JOURNAL OF CATALYSIS
·
2026
·
IF 6
De Xia,Hao Wang,Ben Li,Bing Lu,Yong Wang,Shanjun Mao
This study presents a novel Rh 7 Ni 1 P 4 /SiO 2 catalyst that significantly improves the hydroformylation of olefins, achieving a turnover frequency of 3433h −1 . By incorporating nickel (Ni) and phosphorus (P) into rhodium (Rh), the electronic structure of Rh was effectively modified, enhancing olefin adsorption and reducing CO binding energy. This dual modulation boosts catalytic performance by shifting the rate-determining step from CO insertion to acyl hydrogenation, thereby accelerating the reaction rate. Experimental results, supported by density functional theory (DFT) calculations, reveal that the Rh 7 Ni 1 P 4 /SiO 2 catalyst reduces Rh-CO interactions, minimizes rhodium leaching, and exhibits excellent stability over multiple cycles. This research advances the design of robust and efficient catalysts for industrial hydroformylation processes.
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产品关联
DOI
高影响因子
Journal of Advanced Research
·
2026
·
IF 13
Yimei Zheng,Boyu Chen,Xuanxiang Huang,Chao Ai,Hui Teng,Lei Chen
Introduction The poor bioavailability of luteolin, a potent flavonoid with antioxidant and anti-inflammatory properties, hinders its therapeutic potential. The primary barriers to its absorption are its low solubility and active efflux by P-glycoprotein (P-gp) in the gastrointestinal tract. Objectives To overcome these absorption barriers, we developed a functional self-microemulsifying drug delivery system (SME) incorporating D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), aiming to simultaneously enhance solubility, inhibit P-gp efflux, and improve the oral bioavailability and therapeutic efficacy of luteolin. Methods A TPGS-based luteolin-SME was prepared via self-assembly and characterized for particle size, stability, release profile, and antioxidant capacity. Cellular absorption mechanisms, permeability, and P-gp inhibition were evaluated using Caco-2 monolayers and molecular docking. Pharmacokinetics and biodistribution were assessed in rats, and therapeutic efficacy was examined in a lipopolysaccharide-induced inflammation model. Results The optimized luteolin-SME formed uniform nanodroplets (<50 nm) with high stability and achieved a 4.3-fold higher cumulative release compared to free luteolin. In Caco-2 cells, the formulation significantly enhanced cellular uptake and permeability, primarily via clathrin- and caveolae-mediated endocytosis, and effectively inhibited P-gp efflux. Pharmacokinetically, luteolin-SME provided a 29-fold increase in relative bioavailability (AUC 247.729 vs. 8.628 mg/L·h) and a 16-fold higher Cmax (27.546 mg/L) over free luteolin. In the lipopolysaccharide-induced inflammation model, luteolin-SME markedly attenuated oxidative stress, reducing the TNF-α, IL-6, and IL-1β levels by approximately 37%, 26%, and 39%, respectively. Conclusion The TPGS-functionalized SME effectively overcame the major absorption barriers of luteolin by integrating nanocarrier-enhanced solubilization with active P-gp inhibition. This dual strategy resulted in unprecedented oral bioavailability enhancement and potent efficacy. Our study establishes a robust and clinically promising delivery platform for luteolin and other poorly soluble, efflux-limited bioactive compounds, offering a practical approach to enhance oral therapy for inflammation-related diseases.
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DOI
PubMed
高影响因子
Scientific Reports
·
2020
·Vol. 10
·期 1
·1-12
·
IF 3.998
Bo Caiying,Shi Zhongyu,Hu Lihong,Pan Zheng,Hu Yun,Yang Xiaohui,Jia Puyou,Ren Xiaoli,Zhang Meng,Zhou Yonghong
A novel eco-friendly halogen-free cardanol-based flame retardant with P, Si, and N on the chain backbone (PSNCFR) was synthesized and incorporated into phenolic foams (PFs). PSNCFR was comprehensively investigated via Fourier transform infrared spectroscopy and nuclear magnetic resonance. PSNCFR endowed PFs with flame retardancy, contributed to generating a composite char defense against flames, and efficiently prevented smoking from PFs. PSNCFR introduction improved the flexural strength of the PFs to approximately 155% of that of pristine PF. PSNCFR-modified PFs displayed a high limiting oxygen index value of 41.9%. The results of cone calorimeter show that the mean heat release rate, mean effective heat of combustion, and total heat release of the PSNCFR-modified PFs reduced by 26.92%, 35.71%, and 31.25%, respectively. In particular, the total smoke production of the PSNCFR-modified PFs decreased by 64.55%, indicating excellent smoke inhibition. As for the mechanism, the condensation and gas phases during pyrolysis were responsible for the synergistic flame retardancy in the modified PFs. The findings demonstrate that PSNCFR can be used in PF preparation to overcome their drawbacks of internal brittleness and flammability.
研究领域:
材料科学
·
化学工程
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DOI
高影响因子
CELLULOSE
·
2020
·Vol. 27
·期 7
·4043-4052
·
IF 4.21
Wang Binshou,Shen Peiyan,Zhu Wenyuan,Pang Zhiqiang,Dong Cuihua
Size reduction of biomass is an energy-extensive operation for biorefinery, and fundamentals of size effect on biomass fractionation is pressing to be unraveled. Herein, we investigated effect of ground wood particle size on properties of biomass fractionation using p -toluenesulfonic acid ( p -TsOH) treatment. Both carbohydrates and lignin dissolution increased with smaller ground wood particle size. Comparatively, delignification performance was much affected by ground wood particle size, and the percentage of lignin dissolution was dramatically enhanced at small ground wood particle size. The excellent delignification selectivity was warranted at small ground wood particle size accordingly. In addition, mechanism of ground wood particle size effect on lignin dissolution was proposed. On one hand, dissolution of lignin by p -TsOH primarily was an aggregation effect, and diffusion of lignin from the microfibril network in biomass became growingly troublesome at large size. On the other hand, depolymerization of lignin mainly occurred in the liquid phase, which essentially led to production of large p -TsOH-lignin aggregates with low diffusivity.
研究领域:
生物化学
·
可再生资源工程
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DOI
高影响因子
OZONE-SCIENCE & ENGINEERING
·
2021
·
IF 2.562
Xiaojie Fu,Yuanxing Huang,Yaowei Wang,Manli Liang,Ya Yang,Zhihao Jin,Junhao Yang,Shouxun Hu,Liang Li
Catalyst of Fe–Co-layered double hydroxide (LDH) prepared by co-precipitation could effectively improve the degradation of pharmaceutical intermediate – p-toluenesulfonic acid (p-TSA) in the water during ozonation. The experimental results showed that under the condition of pH 7.9, catalyst dosage 0.1 g/L and aqueous ozone concentration 6.2 mg/L, 20 mg/L of p-TSA obtained a TOC removal percentage of 85%. To search for the mechanism of Fe–Co LDH catalytic ozonation and degradation of organic pollutants, hydroxyl radicals were measured with dimethyl sulfoxide (DMSO) and high-performance liquid chromatography (HPLC). The existence of hydroxyl radicals in catalytic ozonation system was also indirectly detected by observing the influence of quenching agents of HCO3− and PO43- on the p-TSA removal. Furthermore, we used electron paramagnetic resonance (EPR) to directly detect the hydroxyl radicals generated during the catalytic ozonation of p-TSA. The experiment results fundamentally revealed the mechanism of catalytic ozonation to degrade organic pollutants.
研究领域:
环境化学
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水处理技术
·
高级氧化工艺
·
催化
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DOI
高影响因子
ELECTROCHIMICA ACTA
·
2021
·
IF 6.901
Zhaoxiang Zhang,Shaoqi Li,Shilun Gao,Yiyang Pan,Xinyuan Shan,Hao Feng,Dandan Yang,Huabin Yang
Tin/phosphide (Sn/P) based alloys have been regarded as one of the promising anodes for advanced sodium-ion batteries due to their advantages of low-cost and proper redox potentials to Na/Na + . However, because of the serious volume expansion in the Na storage process, Sn/P-based materials generally suffer from rapid capacity decay during the cycle. Herein, a novel tin/phosphorus@graphite-carbon nanotubes (Sn/P@G-CNTs) composite was synthesized via a rational high-energy ball milling (HEBM) method. SEM and TEM results reveal that the separated Sn/P species are homogeneously dispersed in the G-CNTs matrix, which can accommodate large volume expansion and generate good electrical contact during cycle. As a result, the fabricated Sn/P@G-CNTs electrode exhibits a high reversible capacity (1048 mA h g −1 after 100 cycles at 100 mA g −1 ) with an initial Coulombic efficiency of 79.84% and good rate capability, better than those of Sn/P@G and Sn/P@CNTs counterparts. The design strategy and synthesis method of Sn/P@G-CNTs can provide an insight on constructing cost-effective sodium-ion batteries.
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2022
·
IF 10.319
Hongxiang Chen,Sheng Li,Jun Deng,Zhilong Zhang,Jianeng Huang,Fa Chang,Li Huang,Shixuan Du,Pinqiang Dai
321 phases are an atypical series of MAX phases, in which A = As/P, with superior elastic properties, featuring in the MA-triangular-prism bilayers in the crystal structure. Until now, besides Nb 3 As 2 C, the pure phases of the other 321 compounds have not been realized, hampering the study of their intrinsic properties. Here, molten-salt sintering (MSS) and solid-state synthesis (SSS) were applied to synthesize As/P-containing 321 phases and 211 phases. Analyzing the phase composition of the end-product via multiple-phase Rietveld refinement, we found that MSS can effectively improve the purity of P-containing MAX phases, with the phase content up to 99% in Nb 3 P 2 C and 75.4(5)% in Nb 2 PC. In contrast, MSS performed poorly on As-containing MAX phases, only 8.9(4)% for Nb 3 As 2 C and 64(2)% for Nb 2 AsC, as opposed to the pure phases obtained by SSS. The experimental analyses combined with first-principles calculations reveal that the dominant formation route of Nb 3 P 2 C is through NbP + Nb + C → Nb 3 P 2 C. Moreover, we found that the benefits of MSS on P-containing MAX phases are on the facilitation of three considered chemical reaction routes, especially on Nb 2 PC + NbP → Nb 3 P 2 C. Furthermore, the intrinsic physical properties and Fermi surface topology of two 321 phases consisting of electron, hole, and open orbits are revealed theoretically and experimentally, in which the electron carriers are dominant in electrical transport. The feasible synthesis methods and the formation mechanism are instructive to obtain high-purity As/P-containing MAX phases and explore new MAX phases. Meanwhile, the intrinsic physical properties will give great support for future applications on 321 phases.
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Dan Xu,Pengcheng Jian,Weijie Liu,Shizhou Tan,Yiming Yang,Meng Peng,Jiangnan Dai,Changqing Chen,Feng Wu
Modulating the electrical properties of two-dimensional (2D) materials is a fundamental prerequisite for their development to advanced electronic and optoelectronic devices. Substitutional doping has been demonstrated as an effective method for tuning the band structure in monolayer 2D materials. Here, we demonstrate a facile selective-area growth of vanadium-doped molybdenum disulfide (V-doped MoS2) flakes via pre-patterned vanadium-metal-assisted chemical vapor deposition (CVD). Optical microscopy characterization revealed the presence of flake arrays. Transmission electron microscopy, Raman spectroscopy, and X-ray photoelectron spectroscopy were employed to identify the chemical composition and crystalline structure of as-grown flakes. Electrical measurements indicated a light p-type conduction behavior in monolayer V-doped MoS2. Furthermore, the response time of phototransistors based on V-doped MoS2 monolayers exhibited a remarkable capability of 3 ms, representing approximately 3 orders of magnitude faster response than that observed in pure MoS2 phototransistors. This work hereby provides a feasible approach to doping of 2D materials, promising a scalable pathway for the integration of these materials into emerging electronic and optoelectronic devices.
研究领域:
材料科学
·
纳米电子学
·
光电子学
·
二维材料
·
半导体掺杂
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DOI
高影响因子
Journal of Building Engineering
·
2024
·
IF 6.7
Wenxin Wang,Shikun Chen,Xin Chen,Hao Qian,Yajun Zhang,Yi Liu,Dongming Yan
In this study, Mg–P coatings, prepared on steel alloy substrates, were exposed to temperature from 25 °C to 900 °C. The effects of high temperature exposure and the salt spray test on the anti-corrosion ability of Mg–P coating were investigated in detailed. The results show that the corrosion resistance of coatings decreases continuously from 25 °C to 700 °C, then increases at 900 °C of exposure. However, the corrosion resistance of coatings after 2000h salt spray test was significantly improved. In particular, the corrosion rate of the coating is only one-ninth that of the coating before the salt spray test when the temperature is 900 °C. Furthermore, the microscopic characterization test revealed that a dense oxide layer form between the steel alloy substrate and the coating when temperature exceed 400 °C. Besides the crystal phase transition and oxide layer , the synergistic effect of the secondary reaction of the raw material is the key factor to ensure that the coating still has good corrosion resistance at a high temperature.
研究领域:
材料科学
·
腐蚀工程
·
表面涂层
·
高温材料
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DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 138
·期 41
·51218
·
IF 3.125
Di Bao,Fei Xu,Yexiang Cui,Sicheng Yuan,Xiguang Zhang,Yanji Zhu,Yueyang Gao,Huaiyuan Wang
High loadings of fillers are usually needed to achieve high-thermal conductivity (TC) of polymer-based composites, which inevitably sacrifices processability and meanwhile causes high-cost. Therefore, it is of great significance to achieve high-TC composites under low-filler loading. Here, a novel p-phenylenediamine (PPD) modified expanded graphite (EG-PPD)/epoxy (EP) composite with high TC and low-filler content was successfully prepared via pre-dispersion and vacuum assisted mixing strategy. With the improved interfacial compatibility between EG and EP by PPD, the prepared EG-PPD/EP composite exhibited excellent thermal management performance, resulting in the TC of which reached 4.00 W·m −1 ·K −1 with only 10 wt% (5.59 vol%) of EG-PPD, which is approximately 19 times higher than that of pure EP. Meantime, the interface thermal resistance of EG-PPD/EP composite between EG-PPD and EP is reduced by 33% compared with EG/EP composite. This composite with excellent TC property is expected to be used in thermal management field.
研究领域:
材料科学
·
聚合物复合材料
·
热管理
·
纳米复合材料
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DOI
高影响因子
Journal of Materials Chemistry C
·
2018
·Vol. 6
·期 6
·1393-1398
·
IF 5.976
Shengbin Nie,Ao Liu,You Meng,Byoungchul Shin,Guoxia Liu,Fukai Shan
In this study, transparent p-type CuCrxOy semiconductor thin films were fabricated using spin coating and integrated as channel layers in thin-film transistors (TFTs). The structural, morphological components, and optical properties of CuCrxOy thin films, together with device performance, were systematically investigated. The phase conversion from a mixture of CuCr2O4 and CuO to pure CuCrO2 was achieved when the annealing temperature (Ta) was higher than 700 °C. The electrical performance of the CuCrxOy TFTs on SiO2 dielectric is improved with increasing Ta from 500 °C to 800 °C. The optimized CuCrO2 TFT exhibits an on/off current ratio of ∼105 and a hole mobility of 0.59 cm2 V−1 s−1, which is much better than those previous works on solution-processed binary CuxO TFTs. To our best knowledge, this work demonstrates the ternary p-type CuCrO2 TFTs fabricated via a low-cost solution process for the first time, which represents an important advancement towards the development of all-oxide, low-cost p–n junctions and CMOS logic circuits.
研究领域:
材料科学
·
半导体器件
·
薄膜技术
·
电子学
·
纳米技术
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DOI
高影响因子
Journal of Materials Chemistry A
·
2019
·Vol. 7
·期 16
·9665-9672
·
IF 10.733
Kanghua Li,Siyu Wang,Chao Chen,Rokas Kondrotas,Manchen Hu,Shuaicheng Lu,Chong Wang,Wei Chen,Jiang Tang
Sb2Se3 is a promising non-toxic, Earth-abundant, stable thin-film solar cell absorber material. However, the low built-in potential caused by the low intrinsic doping density (∼1013 cm−3) and the low carrier collection efficiency due to the low carrier mobility (∼1.5 cm2 V−1 s−1) hinder further efficiency improvement of Sb2Se3 solar cells. Therefore, an effective hole-transport layer (HTL) is necessary to further boost the built-in potential and assist carrier collection. Herein we attempt to improve the efficiency of Sb2Se3 solar cells by using CuSCN as an HTL. CuSCN as an HTL suppresses the back surface recombination, and enhances the built-in potential and carrier collection efficiency. Meanwhile, materials and physical properties characterization reveals that CuSCN provides Cu ions which induce grain boundary inversion, and therefore separate photo-generated carriers more efficiently. Consequently, we obtained a device efficiency of 7.50%.
研究领域:
光伏技术
·
材料科学
·
半导体器件
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DOI
高影响因子
危险品化学品经营许可证（带存储）