INORGANIC CHEMISTRY
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2017
·
IF 4.857
Yi-Gang Chen,Mei-Ling Xing,Peng-Fei Liu,Yao Guo,Nan Yang,Xian-Ming Zhang
Two new phosphates—Cs6Mg6(PO3)18 (CMP) and Cs2MgZn2(P2O7)2 (CMZP)—have been obtained, using high-temperature molten methods. Crystals of CMP with the polar P21 space group display a new three-dimensional (3D) anionic framework possessing two one-dimensional (1D) [PO3]∞ chains that are interconnected by isolated MgO6 octahedra, while CMZP with centrosymmetric monoclinic space group P21/c possesses a new [MgZn2P4O20]14– structure unit consisting of two isolated P2O7 dimers, one ZnO4, and two disordered Mg/ZnO4 tetrahedral units. The polar phosphate CMP with deep-UV transparency (below 190 nm) shows weak second harmonic generation (SHG) response (0.1 × KDP), and the dipole moment analysis suggests that the weak SHG response mostly originates from much distorted CsOn polyhedron. Some related properties, such as optics, thermostability, and band structure derived from density functional theory, were explored.
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INSTRUMENTATION SCIENCE & TECHNOLOGY
·
2017
·
IF 0.874
Shuyan Niu,Yajie Fang,Kun Zhang,Juan Sun,Jun Wan
A facile and sensitive fluorescent strategy for the determination of dopamine is reported using 2, 3-diaminophenazine. Dopamine caused autooxidation in the presence of oxygen with catalysis by Mn2+ and formed 2, 3-dihydro-1H-indole-5,6-dione. 2, 3-Diaminophenazine provided relatively strong fluorescence. 2, 3-Diaminophenazine in aqueous solution caused fluorescence quenching when the aminochrome condensed with 2, 3-diaminophenazine to allow the determination of dopamine. Under the optimized conditions, the linear dynamic range for dopamine was from 2.0 × 10−6 mol · L−1 to 6.1 × 10−5 mol · L−1 with a detection limit of 1.76 × 10−6 mol · L−1.
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CATALYSIS COMMUNICATIONS
·
2016
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IF 3.389
Xiaomin Xiang,Bin Zhang,Guoqiang Ding,Jinglei Cui,Hongyan Zheng,Yulei Zhu
The oxidation of furfural in H 2 O 2 and H 2 O 2 –Mg(OH) 2 system were systematically investigated and a rational explanation for the reaction mechanism was proposed. 2-formyloxyfuran, from selective oxidation of HC O group in furfural, was a crucial intermediate. The addition of Mg(OH) 2 suppressed the oxidation of furan ring of furfural and enhanced selectivities of 2(5H)-furanone (44.8%) and succinic acid (38.0%). FT-IR, Gaussian calculation and experimental results indicated that the process of furfural oxidation with H 2 O 2 is homogeneous, and the synergy between dissolved Mg 2 + cations and OH − ions facilitates the HOO − attacking the carbon atom of HC O other than the C C bound of furan ring.
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APPLIED SURFACE SCIENCE
·
2017
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IF 3.387
Wanan Cai,Xiaotong Wu,Tiandi Xiao,Haijun Niu,Xuduo Bai,Cheng Wang,Wen Wang,Yanhong Zhang
Herein, five kinds of soluble electrochromic polyarylates were synthesized from the reaction of N,N'-bis(4-carboxyphenyl)-N,N'-di-2-naphthyl-1,4-phenylenediamine with five bisphenols via direct polycondensation process, respectively. These new materials showed no significant decomposition below 400 °C in nitrogen atmosphere. The maximum UV–vis absorption bands of these polyarylates located at 328–348 nm and 327–353 nm for solid films and DMSO solution, respectively. The polyarylate 6a , as an example, exhibited not only aggregation-induced emission (AIE) effect in different fraction tetrahydrofuran/water solution, but also solvatochromism in various polar solvents, markedly. Two reversible pairs of distinct redox peaks were associated with noticeable color changed from original colorless to yellowish orange and green for polymeric film could be observed in the cyclic voltammetry (CV) test. New absorption peaks emerged in near–infrared (NIR) region with increasing voltage in the UV–vis spectra, which indicates these polyarylates can be used as NIR electrochromic materials. These polyarylates performed high contrast of optical transmittance change around 42–53% with the highest coloration efficiency up to 236 cm 2 C −1 .
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WATER ENVIRONMENT RESEARCH
·
2024
·Vol. 96
·期 2
·e10984
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IF 2.5
Xinchao Ruan,Huan Wang,Fengyun Huang,Fanye Wang,Xiaojun Yang
In this study, a highly efficient peroxymonosulfate (PMS) activator, ZnO/ZnMn 2 O 4 , was synthesized using a simple one-step hydrothermal method. The resulting bimetallic oxide catalyst demonstrated a homogenous and high-purity composition, showcasing synergistic catalytic activity in activating PMS for degrading 2, 4-dichlorophenol (2, 4-DCP) in aqueous solution. This catalytic performance surpassed that of individual ZnO, Mn 2 O 3 , and ZnMn 2 O 4 metal materials. Under the optimized conditions, the removal efficiency of 2, 4-DCP reached approximately 86% within 60 min, and the catalytic ability remained almost constant even after four cycles of recycling. The developed degradation system proved effective in degrading other azo-dye pollutants. Certain inorganic anions such as HPO 4 − , HCO 3 − , and NO 3 − significantly inhibited the degradation of 2, 4-DCP, while Cl − and SO 4 2− did not exhibit such interference. Results from electrochemical experiments indicated that the electron transfer ability of ZnO/ZnMn 2 O 4 surpassed that of individual metals, and electron transfer occurred between ZnO/ZnMn 2 O 4 and the oxidant. The primary active radicals responsible for degrading 2, 4-DCP were identified as SO 4 •− , OH • and O 2 •− , generated through the oxidation and reduction of PMS catalyzed by Zn (II) and Mn (III). Furthermore, X-ray photoelectron spectroscopy (XPS) analysis of the fresh and used catalysts revealed that the exceptional electron transfer ability of ZnO facilitated the valence transfer of Mn (III) and the transfer of electrons to the catalyst's oxygen surface, thus enhancing the catalytic efficiency. The analysis of radicals and intermediates indicates that the two main pathways for degrading 2, 4-DCP involve hydroxylation and radical attack on its aromatic ring. Practitioner Points A bimetallic ZnO/ZnMn 2 O 4 catalyst was synthesized and characterized. ZnO/ZnMn 2 O 4 can synergistically activate PMS to degrade 2, 4-DCP compared with single metal oxide. Three primary active radicals, O 2 •− , • OH, and SO 4 •− , were generated to promote the degradation. ZnO promoted electron transfer among the three species of Mn to facilitate oxidizing pollutants. Hydroxylation and radical attack on the aromatic ring of 2, 4-DCP are the two degradation pathways.
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FOOD RESEARCH INTERNATIONAL
·
2017
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IF 3.086
Yajing Fang,Fuqiang Liang,Kunyuan Liu,Shakeel Qaiser,Siyi Pan,Xiaoyun Xu
Flavonoids are a large group of polyphenols and widely distributed in plant foods. Flavonoids exhibit various biological activities, such as anti-cancer, antioxidant and anti-inflammatory while poor oral bioavailability has been considered as a major hurdle in their use as functional foods. Cellular uptake and efflux of flavonoid implicates their bioavailability. To investigate the cellular uptake and efflux of flavonoids, 27 flavonoids were measured for their cellular uptake in Caco-2 cells with (CUV) and without (CU) the inhibitor of P-glycoprotein (P-gp) verapamil. Then, a quantitative structure-absorption relationship (QSAR) model containing 21 compounds as training set was obtained from their corresponding CU. The model showed good robustness and predictivity with a high cross-validation coefficient (Q 2 ) value of 0.809 and Log of the octanol/water partition coefficient (SlogP) and atomic charge on carbon 5 (Q C5 ) were related to flavonoid uptake. The CUV of some flavonoids were significantly ( p < 0.05 or p < 0.01) higher than their CU, suggesting that specific flavonoids are pumped out by P-gp. The structure-affinity relationship of flavonoids as substrates of P-gp was determined with the presence of 4′-OCH 3 , 3′-OCH 3 and the absence of 3′-OH, 3-OH and 4′-OH favorable for the affinity of flavonoids. These results provide valuable information for screening flavonoids with good absorption and low affinity with transporters.
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PROCEEDINGS OF THE COMBUSTION INSTITUTE
·
2024
·
IF 5.3
Mengqi Wu,Zhongkai Liu,Zhaohan Chu,Xiaoqing Wu,Jiabin Huang,Jiuzhong Yang,Bin Yang,Feng Zhang
A combined experimental and theoretical study was conducted to investigate the weight growth routes from 2-naphthylmethyl radical to tricyclic aromatics. Co-pyrolysis of 2-(chloromethyl)naphthalene with two C 3 H 4 isomers (allene and propyne) were experimentally studied using the flash pyrolysis microreactor employing synchrotron vacuum ultraviolet photoionization mass spectrometry (SVUV-PIMS). Abundant propargyl radicals and naphthylmethyl radicals were detected in the two reaction systems. The similar signal intensities and photoionization efficiency spectrum curves of m/z = 180 (C 14 H 12 ) in both reaction systems are dominantly attributed to the products of the radical-radical reaction of 2-naphthylmethyl and propargyl. The possible candidates of m/z = 180 were assigned via the calculated adiabatic ionization energies . Further investigations on the kinetics of the radical-radical 2-naphthylmethyl + propargyl reaction indicate a severe competition among the adducts and tricyclic aromatics at the typical flame temperatures. At low pressures, the tricyclic C 14 H 11 radicals + H products possess overwhelming advantages, which may contribute to the formation of phenanthrene/anthracene or larger polycyclic aromatic hydrocarbons (PAHs) via the subsequent chain reactions. At atmospheric and higher pressures, most of the products are stabilized to the bicyclic adducts. The present work reveals a potential weight growth route from 2-naphthylmethyl radical to tricyclic aromatics, which should be considered in the model for the growth of PAHs.
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
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2024
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IF 2.6
Li Gang,Ren Haifang,Geng Chunping,Wu Xiang
Electrical energy storage devices (EES) play an important role in the development of portable electronic devices, power grids, and electric vehicles. Supercapacitors (SCs) become the focus of the EES field due to their high power density and high energy density. ZnCo 2 O 4 ternary metal oxides show considerable potential as electrodes for SCs. In this work, Ni(OH) 2 and PPy materials are combined on the surface of ZnCo 2 O 4 samples. The synthesized products possess a specific capacitance of 1256 C/g at 1 A/g and an energy density of 69 Wh/kg at 1350 W/kg. Moreover, the assembled device retains 81% of its capacity after being fully charged and discharged 10,000 times.
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JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
·
2025
·Vol. 39
·期 9
·e70449
·
IF 2.8
Dai Lizhi,Yu Tong,Wang Jingxuan,Li Youchong,Cao Zheyuan,Xiao Jianhua
2-ethylhexyl diphenyl phosphate (EHDPHP), a ubiquitous organic phosphorus flame retardant, is extensively employed in food packaging, flame retardancy applications, and other industrial processes as a crucial chemical. However, recent discoveries have underscored its diverse toxic effects, posing a severe potential threat to biological health. Skeletal muscle, vital for locomotion, relies heavily on proper differentiation during development and maintenance for strength and functionality. This study investigated the impact of EHDPHP on skeletal muscle differentiation by culturing C2C12 cells with varying concentrations of EHDPHP during induction of differentiation, as well as constructing a mouse muscle injury repair model through oral administration of 30 μg/kg EHDPHP for 7 weeks. Exposure to EHDPHP was found to impede skeletal muscle differentiation in mice. Utilizing techniques such as western blot analysis, RNA-seq, and qRT-PCR, our preliminary analysis revealed that low concentrations of EHDPHP inhibited the expression of ACTC1, subsequently suppressing MyoG and MYH2 expression levels, thereby hindering C2C12 myoblast differentiation. Furthermore, EHDPHP exposure disrupted the repair process of muscle injury in mice and compromised the integrity of the repaired tissue. In conclusion, these findings elucidate the detrimental effects of EHDPHP exposure on muscle differentiation, uncovering its muscle toxicity.
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JOURNAL OF DRUG TARGETING
·
2025
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IF 3.9
Jing Jiang,Yue Xing,Shumeng Liu,Yue Na,Xia Lei,Fang Geng,Yafeng Zhang,Lihong Yang,Ning Zhang
Naringin (4',5,7-trihydroxyflavanone-7-rhamnoglucoside, NG), a potential treatment for Alzheimer’s disease (AD), has strong neuroprotective effects but is limited by poor solubility, low bioavailability, and limited brain accumulation. To address these issues, we developed ANG-NG-NPs, a novel NG-loaded poly (ethylene glycol)-poly(ε-caprolactone) copolymers (PEG-PCL) nanoparticle modified with the brain-targeting peptide Angiopep-2 (TFFYGGSRGKRNNFKTEEY, ANG). ANG-NG-NPs exhibited an average size of 126.1 ± 4.50 nm, a zeta potential of -2.97 ± 0.29 mV, 73.43% ± 0.80% encapsulation efficiency (EE), and 24.68% ± 0.45% drug loading capacity (LC). In vitro release studies confirmed its sustained-release properties. In vivo, ANG-NG-NPs extended NG’s circulation time and increased brain uptake. Notably, ANG-NG-NPs restored learning and memory in APP/PS1 mice, improved hippocampal cell health, and reduced hyperphosphorylated tau protein (p-Tau) expression. These findings suggest ANG-NG-NPs as a promising brain-targeting system for treating central nervous system disorders.
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ChemistrySelect
·
2025
·Vol. 10
·期 20
·e01019
·
IF 2
Siqi Wang,Yazhou Wang,Yonggang Ji,Zhenye Li,Yueli Dai
Graphical This study investigated the reactivity of nickel phosphide, copper phosphide, and cobalt phosphide catalysts in the hydrodeoxygenation of furfural to 2-methylfuran. Appropriate acidic and adsorbent configurations were employed to facilitate the production of 2-methylfuran. Among the catalysts tested, the copper phosphide catalyst exhibited the highest selectivity for 2-methylfuran. A series of transition metal (Ni, Cu, and Co) phosphides were prepared by temperature programmed reduction method. The effect of the metal species and the initial P/Cu molar ratios on the catalytic activity of furfural hydrodeoxygenation was investigated, and the reaction conditions were optimized. Complete conversion of furfural was achieved under conditions of 220 °C and 15 bar for 4 h over Ni 2 P, CoP, or Cu 3 P catalysts. Notably, a selectivity of 95% of 2-methylfuran was attained when the Cu 3 P-3 was employed as a catalyst. The experimental results showed that a suitable P/Cu molar ratio could promote the conversion of the intermediate furfuryl alcohol to 2-methylfuran while avoiding the generation of overhydrogenation products. Under the optimal reaction conditions, the Cu 3 P-3 catalyst could be used for four times with only a slight decrease in catalytic performance.
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Drug Metabolism and Pharmacokinetics
·
2022
·
IF 2.041
Yu Wang,Haihong Hu,Jing Nie,Hui Zhou,Lushan Yu,Su Zeng
Bile acids , a series of amphiphilic molecules, can interact with several drug transporters and impact drug ADME . Organic anion transporter 2 (OAT2) is exclusively expressed in the liver and kidney. However, the interaction between bile acids and hOAT2 is unelucidated. In this study, we observed that chenodeoxycholic acid , deoxycholic acid , ursodeoxycholic acid , glycochenodeoxycholic acid (GCDCA), glycodeoxycholic acid , glycoursodeoxycholic acid (GUDCA), taurocholic acid (TCA), taurochenodeoxycholic acid (TCDCA), taurodeoxycholic acid , tauroursodeoxycholic acid could all inhibit uptake activity of hOAT2 while glycocholic acid (GCA) and cholic acid could not. Among them, TCDCA was the strongest inhibitor with IC 50 value of 23.01 ± 3.45 μM and GCDCA was the second with IC 50 value of 54.26 ± 5.47 μM. Meanwhile, GCA, GUDCA, TCA and TCDCA were identified as substrates of hOAT2. We further found that bile acid mixture (BA mix) could inhibit hOAT2-mediated uptake of cGMP, 5-fluorouracil, irinotecan and paclitaxel . BA mix could reduce the toxicity of paclitaxel to MDCK-hOAT2 cells. In addition, the uptake activity of three SNPs of hOAT2 (C329T, G571A, and G1514A) was all reduced. In conclusion, this study revealed bile acids could interact with hOAT2, providing new insight into the alteration of drug ADME and therapeutic effect mediated by hOAT2.
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