NF270, the optimized sample denoted as DGA-PEA-NF has a looser structure with stronger negative charge, as well as a higher resistance to both organic fouling and chlorine attack. During the pretreatment of seawater, both the water permeability and SO4 2− /Ca 2+ selectivity of the DGA-PEA-NF membrane were much higher than those of NF270; the seawater permeance and SO 4 2− /Ca 2+ selectivity of DGA-PEA-NF were 10.25 L m −2 ·h −1 ·bar −1 and 7.62, respectively, while those of NF270 were only 5.11 L m −2 ·h −1 ·bar −1 and 2.08. Consequently, the DGA-PEA-NF membrane effectively reduced the gypsum scaling both in NF and RO stages rather than just transferring the fouling problem forwards to NF stage. The implementation of this research is expected to provide guidance for a targeted fabrication of NF membranes, as well as support for the sustainable development of seawater desalination.
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APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
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2023
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IF 3
Zhao Xia,Guo Meijing,Li Xian,Liu Bo,Li Binglin,Wang Jiao
Phospholipase D (PLD) with the higher transphosphatidylation activity was screened from Streptomyces sp. LD0501 basing on the protoplast mutagenesis technology. Then, it was successfully bio-imprinted to form a hyperactivated structure and rigidified by the intramolecular cross-linking, which was immobilized on the nonporous nanoscale silica. Characterization techniques were employed to investigate the structure and physicochemical properties of the catalysts, including Fourier transform infrared (FTIR) spectra and scanning electron microscopy (SEM) analysis. Transphosphatidylation activity and selectivity were improved significantly when immobilized PLD was used. The maximum yield for the production of phosphatidylserine (PS) reached 97% and the side reaction, the hydrolysis, was minimized. These results were further confirmed by the nuclear magnetic resonance (NMR) and mass spectrometry (MS) analysis. The imprint-induced characteristics of PLD was successfully “remembered” even in the present of much water. In addition, this immobilized hyperactivated PLD showed the excellent operational stabilities and environmental tolerances. Graphical abstract
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BIOCATALYSIS AND BIOTRANSFORMATION
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2023
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IF 1.8
Jue Chen,Qibin Cheng,Qianqian Ma,Yuqi Wu,Liwei Zhang
This study aimed to establish a novel method for catalysing salidroside synthesis by immobilized β-D-glucosidase with deep eutectic solvents (DESs) as a new green non-aqueous medium. To this end, the catalytic properties of β-D-glucosidase (i.e. activity, stability, and enzymatic properties) were analysed within sixteen different DESs systems. Although most DESs significantly improved enzyme stability, they also reduced enzymatic activity. This was verified at the molecular level by employing fluorescence spectroscopy to evaluate conformational changes in β-D-glucosidase molecules. Subsequently, chitosan microspheres were used to immobilize β-D-glucosidase; the structures of the microspheres and immobilized enzyme were observed by scanning electron microscopy (SEM). Through single factor experiments and application of a response surface design, the optimal conditions for production of salidroside by the reaction of tyrosol with immobilized β-D-glucosidase were established. These conditions comprised 80 vol% ChCl/G (1:2), 50 °C reaction temperature, 5.8 pH, 100 h reaction time, 45 U/mL enzyme dosage, and a tyrosol/D-glucose molar ratio of 10. Under these conditions, the average conversion rate of the tyrosol substrate was 31.6%. Moreover, a salidroside crude product was obtained with a purity >70% (g/g) and a substrate conversion rate of immobilized β-D-glucosidase >50% of its initial value after five repeated uses. Collectively, this study establishes a novel green reaction system for the efficient preparation of salidroside and other glycoside compounds, while also providing a theoretical foundation for the analysis of β-D-glucosidase catalytic reactions in DESs systems.
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NANO
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2022
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IF 1.438
X. Du,L. Wang,Q. Xia,Q. Hu,A. Zhou
For lithium-ion batteries (LIBs) with high energy density, it is critical to develop reliable and high-capacity anode materials. In this work, d-Ti 3 C 2 T x /h-BN hybrid layered nanocomposites with uniform distribution are synthesized using a simple liquid phase blending method and investigated as an anode material for LIBs. The results reveal that the uniformly dispersed h-BN anchored on the d-Ti 3 C 2 T x nanosheets can effectively prevent the d-Ti 3 C 2 T x nanosheets from restacking during charging and discharging processes, as well as improve the electronic conductivity. The studies show that the electrochemical performance, such as the capacity and cyclic stability, of d-Ti 3 C 2 T x /h-BN electrode is better than that of pure d-Ti 3 C 2 T x materials.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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2022
·Vol. 103
·期 8
·4034-4046
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IF 4.125
Xinlei Zhao,Xue Yang,Yihong Bao,Yang Guo,Jiayuan Luo,Shilong Jiang,Wei Zhang
BACKGROUND The food industry has begun to develop foods fortified with unsaturated fatty acids; however, the susceptibility of pine nut oil to oxidation and other properties limits its use in food production. Researchers often inhibit the oxidation of oil by adding antioxidants. After the combination of polyphenols and proteins, the complex formed can improve or enhance the performance of the emulsion when it stabilizes the emulsion. Encapsulating, protecting, and controlling the release behavior of vitamin D (V D ) during digestion through an emulsion delivery system can effectively overcome limitations such as easy degradation during processing and storage. This research uses tannic acid, gallic acid, tea polyphenol, and vanillic acid to prepare Pickering emulsions, and the type of phenolic compound is explored by multi-dimensional characterization and the amount of emulsion. RESULTS The influence of traits, microstructure, stability, V D load application, and effect on the emulsion matrix's encapsulation rate and bioaccessibility is studied. A method was investigated to enhance the oxidative stability of whey protein isolate-stabilized emulsions by introducing phenol. Pickering emulsions could be obtained in the presence of phenol, while the type of phenol played a relatively important role, probably because the mechanism involved interactions between particles. Viscosity and creaming stability of emulsions increased with crosslinking of phenol in emulsions. In addition, the presence of phenol in emulsions significantly increased the bioaccessibility of encapsulated V D after in vitro digestion. CONCLUSION The method presented in this study was important for improving the oxidative stability of pine nut oil emulsions, expanding the application of pine nut oil in the food industry, and providing the theoretical and application basis of application and active substance emulsion delivery systems. © 2022 Society of Chemical Industry.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2023
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IF 5.2
Tengfei Xiang,Yanli Zhang,Linjing Cui,Jiaqi Wang,Depeng Chen,Shunli Zheng,Yujie Qiang
Herein, the synergistic inhibition of two typical corrosion inhibitors benzotriazole (BTA) and sodium D -gluconate (SD) on the corrosion of Q235 steel in simulated concrete pore solution (SCP) were systematically studied. The results demonstrated that the mixed BTA/SD showed an excellent anti-corrosion performance and the inhibition efficiency of (BTA/SD, 1ː1) was as large as 98.33 % which is higher than that of BTA (88.65 %) and SD (92.16 %). Furthermore, the synergistic inhibition effect of BTA/SD was also researched by surface analysis technologies, the X-ray photoelectron spectroscopy (XPS) result verified that the BTA/SD adsorbed on steel, while both scanning electron microscopy (SEM) and atomic force microscopy (AFM) images proved that the mixed BTA/SD can effectively protect the steel from corrosion in SCP solution which containing corrosive ions. In addition, the anti-corrosion mechanism of the mixed BTA and SD was revealed by adsorption model and molecular dynamics (MD) simulation, the mixed BTA/SD corrosion inhibitors showed the largest K ads , the lowest ∆ G ads and the largest binding energy values , demonstrating the strong adsorption on steel and the best anti-corrosion performance. The results of this work can provide experimental and theoretical references for the corrosion protection of reinforced concrete structures while using synergistic inhibitors.
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INDUSTRIAL CROPS AND PRODUCTS
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2022
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IF 6.449
Shu Diao,Yini Zhang,Qifu Luan,Xianyin Ding,Jiaming Sun,Jingmin Jiang
Oleoresin terpenoids have been widely used in the food , pharmaceutical, and chemical industries. A thorough understanding of oleoresin terpenoid biosynthesis is important for the metabolic engineering of high-valued terpenoid products in plants and microbes and the improvement of oleoresin traits using molecular breeding strategies. TPS-d subfamily members, specific to conifers, determine the oleoresin terpenoid compound diversity. Here, we aimed to identify the TPS-d genes in slash pine ( Pinus elliottii ) and characterize their function and expression patterns in population. Our study reveals two main results: (1) A total of 52 terpene synthase (TPS) candidate genes were identified based on long-read transcripts of slash pine, 12 of which were successfully cloned from the secondary developing xylem RNA. Two levopimaradiene/abietadiene synthases (LAS), one monofunctional isopimaradiene synthase (mISO1)-like, and two α-pinene synthases were identified by comparing with previously known TPS. Next, the two α-pinene synthases and one β-pinene synthase producing multiple products were validated through heterologous expression and in vitro enzyme activity assays, which showed different product profiles from previously identified TPS. (2) The expression status of the cloned TPS genes in 240 slash pine individuals were analyzed. Four exhibited very low expression levels, including those identical to copalyl diphosphate synthases, hemiterpene synthases, diterpene synthases without activity, and one obtained without soluble protein in the heterologous expression. The expression levels of eight TPS genes participating in slash pine oleoresin biosynthesis varied in different individuals and were highly correlated with multiple transcriptional regulators, namely, MYB and MYC. The expression of two α-pinene synthase genes was significantly higher than that of the other TPS genes. Some TPS gene expression levels were positively correlated with the corresponding oleoresin component content. Our results provide an essential reference for exploring the mechanisms of terpene biosynthesis and regulation.
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