SYNTHETIC METALS
·
2014
·
IF 2.222
Peng Liu,Chao Yang,Xue Wang,Jinshan Guo,Baohua Hou
A facile method was developed for growing the alignment of polyaniline (PANI) nanofibers on three-dimensional (3-D) templates, via the chemical oxidative polymerization of aniline in dilute solution at 0–5 °C in presence of sulfonated polystyrene (SPS) microspheres and hydrochloric acid as template and dopant, respectively. Then the “hairy” PANI hollow microspheres were obtained after etching the templates with toluene. It was found that the formation of the “hairy” PANI hollow microspheres could be well controlled by altering the template concentration, thus the possible formation mechanism was deduced. The unique “hairy” PANI hollow microspheres prepared with the template concentration of 2.0 mg mL −1 possessed the specific capacitance of 298 F g −1 and the capacitance retention of 63.6% after 900 cycles.
研究领域:
材料科学
·
电化学
·
纳米技术
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Boheng Chen,Hongpo Liu,Huiyin Zheng,Che Liu,Zhuosen Wang,Yapeng Tian,Xinwei Cui
Lithium oxalate (Li 2 C 2 O 4 ) is regarded as a promising prelithiation agent due to its high specific capacity and cost-effectiveness. However, its intrinsically poor electronic conductivity and sluggish reaction kinetics result in a high lithium liberation potential (typically above 4.5 V), which challenges the stability of electrolytes and electrode materials, and deteriorates overall battery performance. In this work, the intermetallic NiBi 3 catalyst with metallic conductivity and strong interfacial interaction is introduced to promote the low-potential decomposition of Li 2 C 2 O 4 . Benefiting from the synergistic electronic effect between Ni and Bi, the incorporation of Bi effectively modulates the electronic structure of Ni sites via d – p orbital hybridization, thereby enhancing the adsorption and activation of Li 2 C 2 O 4 , weakening the Li 2 C 2 O 4 framework and facilitating its decomposition. When coupled with ultrahigh-Ni NCM96 cathodes, the NiBi 3 -Li 2 C 2 O 4 prelithiation system provides higher charge capacity (273.3 mAh g −1 ) and improved reaction kinetics compared to the pristine counterpart. Furthermore, full-cell configurations based on SiO x anodes exhibit enhanced lithium compensation capability, maintaining a capacity retention of 52.9% after 150 cycles at 0.5C. These results demonstrate that intermetallic NiBi 3 is an efficient catalyst for activating Li 2 C 2 O 4 and provides a viable strategy for developing high-performance cathode prelithiation systems. Download: Download high-res image (119KB) Download: Download full-size image
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Biomaterials Advances
·
2026
·
IF 6.7
Jie Shi,Hongyan Liu,Jiafan Bai,Wenzhen Peng,Jie Weng,Wei Zhi,Jianxin Wang,Min Jia
Engineered HA/D-Mannose nanoparticles with temporal dual-targeting for colitis stages. • Achieved colon-specific drug release via a pH-responsive shell overcoming oral barriers. • Simultaneously targets inflammatory macrophages and damaged intestinal epithelium. • A single nanoparticle enables triple therapy: antioxidant, anti-inflammatory, and barrier repair. • Achieved >80% mucosal healing in ulcerative colitis within 7 days. Ulcerative colitis (UC) is characterized by complex spatiotemporal heterogeneity, which poses significant challenges for effective treatment. Herein, we constructed DS-HDLTQs, a core-shell nanodelivery platform with dynamic dual-targeting capabilities. This platform utilizes hyaluronic acid (HA) and D-mannose (D-Man) to target acute inflammation and promote repair. It also features a dopamine-alginate (DA-SA, or DS) shell to achieve pH-responsive release specifically at colonic lesions. In animal experiments, DS-HDLTQs achieved 83.3% mucosal healing in just 7 days, significantly outperforming single-targeting systems. The DA-SA protective layer ensures pH-responsive release in the colon with an efficiency of up to 92.7%. Such therapeutic enhancement is driven by three synergistic mechanisms: molecular functional synergy (restoring antioxidants), spatiotemporal targeting-pathological process synergy (accelerating barrier reconstruction), and immune-epithelial repair synergy (promoting macrophage polarization and epithelial regeneration). DS-HDLTQs demonstrated a 12.7-fold increase in drug concentration at the lesion site. This design resolves the core contradiction between dynamic pathology and oral delivery efficiency, providing a new paradigm for UC treatment and potential applications in other inflammatory diseases. Download: Download high-res image (527KB) Download: Download full-size image
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ELECTROCHIMICA ACTA
·
2026
·
IF 5.8
Xiang-Dong Xie,Biao Hu,Zhi-Sen Tan,Chuan Wang,Hao Li,Qin-Hao Zhang,Hui-Song Hu,Pan Liu,Lu Ren,Xin-Kun Suo,Fa-He Cao
D-leucine-modified Zr-V coating suppresses localized corrosion of ADC12. • D-leucine seals defects and limits H 2 O/Cl – transport in the coating. • SECM reveals reduced oxygen-consuming local corrosion reactions. • DFT confirmed strong D-leucine adsorption and Zr–O interfacial anchoring on ZrO 2 . ADC12 aluminum (Al) alloy is prone to localized corrosion because its heterogeneous surface microstructure and unstable native oxide film induce spatially non-uniform electrochemical reactions at the alloy/electrolyte interface. Herein, a green D-leucine-assisted zirconium-vanadium conversion coating was fabricated on ADC12 Al alloy via a simple chemical immersion process to regulate coating formation and interfacial electrochemical corrosion behavior. D-leucine acted as a bio-derived interfacial modifier to regulate the deposition, defect evolution and interfacial bonding of Zr-containing oxide/hydroxide species. Surface analyses confirmed the incorporation of D-leucine into the conversion layer and its chemical interaction with Zr-containing species mainly through carboxyl groups, thereby promoting organic-inorganic coupling, defect sealing and coating compactification. The optimized ZRCC+0.5D-AA coating exhibited a low corrosion current density of 4.71×10 −8 A·cm −2 and a corrosion rate of 5.17×10 −4 mm·y −1 , approximately 195 times lower than those of the untreated ADC12 substrate. Scanning electrochemical microscopy further confirmed that D-leucine modification effectively suppressed localized oxygen-consuming corrosion reactions and reduced electrochemical heterogeneity on the coated surface. No visible corrosion was observed after 96 h neutral salt spray exposure. DFT calculations revealed strong dissociative adsorption of D-leucine on monoclinic ZrO 2 (−111), with the vertical bidentate configuration showing a dissociative adsorption reaction energy of −9.88 eV and pronounced interfacial charge redistribution. These results demonstrate that D-leucine-assisted interfacial modification simultaneously regulates coating defects, interfacial anchoring, and local electrochemical activity, providing an effective chromium-free surface finishing and protection strategy for Al alloys. Download: Download high-res image (411KB) Download: Download full-size image D-leucine-assisted interfacial modification suppresses localized electrochemical corrosion of zirconium–vanadium conversion coatings on ADC12 aluminum alloy. D-leucine coordinates with Zr-containing species to form a compact organic–inorganic hybrid interface, sealing defect-assisted pathways and reducing H 2 O/Cl⁻ ingress. This limits mass transfer, charge-transfer reactions, cathodic oxygen reduction, and anodic Al dissolution at the coating/substrate interface. DFT and SECM results reveal strong interfacial anchoring and reduced oxygen-consuming local corrosion activity, leading to optimal long-term protection for the coating containing 0.5 g/L D-leucine.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·Vol. 74
·期 33
·26532-26543
·
IF 6.7
Chen Yuehua,Liu Peng,Sheng Binbin,Xing Jiaxin,Ouyang Jia,Zheng Zhaojuan
Lignocellulosic
biomass is an abundant renewable resource that
is rich in aldohexoses and aldopentoses. Efficient biocatalysts for
aldopentose oxidation remain limited, and few enzymes exhibit high
catalytic efficiency toward both aldohexoses and aldopentoses. Here,
a naturally promiscuous pyrroloquinoline quinone-dependent glucose
dehydrogenase (PQQ-GDH) from Pseudomonas fragi NL20W was selected as an engineering template and tailored by semirational
design to expand aldopentose oxidation while preserving native d -glucose activity. The V706P/L723 M mutant exhibited markedly
enhanced catalytic efficiency toward d -xylose and l -arabinose, reaching 8.0- and 2.4-fold those of the wild-type, respectively,
while its efficiency toward d -glucose was 1.3-fold that of
the wild-type. Molecular simulations suggested that the improved catalysis
was associated with an optimized substrate positioning and enhanced
conformational flexibility of the active-site region. This study highlights
the significance of natural enzyme scaffold selection in substrate
scope engineering and expands the application potential of PQQ-GDH
in the sustainable valorization of lignocellulosic sugars.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2026
·
IF 19.7
Daoyue Xie,Junjie Ni,Huinan Che,Bin Liu,Yanhui Ao
The efficiency of photocatalytic O 2 activation for reactive oxygen species (ROS) generation is limited by kinetically sluggish electron transfer. Overcoming this limitation, we engineered a heterointerface (forming BaTiO 3 /Bi 12 O 17 Cl 2 , BTO/BOC) to facilitate d-p orbital hybridization by strain engineering, thereby creating a surface electron-rich region. Results demonstrate that strain engineering amplifies the d-p orbital hybridization effect, significantly enhancing O 2 adsorption strength. Furthermore, strain application enriches the electronic states near the Fermi level, enabling more electrons to migrate to the material surface to participate in O 2 activation. Consequently, the optimized BTO/BOC-3 exhibits exceptional ROS productivity, with 1.584 and 432.96 µmol g⁻¹ h⁻¹ yields for hydroxyl radical (·OH) and superoxide radical (·O 2 ⁻), respectively. This enables superior sulfamethoxazole (SMX) degradation performance, representing 2.88-fold and 11.08-fold enhancements over photocatalysis and piezo-catalysis, while toxicity simulations confirm reduced ecotoxicity of the degradation intermediates. This work pioneers a novel pathway for efficient piezo-photocatalytic ROS generation, enabling high-performance environment remediation.
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FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Peiying He,Bin Zhang,Xiong Fu,Rungtiwa Wongsagonsup,Namfone Lumdubwong,Qing Gao,Qiang Huang
As a high-value spice and medicinal compound, the volatilization and degradation of D-borneol during processing pose significant challenges in the food and pharmaceutical industries. Considering the size matching, pre-formed V-type starch (V 6 and V 7 -type carrier) was used to improve the retention and stability of D-borneol in different encapsulation methods (Wet, Semi-dry, and Dry). The semi-dry method used with the V 7 -type carrier exhibited the highest loading capacity (90.79 mg/g), significantly higher than those obtained via Wet (55.55 mg/g) and Dry (22.52 mg/g) methods. The good complexation was under the balance of restricted dissolution at the ratio of 6:20 (V 7 -type starch: ethanol, w/v) and mechanical grinding at 25 °C via semi-dry method. The complexes prepared with the semi-dry method below 25 °C and 50 °C showed the lowest D-borneol release rate, primarily governed by concentration diffusion. At higher temperatures (75 °C), the slow release of D-borneol depended on its stable binding with starch helical interaction. These findings highlight the potential of semi-dry encapsulation method as an effective strategy for stabilizing D-borneol and enabling its controlled release in functional food applications.
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JOURNAL OF FLUORESCENCE
·
2025
·
IF 3.1
Hoan Duong Quoc,Cuong Ngo Tuan,Vy Nguyen Thi Ha,Chi Mai Phuong,Thinh Nguyen Huu,Hieu Nguyen Trung,Thao Le Phuong,Vinh Nguyen Thi Ngoc,Hai Le Thi Hong
A novel benzo[ d ]thiazole derivative (B31) was synthesized via a green method. Aggregation–induced emission (AIE) behavior was investigated in a dimethyl sulfoxide (DMSO)/water mixture. The solution of B31 exhibited fluorescence emission at approximately 500 nm with maximum intensity observed at 40% water content. B31 functioned as a selective fluorescence chemosensor for Al 3+ ion with detection limit of 24 nM. In addition, a new complex [Al( B31 –2H)(NO 3 )] (AlB31) was prepared and characterized by electrospray ionization mass spectrometry (ESI–MS), infrared spectroscopy (IR), and proton nuclear magnetic resonance spectroscopy ( 1 H NMR) spectra. Notably, the quantum yields of AlB31 complex in DMSO was approximately 60-foldhigher than that of the free B31 ligand, accompanied a significant Stokes shift. Density functional theory (DFT) calculations were performed to rationalize the optical properties of the studied compounds. The weak fluorescence of B31 is likely caused by the rotation of the naphthalene ring around the –CH = N– bond in the S 1 excited state. A plausible photoemission mechanism for the AlB31 c omplex has also been proposed.
研究领域:
分析化学
·
材料科学
·
理论化学
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JOURNAL OF POWER SOURCES
·
2021
·
IF 9.127
Xiaochen Wang,Hualong Ma,Hanqing Peng,Yingming Wang,Gongwei Wang,Li Xiao,Juntao Lu,Lin Zhuang
H 2 –O 2 polymer electrolyte fuel cells (PEFCs) represent one of the most promising next generation renewable energy conversion technologies. Two of the remaining unsolved key issues relate to inefficient mass transport and water management when working at high current densities . These problems arise from the structure of the existing flow fields and gas diffusion layers (GDLs), as well as the counter propagating flow directions of gas reactants and liquid products. To address these issues, we propose a novel design of an integrated flow field-gas diffusion layer ( i -FF-GDL) generated by 3D printing of TiH 2 followed by high temperature decomposition . In this new i -FF-GDL design, a porous Ti “bone” structure is used to drive water transport through capillary action , while regularly printed gaps transport gases. Benefiting from the separate gas and liquid flow channels, APEFCs using our i -FF-GDL design exhibit up to a 15% increase in peak power density (PPD) under H 2 -air (CO 2 free) and H 2 –O 2 conditions, when compared to traditional APEFCs. Operando electrochemical impedance spectroscopy (EIS) reveals that the enhanced performance arises largely from an increase in the mass transport. This work provides new insights and strategies for achieving high efficiency mass transport for fuel cells, water electrolyzers and related technologies.
研究领域:
能源科学
·
材料科学
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ACS Nano
·
2026
·
IF 16
Kuo Sun,Ningxin Xiao,Shaojian Jiang,Kai Deng,You Xu,Ziqiang Wang,Liang Wang,Hongjie Yu,Hongjing Wang
Electrocatalytic alkynol semihydrogenation (EASH) represents a promising alternative to conventional alkenol production. However, it is plagued by severe overhydrogenation and a competitive hydrogen evolution reaction (HER). In this work, we synthesize a Pd3BiCx intermetallic carbide metallene (Pd3BiCx ene) as a high-performance electrocatalyst for the selective semihydrogenation of 2-methyl-3-butyn-2-ol (MBY). At −0.3 V vs RHE, the catalyst system achieves 94.1% conversion, 95.3% selectivity, and 90.4% Faradaic efficiency while maintaining long-term stability over 70 h. Mechanistic studies demonstrate that carbon doping induces synergistic p-d-p orbital hybridization among Pd, Bi, and C. This electronic structure modulation optimizes the adsorption energy of MBY while facilitating the desorption of 2-methyl-3-buten-2-ol (MBE). Furthermore, carbon doping kinetically hinders overhydrogenation by eliminating subsurface hydrogen species and increasing the energy barrier for the overhydrogenation step. Concurrently, this p-d-p hybridization stabilizes surface adsorbed hydrogen (H*ads), thereby promoting the hydrogenation pathway and suppressing the HER. This work establishes an effective catalyst design strategy for fabricating p-d-p orbital-hybridized intermetallic catalysts, offering an innovative approach for high-efficiency EASH.
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Journal for ImmunoTherapy of Cancer
·
2026
·Vol. 14
·期 5
·e014533
·
IF 11.7
Qindan Du,Zhen Han,Yumeng Zhang,Ying Li,Ao Sun,Bin Wang,Yongquan Chen,Xiaoying Wang
Background The N-terminal domain of gasdermin D (GSDMD) is a known suppressor of prostate cancer (PCa), primarily recognized for its tumoricidal pyroptotic function. However, research on the full-length GSDMD protein and its relationship with PCa remains unexplored. Therefore, the aim of this study was to investigate the potential non-pyroptotic mechanism of action of GSDMD in preventing PCa immune evasion. Methods The study used GSDMD deletion models to assess its impact on tumor progression and immune cell profiles. Molecular techniques, including protein interaction analysis, were employed to identify the binding partner of GSDMD and the subsequent signaling pathways. Correlative analysis was performed between GSDMD expression and immune markers in human PCa samples. Results GSDMD deletion increased tumor progression and reduced survival, cytotoxic T lymphocyte (CTL) activation/infiltration and tumor cell susceptibility to T-cell death, promoting an immunosuppressive tumor microenvironment (TME). GSDMD-bound laminin subunit gamma-2 (LAMC2), thus inducing its ubiquitin-mediated degradation. Consequently, GSDMD deficiency stabilized LAMC2, driving M2 macrophage polarization and CXC motif chemokine ligand 5 (CXCL5) secretion. CXCL5 interacted with CXCR2 to activate the AKT/NF-κB axis, increasing vascular endothelial growth factor (VEGF)/vascular endothelial growth factor receptor 2 (VEGFR2) and suppressing CTL activity. GSDMD expression in human PCa positively correlated with CD8 + T-cell infiltration and negatively with M2-phenotype tumor-associated macrophages. Conclusion This study reveals a novel non-pyroptotic pathway through which GSDMD inhibits PCa immune evasion by targeting LAMC2 for degradation, thereby preventing the establishment of an immunosuppressive TME. The findings suggest that activating GSDMD represents a promising therapeutic strategy to reprogram the TME from immunosuppressive (“cold”) to immunoreactive (“hot”), potentially enhancing the efficacy of immunotherapy in advanced PCa.
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Antioxidants
·
2026
·Vol. 15
·期 5
·652
·
IF 8.2
Haoyang Dai,Qinqin Zhang,Pei Chen,Suiqing Chen
The pathogenesis of acute liver injury (ALI) involves the loss of hepatic detoxification function, massive death of liver parenchymal cells within a short period, and excessive inflammatory responses. Studies have shown that Esculetin (Esc) possesses potent anti-inflammatory, antioxidant, and anti-tumor properties. In this study, we investigate whether Esc has a protective effect against ALI in mice and its potential mechanism. Esculetin markedly decreased ROS, MitoSOX, and apoptosis levels in AML12 cells and restored MMP. H&E staining demonstrated that Esc alleviated hepatic histopathological injury, and its intervention reduced serum ALT and AST levels. Moreover, Esc diminished ROS and apoptosis levels in the liver. Hepatic proteomic profiling identified the AMPK signaling pathway. Esc reduced the protein levels of p-AMPK/AMPK, PGC-1α, p-SIRT1/SIRT1, and BAX and upregulated the levels of Bcl-2 in liver tissue. Concomitantly, we added inhibitor Compound C (CC) to the AML12 cells to assess whether Esc acted through the AMPK pathway. The results showed that CC exacerbated the degree of liver injury, whereas Esc was able to reverse these phenomena, thus exerting an anti-liver injury effect. These findings provide mechanistic insights into the protective effects of Esc against ALI and support its potential as a therapeutic candidate for ALI.
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