SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Xinlu Li,Yong Cao,Jie Tang,Yihan Zhao,Subhan Mahmood,Shun Yao
Snake shedding skin (snake molt) exhibits good potential for nutritional and functional applications, yet current methods for sustainable and efficient extraction of protein peptides from such an animal raw material are relatively limited. Herein, we reported novel foaming deep eutectic solvents (FDES) loaded effervescent discs for enriching target protein peptides in hydrolyzed extract of snake molt. Two kinds of natural sweeteners were used in the FDESs, which played an important role on foam stabilization and endowed FDESs with higher biocompatibility. After comprehensive characterizations, the discs exhibited good properties and expected forming performance. Under the ideal conditions, the effervescent discs enriched 91.40% protein peptides within 4 min, which was much higher than the alcohol precipitation method (40.12% within 3 d) and the aqueous two-phase system (80.67% within 1 h). Green assessment and scale-up experiments were also carried out for possible actual applications. Finally, the enriched product was analyzed by comprehensive physicochemical characterizations confirmed structural integrity and performance. The developed method offers a rapid, sustainable approach for obtaining peptides from natural products.
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Journal of Cleaner Production
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2026
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IF 10.7
Yan Zhou,Yue Zhao,Lin Su,Kangjia Sun,Jianguang Qi,Yinglong Wang,Yufeng Hu
Acetic acid is an irreplaceable raw material for the synthesis of key chemicals. However, its production is accompanied by the generation of large volumes of acidic wastewater, posing a significant environmental challenge. The strong polarity of acetic acid and water complicates its separation. The present study examines the effectiveness of binary and ternary deep eutectic solvents (DESs) in extracting acetic acid. A novel ternary DES composed of tri-n-butyl phosphate (TBP), tri-n-octylphosphine oxide (TOPO), and 1-Octanol was successfully synthesized and characterized using spectroscopic techniques. The ternary DES exhibited significantly higher extraction efficiency (up to 73.18 %) than the binary DES (TBP-1-Octanol), underscoring the synergistic effect of the third component. Cyclic extraction experiments demonstrated excellent recyclability, with a single-cycle efficiency loss of less than 2 % after six cycles. Molecular dynamics simulations further elucidated the extraction mechanism. This DES minimizes energy input and solvent emissions, thereby offering a low-energy, low-waste, and environmentally compatible alternative to conventional organic solvents.
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Food Science & Nutrition
·
2026
·
IF 5
Shuzhen Fang,Kangyi Zhang,Xiang Fang,Danqing Liu,Yulong Yang,Guijie Chen,Wenming Yang
Wilson's disease (WD) is a rare autosomal recessive disorder characterized by impaired copper metabolism and progressive multi‐organ damage. Emerging evidence suggests that gut microbiota dysbiosis and reduced microbial fermentation capacity may contribute to the progression of liver diseases. However, whether the gut microbiota can serve as a therapeutic target in WD remains unclear. This study aimed to investigate the modulatory effects of Lycium barbarum polysaccharides (LBPs), a bioactive component of the traditional Chinese medicine Gan‐Dou‐Fu‐Mu decoction, on gut microbiota composition and short‐chain fatty acids (SCFAs) production in WD, and to explore their potential as microbiota‐targeted prebiotic interventions. WD‐associated microbiota exhibited decreased microbial diversity and significantly lower SCFAs production, particularly acetic acid and total SCFAs, compared to healthy controls. LBPs supplementation significantly increased the relative abundances of beneficial genera, including Lactobacillus , Lacticaseibacillus , and Paraeggerthella , as well as SCFAs‐producing species such as Bacteroides fragilis and Lactobacillus delbrueckii . Notably, LBPs markedly enhanced acetic acid and total SCFA concentrations in WD microbiota, outperforming the standard treatment agent penicillamine. These findings highlight the promising prebiotic potential of LBPs and support their application as a novel microbiota‐targeted adjunctive therapy for WD. Schematic overview of the experimental workflow investigating the effects of LBPs on gut microbiota.
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Nanoscale
·
2026
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IF 5.2
Zewen Shen,Tao Jiang,Gehong Liu,Jiayi Liu,Yezi Hu,Haotian Zhang,Huihui Jin,Bingfeng Li,Shuxian Hu,Xiangke Wang,Guixia Zhao,Xiubing Huang
Nuclear energy has emerged as a vital clean energy source with super-high energy density. As a representative of fourth-generation nuclear reactors, High-Temperature Gas-Cooled Reactor (HTGR) generates substantial amounts of tetrahydrofurfuryl alcohol (THFA)-containing wastewater, for which effective treatment methods are rarely explored. Here, we present a selective and efficient approach employing anatase TiO2 as a photocatalyst to upcycle THFA into γ-hydroxybutyric acid (GHB), which can be used as a valuable bifunctional monomer to successful synthesize biodegradable poly(4-hydroxybutyrate). With optimized TiO2 catalyst, a THFA conversion of 87.6% and a GHB yield of 0.198 g/h/m2 were achieved. It was further elucidated that the •OH radicals generated by UV-excited TiO2 initiate the rapid transformation of THFA into GHB through two parallel pathways and the sluggish oxidation of GHB thereby facilitates its accumulation. The developed flow reactor could lead to the total conversion of THFA with GHB as main product that can be purified and separated, demonstrating the practical feasibility of the proposed strategy. This approach showcases the potential for converting THFA-containing wastewater into high-value chemicals through photocatalysis, offering an eco-friendly solution for THFA-containing wastewater treatment.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 4.1
Xiao Le,Zheng Yuanyuan,Jiang Xingyi,Wang Manyi,Luo Yanbo,Pang Yongqiang,Wang Hongjuan,Chen Di
This study presents a liquid-filled stick microextraction method with a built-in acidifier (LFSME-BA) that enables ready-to-use, pH-adjustment-free extraction of non-steroidal anti-inflammatory drugs (NSAIDs) from complex herbal matrices. Similar to an alcohol swab, the device contains an H 3 PO 4 -saturated hydrophobic deep eutectic solvent (DES) loaded inside a hollow plastic stick and a polypropylene fabric tip. Upon use, the acidified DES is released and absorbed by the fabric tip. When immersed in the sample solution, H 3 PO 4 gradually diffuses outward and, in the aqueous model solution used in this study, reduces the sample pH to approximately 1.97. This in situ acidification converts the NSAIDs from their ionized forms to their neutral molecular species, markedly increasing hydrophobicity, thereby facilitating their diffusion into the DES phase. Following desorption with 0.4 mL acetonitrile and LC–UV analysis, the LFSME-BA method provided excellent linearity ( R 2 ≥ 0.994, 20–2000 ng/mL), low detection limits (3.04–5.80 ng/mL), and satisfactory accuracy (93.7–102.5%) and precision (RSD ≤ 8.3%). Application to herbal oral liquids and granules yielded relative recoveries of 85.1%–108.8%, further confirming the method’s reliability. This ready-to-use, disposable platform combines extraction and pH self-regulation in one step, offering a simple and efficient approach for screening adulterated pharmaceuticals in herbal products. Graphical
The alternative text for this image may have been generated using AI.
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WATER RESEARCH
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2026
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IF 12.8
Liang Hu,Huimin Yu,Xiong Yang,Shulian Wang,Yafei Shi,Zhu Li,Kewu Pi,Gary Owens,Pan Wu
A global increase in freshwater scarcity coupled with a heterogeneous distribution of water treatment infrastructure highlights an urgent need for decentralized, low-energy water treatment solutions, particularly in remote off-grid regions. Here, a rooftop-based, solar-driven in situ rainwater evaporation and purification system (IREPS) was developed to address these issues. The system was enabled using a dual-network hydrogel (CSA-Fe), formed from chitosan and sodium alginate networks embedded with Fe₃O₄ nanoparticles. The coupling of rainwater harvesting during wet periods with solar-driven evaporation on sunny days, enabled the IREPS system to sustain an average water production flux of 4.1 kg m⁻² d⁻¹ and a peak flux of over 6.6 kg m⁻² d⁻¹ during a 70-day continuous outdoor trial. The collected water was suitable for drinking having consistently met the World Health Organization (WHO) drinking-water standards. The system was also relatively cost effective with a techno-economic analysis revealing a treatment cost of only USD 3.85 per cubic meter, significantly lower than other reported rainwater purification approaches. To assess global potential, the Solar Rainwater Purification Suitability Index (SRPSI) was calculated using multi-source geographic and socio-economic datasets coupled with machine learning, which identified Central Africa, South Asia and Southeast Asia as priority deployment regions. This work successfully demonstrated a practical, scalable strategy for decentralized rainwater purification that combined material design, system integration and global assessment, offering a feasible pathway for clean water access in remote, arid and resource-constrained settings.
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Frontiers in Pharmacology
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2026
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IF 5.4
Chenyang Jiang,Xinshu Feng,Mingyu Qi,Shaojuan Wu,Qiuyu Wang,Yawen Zhou,Xiaoshan Zheng,Zhuogui Liang,Jianhua Tan,Yudong Zhang,Qingquan Guo,Haishan Zhao
Licorice ( Glycyrrhiza genus ) is a traditional medicinal herb that has also been widely used in the food and cosmetic industries, leading to widespread human exposure. Currently, many components have been identified as active ingredients in licorice; however, the toxic impurities and quality markers still require further investigation. Glabrol has been identified as a potentially toxic component in glabridin (an extract from licorice). In this study, we sought to evaluate the toxicity of glabrol in commercial licorice extracts and investigated the toxicological mechanism. The content of glabrol and the acute toxicity in ten commercial licorice extracts from different vendors were quantified using HPLC. The toxicity was further verified in zebrafish, cells in vitro and mammals in vivo mouse models . For the in vivo experiments, C57BL/6 mice received daily oral gavage of licorice extracts with (Sample C: 319.23 μg/g) o low (Sample B: 1.54 μg/g) glabrol content for 7 days. Locomotion was assessed via Open Field Test and Elevated Plus Maze, followed by blood and organ collection for pathological and biochemical analyses. To investigate the toxicological mechanism of glabrol, RNA - seq was performed on zebrafish embryos exposed to glabrol. Morphological and histopathological evaluations in zebrafish treated with the glabrol standard were carried out using phalloidin staining, transmission electron microscopy, and alizarin red staining. Our results indicated that glabrol was detected in all tested commercial licorice extracts, and its content showed a significant positive correlation with toxicity in cells and zebrafish. In mice, licorice extracts with higher glabrol levels led to low survival rates, hypoactivity, acute liver and kidney injury, and significantly elevated plasma inflammatory cytokines. Transcriptomic and mechanistic studies revealed that glabrol disrupted AP-1 signaling pathways and may impair myo-fiber organization, osteoclast differentiation, and inflammatory responses. This study establishes glabrol as a prevalent risk-associated impurity in licorice extracts and reveals that its toxicity is mediated via the AP-1 signaling pathway.
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ACS Applied Energy Materials
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2026
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IF 5.5
Wenxin Shi,Qingmei Su,Xuan Li,Huayu Li,Siyu Wang,Weihao Shi,Liming Wang,Yinyin Song,Shan Yang,Gaohui Du,Miao Zhang,Wenqi Zhao,Bingshe Xu
The development of composite solid electrolytes with high ionic conductivity and superior interfacial stability is crucial for practical all-solid-state lithium metal batteries (ASSLMBs). Herein, a high-performance bilayer composite separator is designed by integrating Li0.33La0.557TiO3 (LLTO) nanofibers into a poly(vinylidene fluoride) (PVDF) matrix, which is coated onto a polyethylene (PE) substrate. The interconnected LLTO nanofibers construct three-dimensional continuous ion-conducting pathways and reduce the crystallinity of the polymer matrix, endowing the optimized separator (with 60 wt % LLTO) with a high ionic conductivity of 5.17 × 10–4 S cm–1, a large lithium-ion transference number (tLi+= 0.81), and a wide electrochemical stability window up to 4.87 V. The unique bilayer architecture, where the LLTO/PVDF layer facilitates rapid Li+ transport and the PE layer ensures interfacial compatibility, enables stable lithium plating/stripping over 500 h and yields a high critical current density of 2.9 mA cm–2. Furthermore, the robust mechanical properties of the separator ensure uniform lithium-ion flux and effectively resist lithium dendrite penetration. When applied in NCM811/Li metal battery, this modified solid-state electrolyte separator enabled remarkable cycling stability (89.8% capacity retention after 200 cycles at 5C) and exceptional rate performance (115.4 mAh g–1 at 5C). This work provides a feasible and effective strategy for designing composite separators toward high-energy-density and dendrite-free ASSLMBs.
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Wood Material Science & Engineering
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2026
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IF 1.9
Yuzhen Pan,Xinru Cui,Lu Zhang,Yuhui Zhang,Jianmin He,Zhongyang Bai,Yingcheng Hu
Densified wood holds great promise as a high-strength material for future construction; however, its practical application is severely constrained by poor fire resistance. Herein, this paper produced a high-strength and fire-resistant wood-based material by combining delignification, vacuum (phosphorylation) impregnation and hot-press densification techniques. With a density of 1180 kg/m³, densified phosphorylated wood is 2.74 times denser than natural poplar (430 kg/m³) and 1.25 times denser than densified wood (94 kg/m³).The bending strength and tensile strength of modified densified poplar wood reached 273 MPa and 208 MPa, respectively, representing 1.31 times and 1.14 times the values of densified wood, and the impact strength was 2.06 times that of densified wood. Furthermore, phosphorylation endows densified wood with outstanding flame-retardant properties. All modified wood achieved the highest flame-retardant grade (V-0) in the UL 94 vertical burning test. This superior performance is evidenced by a 29% reduction in total heat release (THR), a 96% decrease in total smoke production (TSP), and a limiting oxygen index (LOI) elevated to 42%, which is 1.68 times the value of natural wood. This modified densified wood exhibits favorable mechanical properties alongside its highly effective flame retardancy, demonstrating significant application potential in green building as well as furniture materials.
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Gels
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2026
·Vol. 12
·期 3
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IF 6.4
Yongxin Guo,Jianxun Ma,Yuhan Zheng,Gang Wang,Hongda Zhang,Yong Yu,Jinpeng Zhang
Sustainable agricultural techniques can ensure food security around the world. Hydrogel based soilless culture is an ecological and efficient alternative compared to conventional agriculture. Here, a multi-component hydrogel (pectin, Kelcogel, and chitosan/Se hydrogel, PKCH) was prepared by synthesizing natural biomolecules to cultivate dandelion for stimulate dandelion growth and improve nutritional value. The germination percentage of dandelion on PKCH (88.89%), was significantly higher than that in traditional hydroponics and pure Kelcogel (p< 0.05). Compared with hydroponics, the long-term dandelion cultivation experiments demonstrated that the PKCH cultivation mode enhanced root vitality, further increasing the growth and yield of dandelions (shoot length: 18.36 ± 0.30 cm, root length: 9.28 ± 0.21 cm, main root diameter: 0.94 ± 0.02 cm). The hydrogel substrate was associated with improved nutrient solubilization and sustained release, which may be linked to the accumulation of low-molecular-weight organic acids in the rhizosphere. Exogenous Se was effectively assimilated and transported to the above-ground parts of dandelion, which stimulated the photosynthetic efficiency and nutritional accumulation of dandelion. The polysaccharide content of dandelion reached 69.40 ± 0.13% (expressed as glucose-equivalent total sugars), which demonstrated the potential antioxidant properties and medicinal value. Technical economic analysis revealed the cost-effectiveness of PKCH synthesis and application. This study enriches the application of hydrogels in dandelion cultivation and provides an alternative approach for cultivating dandelion in soilless environments and medicinal crop production techniques.
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BIOSENSORS & BIOELECTRONICS
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2026
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IF 11.8
Binnan Shi,Zhuangzhuang Ru,Dehao Jia,Yu Du,Lihua Hu,Shuyuan Liu,Shan Wang,Hongying Jia,Qin Wei
An ultrasensitive electrochemiluminescence (ECL) biosensor was developed for the detection of the acute myocardial infarction (AMI) biomarker miRNA-499 by synergistically integrating an iridium-metallized covalent organic framework (Ir@TpBpy) with enzyme-assisted Y-shaped DNA amplification. The Ir@TpBpy COF was synthesized via post-metallization of a bipyridine-rich TpBpy framework with Ir(III) complexes. This design significantly enhances the ECL performance not only through material loading but also via a synergistic optimization strategy: (1) the conjugated framework constructs continuous charge transport pathways to accelerate electron transfer; and (2) the porous architecture induces a guest confinement effect that locally enriches the coreactant triethylamine (TEA), facilitating radical kinetics. Concurrently, a Y-shaped DNA amplification strategy, driven by Klenow fragment and Nt. Bbv Cl enzymes, facilitated exponential signal enhancement via cascade strand displacement reactions. The generated output strands triggered the displacement of pre-immobilized WO 3 /CuO quenchers from the electrode surface, thereby restoring the luminescence of Ir@TpBpy and achieving a sensitive “signal-on” readout. Benefiting from this dual-amplification approach, the biosensor achieved an exceptionally low limit of detection (LOD) of 0.81 aM across a linear range from 1 aM to 1 nM in human serum and cellular lysates. Clinical validation using Bland-Altman analysis demonstrated 95% agreement with qRT-PCR results, confirming that this synergy of coordination modulation and guest confinement offers a robust and precise platform for early AMI diagnosis.
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ENGINEERING GEOLOGY
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2026
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IF 10.3
Yu Liu,Simin Hu,Lezhang Wei,Dinggui Luo,Tangfu Xiao
The natural barrier properties of low-permeability clay layers have led to widespread interest in their application in the environmental field. Research on the protective and retardant effects of clay layers on low concentrations of highly toxic thallium is limited. A comparison revealed that the proportion of the active fraction of thallium in illite and montmorillonite was relatively low, indicating that these clays play an important role in thallium fixation. The focus of this work was an experimental investigation of the semipermeable membrane behaviour of illite and montmorillonite. Chemical osmotic differential pressure tests were performed at five thallium concentrations (0.5 mg/L to 50 mg/L), and the chemico-osmotic efficiency coefficients (ω) were calculated. Montmorillonite (ω, 0.048–0.651) has greater chemico-osmotic efficiency coefficients than illite (ω, 0.045–0.437). ω increased as the concentration of dissolved thallium decreased, indicating that the semipermeable membrane effects of the illite and montmorillonite layers were stronger at low thallium concentrations. The effective diffusion coefficients and retardation factors for thallium in illite and montmorillonite were calculated. The findings of this study must be considered in the context of ion competition effects within complex chemical environments. Studying the semipermeable membrane effect of clays on low concentrations of dissolved Tl may aid in clarifying the natural cleaning and barrier properties of clay, as well as support its potential use as an artificial remediation material.
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