Journal of Materials Chemistry A
·
2014
·Vol. 2
·期 25
·9559-9565
·
IF 0
Fei Xue,Zihui Meng,Fengyan Wang,Qiuhong Wang,Min Xue,Zhibin Xu
A novel 2-D photonic crystal (PC) sensing material for the visual detection of glucose with high selectivity at a physiological ionic strength (150 mM) is developed. A monolayer polystyrene crystalline colloidal array (CCA) is embedded in a phenylboronic acid (PBA) functionalized hydrogel film to diffract light to sensitively report on the hydrogel surface area. This 2-D PC sensor is superior to the previously reported 3-D PC sensors due to its fast preparation and simple detection. The binding of glucose would increase the cross-linking of the hydrogel that could shrink the hydrogel to increase the Debye diffraction ring diameter. At a physiological ionic strength of 150 mM, the 2-D PC sensor exhibits significant sensitivity for glucose across the entire human physiological glucose range. Additionally, the 2-D PC sensor shows high selectivity for glucose rather than other sugars (fructose and galactose). The diffraction color change of the 2-D PC sensor can be observed. For validation, the prepared 2-D PC hydrogel sensor is applied for the sensing of glucose in the artificial tear fluid.
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APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Wanan Cai,Xiaotong Wu,Tiandi Xiao,Haijun Niu,Xuduo Bai,Cheng Wang,Wen Wang,Yanhong Zhang
Herein, five kinds of soluble electrochromic polyarylates were synthesized from the reaction of N,N'-bis(4-carboxyphenyl)-N,N'-di-2-naphthyl-1,4-phenylenediamine with five bisphenols via direct polycondensation process, respectively. These new materials showed no significant decomposition below 400 °C in nitrogen atmosphere. The maximum UV–vis absorption bands of these polyarylates located at 328–348 nm and 327–353 nm for solid films and DMSO solution, respectively. The polyarylate 6a , as an example, exhibited not only aggregation-induced emission (AIE) effect in different fraction tetrahydrofuran/water solution, but also solvatochromism in various polar solvents, markedly. Two reversible pairs of distinct redox peaks were associated with noticeable color changed from original colorless to yellowish orange and green for polymeric film could be observed in the cyclic voltammetry (CV) test. New absorption peaks emerged in near–infrared (NIR) region with increasing voltage in the UV–vis spectra, which indicates these polyarylates can be used as NIR electrochromic materials. These polyarylates performed high contrast of optical transmittance change around 42–53% with the highest coloration efficiency up to 236 cm 2 C −1 .
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Drug Design Development and Therapy
·
2015
·
IF 3.028
Jing Sun,Xueqi Fu,Ye Liu,Yongsen Wang,Bo Huo,Yidi Guo,Xuefeng Gao,Wannan Li,Xin Hu
Background Honokiol is one of the main bioactive constituents of the traditional Chinese herbal drug Magnolia bark (Cortex Magnoliae officinalis , Hou Po). The aim of this study was to probe its anti-type 2 diabetes mellitus effects and the underlying mechanism. Methods Type 2 diabetic mouse model was established by intraperitoneally injecting with streptozotocin. Fasting blood glucose, body weight, and lipid profile were measured. The subcutaneous adipose tissue, skeletal muscle, and liver were isolated as well as homogenized. The phospho-insulin receptor β-subunit (IRβ), IRβ, phospho-AKT, AKT, phospho-ERK1/2, ERK1/2, phosphotyrosine, and actin were examined by Western blot assay. Cell viability or cytotoxicity was analyzed by using MTT method. The inhibitory potencies of honokiol on the protein tyrosine phosphatase 1B (PTP1B) activity were performed in reaction buffer. Molecular docking and dynamic simulation were also analyzed. Results In in vivo studies, oral treatment with 200 mg/kg honokiol for 8 weeks significantly decreases the fasting blood glucose in type 2 diabetes mellitus mice. The phosphorylations of the IRβ and the downstream insulin signaling factors including AKT and ERK1/2 significantly increase in adipose, skeletal muscle, and liver tissue of the honokiol-treated mice. Moreover, honokiol enhanced the insulin-stimulated phosphorylations of IRβ, AKT, and ERK1/2 in a dose-dependent manner in C2C12 myotube cells. Meanwhile, honokiol enhanced insulin-stimulated GLUT4 translocation. Importantly, honokiol exhibited reversible competitive inhibitory activity against PTP1B with good selectivity in vitro and in vivo. Furthermore, using molecular docking and dynamic simulation approaches, we determined the potential binding mode of honokiol to PTP1B at an atomic level. Conclusion These findings indicated the hypoglycemic effects of honokiol and its mechanism that honokiol improved the insulin sensitivity by targeting PTP1B. Therefore, our study may highlight honokiol as a promising insulin sensitizer for the therapy of type 2 diabetes.
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INORGANIC CHEMISTRY
·
2017
·
IF 4.857
Yi-Gang Chen,Mei-Ling Xing,Peng-Fei Liu,Yao Guo,Nan Yang,Xian-Ming Zhang
Two new phosphates—Cs6Mg6(PO3)18 (CMP) and Cs2MgZn2(P2O7)2 (CMZP)—have been obtained, using high-temperature molten methods. Crystals of CMP with the polar P21 space group display a new three-dimensional (3D) anionic framework possessing two one-dimensional (1D) [PO3]∞ chains that are interconnected by isolated MgO6 octahedra, while CMZP with centrosymmetric monoclinic space group P21/c possesses a new [MgZn2P4O20]14– structure unit consisting of two isolated P2O7 dimers, one ZnO4, and two disordered Mg/ZnO4 tetrahedral units. The polar phosphate CMP with deep-UV transparency (below 190 nm) shows weak second harmonic generation (SHG) response (0.1 × KDP), and the dipole moment analysis suggests that the weak SHG response mostly originates from much distorted CsOn polyhedron. Some related properties, such as optics, thermostability, and band structure derived from density functional theory, were explored.
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INSTRUMENTATION SCIENCE & TECHNOLOGY
·
2017
·
IF 0.874
Shuyan Niu,Yajie Fang,Kun Zhang,Juan Sun,Jun Wan
A facile and sensitive fluorescent strategy for the determination of dopamine is reported using 2, 3-diaminophenazine. Dopamine caused autooxidation in the presence of oxygen with catalysis by Mn2+ and formed 2, 3-dihydro-1H-indole-5,6-dione. 2, 3-Diaminophenazine provided relatively strong fluorescence. 2, 3-Diaminophenazine in aqueous solution caused fluorescence quenching when the aminochrome condensed with 2, 3-diaminophenazine to allow the determination of dopamine. Under the optimized conditions, the linear dynamic range for dopamine was from 2.0 × 10−6 mol · L−1 to 6.1 × 10−5 mol · L−1 with a detection limit of 1.76 × 10−6 mol · L−1.
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WATER ENVIRONMENT RESEARCH
·
2024
·Vol. 96
·期 2
·e10984
·
IF 2.5
Xinchao Ruan,Huan Wang,Fengyun Huang,Fanye Wang,Xiaojun Yang
In this study, a highly efficient peroxymonosulfate (PMS) activator, ZnO/ZnMn 2 O 4 , was synthesized using a simple one-step hydrothermal method. The resulting bimetallic oxide catalyst demonstrated a homogenous and high-purity composition, showcasing synergistic catalytic activity in activating PMS for degrading 2, 4-dichlorophenol (2, 4-DCP) in aqueous solution. This catalytic performance surpassed that of individual ZnO, Mn 2 O 3 , and ZnMn 2 O 4 metal materials. Under the optimized conditions, the removal efficiency of 2, 4-DCP reached approximately 86% within 60 min, and the catalytic ability remained almost constant even after four cycles of recycling. The developed degradation system proved effective in degrading other azo-dye pollutants. Certain inorganic anions such as HPO 4 − , HCO 3 − , and NO 3 − significantly inhibited the degradation of 2, 4-DCP, while Cl − and SO 4 2− did not exhibit such interference. Results from electrochemical experiments indicated that the electron transfer ability of ZnO/ZnMn 2 O 4 surpassed that of individual metals, and electron transfer occurred between ZnO/ZnMn 2 O 4 and the oxidant. The primary active radicals responsible for degrading 2, 4-DCP were identified as SO 4 •− , OH • and O 2 •− , generated through the oxidation and reduction of PMS catalyzed by Zn (II) and Mn (III). Furthermore, X-ray photoelectron spectroscopy (XPS) analysis of the fresh and used catalysts revealed that the exceptional electron transfer ability of ZnO facilitated the valence transfer of Mn (III) and the transfer of electrons to the catalyst's oxygen surface, thus enhancing the catalytic efficiency. The analysis of radicals and intermediates indicates that the two main pathways for degrading 2, 4-DCP involve hydroxylation and radical attack on its aromatic ring. Practitioner Points A bimetallic ZnO/ZnMn 2 O 4 catalyst was synthesized and characterized. ZnO/ZnMn 2 O 4 can synergistically activate PMS to degrade 2, 4-DCP compared with single metal oxide. Three primary active radicals, O 2 •− , • OH, and SO 4 •− , were generated to promote the degradation. ZnO promoted electron transfer among the three species of Mn to facilitate oxidizing pollutants. Hydroxylation and radical attack on the aromatic ring of 2, 4-DCP are the two degradation pathways.
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2020
·
IF 2.985
Ruixue Wang,Lianyun Lin,Yiqiang Zheng,Peng Cao,Zhiguang Yuchi,Hui-Yuan Wu
Cytosolic carboxypeptidases (CCPs) comprise a unique subfamily of M14 carboxypeptidases and are erasers of the reversible protein posttranslational modification– polyglutamylation . Potent inhibitors for CCPs may serve as leading compounds targeting imbalanced polyglutamylation. However, no efficient CCP inhibitor has yet been reported. Here, we showed that 2-phosphonomethylpentanedioic acid (2-PMPA), a potent inhibitor of the distant M28 family member glutamate carboxypeptidase II (GCPII), rather than the typical M14 inhibitor 2-benzylsuccinic acid, could efficiently inhibit CCP activities. 2-PMPA inhibited the recombinant Nna1 (a.k.a. CCP1) for hydrolyzing a synthetic peptide in a mixed manner, with Ki and Ki’ being 0.11 μM and 0.24 μM respectively. It inhibited Nna1 for deglutamylating tubulin, the best-known polyglutamylated protein, with an IC 50 of 0.21 mM. Homology modeling predicted that the R-form of 2-PMPA is more favorable to bind Nna1, unlike that GCPII prefers to S-form. This work for the first time identified a potent inhibitor for CCP family.
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IEEE SENSORS JOURNAL
·
2024
·
IF 4.3
Yunjie Cao,Xijie Feng,Wenbo Sui,Yufei Shi,Zihan Xie,Xinyan Xian,Jun Wu,Jun Zhou,Jie Dong,Changyu Shen
Mercury is a toxic heavy metal that can easily cause serious harm to human health and the environment. To quickly and sensitively measure the concentration of mercury ions (Hg
2+
), a fiber optic sensor based on Polyacrylamide/2-Thiophenecarboxaldehyde(PAM-TH)-functionalized Mach-Zehnder interferometer (MZI) is proposed and demonstrated experimentally. The prepared modified polyacrylamide and 2-Thiophenecarboxaldehyde are combined by Schiff base reaction to form a three-dimensional network hydrogel with specific binding properties for Hg
2+
. The ultra-sensitive Hg
2+
detection is realized by coating hydrogel on the surface of highly sensitive MZI based on polarization maintaining photonic crystal fiber. The experimental results verify a limit of detection of approximately 0.87 fM, which is two orders better than that of the reported fiber-based Hg
2+
sensors. Through the desorption of mercury ions in the sensor film by ethylenediaminetetraacetic acid (EDTA), the proposed sensor demonstrates good reusability under a wide dynamic detection range from 0.01 pM to 10 nM.
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Advanced Optical Materials
·
2024
·
IF 8
Muhammad Arif,Xu Liu,Zijian Li,Hangwei Jia,Yansheng Jiang,Zhihua Yang,Xueling Hou,Shilie Pan
Salts and co-crystals composed of planar π -conjugated functional units represent a fascinating class of materials, featuring both enlarged birefringence and a strong SHG effect. Herein, the optical properties of π -conjugated (C 4 H 7 N 3 ) 2+ functional unit within 2-aminopyrimidine (2-AP) family are investigated for the first time. Furthermore, twelve novel compounds are successfully synthesized by applying four different strategies. In these strategies, (C 4 H 7 N 3 ) 2+ , (C 4 H 6 N 3 ) + , and (C 4 H 5 N 3 ) functional units are introduced into the crystal structure, both solely and in combination, to analyze the alteration in birefringence. Remarkably, a birefringence rule with (C 4 H 7 N 3 ) 2+ < (C 4 H 6 N 3 ) + < (C 4 H 5 N 3 ), stating that an increase in net charge over π -conjugated functional unit leads to a reduced birefringence, is discovered. Consequently, the inclusion of a charge-neutral (C 4 H 5 N 3 ) functional unit within the crystal structure along with coplanar arrangement is a promising approach to enhance birefringence. Furthermore, D-2 [(C 4 H 5 N 3 )(H 3 C 3 N 3 O 3 )] realizes Δn calc = 0.412 maximum in the (2-AP) family. Notably, both A-1 [(C 4 H 7 N 3 )(CF 3 SO 3 ) 2 ] and B-1 [(C 4 H 6 N 3 ) 2 (IO 3 ) 2 (H 2 O)] crystalize in the non-centrosymmetric space groups, with B-1 exhibiting SHG efficiency of ≈1.4 × KDP @ 1064 nm, with the shortest λ PM at 384 nm. This work provides new insight into discovering novel birefringent and non-linear optical materials with high performances in the wide chemical space.
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MOLECULES
·
2024
·Vol. 29
·期 8
·1721
·
IF 4.2
Shoudong Wang,Lei Zhou,Hongyun Qin,Zixu Dong,Haoyuan Li,Bo Liu,Zhilu Wang,Lina Zhang,Qiang Fu,Xia Chen
Hydrofluorocarbons (HFCs) have important applications in different industries; however, they are environmentally unfriendly due to their high global warming potential (GWP). Hence, reclamation of used hydrofluorocarbons via energy-efficient adsorption-based separation will greatly contribute to reducing their impact on the environment. In particular, the separation of azeotropic refrigerants remains challenging, such as typical mixtures of CH2F2(HFC-23) and CHF3(HFC-32), due to a lack of adsorptive mechanisms. Metal–organic frameworks (MOFs) can provide a promising solution for the separation of CHF3–CH2F2mixtures. In this study, the adsorption mechanism of CHF3–CH2F2mixtures in TIFSIX-2-Cu-i was revealed at the microscopic level by combining static pure-component adsorption experiments, molecular simulations, and density-functional theory (DFT) calculations. The adsorption separation selectivity of CH2F2/CHF3in TIFSIX-2-Cu-i is 3.17 at 3 bar under 308 K. The existence of similar TiF62−binding sites for CH2F2or CHF3was revealed in TIFSIX-2-Cu-i. Interactions between the fluorine atom of the framework and the hydrogen atom of the guest molecule were found to be responsible for determining the high adsorption separation selectivity of CH2F2/CHF3. This exploration is important for the design of highly selective adsorbents for the separation of azeotropic refrigerants.
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JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
·
2025
·Vol. 39
·期 9
·e70449
·
IF 2.8
Dai Lizhi,Yu Tong,Wang Jingxuan,Li Youchong,Cao Zheyuan,Xiao Jianhua
2-ethylhexyl diphenyl phosphate (EHDPHP), a ubiquitous organic phosphorus flame retardant, is extensively employed in food packaging, flame retardancy applications, and other industrial processes as a crucial chemical. However, recent discoveries have underscored its diverse toxic effects, posing a severe potential threat to biological health. Skeletal muscle, vital for locomotion, relies heavily on proper differentiation during development and maintenance for strength and functionality. This study investigated the impact of EHDPHP on skeletal muscle differentiation by culturing C2C12 cells with varying concentrations of EHDPHP during induction of differentiation, as well as constructing a mouse muscle injury repair model through oral administration of 30 μg/kg EHDPHP for 7 weeks. Exposure to EHDPHP was found to impede skeletal muscle differentiation in mice. Utilizing techniques such as western blot analysis, RNA-seq, and qRT-PCR, our preliminary analysis revealed that low concentrations of EHDPHP inhibited the expression of ACTC1, subsequently suppressing MyoG and MYH2 expression levels, thereby hindering C2C12 myoblast differentiation. Furthermore, EHDPHP exposure disrupted the repair process of muscle injury in mice and compromised the integrity of the repaired tissue. In conclusion, these findings elucidate the detrimental effects of EHDPHP exposure on muscle differentiation, uncovering its muscle toxicity.
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POLYHEDRON
·
2025
·
IF 2.6
Chaochao Fan,Huanhuan Duan,Yue Wang,Wei Zuo,Wei Sun,Chuandong Jia
The assembly of hydrogen-bonded organic frameworks (HOFs) has been one of the focuses of supramolecular chemistry, while the HOFs based on organophosphate anion and neutral tecton have rarely been reported. Herein we utilized the emerging anion coordination-driven assembly (ACDA) strategy to successfully construct one novel two dimensional (2D) porous hydrogen-bonded organic framework ( 1 ) formed by the anion coordination of neutral and commercially available 2-benzimidazolone as hydrogen bonding donor, namely ligand L 1 , with organophosphate anion (PhOPO 3 2− ) as hydrogen bonding acceptor in a single-step crystallization. The assembly of organophosphate-directed 2D HOF was elucidated by single crystal X-ray diffraction analysis, in which the bridged water molecule played a significant role in respect of the formation of the O H⋯O hydrogen bonds and N H⋯O hydrogen bonding. Interestingly, TEA + cations were encapsulated within the aromatic cavities of the grid-like HOF mainly through C H⋯π interactions. This study is looking forward to furnishing new insights into the construction of hydrogen-bonded molecular frameworks with porosity utilizing anion coordination chemistry.
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