Scientific Reports
·
2017
·Vol. 7
·期 1
·1-10
·
IF 4.259
Huang Renkun,Liang Ruowen,Fan Haimei,Ying Shaoming,Wu Ling,Wang Xuxu,Yan Guiyang
With increasingly stringent environmental regulations, the removal of nitrogen-containing compounds (NCCs) from gasoline fuel has become a more and more important research subject. In this work, we have successfully synthesized TiO 2 /α-Fe 2 O 3 heterogeneous photocatalysts with different mass ratios of TiO 2
vs . α-Fe 2 O 3 . Taking photocatalytic denitrification of typical alkali NCCs, pyridine, in gasoline fuel under visible light irradiation (λ ≥ 420 nm) as the model reaction, the TiO 2 /α-Fe 2 O 3 hybrids have exhibited enhanced photocatalytic activity compared with pure TiO 2 and α-Fe 2 O 3 , giving a pyridine removal ratio of ∼ 100% after irradiation for 240 min. The improved photocatalytic performance can be attributed to the integrative effect of the enhanced light absorption intensity and more efficient separation of photogenerated electron-hole pairs. Importantly, this type of heterogeneous photocatalysts can be easily separate in the reaction medium by an external magnetic field that is very important for industrial purpose. In addition, major reaction intermediates have been identified by the liquid chromatograph-mass spectrometer (HPLC-MS) and a tentative photocatalytic denitrification mechanism has been proposed.
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CHEMICAL ENGINEERING JOURNAL
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2024
·
IF 13.3
Defu Yin,Zewei Hu,Mingya Liu,Jingyun Zhang,Hanli Zheng,Yunxi Hou,Shitao Yu,Lu Li,Shiwei Liu,Yue Liu
The highly stereoselective hydrogenation of α-pinene was very important and challenging in the utilization of natural products at mild conditions. Here, we reported a core–shell catalyst coated with Ir metal particles by mesoporous silica shell, and revealing the dependence of reducing agents during the preparation process. The prepared nano catalyst exhibited excellent performance in the hydrogenation of chiral substance α-pinene, especially under very mild conditions (40 °C, 1 MPa H 2 and 2 h), with a yield of cis -pinane reaching ∼99 %. The characterization methods revealed that the excellent performance was attributed to the strong hydrogenolysis ability of Ir particles. DFT results further indicated that α-pinene can stably adsorb on the edge sites of Ir metal in a cis structure, thereby achieving highly stereoselective hydrogenation. This work utilized heterogeneous catalysis to achieve performance close to that of homogeneous catalysts. The stable core shell structure greatly prolonged the lifespan of the catalyst and overcame the drawbacks of homogeneous catalysts. This work provided more reference cases for chiral hydrogenation.
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Polymers
·
2024
·Vol. 16
·期 23
·3254
·
IF 4.7
Jiaqi Wang,Zhaoyutian Chu,Sijia Zheng
Considering the demand for the construction of a sustainable future, it is essential to endow the conventional thermoset silicone adhesive with reuse capability and recyclability. Although various research attempts have been made by incorporating reversible linkages, developing sustainable silicone adhesives by natural linkers is still challenging, as the interface between the natural linker and the silicone is historically difficult. We exploited the possibility of utilizingα-lipoic acid, a natural linker, to construct a sustainable silicone adhesive. Via the simultaneous ring-opening reaction between the COOH and epoxide-functionalized silicone and the polymerization of theα-lipoic acid, the resulting network exhibited dynamic properties. The shear strength of the LASA90 presented strong adhesion (up to 88 kPa) on various substrates including steel, aluminum, PET, and PTFE. Meanwhile, reversible adhesion was shown multiple times under mild heating conditions (80 °C). The rheology, TG-DTA, DSC, and1H NMR showed that the degradation of the LASA occurred at 150 °C via the retro-ROP of the five-membered disulfide ring, indicating their recyclability after usage. Conclusively, we envision that a silicone adhesive based onα-lipoic acid as a natural linker is more sustainable than conventional silicone thermosets because of its desired properties, strong adhesion, reversibility, and on-demand heat degradation.
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ChemistrySelect
·
2024
·Vol. 9
·期 1
·e202304480
·
IF 1.9
Lu Xiong,Haisheng Hu,Meitang Liu,Lun Zhuang,Yunfei Li
Graphical The graphical summary shows the preparation of lithium carbonate from α -lithium pyroxene using an alkaline roasting process in a low-energy method. This new method achieves the full utilization of spodumene with lower energy consumption and demonstrates great potential for industrial applications. Extracting lithium from spodumene by sulfuric acid roasting is the largest commercialized way at present, which not only consumes a large amount of energy but also produces massive waste residue that will cause environmental problems. In this work, a new process for extracting lithium by directly decomposing α -spodumene through alkali calcination is designed. The reaction of α -spodumene with Na 2 CO 3 at 750 °C for 2 h can decompose it and form nepheline and lithium silicate/sodium silicate. The nepheline and soluble lithium silicate/sodium silicate are separated by water leaching, and 93.9 % of lithium can be leached under optimal conditions. In addition, the synthesis of nano-kaolinite is investigated with nitric acid solutions. Conversions of 98.7 % were obtained with 0.4 M nitric acid at 250 °C and an L/S ratio of 17.5 L/kg. The water leachate can precipitate Li 2 CO 3 with a purity of 99.0 % by CO 2 after desilicated by CaO. The final yields of Li 2 CO 3 and kaolinite relative to the Li and Si content of the starting minerals are 91.4 % and 48.5 %, respectively. This new method achieves the full utilization of spodumene with lower energy consumption and demonstrates great potential for industrial applications.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2024
·
IF 6
Yanan Wang,Xuezhi Tian,Zehua Zhang,Meiling Tian,Fusheng Zhang
The aim of this study is to enhance the efficiency of enzymes, reduce operational costs, and increase production output. Experimental research shows that ultrasound positively impacted the activity of α-amylase and glucoamylase, with the peak α-amylase activity observed at 30 W for 5 min and the highest glucoamylase activity at 60 W for 3 min. Ultrasonication extended the optimal temperature of both enzymes, but had no effect on the optimal pH. According to the kinetic experiments, ultrasonic treatment could improve the catalytic efficiency of α-amylase and glucoamylase. Furthermore, the SDS-PAGE results revealed that ultrasound treatment did not alter the molecular weights of the enzymes and their primary structures; The circular dichroism and fluorescence spectroscopy analysis indicated the secondary structural components, especially the α-sheet and the tryptophan fluorescence intensity, were notably affected by ultrasound. The changes in the secondary and tertiary structure of α-amylase and glucoamylase suggest that ultrasonic treatment may enhance their activities. Our findings provide a theoretical basis for the efficient utilization of α-amylase and glucoamylase through understanding the enzyme structure changes after ultrasound.
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MEDICINAL CHEMISTRY RESEARCH
·
2024
·
IF 2.6
Cheng Wenhui,Zhang Yuejuan,Chen Cheng,Gao Lei,Lv Yuwei,Yu Dian,Chen Bin,Wan Yi
The production of carbapenemases is a significant mechanism contributing to carbapenem resistance in Enterobacteriaceae . Among these carbapenemases, OXA-48 presents a distinct challenge and threat, as most β-lactamase inhibitors do not effectively inhibit its activity. In this study, we investigated the inhibitory potential of α-mangostin against OXA-48 with an IC 50 value of 0.52 μM. Enzyme activity assays demonstrated that α-mangostin inhibited OXA-48 reversibly through a non-competitive and dose-dependent inhibition mode. The docking analysis revealed that the 7-hydroxyl group of α-mangostin formed hydrogen bonds with Thr197 and Trp222, whereas the 5-hydroxyl group and the 4-carbonyl group interacted with Lys116 and Met115. Our study indicates that α-mangostin exhibits significant inhibition against OXA-48 and holds promise as a potential compound for the development of β-lactamase inhibitors.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2011
·
IF 2.78
Haiyan Wang,Dongyan Sun,Zhian Tan,Wu Gong,Lun Wang
In this work, an electrochemiluminescence (ECL) immunosensor for ultrasensitive detection of α-fetoprotein (AFP) was fabricated using Ru(bpy) 3 2+ -encapsulated liposome as the label and electrodeposited gold nanoparticles (GNPs) as the immobilizing support. Great signal amplification was achieved since liposome could encapsulate large amount of reporter molecules and GNPs could provide large active surface. Under optimized conditions, with sandwich type format, a linear range of AFP from 0.005 to 0.2 pg/mL and an extremely low detection limit of 0.001 pg/mL was obtained, much lower than that in previous reports. The proposed ECL immnuosensor showed high sensitivity, specificity, and good stability, which may open a new door to ultrasensitive detection of proteins in clinical analysis.
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MOLECULES
·
2024
·Vol. 29
·期 8
·1861
·
IF 4.2
Shuhui Niu,Fang Liu,Yaping Wang,Ben Rao,Yueying Wang
Alpha-ketoglutaric acid (α-KG), as an intermediate product of the tricarboxylic acid cycle, plays a crucial role in peptide and amino acid synthesis. In order to reduce costs and improve efficiency in the oxidative production of α-ketoglutaric acid, this study successfully synthesized and expressed L-glutamate oxidase (LGOXStr) fromStreptomyces viridosporusR111 and catalase (KatGEsc) fromEscherichia coliH736. Two immobilization methods and the conditions for one-step whole-cell catalysis of α-ketoglutaric acid were investigated. α-Ketoglutaric acid has broad applications in the pharmaceutical, food, and chemical industries. The specific research results are as follows: (1) By fusing the sfGFP tag, L-glutamate oxidase (LGOXStrr) and catalase (KatGEsc) were successfully anchored to the outer membrane ofEscherichia colicells, achieving one-step whole-cell catalysis of α-ketoglutaric acid with a conversion efficiency of up to 75%. (2) Through the co-immobilization of LGOXStrand KatGEsc, optimization of the preparation parameters of immobilized cells, and exploration of the immobilization method usingE.coli@ZIF-8, immobilized cells with conversion rates of over 60% were obtained even after 10 cycles of reuse. Under the optimal conditions, the production rate of α-ketoglutaric acid reached 96.7% in a 12 h reaction, which is 1.1 times that ofE. coli@SA and 1.29 times that of free cells.
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Polymer Chemistry
·
2024
·Vol. 15
·期 47
·4835-4841
·
IF 4.1
Yiyang Xiao,Zepeng Zhang,Yan Xu,Jianbo Wang
Here, α-styrylboronic acid pinacol ester (StBpin) has been found to undergo alternating radical copolymerization with electron-deficient olefin comonomers, including n-butyl acrylate, N,N-dimethylacrylamide, acrylonitrile, and N-ethylmaleimide. Compared with styrene, which also copolymerizes with these electron-deficient olefins in an alternating manner, StBpin resulted in the formation of copolymers with higher alternating selectivity, but lower yields and low molecular weights due to its diminished reactivity.
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Food Science and Human Wellness
·
2024
·
IF 5.6
Huafang Ding,Shouhe Huang,Chui Yiu Chook,Erika Kwek,Chi Yan,Kaying Ma,Jianhui Liu,Hanyue Zhu,Zhenyu Chen
α -Glucosidase inhibitors are effective in controlling postprandial hyperglycemia, which play crucial roles in the management of type 2 diabetes. Protocatechuic acid (PCA) is one of phenolic acids existing not only in various plant foods but also as a major microbial metabolite of dietary anthocyanins in the large colon. The present study investigated the inhibitory mechanism of PCA on α -glucosidase in vitro and examined its effect on postprandial blood glucose levels in vivo . Results from in vitro experiments demonstrated that PCA was a mix-type inhibitor of α -glucosidase. Driven by hydrogen bonds and van der Waals interactions, PCA reversibly bound with α -glucosidase to form a stable α -glucosidase-PCA complex in a spontaneous manner. The computational simulation found that PCA could insert into the active cavity of α -glucosidase and establish hydrogen bonds with catalytic amino acid residues. PCA binding aroused the steric hindrance for substrates to enter active sites and caused the structural changes of interacted catalytic amino acid residues. PCA also exhibited postprandial hypoglycemic capacity in diabetic mice. This study may provide the theoretical basis for the application of PCA as an active ingredient of functional foods in dietary management of diabetes.
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CONSTRUCTION AND BUILDING MATERIALS
·
2024
·
IF 7.4
Baolin Xia,Ruohan Shi,Wei Wang,Weijun Peng,Yijun Cao,Yukun Huang,Guixia Fan
A substantial stockpile of phosphogypsum (PG) not just consumes land resources, but also poses environmental contamination risks. Herein, the conversion of PG into high-value α-hemihydrate gypsum (α-HH) whisker by the atmospheric pressure salt solution method with simple process, high efficiency and low energy consumption was investigated. Sodium nitrate was found to accelerate the conversion of PG into α-HH, and sorbitol could modify the α-HH into rod-like morphology with high aspect ratios . The α-HH whiskers with an average length of 96.28 µm and an average aspect ratio of 25.47 were prepared within 1.5 h under the optimal parameters of 80 ℃, sodium nitrate-30 wt%, PG-12 wt%, and sorbitol-1 wt%. The modulation mechanism was that hydroxyl groups in sorbitol formed strong hydrogen bonds with the sulfate groups on the lateral of the crystals, which promoted the growth of α-HH along the c-axis. Moreover, the filtrate could be effectively recycled by adding salt medium and crystallization modifier. Such technique provides a theoretical basis for the high-value utilization of PG.
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MOLECULAR NUTRITION & FOOD RESEARCH
·
2025
·
IF 4.2
Yi Wang,Suqing Lan,Laiming Zhang,Yunxuan Li,Ziyang Deng,Xingqian Ye,Haibo Pan,Shiguo Chen
Scope: Polyphenols reportedly possess strong in vitro α-glucosidase inhibitory activity, even higher than acarbose, but their in vivo regulation on postprandial hyperglycemia is poor. So far this typical problem of polyphenols remains unsolved, greatly hindering their application as α-glucosidase inhibitors. Methods and results: Here, we identify the small intestinal mucus layer acts as a barrier to significantly reduce in vivo α-glucosidase inhibitory activity of epigallocatechin gallate, prodelphinidin B digallate (proDB DG), and proanthocyanidins from Chinese bayberry leaves. Multispectroscopy, rheology, solvent method, and molecular docking analysis showed that these pyrogallol-based polyphenols, especially proDB DG strongly interacted with small intestinal mucins through hydrogen bonding, hydrophobic interactions, and electrostatic interactions. These interactions block polyphenols from penetrating the mucus layer, resulting in their low binding rates with α-glucosidase in vivo. Besides, polyphenol-driven aggregation of the mucins enhanced the barrier function and reduced the permeability of the mucus layer, resulting in delayed digestion and absorption of carbohydrates. Conclusions: The mucus barrier weakens the inhibitory activity of pyrogallol-based polyphenols against α-glucosidase. Hence, overcoming the mucus barrier is a promising strategy to improve the regulation of pyrogallol-based polyphenols against postprandial hyperglycemia in vivo, which helps them to become novel α-glucosidase inhibitors in the clinic.
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