Scientific Reports
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2025
·Vol. 15
·期 1
·1-13
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IF 3.9
Xia Meng,Cao Shisheng,Liu Zeqi,Zhao Jiakang,Yuan Yibo,Ni Jianhui,Guo Zhengjian,Wang Weihan,Yin Huijuan,Zou Zhaohui
Persistent or refractory apical periodontitis is primarily caused by microbial retention, as conventional root canal treatment often fails to eliminate infections completely, and systemic antibiotic therapy is insufficient to achieve effective concentrations for eradicating bacterial biofilms within root canals. This highlights the urgent need for novel therapeutics offering safe and effective antimicrobial strategies. Antimicrobial photodynamic therapy (aPDT) is a promising approach for root canal disinfection. However, commonly used photosensitizers such as Ce6 suffer from poor water solubility and strong aggregation tendencies, resulting in limited penetration into infected sites. In this study, we developed a DNase I-Lip@Ce6 nanodelivery system by combining deoxyribonuclease I (DNase I) with liposome-encapsulated Ce6. The liposomal carrier facilitated efficient delivery of Ce6 into target bacterial cells, while DNase I degraded extracellular DNA in the biofilm matrix, weakening its protective barrier. This synergistically enhanced Ce6 penetration and therapeutic efficacy, leading to the successful eradication of planktonic Enterococcus faecalis and in vitro biofilms. This strategy offers a novel approach for the precision treatment of persistent oral infections and holds strong potential for clinical translation.
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ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Fanfan Guo,Yuanyuan Hu,Huiwen Zhou,Yuanjin Li,Jiadi Li,Guichuan Wei,Jing Long Han,Wenyue Gao,Sisi He,Wenxin Niu,Ling Zhang
NIR-I electrochemiluminescence (ECL) is emerging as highly sensitive detection strategy due to its low background at the ambient conditions. Nonetheless, the applications of current NIR-I ECL nanoprobes are limited to the harsh synthetic/testing condition, high toxicity, low signal, and poor biocompatibility. In this study, glutathione/lipoic acid-protected trimetallic Au 6 PtAg nanoclusters (GSH/LA/Au 6 PtAg NCs) are demonstrated as an efficient nanoprobe with strong ECL signals around 850 nm in the presences of triethylamine. Critically, the alloying of Ag + into the bimetallic Au 2.5 Pt NCs altered the electronic structures of Pt(II), valences of Au(0), and the zata potentials of NCs, promoting the ECL intensities at 850 nm by 1.0 time. Additionally, the partly ligand-exchange of GSH by LA further increased the ECL intensities at 850 nm by 2.2 times through accelerating electron transfer processes. Meanwhile, the NIR-I fluorescence ( λ emit = 910 nm) was enhanced. More importantly, the utilization of GSH/LA/Au 6 PtAg NCs μg −1 is enhanced by 3000 times after embedding into SiO 2 microspheres ( D , 318 nm). Because noradrenalin has substantial inhibition effects to NIR-I ECL of GSH/LA/Au 6 PtAg/SiO 2 , 1.0 nM−0.1 mM noradrenalin was detected with the low limit of detection as 0.04 nM (S/N = 3) selectively. Biomolecules, glucose, ascorbic acid, or uric acid didn't interrupt the detection of noradrenalin. The sensitivity of this ECL method to detect noradrenalin is much higher than those in previous reports, enabling the early diagnosis of neurogenic diseases.
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JOURNAL OF MOLECULAR STRUCTURE
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2025
·
IF 4.7
Xinrong Li,Shuliang Chen,Xianzhi Hu,Futing Zi
A key challenge in the recovery of Au ions from thiosulfate gold leaching solutions is the design of adsorbents with abundant active adsorption sites, exhibiting high affinity and selectivity toward Au(I), thus enabling its fast, high-purity, and large-capacity recovery. Guided by theoretical calculations, in this study a polychloromethylstyrene (PCMS) material capable of supplying additional charges was functionalized by triethylamine (TEA) to selectively recover gold from a thiosulfate leaching solution. The adsorption of Au(S₂O₃)₂³⁻ onto the functionalized PCMS–TEA followed pseudo-second-order kinetics and was consistent with the Langmuir isotherm model, suggesting a single-molecular-layer chemisorption process. PCMS–TEA exhibited a significant Au-ion loading capacity (81.50 kg/t), highlighting the potential of benzene rings to enhance the charge intensity of ionic adsorbents. Furthermore, PCMS–TEA exhibited good Au-ion selectivity in a copper–ethylenediamine–thiosulfate Au leaching solution. The adsorption mechanism of Au ions on PCMS–TEA involved ion exchange between Cl − in the adsorbent and Au(S 2 O 3 ) 2 3− complex ions. The visual analysis of density functional theory results, based on the Multiwfn and Visual Molecular Dynamics programs, confirmed the presence of a weak interaction between PCMS–TEA and Au(S 2 O 3 ) 2 3− , dominated by van der Waals forces. After five desorption cycles, the adsorption rate of Au ions was approximately 90%, and NaCl was used as the elution reagent. This study introduces a promising adsorbent for the selective recovery of Au ions from thiosulfate Au leaching solutions.
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ACS Applied Nano Materials
·
2025
·
IF 5.5
Qi He,Qiuping Yang,Xiangyu Tong,Xiaotong Zhang,Yi Wang,Xiaohu Wu,Yanyun Ma,Yiqun Zheng
Precise spectral modulation of plasmonic absorptions in the near-infrared (NIR-I and NIR-II) regions is crucial for matching laser wavelengths in practical applications, driving significant interest in sensing, photothermal therapy, and bioimaging. In this work, we show that silver (Ag) alloying in gold (Au) nanosheets provides tunable plasmonic absorption across both NIR-I (700–950 nm) and NIR-II (1000–1350 nm) spectral windows while preserving their intrinsic two-dimensional morphology. Through controlled variation of the Ag/Au ratio in a seed-mediated synthesis, we observe a continuous blue-shift of the in-plane dipole plasmon resonance from 1000 nm (NIR-II) to 700 nm (NIR-I). Theoretical simulations confirm that Ag incorporation tunes plasmonic responses by modulating both the free electron density and local dielectric environment. This morphology-preserved alloying approach establishes a versatile platform for developing optically switchable nanomaterials with promising applications in multiplexed biosensing and wavelength-selective photothermal therapy.
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Cell Reports
·
2025
·
IF 6.9
Li Chai,Chaoqun Li,Xuefeng Wang,Yanyang Qin,Hemin Sun,Jie Du,Liu Yang,Dongmei Hu,Jianan Xiong,Zhiyuan Zhao,Rong Gong,Tao Wu,Meng Wu,Meng Nie,Jialin Gao,Jihui Jia,Chengjiang Gao,Wei Zhao,Huan Zhou,Dongwei Kang,Mutian Jia
Perturbation of energy metabolism is an essential feature during infection and inflammation. TANK-binding kinase 1 (TBK1) is crucial for initiating the innate immune response against viral infection, although aberrant and ongoing TBK1 activation induces excessive production of type I interferons (IFN-I). Nonetheless, the mechanisms whereby energy metabolism controls TBK1 activation remain unclear. Here, we elucidate a mechanism linking energy metabolism to the inhibition of TBK1-induced IFN-I responses via the immune response gene 1 (IRG1)-itaconic acid axis. Mechanistically, itaconic acid and its derivatives alkylated TBK1 at Cys605, thereby disrupting TBK1 dimerization and rapid activation. IRG1, the enzyme that catalyzes itaconic acid production, is upregulated during late-phase viral infection and acts as a feedback regulator to restrain TBK1 activity. We developed itaconic acid-based compounds ITA-5/ITA-9 as alternative TBK1 inhibitors. ITA-5/ITA-9 effectively limited excess IFN-I-mediated hyperinflammation. These findings provide a promising therapeutic strategy for treating diseases mediated by aberrant TBK1 activation.
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Small
·
2024
·
IF 13
Yi-Ran Du,Xiao-Qiang Li,Xian-Xia Yang,Guo-Yi Duan,Yong-Mei Chen,Bao-Hua Xu
In this study, the copper-nickel (Cu–Ni) bimetallic electrocatalysts for electrochemical CO 2 reduction reaction(CO 2 RR) are fabricated by taking the finely designed poly(ionic liquids) (PIL) containing abundant Salen and imidazolium chelating sites as the surficial layer, wherein Cu–Ni, PIL–Cu and PIL–Ni interaction can be readily regulated by different synthetic scheme. As a proof of concept, Cu@Salen-PIL@Ni(NO 3 ) 2 and Cu@Salen-PIL(Ni) hybrids differ significantly in the types and distribution of Ni species and Cu species at the surface, thereby delivering distinct Cu–Ni cooperation fashion for the CO 2 RR. Remarkably, Cu@Salen-PIL@Ni(NO 3 ) 2 provides a C2+ faradaic efficiency (FE C2+ ) of 80.9% with partial current density ( j C 2+ ) of 262.9 mA cm −2 at −0.80 V (versus reversible hydrogen electrode, RHE) in 1 m KOH in a flow cell, while Cu@Salen-PIL(Ni) delivers the optimal FE C2+ of 63.8% at j C2+ of 146.7 mA cm −2 at −0.78 V. Mechanistic studies indicates that the presence of Cu–Ni interfaces in Cu@Salen-PIL@Ni(NO 3 ) 2 accounts for the preserve of high-valence Cu(I) species under CO 2 RR conditions. It results in a high activity of both CO 2 -to-CO conversion and C–C coupling while inhibition of the competitive HER.
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ADVANCED MATERIALS
·
2025
·
IF 26.8
Tianrui Li,Baoling Tang,Jiance Jin,Kai Han,Haoran Zhang,Hailian Zhao,Xuejie Zhang,Maxim Molokeev,Yuzhen Wang,Zhiguo Xia,Bingfu Lei
Cu(I)-based halide scintillators are promising candidates for X-ray detection due to excellent scintillation and low-cost solution processability. However, the rational design of Cu(I)-based halide scintillators remains challenging due to insufficient theoretical frameworks elucidating their structure-property correlations. In this work, two Cu(I)-based hybrid metal halides, Cu 2 I 4 -IC (Ionic compound) are designed and Cu 4 I 4 -CC (Coordination compound) via bonding mode control engineering. The Cu 2 I 4 -IC exhibits blue emission, and the Cu 4 I 4 -CC exhibits yellow emission, and the photoluminescence quantum yield (PLQY) of Cu 2 I 4 -IC and Cu 2 I 4 -IC are 91% and 100% respectively. The non-radiative transitions are reduced due to the high rigidity of Cu 4 I 4 , resulting in a light yield up to 67 500 photons MeV −1 and a detection limit as low as 47.3 nGy s −1 of Cu 4 I 4 -CC. Additionally, a high-performance scintillator hydrogel based on Cu 4 I 4 -CC with polyvinyl alcohol (PVA),H 2 O and dimethyl sulfoxide (DMSO) is innovatively developed. Owing to the high transmittance, the large-area scintillator hydrogel film (10 × 10 cm 2 ) achieves an X-ray imaging resolution of 14 lp mm −1 . Furthermore, the synergistic effects of hydrogen bonding and coordination bonding endow the hydrogel scintillator with excellent plasticity and flexible stretchability. The Cu 4 I 4 -CC@PVA hydrogel proves promising for X-ray imaging with excellent stability in harsh environments, matching state-of-the-art scintillators.
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ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Xuefei He,Shuai Zhang,Yuzhen Wang,Kai Han,Zhiguo Xia
Hybrid luminescent metal halides has emerged as the state-of-the-art scintillators, while remaining challenges for enhancing light yield and X-ray imaging capability. Herein, halogen engineering is reported to optimize Cu(I)-based hybrid halides by enhancing the X-ray absorption cross-section, resulting in an increase of light yield by 188% to 79,770 photons MeV −1 from (C 12 H 30 N 2 ) 2 Cu 6 Cl 10 to optimized (C 6 H 15 N) 2 CuI 3 . The transparent glassy scintillation screen with optical transparency beyond 82% demonstrates good thermal stability and high mechanical flexibility. More importantly, the high X-ray imaging resolution of 20.5 lp mm −1 is achieved based on the Cu-I-based glassy scintillation screen. The combined merits of enhancing scintillation performance and X-ray imaging resolution provide a platform for developing halide glass scintillators and enriching their applications in radiology and security screening.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2020
·
IF 4.192
Li Hao,Xinchang Gao,Tingyi Zhou,Jinxuan Cao,Yangying Sun,Yali Dang,Daodong Pan
Umami peptides can help reduce the salt content in foods while still maintaining a savory taste. Few studies have reported the bioactivity of umami peptides after consumption. We studied the bioactivities of 12 umami peptides after gastrointestinal digestion. Three umami peptides exhibited angiotensin I-converting enzyme (ACE) inhibitory and antioxidant activity after digestion. Six novel peptides were identified from digestion solutions of the peptides by HPLC-MS/MS. Among them, CC, CCNK, and HCHT had both ACE inhibitory activity (IC50 values were 9.81, 9.00, and 114.99 μM, respectively) and antioxidant activity (strong 1,1-Diphenyl-2-pycryl-hydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) free radical scavenging activities). AHSVRF had strong ACE inhibitory activity. These peptides increased the nitric oxide concentration and decreased the content of endothelin-1 in a medium of human umbilical vein endothelial cells in a dose-dependent manner. Experiments with damaged HepG2 cells showed that peptides CC, CCNK, and HCHT had antioxidant activity through their cytoprotective effects and by reducing the reactive oxygen species content. The results indicated that umami peptides may provide many health benefits after consumption.
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ANALYTICAL CHEMISTRY
·
2020
·
IF 6.785
Jiao Cao,Shanyu Zhang,Jinyue Zhang,Sha Wang,Wendong Jia,Shuanghong Yan,Yuqin Wang,Panke Zhang,Hong-Yuan Chen,Shuo Huang
Gold(I) compounds are known to bind sulfur-containing proteins, forming the basis in the design of gold(I)-based drugs. However, the intrinsic molecular mechanism of the chemical reaction is easily hidden when monitored in ensemble. We have previously demonstrated that Mycobacterium smegmatis porin A (MspA) can be engineered (MspA-M) to contain a specialized nanoreactor to probe chemical reactions involving tetrachloroaurate(III). Here, we provide further investigations of coordination interactions between dichloroaurate(I) and MspA-M. Gold compounds of different coordination geometry and valence states are as well probed and evaluated, demonstrating the generality of MspA-M. With single-molecule evidence, MspA-M demonstrates a preference for dichloroaurate(I) than tetrachloroaurate(III), an observation in a single molecule that has never been reported. By counting the maximum number of simultaneous ion bindings, the narrowly confined pore restriction also efficiently distinguishes dichloroaurate(I) and tetrachloroaurate(III) according to their differences in geometry or size. The above demonstration complemented a previous study by demonstrating other possible gold-based single-molecule chemical reactions observable by MspA. These observations bring insights in the understanding of gold-based coordination chemistry in a nanoscale.
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ANALYTICA CHIMICA ACTA
·
2020
·
IF 5.977
Dengwang Luo,Chaoyu Zhang,Yao Fang,Yiping Shen,Yuan Liang,Yaokun Xia,Fang Wu,Xiaosong Chen,Jingrong Liu,Jinghua Chen,Chunyan Li,Jianming Lan
Phospholipase A 2 (PLA 2 ) may be a vital biomarker for the prediction and diagnosis of some diseases. Consequently, it is of great significance to quantitatively detect PLA 2 in biologic samples. Herein, on the basis of the principle of luminescence resonance energy transfer (LRET) between upconversion nanoparticles (UCNPs) and SYBR Green I (SG), we proposed a technology for the highly sensitive detection of PLA 2 amount. Therein, as an energy receptor, SG will be quantitatively loaded into liposomes firstly. Then, due to the hydrolysis of liposomes under the catalysis of PLA 2 , SG will be released and inserted into the double-stranded DNA (dsDNA) on the surface of UCNPs, which triggers the LRET because of the shortening of effective spatial distance between UCNPs and SG. Under exciting of NIR light, UCNPs emit luminescence at 476 nm, which makes SG emit fluorescence at 522 nm through LRET. Under optimal conditions, the emission intensity ratio (I 522 nm /I 476 nm ) increased linearly with the PLA 2 amount in the range of 20 U/L to 400 U/L, and the limit of detection (LOD) reached 15 U/L. Here, after comparing with the clinical standard method, it is found that the biosensor is expected to provide a convenient and sensitive assay for the detection of PLA 2 in actual serum samples. Furthermore, such biosensor can also be used to test the inhibitor of PLA 2 .
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CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Cheng Chen,Li Liu,Jing Guo,Lixiang Zhou,Yeqing Lan
Sulfur-doped copper-cobalt bimetallic oxides (S-CuYO) with abundant Cu(I) were successfully synthesized by a co-precipitation method and were for the first time utilized to activate peroxymonosulfate (PMS) for the degradation of chloramphenicol (CAP). For comparison purposes, sulfur-doped monometallic oxides (S-CuO and S-CoO) and non-doped copper-cobalt bimetallic oxide (CuCoO-1) were also prepared via the same processes. The results demonstrated that S-CuCoO had the highest catalytic activity among the catalysts. The sulfur-doped catalyst significantly improved the catalytic performance and stability. More than 98% of CAP (20 mg/L) was removed within 15 min at the initial pH = 5. The superior catalytic activity of S-CuCoO mainly resulted from the synergy of Cu(I) and Co(II). The presence of Cu(I) improved the conversion of Co(III) to Co(II), which maintained the high catalytic performance of S-CuCoO. In addition, the produced Cu(II) was further converted to Cu(I) by lattice oxygen (O 2− ), ensuring an adequate supply of Cu(I) in the catalyst. Radical quenching experiments revealed that both the SO 4 − and OH radicals were generated by the interaction of S-CuCoO with PMS, thereby contributing to the efficient degradation of CAP and the OH radicals played a larger role. The main intermediates of the CAP degradation were identified by high-performance liquid chromatography–mass spectrometry (HPLC-MS/MS). Theoretical calculations of the frontier electron densities (FEDs) were performed to determine the possible degradation pathways of CAP.
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